• Child Health Nursing Research
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• 제8권4호
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• pp.458-468
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• 2002

The purpose of this study was to identify metacommunicative behaviors between nurses and patients in a pediatric unit. The research method included observation using videotaping. Data were collected from December, 2001 to February, 2002. Total six nurses, and eight patients and their mothers in a pediatric unit participated in this study. The interactions were videotaped under the participants' consent. The participants were observed for total 8 hours over 2-day period. Special episodes which were identified as metacommunicative behaviors in the taped interactions were transcribed. Transcription included verbal and nonverbal interactions. Selected episodes were classified using Mitchell's definition. Each classified definitions were named, and categorized by its purpose. The results were as follows: Nineteen metacommunicative behaviors which used frequently by nurses-approaching, mediating eye level, eye contact, touching, encouraging, turnabout, mimic voice, giving choices, friendly demand, expansion, tagging, repeating and confirming, identification, reflection, baby talk, symbolization, description of acts, relaxed posture, turning away- were identified and organized into four categories. They were call for attention, facilitating response, empathy, and tension release. In conclusion, nurses in this study used metacommunicative behaviors frequently and these behaviors were effective in interacting with children. It is suggested that any educational programs to teach communication skills to nurses need to include techniques on metacommunicative behaviors. This will help nurses to be more sensitive to different characteristics of their patients.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2003년도 제2차 연례학술대회 발표논문집
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• pp.26-51
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• 2003

Large scale protein interaction maps provide a new, global perspective with which to analyse protein function. PSIMAP, the Protein Structural Interactome Map, is a database of all the structurally observed interactions between superfamilies of protein domains with known three-dimensional structure in thePDB. PSIMAP incorporates both functional and evolutionary information into a single network. It makes it possible to age protein domains in terms of taxonomic diversity, interaction and function. One consequence of it is to predict the most important protein domain structure in evolution. We present a global analysis of PSIMAP using several distinct network measures relating to centrality, interactivity, fault-tolerance, and taxonomic diversity. We found the following results: ${\bullet}$ Centrality: we show that the center and barycenter of PSIMAP do not coincide, and that the superfamilies forming the barycenter relate to very general functions, while those constituting the center relate to enzymatic activity. ${\bullet}$ Interactivity: we identify the P-loop and immunoglobulin superfamilies as the most highly interactive. We successfully use connectivity and cluster index, which characterise the connectivity of a superfamily's neighbourhood, to discover superfamilies of complex I and II. This is particularly significant as the structure of complex I is not yet solved. ${\bullet}$ Taxonomic diversity: we found that highly interactive superfamilies are in general taxonomically very diverse and are thus amongst the oldest. This led to the prediction of the oldest and most important protein domain in evolution of lift. ${\bullet}$ Fault-tolerance: we found that the network is very robust as for the majority of superfamilies removal from the network will not break up the network. Overall, we can single out the P-loop containing nucleotide triphosphate hydrolases superfamily as it is the most highly connected and has the highest taxonomic diversity. In addition, this superfamily has the highest interaction rank, is the barycenter of the network (it has the shortest average path to every other superfamily in the network), and is an articulation vertex, whose removal will disconnect the network. More generally, we conclude that the graph-theoretic and taxonomic analysis of PSIMAP is an important step towards the understanding of protein function and could be an important tool for tracing the evolution of life at the molecular level.

• 한국수자원학회논문집
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• 제53권spc1호
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• pp.755-764
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• 2020

현재 우리나라는 수자원단위지도의 표준유역(850개) 및 KRF의 집수구역(7,807개) 등의 기준 도면이 수자원 정책 수립의 기본 도면으로 활용되고 있으나, 물관리 일원화 시점에 맞추어 지표수-지하수의 연계 관리 및 수량-수질 통합관리를 위해서는 보다 적절한 규모의 표준 도면 설정이 필요해 보인다. 지표수에 비하여 지하수는 느린 이동 속도를 보이고 3차원 흐름 특성을 갖고 있으므로 지표수-지하수 연계 평가를 위해서는 광역적 규모의 유역 보다는 준 유역 규모가 보다 효과적인데, 표준유역보다 평균 면적이 작은 KRF 집수구역은 1차 또는 2차 지류를 포함하는 준 유역 규모에 해당한다. 그러나, KRF는 지표수 수계를 기준으로 구역을 구분하였기 때문에 넓은 평지 또는 높은 산악지역에서는 지나치게 작거나 큰 면적을 갖고 있다. 따라서, 지표수-지하수 연계 통합 관리에 적합한 단위 유역은 기존 KRF 집수구역을 수정하여 설정하는 것이 필요하다. 이로부터 설정될 개소 당 약 5 ~ 15 ㎢ 면적의 단위 유역은 지류의 구성과 관정의 위치를 고려할 때 지방자치단체의 수자원 관리의 기본 단위가 될 수 있으며, 물수요-공급 평가, 수문 계측 시스템의 배치, 지하수 허가 총량 기준, 오염의 평가, 정책의 우선 순위 결정 등 실질적인 수자원 통합관리의 기본 수단으로 활용 가능할 것이다.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2002년도 학술논문발표회
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• pp.91-96
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• 2002

