• Clinical and Experimental Reproductive Medicine
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• 제43권2호
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• pp.112-118
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• 2016

Objective: Ovarian reserve tests are commonly used to predict ovarian response in infertile patients undergoing ovarian stimulation. Although serum markers such as basal follicle-stimulating hormone (FSH) or random $anti-M{\ddot{u}}llerian$ hormone (AMH) level and ultrasonographic markers (antral follicle count, AFC) are good predictors, no single test has proven to be the best predictor. In this study, we developed appropriate equations and novel nomograms to predict the number of oocytes that will be retrieved using patients' age, serum levels of basal FSH and AMH, and AFC. Methods: We analyzed a database containing clinical and laboratory information of 141 stimulated in vitro fertilization (IVF) cycles performed at a university-based hospital between September 2009 and December 2013. We used generalized linear models for prediction of the number of oocytes. Results: Age, basal serum FSH level, serum AMH level, and AFC were significantly related to the number of oocytes retrieved according to the univariate and multivariate analyses. The equations that predicted the number of oocytes retrieved (log scale) were as follows: model (1) $3.21-0.036{\times}(age)+0.089{\times}(AMH)$, model (2) $3.422-0.03{\times}(age)-0.049{\times}(FSH)+0.08{\times}(AMH)$, model (3) $2.32-0.017{\times}(age)+0.039{\times}(AMH)+0.03{\times}(AFC)$, model (4) $2.584-0.015{\times}(age)-0.035{\times}(FSH)+0.038{\times}(AMH)+0.026{\times}(AFC)$. model 4 showed the best performance. On the basis of these variables, we developed nomograms to predict the number of oocytes that can be retrieved. Conclusion: Our nomograms helped predict the number of oocytes retrieved in stimulated IVF cycles.

• Clinical and Experimental Reproductive Medicine
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• 제35권3호
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• pp.231-238
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• 2008

목 적: 조기난소부전 환자의 10$\sim$20%에서 난소기능이 회복될 수 있다고 하며 간헐적으로 배란이 되고 심지어는 임신이 가능할 수 있다는 보고가 있다. 그러나 한국의 조기난소부전 여성의 임상적 특징과 배란가능성은 논의된 적이 없다. 이 연구의 목적은 한국인 조기난소부전 환자에서 자연 난포의 발생 빈도와 배란유도의 가능성을 평가하는 것이다. 연구방법: 특발성 조기난소부전으로 진단된 15명 여성의 전체 진료기록을 후향적으로 연구하였다. 환자별로 6번 이상의 초음파 검사를 시행하였고 36개월 이상의 기간 동안 추적관찰을 하였다. 또한 4명의 환자에서 6주기의 배란유도시도를 하였다. 조사항목은 초음파 검사에서 난포의 발견율, 자연 난포 성장률과 배란유도를 시행한 경우에 그 반응을 평가하여 결과를 분석하였다. 결 과: 15명 중 6명은 초음파상 난포가 발견되었나 (40%) 초음파 검사 당 난포 발견 빈도는 7%였다 (115회 중 8회). 6명 중 한 명은 초음파 추적관찰 상 배란이 확인되었고 나머지 5명은 크기에 변화가 없었다. 배란유도를 시도한 6명 중 성공적인 난포 성장이 관찰된 예는 없었다. 결 론: 한국인 조기난소부전 환자에서 난포의 발견율은 이전 서양 연구에 비하여 낮다고 생각되지만 관찰 방법에 차이가 있어 직접비교는 불가능하다. 배란유도의 성공율은 0%로서 이전 연구에서 발표된 수준보다 낮았다.

• 한국임상수의학회지
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• 제27권5호
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• pp.600-604
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• 2010

10년령의 암컷 잡종견이 식욕부진, 쇠약, 혈색소뇨를 주증으로 충북대학교 동물의료센터에 내원하였다. 환자는 내원 하루 전 지역동물병원에서 효소 면역 측정법에 의해 심장사상충증을 진단 받았으며 성충구제제를 투여 받았다. 혈액검사를 통해 저색소성 소적혈구성 재생성 빈혈과 혈소판감소증, 중등도의 호중구증가증, ALT AST ALP의 상승이 확인되었다. 방사선 촬영을 통해 주페동맥의 확장, 폐침윤, 복부 선예도 감소, 경증의 간비대가 확인되었다. 복부 초음파 검사에서 경증의 복수, 간문 수준의 문정맥과 비장정맥에서 고에코성의 혈전이 확인되었다. 조영 증강 컴퓨터 단층촬영을 통해 문정맥 내강내 저밀도 영역과 혈관내 충진결손을 확인하였다. 환자는 항응고제와 혈전용해제로 치료를 받았으며, 42일 동안의 치료 후 혈전의 완전한 용해를 복부 초음파 검사를 통해 확인하였으며 임상 증상의 개선이 관찰되었다.

