• Asian-Australasian Journal of Animal Sciences
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• v.25 no.7
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• pp.988-993
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• 2012

Four experimental diets were formulated to contain 700 g/kg cereal with decreasing levels of wheat:barley inclusion. Diet 1 contained 700 g/kg wheat, diet 2 contained 600 g/kg wheat and 100 g/kg barley, diet 3 contained 500 g/kg wheat and 200 g/kg barley and diet 4 contained 400 g/kg wheat and 300 g/kg barley. The diets were offered to pigs on three trials to investigate effects on the performance of individually (n = 72) and group housed (n = 480) pigs and on nutrient digestibility in pigs housed in metabolizm crates (n = 24). Performance was assessed from 10 wks of age until slaughter and carcass characteristics were measured. For the group performance study, one pig from each pen (in total 24) at 10, 15 wks and at finish were slaughtered to ascertain scores for stomach ulceration, stomach weights and intestinal length. Level of wheat inclusion did not significantly (p>0.05) affect liveweight gain (LWG) or feed conversion ratio (FCR). Feed intake was lowest (p<0.05) for individually housed pigs offered diets containing 700 g/kg wheat during the 10-15 wk period, which indicated that individually housed pigs attempted to eat to a constant energy intake. There was little evidence of stomach ulceration across treatments and increasing wheat inclusion had no detrimental effect. Higher levels of wheat inclusion tended to increase backfat depth at the $P_2$ position which could lead to increasing grading penalties in a commercial situation although more research is required in this area. Increasing level of wheat inclusion increased digestible energy (DE) content but the lack of effect on FCR and killing out percentage indicated that utilization of energy from barley and wheat was similar. Digestibility coefficients increased linearly with increasing wheat content, which can be attributed to the lower level of fibre and higher level of starch in wheat compared with barley.

• Clinical and Experimental Pediatrics
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• v.53 no.1
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• pp.89-92
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• 2010

Perianastomotic ulceration (PAU) rarely occurs after small bowel resection in infancy. Since the understanding of its pathogenesis is incomplete, an effective method of treatment has not yet been discovered. We report the first case in Korea of a 10-year-old girl with chronic iron deficiency anemia (IDA) and growth failure who was diagnosed with PAU at colonoscopy. Seven years were required to identify the cause of IDA. After surgical resection and revision of anastomosis, a close follow-up is being conducted due to the risk of recurrence. Here, we also review reports on 25 pediatric patients with PAU derived from a search of the English-language literature and describe the clinical features of PAU along with the results of treatment.

• The Korean Journal of Physiology
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• v.14 no.1
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• pp.1-5
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• 1980

This study was under taken to investigate the influences of predictable or unpredictable stress upon gastric ulceration, and the hippocampectomy upon the ulceration order the stressful conditions. Sixty male albino rats(Sprague-Dawley strain) were divided equally into 3 groups: One was the hippocampal group(N=20) which received hippocampal ablation by suction, another was the cortical control group(N =20) which received partial cortical ablation over the hippocampus, and a third was the normal control group(N=20). Each group was further divided into two subgroups: One was the predicted subgroup(N=10) in which animals could predict the imminent stressful stimuli by hearing a sound(1,000 Hz, 2 sec in duration) 3 sec before the onset of the stress, and the other was the unpredicted subgroup(N=10). After starvation for 24 hours, but water ad libitum, each rat received the electric stimulation(3 mA, 60 Hz, 2 sec in duration, and once per minute in average) for 6 hours via a pair of electrodes attached on the tale. The electric stimulation served as the stress causing the gastric ulcer. Five hours after completion of stimulation, the stomach filled with the physiological saline was removed under deep anesthesia and spread out on a small glass plate. The numbers of the ulcer in each stomach were counted and the shape was examined under the dissecting microscope. Results obtained were as follows: 1. The mean numbers of the ulcer of the predicted subgroups were significantly larger than those of the unpredicted subgroups in the normal control and the cortical control groups, but there was no difference between the values of the two subgroups in the hippocampal group. 2. The mean numbers of the ulcer of the predicted subgroups in the normal control and the cortical control groups were larger(but not significant) than that in the hippocampal group. It is inferred from the above results that the prediction of the stress strengthens the effect of the stress on the gastric ulceration, and the hippocampus facilitates the effect of the prediction of the stress.

