• Molecules and Cells
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• 제37권3호
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• pp.213-219
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• 2014

MicroRNAs (miRNAs) represent a class of small non-coding regulatory RNAs that play important roles in normal hematopoiesis, including erythropoiesis. Although studies have identified several miRNAs that regulate erythroid commitment and differentiation, we do not understand the mechanism by which the crucial erythroid transcription factors, GATA-1and NF-E2 directly regulate and control differentiation via miRNA pathways. In this study, we identified miR-199b-5p as a key regulator of human erythropoiesis, and its expression was up-regulated during the erythroid differentiation of K562 cells. Furthermore, the increase of miR-199b-5p in erythroid cells occurred in a GATA-1- and NF-E2-dependent manner during erythrocyte maturation. Both GATA-1 and NF-E2 bound upstream of the miR-199b gene locus and activated its transcription. Forced expression of miRNA-199b-5p in K562 cells affected erythroid cell proliferation and maturation. Moreover, we identified c-Kit as a direct target of miR-199b-5p in erythroid cells. Taken together, our results establish a functional link among the erythroid transcription factors GATA-1/NF-E2, miR-199b-5p and c-Kit, and provide new insights into the coupling of transcription and post-transcription regulation in erythroid differentiation.

• 한국경제지리학회지
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• 제19권2호
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• pp.265-285
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• 2016

이 논문은 경북 동해안 지역금융시장을 분석하고 있다. 분석결과에 따르면 신용협동기구는 지역의 영세기업의 금융제약을 완화하기 위해 충분한 노력을 기울이지 않고 있다. 많은 논의는 신용협동기구가 지역에 밀착된 경영을 통해 자신의 경쟁력을 강화하고 나아가 안정적인 성장을 도모해야 한다고 제안한다. 그러나 현재 그들은 차입자의 사적인 정보를 획득하기 위한 노력을 충분히 기울이고 있지 않은 채, 신용평점제도와 담보에 의존하여 자금을 운용하고 있다. 이 자체 그들의 취약한 경쟁력의 근저에 놓여있는 문제이다. 이러한 문제를 극복하기 위해 신용협동기구는 지역사회개발에 적극 참여해야 한다. 다른 한편 정부도 이들의 육성에 힘을 기울여야 한다. 이들의 기능이 활성화될 때 지역금융시장의 효율성이 제고되고 지역경제도 순조롭게 성장할 수 있을 것이다.

• Architectural research
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• 제9권1호
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• pp.19-30
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• 2007

This study explores the issue of campus expansion of an urban university using an in-depth case study of New York University in New York City, USA. It investigates the physical pattern and development mechanism of the campus expansion process on a city grid structure. The three elements that characterize NYU's recent campus expansion, are (1) the university's commitment to building a student community around a public open space on a subway network, (2) four types of property acquisition and building development practiced by the university with private developers for space leasing, building renovation and development under changing local development circumstances, and (3) the city's initiative for attracting the private sector whose development activities influence the university's development dynamics. These findings suggest that the expansion planning of an urban university, due to its location in a city, should be placed on a local planning agenda, which can positively contribute to public goals through the collaborative engagement of the private and public sectors.

• 대한인간공학회지
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• 제25권4호
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• pp.153-157
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• 2006

The objective of this study was to establish a systematic ergonomic program for the prevention and control of work-related musculoskeletal disorders(WMSDs) in a machinery manufacturing company. The steps such as looking for the signs of WMSDs problems, setting the stage for action, training-building in-house expertise, gathering and examining the evidence of WMSDS, developing controls of health care management, and proactive ergonomic interventions were applied. The primary success factors were management commitment and encouragement, and harmonious union-management relations.

• International Journal of Advanced Culture Technology
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• 제11권2호
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• pp.82-108
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• 2023

As tension escalates between the US and China, scenarios for maintaining peace in Northeast Asia imply that secondary powers will perceive increasing incentives to reappraise their respective international roles. This analysis proposes that an analysis of France's Cold War role in Europe and the world under President Charles de Gaulle provides insights into conflict management in an increasingly multipolar international political environment. Their respective interests in preventing a so-called new Cold War emerging between the US and China include avoiding its excessive economic costs, if only because China is a massive trade partner. This study engages in theoretical framework-informed process tracing of de Gaulle's role. It explicates the assumptions that functionally underpinned de Gaulle's policy of soft balancing between the US and China. The analysis explores de Gaulle's contribution to the decay of the Cold War. It illuminates de Gaulle's contribution to a regional international environment that made West German Chancellor Willy Brandt's Ostpolitik strategy more feasible politically. This study applies these findings in the formulation of strategy recommendations focusing on Japan. Valid inferences regarding the predominant motivations driving American and Chinese international interaction are necessary for this task. To the extent to which the US and China have entered into a conflict spiral, Japan's hedging towards Washington is further incentivized. Tokyo would necessarily need to convince the Chinese that Japan is no longer Washington's unsinkable aircraft carrier off its coast. Tokyo, like de Gaulle's France, would maintain close relations with Washington, but it would need to project to its interlocutors its commitment to its own strategic autonomy. Tokyo's emphasis on closer relations with liberal democratic Indo-Pacific actors would potentially fit well with a commitment to strategic autonomy to defend the global liberal order.