This study is to investigate the insulation performance of lightweight concrete using recycled lightweight aggregate, to develop lightweight concrete products which have an excellence on the insulation performance are satisfied with properties of building materials. As a result of this study, recycled EPS aggregate is considered to have an independent pores which is closed by dense partitions. So, it is showed that the insulation performance of lightweight concrete using recycled EPS aggregate are excellent. Especially, in the case of lightweight concrete under conditions of replacement ratio over 100%, it is considered that insulation performance is very excellent as thermal conductivity is showed about 0.2kcal/mh$^{\circ}C$. According to considering the relation between ultrasonic pulse velocity, unit weight and thermal conductivity through the graph, the result of relation between ultrasonic pulse velocity, unit weight and thermal conductivity on the graph expressed their high interaction shown as direct proportion on the graph. So that it is possible to extract the insulation performance of lightweight concrete using recycled EPS aggregate by ultrasonic pulse velocity and unit weight.

• 한국실내디자인학회논문집
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• 제14권1호
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• pp.81-90
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• 2005

This study was intended to suggest the design guidelines of digital home on the basis of digital-related human behavior. In order to achieve this, what and how often internet was used in the home, how living pattern and space usage was changing according to digitalization were examined and lastly, the design guidelines of digital home based on these findings were suggested. The subjects were 400 housewives who lived In 85m'-sized housing unit of the new apartment complex in Busan. They were average age of 38 and their eldest children were in the stage of elementary schooling or preschooling. Many of them had relatively high educational level and middle income level. The results of the study were as follows; 1) The respondents used internet more frequently for information searching, children's education, and Internet shopping. Therefore, it would be desirable to divide zoning of housing unit into space for routine activities, space for working, and for cultural activities. 2) Digitalization changed human living pattern like follows; it reduced time of shopping, information searching, banking, and going out. Also, it increased time of spending alone, watching movie, and playing game. Therefore, digital home should be designed to facilitate social Interaction between family members, cultural and recreational activities, and indoor or outdoor exercise within each housing unit or in apartment complex.

• 한국컴퓨터정보학회논문지
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• 제28권11호
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• pp.125-134
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• 2023

본 논문은 함정 전투체계에서 효율적인 탐색레이더 연동단 설계 방법을 제안한다. 제안된 탐색 레이더 연동단은 함정 전투체계 소프트웨어에서 공용화 모듈(Module)을 표준화한 구조를 적용하였다. 링크(Link)별 오류탐지 기능을 구현하여 링크 단절시 링크 단절에 대한 인지 속도를 높였다. 또한 HCI(Human-Computer Interaction)를 위해 주기적으로 전송하던 메시지를 데이터그램(Datagram)의 변화가 있을 때만 송신하여 콘솔(Console)의 처리 부하를 줄일 수 있다. 특히 제안 방법은 함정에서 저가형 상용 탐색레이더 채택 등으로 프로세싱(Processing) 능력이 뛰어나지 못한 경우 사격에 대한 명중 확인 및 영점 조절과 관련하여 워터폴 스코프(Waterfall Scope)와 시간 제한 물기둥 인지 방법으로 탐색레이더의 기능을 보완해줄 수 있다. 이를 통해 운용자의 사격 명중 판단이 용이해지고, 오인지 확률을 줄일 수 있으며, 탐색레이더의 가용자원을 추가로 확보할 수 있다.