• The Korean Journal of Physiology
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• v.10 no.2
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• pp.39-45
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• 1976

This study was conducted to see whether the hippocampectomy exerted facilitatory influence upon gastric ulceration in animals, and if so, whether the effect of hippocampectomy could be suppressed by adrenalectomy. 107 male rats were divided into 5 groups: rats that had over 90% of their hippocampal tissue removed through an opening on each side of the cerebral cortex(hippocampal group, N=21), rats that received bilateral adrenalectomy(adrenal group, N=29), rats that received adrenalectomy as well as hippocampectomy(hippocampo-adrenal group, N=10), rats that received damage to each side of the cortex over the hippocampus(cortical control group, N=20), and rats that had solely their head skin incised(normal control group, N=27). All rats were kept without restraint or food deprivation until on the 25th day after surgery, the stomach of each rat was inflated with 7ml of physiological saline and then removed under deep anesthesia. The mucosal surface was sketched under dissecting microscope, and enlarged photographs$(4{\times})$ were taken. The percentage of animals developing gastric ulcer in each animal group was calculated, the number of ulcer in each stomach was counted, and the total area of ulceration per stomach was measured on the Photograph with the aid of superimposed graph paper and expressed as permillage of total area of the glandular mucosa. Results obtained were as follows: 1. The percentage of animals developing gastric ulcer was significantly larger in the hippocampal group than they were in the hippocampo-adrenal, the adrenal, the cortical, and the normal control groups. 2. The mean number of ulcer per stomach was significantly larger in the hippocampal group than they were in the adrenal, the cortical control, and the normal control groups, while no significant difference existed between the hippocampal and the hippocampo-adrenal groups. 3. Total area of ulcer per stomach was significantly larger in the hippocampal group than they were in the cortical control and the normal control groups, but no significant differ-ence existed among the hippocampal, the adrenal, and the hippocampo·adrenal groups. 4. All measured values of the adrenal group were not significantly different from those of the hippocampo-adrenal, the cortical control, and the normal control groups. It is inferred from the above results that the hippocampus exerts an inhibitory influence upon gastric ulceration and that the hippocampal influence is mediated only partly through suppression of pituitary·adrenal activity.

• Archives of Plastic Surgery
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• v.37 no.4
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• pp.415-420
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• 2010

Purpose: Heterotopic calcification is a pathological event in which deposits of calcium salts build up, usually in the joint area or soft tissues. It can occur under many conditions and in some rare cases may develop in burn scars. In particular, ulcerations in burn scars accompanied by heterotopic calcification are difficult to treat through conservative treatment. This study reports methods for accurate diagnosis and adequate treatment of ulceration in burn scars accompanied by heterotopic calcification. Methods: Fourteen patients who visited our hospital from March 2008 to January 2010 were subjected to this study. Their sex, age, modes of burn, degree, TBSA (%), ulcerated area, the time of occurrence of the ulcerations in the burn scars were investigated. In addition, radiological examination and biopsy was performed to diagnose heterotopic calcification. Results: Among the 14 cases, 6 were male and 8 were female. The average age of the patients was 48.2 (27 - 69 yrs). As for the mode of burn, 11 were flame burns and 3 were scalding burns. The average time of occurrence of the ulcerations in the burn scars was 4.5 months. The ulcerated areas were situated in the legs in 12 cases, arms in 1 case, and torso in 1 case. The diagnosis was confirmed through X-ray and biopsy, and skin graft was performed after wide excision. Conclusion: Diagnosis of the ulceration in burn scars accompanied by heterotopic calcification is possible through radiological and pathologic studies. Surgical treatment is the most reliable method of treatment, and we chose to perform skin graft after wide excision. Also, we learned that the complete removal of the calcified tissue and the inflammatory fibrotic tissues is crucial in preventing recurrence. Also, in contrast to Marjolin's ulcer, heterotopic calcification had a small size, little or no granulation tissue, and lacked fungating type ulceration. Therefore, favorable prognosis could be achieved through adequate treatment.