• Journal of Plant Biotechnology
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• 제4권3호
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• pp.103-107
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• 2002

The Good Agriculture Practice (GAP) program, being established in China, is an optimal way for the sustainable utilization of the medicinal plant and animal resources. Most frequently used Chinese materia medica will be mainly produced from the GAP bases in the future. To assure the successful operation of GAP program, standard operating procedure (SOP) should be implemented for specific plants or animals. Both GAP and SOP include the requirements in many aspects from the ecological environment of cultivation place, germplasm and varieties, seedling and transplant, fertilization, irrigation, and field care, to harvest and process, package, transport and storage. As a complex system, GAP demands strong commitment from the pharmaceutical industry, local administrative involvement, long term R&D support, and years of time of development before a satisfactory result can be achieved.

• Environmental Engineering Research
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• 제15권2호
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• pp.105-109
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• 2010

The European Union (EU) Water Framework Directive (WFD) (2000/60/EC) was transposed into Irish law by Statutory Instrument Nos. 722 of 2003, 413 of 2005 and 218 of 2009, which set out a new strategy and process to protect and enhance Ireland's water resources and water-dependent ecosystems. The Directive requires a novel, holistic, integrated, and iterative process to address Ireland's natural waters based on a series of six-year planning cycles. Key success factors in implementing the Directive include an in-depth and balanced treatment of the ecological, economic, institutional and cultural aspects of river basin management planning. Introducing this visionary discipline for the management of sustainable water resources requires a solemn commitment to a new mindset and an overarching monitoring and management regime which hitherto has never been attempted in Ireland. The WFD must be implemented in conjunction with a myriad of complimentary directives and associated legislation, addressing such key related topics as flood/drought management, biodiversity protection, land use planning, and water/wastewater and diffuse pollution engineering and regulation. The critical steps identified for river basin management planning under the WFD include: 1) characterization and classification of water bodies (i.e., how healthy are Irish waters?), 2) definition of significant water pressures (e.g., agriculture, forestry, septic tanks), 3) enhancement of measures for designated protected areas, 4) establishment of objectives for all surface and ground waters, and 5) integrating these critical steps into a comprehensive and coherent river basin management plan and associated programme of measures. A parallel WFD implementation programme critically depends on an effective environmental management system (EMS) approach with a plan-do-check-act cycle applied to each of the evolving six-year plans. The proactive involvement of stakeholders and the general public is a key element of this EMS approach.

• 미술이론과 현장
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• 제7호
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• pp.125-163
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• 2009

The artworks of Socialist Realism of the former Soviet Union, with the beginning of the 21st century, are gaining a new attention from art collectors. One reason for this might consist in the fact that relevant art pieces exemplify the ways in which they visualize ideas on the basis of their high-profile art tradition and also in which they integrate their utopian ideals with mysticism. These aspects of the Soviet art goes far beyond the wide-spread assumption that their art, as a means of propaganda, principally represents a political allegiance to the system. With Stalin coming into power in the 1930s, the artistic trend of Socialist Realism obtained a nationwide sympathy and support from people, giving birth to a new art which essentially corresponded to the demands of the political power. An official art current of the USSR over the period from the 1930s to 1950s, Socialist Realism was in tandem with the Communist commitment to the party and popularity, symbolizing a loyalty to the cause. It was thus characterized by plainness and lucidity so that ordinary people could gain easy access to art. Its salient feature, over an entire range of art, was an optimistic pursuit of a utopian dream. Therefore, it tallied with the popular sentiment for a Communist paradise, giving form to their beliefs in human agency working at the materialist world and also to such abstract concepts as force, fitness, and beauty by adding even mythical ideals. Its main subject matter includes harvest feasts of collective farms, imaginary socialist cities, grand marches of heroic laborers and in this way it served as a propaganda for a sacred utopia of socialist totalitarianism. On the other end of the spectrum, however, rose the second camp of art, which put an emphasis on bona-fide artistic activities of plastic art and on an artist's personal expression and freedom, as opposed to the surface optimism of Socialist Realism. Central to the Russian Avant Garde art, which prized the above-mentioned values, were Malevich's Geometric Abstraction and A. Rodchenko's Constructivism. Furthermore, in the transitional era of the late 20th century and the 21st century it was recognized that film art or electronic media art, rather than traditional genre of paintings, would function as a more efficient way of propaganda. These new genres were made possible by ridiculing the stereotypes of the Russian lifestyle and also by ignoring ethical or professional dimensions of artworks. That is, they reinvented themselves into a sort of field art, seemingly degrading the quality of artworks and transforming them into artifacts or simulacres in the very sense of post-modernism. The advent of the new era brought about the formation and occupation of pop culture of the younger generations, calling into question the idea of art as the class-determined. It also increased the attention to field art, which extensively found way to modern art centers, galleries, and exhibition projects. It can be stated that this was a natural outcome of human nature.

