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Synthesis and In Vitro Cytotoxicity of 1-Azanthraquinone-3-Carboxamides

  • Lee, Hee-Soon;Lee, Chang-Wook;Yang, Sung-Il
    • Archives of Pharmacal Research
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    • v.22 no.4
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    • pp.380-383
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    • 1999
  • Five 1-azzanthraquinone-3-carboxamides were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines. The most active compound, 7b, exhibited cytotoxic activity comparable to doxorubicin.

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A Novel Synthetic Method for 3-Hydroxyhomoisoflavanone

  • Jew, Sang-Sup;Kim, Hyun-Ah;Park, Hyeung-Geun
    • Archives of Pharmacal Research
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    • v.20 no.2
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    • pp.144-147
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    • 1997
  • A novel synthetic method was developed for 3-hydroxyhomoisoflavanone. Treatment of aryllithium 14 to aldehyde 13 which was obtained from dihydroxylation of 10, followed by cycloetherification to give 3-hydroxyhomoisoflavanones.

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Total Synthesis of Fentanyl

  • Suh, Young-Ger;Cho, Kyung-Ho;Shin, Dong-Yoon
    • Archives of Pharmacal Research
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    • v.21 no.1
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    • pp.70-72
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    • 1998
  • Fentanyl of a potent anilidopiperidine analgesic has been synthesized from a simple phenyle-thylamine by four step sequence. The key part of this synthesis involves an efficient construc-tion of phenylethylpiperidone skeleton via aminomethano desilyation-cyclization followed by Swern oxidation.

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3',4'7-Trihydroxyflavone in Albizzia julibrissin

  • Prapaipit-Chamsuksai;Choi, Jae-Sue;Woo, Won-Sick
    • Archives of Pharmacal Research
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    • v.4 no.2
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    • pp.129-131
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    • 1981
  • From the steambark of Albizzia julibrissin, 3', 4' 7-trihydroxyflavone and .alpha.-spinasteryl-D-glucoside were isolated.

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Lingans from Korean Red Ginseng

  • Huh, Bong-Hee;Lee, Ihn-Ran;Han, Byung-Hoon
    • Archives of Pharmacal Research
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    • v.13 no.3
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    • pp.278-281
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    • 1990
  • Two lingans were isolated from hexane-soluble fraction of Korean red ginseng. Their chemical structures were elucidated as gomisin N and gomisin A by spectrometric analysis.

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A Lignan from Rubia akane

  • Han, Byung-Hoon;Park, Man-Ki;Park, Yeon-Hwa
    • Archives of Pharmacal Research
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    • v.13 no.3
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    • pp.289-291
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    • 1990
  • A lignan (+) isolariciresinol, was isolated from Rubia akane Nakai. This is the first reporting form Rubiaceae.

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