• Journal of Pharmaceutical Investigation
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• v.27 no.4
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• pp.303-311
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• 1997

Proliposomal patch of clenbuterol, ${\beta}_2-agonist$ bronchodilator, was prepared and its feasibility as a novel transdermal drug delivery system was examined. Proliposomal granules containing clenbuterol was prepared by a standard method using sorbitol and lecithin with (Rx 2) or without cholesterol (Rx 1). The porous structure of sorbitol in the proliposomes was maintained allowing tree flowability of the granules. Following contact with water, the granules were converted probably to liposomes almost completely within several minutes. It indicates that proliposomes may be hydrated, when they are applied on the skin under occlusive condition in vivo, by the sweat to form liposomes. Clenbuterol release from Rx 1 and Rx 2 proliposomes to pH 7.4 isotonic phospate buffer (PBS) across cellulose membrane (mol. wt. cut-off of 12000-14000) was retarded significantly compared with that from the mixture of clenbuterol powder and blank proliposomes. Interestingly, proliposomes prepared with lecithin and cholesterol (i.e., Rx 2 proliposomes) showed much more retarded release of clenbuterol than proliposomes prepared only with lecithin (i.e.. Rx 1 proliposomes), indicating that clenbuterol release from proliposomes can be controlled by the addition of cholesterol to the proliposomes. Proliposomal patches were prepared using PVC film as an occlusive backing sheet, two sides adhesive tape (urethane, 1.45 mm thickness) as a reservoir for proliposome granules and Millipore MF-membrane (0.45 mm pore size) as a drug release-controlling membrane. Rx 1 or Rx 2 proliposomes containing 4.6 mg of clenbuterol were loaded into the reservoir of the patch. Clenbuterol release from the patches to pH 7.4 PBS was determined using USP paddle (50 rpm)-over-disc release method. Clenbuterol release from the proliposomal patches was much more retarded even than from a matrix type clenbuterol patch (Boehringer Ingelheim ltd). Being consistent with clenbuterol release from the proliposomal granules, the release from the patches was highly dependent on the presence of cholesterol in the proliposomes : Patches containing Rx 2 proliposomes showed several fold slower drug release than patches containing Rx 1 proliposomes. When the patch containing Rx 1 proliposomes was applied on to the back of a hair-removed rat, clenbuterol concentration in the rat blood was maintained during 6-72 hrs. Transdermal absorption of clenbuterol from the patch was accelerated when the patch was prehydrated with 50 ml of pH 7.4 PBS before topical application. Above results indicate that sustained transdermal delivery of clenbuterol is feasible using proliposomal patches if the cholesterol content and pore size of the release rate-controlling membrane of patches, for example, are appropriately controlled.

• Archives of design research
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• v.15 no.4
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• pp.129-138
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• 2002

Against the projection that the volume of filing would be drastically cut in the Information Age, the needs for filing in this age increases gradually. In this respect, it is critical to study the design of office filing system furniture. Through this study, we could find out what shall be the major requirements for office lijillg system furniture. This study would also provide important raw data for developing more efficient and more satisfactory office filing system furniture. Subject for this study includes 6 representative filing system furniture including a lateral file cabinet. For the design analysis, we used catalogues of foreign and domestic office furniture, particularly filing system furniture. The analysis is classified into the following six categories such as size, shape, color, material, handle, and filing method, mobility, flexibility, and so on. According to the analysis of office furniture in the market, requirements of furniture fit for office environment are found to be as follows. -Instead of the fixed-type furniture, movable furniture is more adaptable to the ever-evolving office environment. -Design the office furniture in accordance with a standardized module would provide a more unity and diversity of arrangement in space particularly when it is arranged with other furniture. -Development of more diverse color, which ranges from achromatic color to wooden color to other various colors, is more favored in the ever-changing office environment. -As the grip provides a variety of image to the furniture let alone its function, its development is required to be more diverse and more conforming 10 the design of Ihe furniture. -The filing methods in general are with drawer and shelf, among which the drawers design is usually fixed. However, under the evolving office furniture environment, the design of Ihe drawer, bolh inlerior and exterior, shall be more diverse and flexible.