• Journal of Ship and Ocean Technology
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• 제6권1호
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• pp.27-33
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• 2002

Recently, the application of the electric propulsion system becomes popular because of its advantage over conventional propulsion. However, the complicated flow mechanism and interaction around the azimuth thruster are not fully understood yet, and the studies on the powering performance characteristics with azimuth/pod thrusters are now in progress. The experimental method developed in KRISO(Korea Research Institute of Ships & Ocean Engineering) is introduced and the results of the powering performance tests, consisting of resistance, self-propulsion and propeller open water tests for a cable layer with two azimuth thrusters are presented. For the analysis of powering performance with azimuth thrusters, it is necessary to evaluate the thrust/drag for components of a thruster unit, Extrapolation results could differ according to the various definitions of the propulsion unit; that is the pod, thruster leg and/or nozzle can be treated as hull appendages or as part of propulsion unit, The powering performances based on several definitions are investigated for this vessel. The results of the measurements for the 3-dimensional velocity distribution on the propeller plane are presented to understand the basis of the difference in propulsion characteristics due to the propeller rotational directions.

• 대한간호학회지
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• 제44권2호
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• pp.198-208
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• 2014

Purpose: This research was an empirical study designed to identify precursors and interaction effects related to nurses' patient identification behavior. A multilevel analysis methodology was used. Methods: A self-report survey was administered to registered nurses (RNs) of a university hospital in South Korea. Of the questionnaires, 1114 were analyzed. Results: The individual-level factors that had a significantly positive association with patient identification behavior were person-organization value congruence, organizational commitment, occupational commitment, tenure at the hospital, and tenure at the unit. Significantly negative group-level precursors of patient identification behavior were burnout climate and the number of RNs. Two interaction effects of the person-organization value congruence climate were identified. The first was a group-level moderating effect in which the negative relationship between the number of RNs and patient identification behavior was weaker when the nursing unit's value congruence climate was high. The second was a cross-level moderating effect in which the positive relationship between tenure at the unit and patient identification behavior was weaker when value congruence climate was high. Conclusion: This study simultaneously tested both individual-level and group-level factors that potentially influence patient identification behavior and identified the moderating role of person-organization value congruence climate. Implications of these results are discussed.

• Mass Spectrometry Letters
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• 제12권2호
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• pp.53-58
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• 2021

Previous in vitro studies have demonstrated that ginsenoside Rc inhibits UGT1A9, but there are no available data to indicate that ginsenoside Rc inhibits UGT1A9 in vivo. The effect of single and repeated intravenous injection of ginsenoside Rc was evaluated on the pharmacokinetics of mycophenolic acid. After injection of ginsenoside Rc (5 mg/kg for one day or 3 mg/kg for five days), 2-mg mycophenolic acid was intravenously injected, and the pharmacokinetics of mycophenolic acid and mycophenolic acid-β-glucuronide were determined. Concentrations of mycophenolic acid and its metabolite from rat plasma were analyzed using a liquid chromatography-triple quadrupole mass spectrometry. Single or repeated pretreatment with ginsenoside Rc had no significant effects on the pharmacokinetics of mycophenolic acid (P > 0.05): The mean difference in maximum plasma concentration (C_max) and area under the concentration-time curve (AUC_inf) were within 0.83- and 0.62-fold, respectively, compared with those in the absence of the ginsenoside Rc. These results indicate that ginsenoside Rc has a negligible effect on the disposition of mycophenolic acid in vivo despite in vitro findings indicating that ginsenoside Rc is a selective UGT1A9 inhibitor. As a result, ginsenoside Rc has little possibility of interacting with drugs that are metabolized by UGT1A9, including mycophenolic acid.

• 분석과학
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• 제35권2호
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• pp.60-68
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• 2022

In this study, we developed and validated a sensitive analytical method to quantify baphicacanthin A in mouse plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The standard calibration curves for baphicacanthin A ranged from 0.5 to 200 ng/mL and were linear, with an r² of 0.985. The inter- and intra-day accuracy and precision and the stability fell within the acceptance criteria. Besides, we investigated the pharmacokinetics of baphicacanthin A following its intravenous (5 mg/kg) and oral administration (30 mg/kg). Intravenously injected baphicacanthin A showed biphasic elimination kinetics with high clearance and volume of distribution values. Furthermore, baphicacanthin A showed a rapid absorption but low aqueous solubility (182.51±0.20 mg/mL), resulting in low plasma concentrations and low oral bioavailability (2.49 %). Thus, we successfully documented the pharmacokinetic properties of baphicacanthin A using this newly developed sensitive LC-MS/MS quantification method, which could be used in future lead optimization and biopharmaceutic studies.