• 한국동물위생학회지
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• 제35권3호
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• pp.239-243
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• 2012

We reported an outbreak of Aeromonas (A.) veronii responsible for ulcerative dermatitis in Israeli carp (Cyprinus carpio). The major clinical signs were darkening body, abdominal extension, exophthalmos and severe ulcerative necrosis in the skin. The necropsy showed yellowish ascites, necrosis in liver and enlargement of kidney and spleen in the morbid fish. In blood agar for culturing bacteria, three different colonies were identified as A. veronii, Plesimonas shigelloides and Shewanella putrefaciens by phylogenetic identification using 16S rRNA or gyrB gene sequences. A. veronii was the most dominant species among them and was resistant to ampicillin, nalidixic acid and oxytetracycline.

• 한국임상수의학회지
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• 제30권3호
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• pp.210-213
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• 2013

고양이 헤르페스 바이러스-1 감염과 관련된 고양이의 괴사성 안면 피부염의 증례를 보고하고자 한다. 3살된, 미거세 수컷 도메스틱 숏헤어 고양이가 2년간 지속된 소양성 피부염을 주증으로 내원하였다. 환자는 생후 약 2개월령부터 지속적인 눈꼽과 결막염을 가지고 있었으며, 눈 주위부터 안면 전체로 확대된 피부염의 병력을 가지고 있었다. 내원 당시에는 가피로 덮여있는 미란과 궤양성의 피부병변이 안면과 회음부에서 주로 관찰되었다. 피부 병변부위의 조직학적 검사 결과, 경계면 피부염을 동반한 기저층의 수포변성과 각질세포의 단세포 괴사 소견이 관찰되었으며, 호산구 침윤을 동반한 표피와 진피의 괴사와 각질세포의 핵내 봉입체도 관찰되었다. 이에 가피 부위의 가검물을 이용하여 PCR검사를 수행하였고, 그 결과 고양이 헤르페스 바이러스-1의 유전자가 검출되었다. 위의 소견으로부터, 본 증례는 고양이 헤르페스 바이러스-1 감염과 관련된 궤양성 피부염으로 진단되었고, 아시클로버의 경구투여와 고양이 인터페론 오메가의 국소투여로 피부 및 점막 병변의 뚜렷한 개선을 볼 수 있었다.

• Journal of Ginseng Research
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• 제43권3호
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• pp.342-348
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• 2019

Panax ginseng Meyer (P. ginseng; Korean ginseng) is well known for its medicinal properties. It can alleviate pathological symptoms, promote health, and prevent potential diseases via its anti-inflammatory, antioxidant, homeostatic, and other positive effects on biological metabolism. Although many studies have determined effects of P. ginseng on various diseases, such as cardiovascular, neurological, and immunological diseases, little is known about the effect of P. ginseng on autoimmune diseases. Here, we review a few reports about effects of P. ginseng on autoimmune diseases (e.g., multiple sclerosis, Crohn's disease, ulcerative colitis, atopic dermatitis, and rheumatoid arthritis) and suggest the possibility of P. ginseng as a candidate herbal medicine to prevent and treat autoimmune diseases as well as the need to study it.

• 한국임상수의학회지
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• 제36권6호
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• pp.345-348
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• 2019

A four-year old, indoor-living neutered male Old English Bulldog was presented for generalized ulcerative dermatitis. Generalized alopecia and multifocal papules and ulcers with crusting were observed mainly in the dorsal trunk. Cytology of the skin lesions revealed a pyogranulomatous inflammation comprising macrophages and nondegenerate neutrophils. Histopathology also revealed a nodular dermatitis characterized by mixed infiltration of monocytes and neutrophils involving the superficial and deep dermis. Neither of bacteria nor fungus was identified in microscopic exam and culture. From those findings, a diagnosis of cutaneous sterile pyogranuloma/granuloma syndrome (SPGS) was made. Treatment with immunosuppressive drugs of prednisone and cyclosporine was performed and visible ulcerative skin lesions were resolved after 4 weeks of initiation of therapy. Treatment with combination of cyclosporine and prednisone may be effective for the case of SPGS.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2020년도 춘계학술대회
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• pp.9-9
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• 2020

Many modern people are exposed to chronic inflammatory diseases, such as inflammatory bowel disease (IBD), atopic dermatitis and immune disorder. Among those chronic diseases, the incidence ratio of IBD has been increased. IBD, including Crohn's disease and ulcerative colitis (UC), is known to cause abnormal inflammation in intestinal tissue. UC is accompanied by abdominal pain, bloody stool and diarrhea. Many therapeutic agents, such as sulfasalazine, corticosteroids, immunosuppressive agents, have been used for treating UC. However, those agents have side-effects and temporary effects on UC. The aim of this study was to investigate the effect of herbal medicine on UC and relationship between UC and intestinal bacteria according characteristic of herbal medicine. To determine the effect of herbal medicine on UC, various herbal medicine were chosen within oriental medicine category such as cheongyeol and onyeol medicine. In this study, we found carthami fructus, included in cheongyeol medicine, had stronger effect than onyeol medicine. Also, we determined influence of carthami fructus against lactic acid bacteria. Catthami fructus and lingon berry extracts affected the composition of mice intestinal bacteria in mice fecal. The symptoms of UC could be regulate by using herbal medicine, according to characteristic of herbal medicine. Also, herbal medicine might be change body condition to healthy by controlling intestinal bacteria composition. Herbal medicine characteristic could be a therapeutic agent by revealing relationship between intestinal bacteria and UC.

• 한국임상수의학회지
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• 제27권4호
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• pp.445-449
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• 2010

10세령의 암컷 말티즈가 족부 괴양 및 안면부 괴양성 피부병으로 서울대학교 수의과대학 동물병원에 내원하였다. 환자는 장기간의 페노바르비탈 투여 경력을 가지고 있었으며, 안면부 및 족부의 피부병변의 분포 양상과 간효소 수치의 상승 및 초음파 영상에서의 간의 저에코성병변들을 참고하여, 최종적으로 피부 생검을 통해 표재성 괴사성 피부염으로 진단하였다. 8개월간의 간보조제 경구 투여 및 아미노산제제의 말초 혈액 투여로 피부 증상은 약간 호전되었으나, 비가역적인 간의 손상은 회복이 힘들었으며, 8개월간의 치료 후 사망하였다.