• 환경영향평가
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• 제14권5호
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• pp.347-353
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• 2005

The risk assessment is the qualitative or quantitative evaluation of the risk posed to human health and the environment by the actual or potential presence or release of hazardous substances, pollutants or contaminants. The environmental impact assessment (EIA) is assessed by the environmental criteria, and risk assessment is assessed by the risk rate. Risk rate based on dose-response values may not be easy to apply on regulatory basis like EIA for uncertainty. Internationally there is an example of OECD program. Risk assessment of High Production Volume (HPV) Chemicals has started since the OECD Program with the 1990 Council Act on the Co-operative Investigation and Risk Reduction of Existing Chemicals. These HPV chemicals include all chemicals produced or imported at levels greater than 1,000 tonnes per year in at least one Member country or in the European Union region. The SIDS called the Screening Information Data Set is regarded as the minimum information needed to assess an HPV chemical to determine whether any further work should be carried out or not. All the data elements of SIDS including assessment for environment and health are prepared as three formats of the full SIDS Dossier, the SIDS Initial Assessment Report (SIAR), and the SIDS Initial Assessment Profile (SIAP) of an HPV chemical. In 1998 the global chemical industry through the International Council of Chemical Associations (ICCA) has joined to work with OECD. The OECD has assessed approximately 1,000 chemicals from 1991 through 2004 with ICCA. Till the February of 2005, 592 chemicals of those chemicals completed SIDS reports. Member countries have been targeted the goal of 1,000 new chemicals from 2005 to 2010 and Korea shared 36 chemicals from the 1,000 new chemicals. Currently Korea has completed SIDS reports of 7 chemicals among sponsored 24 chemicals. In conclusion SIDS project will be linked to national program for outputs application with more reliable production. Both the OECD and industry will carry out their commitment to complete assessments for more and the remaining chemicals assessment. The major outputs will contribute to cope with international chemical management.

• 항공우주정책ㆍ법학회지
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• 제21권1호
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• pp.135-167
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• 2006

유럽연합의 통합과정에서 대두되는 EU와 제3국과의 항공교섭 상에서 기존의 EU회원국가들이 체결하고 있는 제3국과의 양국간 항공협정의 처리에 관한 문제가 대두하고 있다. 2004년 4월 29일의 유럽재판소의 판결기준에 대한 국제항공 공법적 차원에서 기존의 국제항공질서의 변화를 모색할 필요성이 강력하게 등장하게 된다. 이러한 점에서 특히 미국과의 기존의 양자관계를 다자관계로 변경하여야 하는 문제가 중요하다. 한국과도 향후 협상에 중요한 참고사항이 될 것이다. 이러한 점에서 특히 유럽연합과 미국의 기존의 양자관계에서 다자간 관계로 변형시켜 나가는 문제가 향후 국제항공질서에 커다란 영향을 미칠 것으로 보인다. 이러한 관점에서 새로운 방향전환을 위한 국제항공질서를 재정립할 대안모색을 해 본다. 결론적으로 대안모색으로서는 첫째, 기존의 시카고 협약에서 설정된 하늘에 대한 자유에 추가적인 질서형성을 위해 양국간 협정의 표본인 Bermuda I, II에 대체할 수 있는 어떤 다자간 제3의 Bermuda III와 같은 국제항공질서를 설정해야 한다. 둘째, 새로운 다자간 협정에 적용되어야 할 하늘의 자유는 양측의 자유만을 최대한 보장하는 형태가 아닌 양측의 주장을 조절하는 구체적인 것이 되어야 한다. 셋째, 또한 새로운 다자간 국제항공질서는 단순한 지역적 경계를 넘어서 전 지구적 문제로 접근한다는 점에서 최근 사회과학 연구에서 등장하는 복잡계이론을 도입할 필요가 있다. 이와 같은 대안모색에서 필요한 사항들을 점검하고 입장차를 줄여 나가는 방향으로 정리되어야 할 것으로 본다.