• Journal of the Korean Society for Marine Environment & Energy
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• v.7 no.3
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• pp.122-130
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• 2004

Crude oil is complex mixture of thousands of different organic compound formed from a variety of organic materials that are chemically converted under differing geological conditions over long periods of time. Also oil composition varies according to crude source, refining, processing, handling and storage. The oil fingerprint method is application of specific knowledge of petrochemicals and use of sophisticated analytical equipment and techniques to identify the source(s) of oil pollution. KNMPA currently utilizes three primary analytical techniques: Gas Chromatography (GC), Fluorescence Spectroscopy(FL) and Infrared Spectroscopy(IR). Of all these techniques, GC technique are most widely used. Gas Chromatography is used as a primary analytical method because high reliableness, high separating efficiency and repeatability, but it is timeconsumable. The study results of identification of waterborne spilled oil by Fast Gas Chromatograph method showed that analytical time is cut down to 30minutes in comparison with packed column method and chromatograms represent high resolution and high repeatability.

• Journal of Yeungnam Medical Science
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• v.33 no.1
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• pp.8-12
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• 2016

Background: The decision to administer oral anticoagulation therapy depends on accurate assessment of stroke risk in patients with atrial fibrillation (AF). Various stroke risk stratification schemes have been developed to help inform clinical decision making. The CHADS2 and CHA2DS2-VASc scores have been used in estimating the risk of stroke in patients with AF. Recently R2CHA2DS2-VASc score was developed. The objective of the current study is to validate the usefulness of the R2CHA2DS2-VASc score and to compare the accuracy of the CHADS2, CHA2DS2-VASc, and R2CHA2DS2-VASc scores in predicting a patient's risk of stroke. Methods: Based on medical records, we conducted a retrospective study of patients hospitalized with AF from March 2011 to July 2013. A total of 448 AF patients were included in this study. The receiver operating characteristic (ROC) curve analysis in MedCalc was used for comparison with respective diagnostic values. Results: The patient characteristics showed male predominance (60.9%). Among the 448 AF patients, 131 (29.2%) patients had strokes during the study. A R2CHA2DS2-VASc score of more than 5 is the optimal cut-off value for prediction of stroke. A risk score of three, the area under the ROC curve (AUC) of R2CHA2DS2-VASc score (AUC 0.631; 95% confidence interval, 0.585-0.679) was the highest. A significant difference was observed between AUC for R2CHA2DS2-VASc, CHADS2, and CHA2DS2-VASc scores, but no meaningful difference between CHADS2 and CHA2DS2-VASc scores. Conclusion: We determined the usefulness of the R2CHA2DS2-VASc score, which showed better association with stroke than the CHADS2 and CHA2DS2-VASc scores.

• The Journal of the Korea Contents Association
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• v.18 no.4
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• pp.314-322
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• 2018

In recent times, increasing is the number of civic participation government policy decision models through the application of the service design process. It's because the effect of a policy is cut in half due to the low acceptance will for police execution, which could occur in the supplier-oriented policy-decision process in the past. For solving out such a problem, civic participation policy service design has been under way in the name of 'National Design Group' led by the Ministry of Government Administration and Home Affairs starting 2014. A sharing village is a village community in a broad sense for the purpose of giving effect to sharing economy, aiming to maintain sustainability through sharing consciousness raising between village members, coexistence and cooperation. This study presented a solution to the 3 sorts of city problems, i.e. sharing village, urban generation and youth employment settlement in combination by grasping the problems of the existing sharing village, and using service design method Toolkit However, there needs to be a follow-up research through continuous verification, and improvement of problems for the time to come because the casual relationship between research subjects is extensive, and this study has limitations in the satisfaction survey for verifying the result satisfaction, which individual subjects have, consequent on the suggestion of the way of solution, and the research period as well.