• 한국임상수의학회지
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• 제27권5호
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• pp.593-599
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• 2010

7년령의 중성화한 수컷 Basset hound 가 식욕부진, 체중 감소, 혈변, 구토의 증상을 4개월 동안 보이며 내원하였다. 혈액 검사상, 소적혈구성, 저색소성 빈혈을 보였으며, 그 외 임상검사 소견은 정상이었다. 방사선 단순 촬영 시연부 조직 음영이 증가 된 것을 우측 상복부에서 관찰할 수 있었으며, 초음파와 컴퓨터 단층 촬영에서는 내림 십이지장의 벽이 전반적으로 비후되어 있는 것을 확인할 수 있었다. 생검을 통해 조직의 만성 염증 소견과 점막밑까지 침투되어있는 증식된 점막과 다수의 작은 샘과 같은 구조들을 확인하였고, 장샘암종을 확진 하였다. 13개월 동안의 대증치료 후에 환자는 폐사하였다. 본 증례는 개에서 드문 십이지장 샘암종의 임상학적, 영상진단학적, 조직병리학적 검사와 그 결과에 대해 기술하고자 한다.

• 한국전문물리치료학회지
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• 제23권3호
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• pp.11-20
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• 2016

Background: A forward head posture (FHP) is one of the most common types of poor head posture in patients with neck disorder. A prolonged FHP might increase pressure on the posterior cranio-cervical structure and exhibit reduced performance on a cranio-cervical flexion test (CCFT). CCFT is included to activate deep cervical flexor muscles and inhibit excessive activation of superficial cervical flexor muscles. Therefore, the selective activation of deep cervical flexors is needed for effective exercise for FHP. Objects: The purpose of this study was to compare muscle thickness between longus colli (Lco) and sternocleidomastoid (SCM) using ultrasonography in subjects with FHP depending on head support. Methods: This was a cross-sectional, case-control research design study. The ultrasonographic images of Lco and SCM were taken in 17 subjects with FHP during the 5 phases of the CCFT with and without a head support. Towel was used for supporting head to make the neutral head position in supine. Changes in muscle thickness during the test were calculated to infer muscle activation. Data were analyzed using repeated measures of two-way analysis of variance with the significance level of .05. Results: When subjects performed the CCFT with head support, there was a significant difference in muscle thickness of Lco and SCM (p<.05). According to a post hoc paired t-test, change of thickness of Lco was greater at all phases, and change of thickness of SCM muscle was less at phase 4 and 5 in condition with head support (p<.01) compared to condition without head support (p<.01). Conclusion: The result of this study suggest that applying head support for neutral head position during CCFT could be a useful method for activating Lco muscle without excessive activation of SCM muscle.

• 한국전문물리치료학회지
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• 제24권2호
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• pp.27-36
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• 2017

Background: Research efforts to improve the pulmonary function of people with limited chest function have focused on the diaphragmatic ability to control breathing pattern. Real-time ultrasonography is appropriate to demonstrate diaphragmatic mechanism during breathing. Objective: The purpose of this study was to investigate the effects of diaphragmatic breathing training using real-time ultrasonographic imaging (RUSI) on the chest function of young females with limited chest mobility. Methods: Twenty-six subjects with limited chest mobility were randomly allocated to the experimental group (EG) and control group (CG) depending on the use of RUSI during diaphragmatic breathing training, with 13 subjects in each group. For both groups, diaphragmatic breathing training was performed for 30-min, including three 10-min sets with a 1-min rest interval. An extra option for the EG was the use of the RUSI during the training. Outcome measures comprised the diaphragmatic excursion range during quiet and deep breathing, pulmonary function (forced vital capacity; FVC, forced expiratory volume in 1-sec; FEV1, tidal volume; TV, and maximal voluntary ventilation; MVV), and chest circumferences at upper, middle, and lower levels. Results: The between-group comparison revealed that the diaphragmatic excursion range during deep breathing, FVC, and middle and lower chest circumferences were greater at post-test and that the changes between the pretest and post-test values were greater in the EG than in the CG (p<.05). In addition, the subjects in the EG showed increased post-test values for all the variables compared with the pretest values, except for TV and MVV (p<.05). In contrast, the subjects in the CG showed significant improvements for the diaphragmatic excursion range during quiet and deep breathings, FVC, FEV1, and middle and lower chest circumferences after the intervention (p<.05). Conclusion: These results indicate that using RUSI during diaphragmatic breathing training might be more beneficial for people with limited chest mobility than when diaphragmatic breathing training is used alone.

• Journal of Yeungnam Medical Science
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• 제2권1호
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• pp.87-93
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• 1985

1983년 5월부터 1985년 11월까지 영남대학교 의과대학 부속병원에서 복부농양을 의심하여 초음파검사를 시행후 확진된 48명의 환자에서 초음파소견을 분석하여 다음과 같은 결과를 얻었다. 1) 농양의 위치는 복강내 농양이 30예, 내장 농양이 13예, 후북막강농양이 5예였다. 2) 원인별로는 복강내 농양의 25예는 충수돌기염에 의하였고. 5예는 수술후 합병증으로 생겼다. 후복막강농양 5예는 전부 요근농양으로, 결핵성 및 화농성이 각각 2예, 후복막강에 위치한 충수돌기 염증이 1예였다. 내장농양은 12예가 간농양으로 이 중 9예는 화농성, 3예는 아메바성이었고 췌장염에 의한 췌장미부농양이 l예였다. 3) 형태는 총 48예중 26예(54%)에서 구형 또는 난원형이었으며, 특히 내장농양이 복강내 농양에 비해 구형 또는 난원형이 많았다. 4) 병변의 크기는 26예(54%)에서 5~10cm사이였으며, 내부echo는 33예(69%)에서 낭포성이었다.