• Journal of Pharmaceutical Investigation
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• v.10 no.4
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• pp.1-7
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• 1980

Geranii Herba water extract orally administered shows remarkable inhibitory effect on peptic activity in pylorus ligated and antiulcerous effect on Shay ulcer in rats.

• The Journal of the Korean dental association
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• v.12 no.7
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• pp.477-480
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• 1974

This case of acute necorotizing ulcerative gingivitis was presented pseudomembrane, necrosis, ulceration, gingival bleeding and pain. The etiology of this case seemed malhygiene and malnutrition. Patient was managed by local treatment with subgingival curettage and systemic antibiotic therapy.

• The Journal of Internal Korean Medicine
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• v.39 no.4
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• pp.846-852
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• 2018

Objective: The aim of this report is to report the effects of Danggwisaeyeok-tang (當歸四逆湯) on Raynaud phenomenon in a patient. Methods: A 57-year-old male diagnosed in 2016 with Raynaud's phenomenon complained of pain, digital ulceration, and discoloration of his fingers. He underwent acupuncture and electroacupuncture treatment, but the symptoms gradually worsened, so we administered herbal medicine, Danggwisaeyeok-tang (當歸四逆湯). Visual observation of the affected part, changes in subjective symptoms, and a verbal numerical rating scale (VNAS) were used to assess the clinical response. Results: After treatment with Danggwisaeyeok-tang, the patient reported improvement in his symptoms of cold sensation, ulceration, and sclerosis of his digits. Furthermore, the patient exhibited no general adverse effects. Conclusions: Danggwisaeyeok-tang (當歸四逆湯) significantly improved the patient's clinical symptoms. This case suggests that Danggwisaeyeok-tang (當歸四逆湯) may represent a good option for the treatment of Raynaud's phenomenon.

• Journal of the Korean Society of Food Science and Nutrition
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• v.22 no.4
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• pp.374-380
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• 1993

Effect of green tea extract, on duodenal ulceration was studied in male Sprague Dawley rats treated with cysteamine, a drug, which causes duodenal ulcers in experimental animal. As a result, in the proximal duodenum, a significant decrease of ulceration was detected twenty four hours after cysteamine injection in rats raised in green tea extract for 63days. Special reference to duodenal alkaline phosphatase activity was measured in mucosal homogenates. In control rats raised in tap water Riven saline, significant decrease was observed in proximal duodenal alkaline phosphataes activity. The decrease effect seems site specific, since the enzyme in the distal duodenum remains. Moreover the effect cysteamine in control rats alkaline phosphatase is specific, because, in rats raised in green tea extracts did not show significant change in activity. It is suggested that green tea extract acts in ideal properties as an anti-duodenal ulcer agent.

• Journal of Yeungnam Medical Science
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• v.3 no.1
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• pp.307-311
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• 1986

Beh,cet's disease was originally described as a triple symptom complex of oral aphthous ulceration, genital ulceration, and hypopyon iritis. It is now known to have a wide systemic manifestations. Among them, the central nervous system involvement should be diagnosed earlier because of it's lethal potential. Recently the authors experienced a case of Behcet's disease with CNS involvement. A 51-year-old female patient was admitted due to deterioration of mentality and generalized ache since 2 years prior to admission. The findings on physical examination were compatible with Behcet's disease, but without cerebrospinal pleocytosis. The manifestations were improved with medications of prednisolone, chlorambucil, colchicine, but relapsed 2 months later during subsequent tapering of prednisolone and chlorambucil. The patient is now on medication again. A case of Beh,cet's disease with CNS manifestations is reported with review of literature.