• The Korean Journal of Quaternary Research
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• v.17 no.2
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• pp.167-168
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• 2003

The Upo wetland, the largest natural wetland in Korea, is located in Changnyeong-gun, Gyeongsannam Province ($35^{\circ}33'$ N, $128^{\circ}25'$ E), and 70 km upstream from the Nakdong River estuary. Unlike most other Korean wetlands that have been destroyed under the name of economic development, the Upo wetland has been able to preserve its precious ecosystem throughout the years. Thanks to increased public awareness about natural wetlands and environmental conservation, the Korean Ministry of Environment designated the Upo wetland an 'Ecological Conservation Area' on July 26th, 1997. On March 2nd of the following year, the Upo wetland (8.54 $\textrm{km}^2$) was designated a 'Protected Wetland' in accordance with the international Ramsar Treaty. A 4.49m long (from 9.73 to 5.24 m in altitude) UP-1 core ($35^{\circ}33'05"N$, $128^{\circ}25'17"E$), recovered in the marginal part of the Upo wetland, is divided into eight buried paleosol units of different ages on the basis of the abundance of color mottles and vertical color variations (Aslan et al., 1998). Radiocarbon datings suggested that the paleosol profile represent the last 5700 years. The entire section of the core was more or less subjected to pedogenetic processes, and shows very weak to moderate soil profile development. These Holocene paleosols are therefore regarded as synsedimentary soils of deluvium (deposits formed by floods) origin (Sycheva et al., 2003). Unit 1 to 5 paleosols are generally silt-rich and exhibit moderate profile development. The boundaries between the units are somewhat distinguishable, but not so clear cut. This is due to variable repeated combination of accumulation, denudation and soil forming processes within various periods. Mottle textures gradually decrease in abundance with increasing clay content in Unit 6, which results in weak profile development. The lower boundary of Unit 6 lies around about 2000 yrBP, the beginning of Subatlantic in Korea (Kim et al., 2001). Abrupt sediment textural change is detected in Unit 7, which is interpreted to indicate the human activities on the Upo wetland. Unit 8 represents the recent soil forming processes. The preliminary results of this ongoing study imply the primary factor for pedogenetic processes is the water table fluctuations related to the sedimentary textures like grain size distributions, and the geomorphological stability of the Upo wetland.o wetland.

• Journal of Conservation Science
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• v.28 no.3
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• pp.257-264
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• 2012

Ancient mirrors are generally made of bronze, and it is very rare to find cases of iron mirrors excavated domestically. In this study, the unidentified ferrous artifact was treated for conservation, and was identified as a mirror. In this process, the sample was taken and analyzed for microstructure, and the manufacturing technology was studied. Analysis involved optical microscope, micro-hardness tester, and SEM-EDS. As the result of analysis, iron mirror structure exist not almost non-metallic inclusions, and partially network cementite was observed. This appears to have been caused by reduced carbon content due to decarburizing the cast iron in the solid state mirror which was created by cast iron. The ledeburite structure of the casting has difficult to cut or polish because has great hardness by high carbon content. Thus, the cast iron mirror was decarburized at a temperature under $850^{\circ}C$ with CO or $CO_2$ blocked, which reduced the hardness of the iron mirror and made it possible to polish the mirror surface. This deformation of structure according to carbon content results from such manufacturing technology.

• Journal of Korea Multimedia Society
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• v.16 no.6
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• pp.678-688
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• 2013

Different Different from a single attack, in DDoS Attacks, the botnets that are distributed on network initiate attacks against the target server simultaneously. In such cases, it is difficult to take an action while denying the access of packets that are regarded as DDoS since normal user's convenience should also be considered at the target server. Taking these considerations into account, the DDoS botnet detection system that can reduce the strain on the target server by detecting DDoS attacks on each user network basis, and then lets the network administrator to take actions that reduce overall scale of botnets, has been implemented in this study. The DDoS botnet detection system proposed by this study implemented the program which detects attacks based on the database composed of faults and abnormalities collected through analyzation of hourly attack traffics. The presence of attack was then determined using the threshold of current traffic calculated with the standard deviation and the mean number of packets. By converting botnet-based detection method centering around the servers that become the targets of attacks to the network based detection, it was possible to contemplate aggressive defense concept against DDoS attacks. With such measure, the network administrator can cut large scale traffics of which could be referred as the differences between DDoS and DoS attacks, in advance mitigating the scale of botnets. Furthermore, we expect to have an effect that can considerably reduce the strain imposed on the target servers and the network loads of routers in WAN communications if the traffic attacks can be blocked beforehand in the network communications under the router equipment level.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.10003-10008
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• 2014