• Advances in pediatric surgery
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• 제2권1호
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• pp.17-25
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• 1996

Acute pancreatitis(AP) in children is not common but can be associated with severe morbidity rates and its diagnosis is often delayed. Thus, reported mortality rates range from 0 to 78%. We have treated 26 patients with AP from 5 to 17 years of age over the past 17 years. We are intended to assess the relevance of the prognostic criteria used to assess severity of adult AP and to review the etiology, clilical presentation, diagnosis, and management of AP in children. The authors retrospectively reviewed 26 children with AP managed in Kyung Hee University Hospital from 1978 to 1995. Among 26 patients with AP, male were 12, and female were 14. And the mean age of patients was 11.8 years. In 9(34.6%), no definitive cause was identified. Common causes of AP were trauma(23.1%) and biliary tract disease(23.1%). Other etiologies were viral infection(15.4%) and post ERCP(3.8%). The presenting features were abdominal pain(92.3%), vomiting(61.5%), fever(19.2%), submandibular pain(11.5%), and abdominal mass(7.6%). Back pain was rare(3.8%). Abdominal ultrasonographic findings were abnormal in 10 of 16 patients(62.5%) and abdominal CT findings were abnormal for 9 of 9 patients(100%). Seventeen patients(65.3%) were managed conservatively, and nine patients(34.6%) required surgical treatment. There was no mortality. To evaluate the severity of disease, we used the Imrie prognostic criteria used to assess the severity in adult AP. The number of positive criteria was correlated to the duration of hospitalization(r2=0.91) but statistically insignificant(p>0.05). But, the number of positive criteria was correlated to the operative incidence(r2=0.93) and statistically significant(p<0.05). The common causes of AP in children were unknown origin(34.6%), trauma(23.1%), and biliary tract disease(23.1%). Ultrasonography and computed tomography were useful imaging tools of AP in children. The Imrie criteria used to evaluate the severity in adult AP were suspected to be valuable to assess the severity of AP in children.

• Clinical and Experimental Reproductive Medicine
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• 제37권3호
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• pp.253-259
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• 2010

목 적: 과배란유도 환자에서의 우성난포의 성장속도와 임상인자들과의 연관성을 평가하고자 하였다. 연구방법: 체외수정시술을 위한 과배란유도 313주기를 대상으로 혈중 호르몬 농도를 측정하고 과배란유도 주기 중 난포 직경의 변화를 초음파를 이용하여 연속적으로 측정하였다. 우성난포의 성장 속도를 계산하고, 임상지표와의 연관성을 분석하였다. 결 과: Gonadotropin releasing hormone 작용제와 길항제 주기 사이에 우성난포의 성장속도의 유의한 차이는 관찰되지 아니하였다. 우성난포의 성장속도와 환자의 연령, 체질량 지수, 생리 시작 3일의 follicle stimulating hormone, luteinizing hormone, 에스트라디올, 획득 난자의 수, 수정률 등의 임상지표는 유의한 연관성이 없었다. 결 론: 본 연구 결과는 우성난포의 성장속도는 난소 반응을 포함한 임상지표와 연관성이 없는 독립적인 변수임을 시사한다.

• 한국수정란이식학회지
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• 제29권3호
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• pp.273-281
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• 2014

This study was carried out to establish the system of OPU derived embryo production, management of recipients as well as offspring production. OPU derived embryo production system was carried out of aspiration of immature oocytes 2 times per week, total 24 times for 3 months by an ultrasonographic guided follicular aspiration system and then produced in vitro-produced blastocysts by in vitro maturation, fertilization and culture system. This work was collected total 13,866 oocytes, average $8.2{\pm}4.5$ oocytes per session and 8,170 G1 + G2 grade oocytes, average 4.8 oocytes per session by 1,692 times session of total 71 donors for 4 years from 2010 to 2013. The rate of cleavage and blastocyst developmental competence were obtained 11,825 (85.3%) and 5,032 (36.3%) that was $7.0{\pm}3.8$ cleaved embryos and $3.0{\pm}2.5$ blastocysts per session. OPU derived embryo transfer were taken place in 2, 4, 6 and 7 local governments at 2010, 2011, 2012 and 2013 for 4 years and pregnancy rate were obtained 41.2, 43.9, 46.5 and 49.7% in each years. It means that pregnancy rate was continuously improved according of every year for 4 years. Pregnancy rate was significantly different according to individual local government in which was 62.7% in B, but 24.2% in F at 2012. Paternity identification was carried out total 26 offspring in C local government of 2012 and then confirmed 100% agreement of its analysis. In conclusion, the results obtained the possibility of mass production of elite cow embryos as well as offspring by OPU derived embryo production system, of which could be decreased the required time of genetic improvement.