Background: Cervical cancer has been a leading female cancer in Thailand for decades, and has been second to breast cancer after 2007. The Ministry of Public Health (MoPH) has provided opportunistic screening with Pap smears for more than 30 years. In 2002, the MoPH and the National Health Security Office provided countrywide systematic screening of cervical cancer to all Thai women aged 35-60 years under universal health care coverage insurance scheme at 5-year intervals. Objectives: This study characterized the cervical cancer incidence trends in Songkhla in southern Thailand using joinpoint and age period cohort (APC) analysis to observe the effect of cervical cancer screening activities in the past decades, and to project cervical cancer rates in the province, to 2030. Materials and Methods: Invasive and in situ cervical cancer cases were extracted from the Songkhla Cancer Registry from 1990 through 2010. Age standardized incidence rates were estimated. Trends in incidences were evaluated by joinpoint and APC regression models. The Norpred package was modified for R and was used to project the future trends to 2030 using the power of 5 function and cut trend method. Results: Cervical cancer incidence in Songkhla peaked around 1998-2000 and then dropped by -4.7% per year. APC analysis demonstrated that in situ tumors caused an increase in incidence in early ages, younger cohorts, and in later years of diagnosis. Conclusions: Both joinpoint and APC analysis give the same conclusion in continuation of a declining trend of cervical cancer to 2030 but with different rates and the predicted goal of ASR below 10 or even 5 per 100,000 women by 2030 would be achieved. Thus, maintenance and improvement of the screening program should be continued. Other population based cancer registries in Thailand should analyze their data to confirm the success of cervical cancer screening policy of Thailand.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7635-7638
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• 2013

Background: Sperm-associated antigen 9 (SPAG9) has been recently proposed as a novel biomarker for early diagnosis of several human tumors, including ovarian, cervical and breast cancers. Its clinical value remains to be clarified for endometrial cancer (EC). In this study, we investigated the utility of serum SPAG9 levels in diagnosis of EC and its association with important clinicopathological parameters. Materials and Methods: This cross-sectional study was performed at a tertiary women's referral center in Ankara, Turkey. Preoperative serum samples were collected from patients surgically treated for endometrial cancer between June 2012-April 2013. Similar aged women with a biopsy proven benign endometrium were used as controls. Serum SPAG9 levels were measured with an enzyme-linked immunosorbent assay (ELISA) method and assessed for links with clinicopathological factors. Receiver operating characteristic (ROC) curve analysis was performed to assess power of SPAG9 levels for EC prediction. P values less than 0.05 were considered statistically significant. Results: A total of 63 women with EC and 27 with benign endometrium were included in the study. Mean age in the EC group was $58.7{\pm}1.1$. Median SPAG9 levels in the EC and control groups were 18.3 (range, 12.7-53.8) and 14.1 (range, 4.3-65.3), respectively (p<0.001). A cut-off value of 17 ng/ml for SPAG9 predicted presence of malignant endometrium with 74% sensitivity and 83% specificity [Area under curve (AUC)=0.82, p<0.001]. SPAG9 levels did not demonstrate any significant association with histological type, FIGO stage, tumor grade, size, myometrial invasion, lymphovascular space invasion, cervical involvement, adnexal involvement, peritoneal cytology or lymph node status (all p>0.05). Conclusions: Testing for SPAG9 may be useful for early detection of EC in asymptomatic high-risk women. Its role in post-treatment follow-up and early detection of recurrence should be assessed in future trials.