• Journal of Ginseng Research
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• v.32 no.1
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• pp.48-56
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• 2008

Chronic ultraviolet (UV) exposure is the major cause of photoaging that causes skin wrinkling, roughness, dryness, laxity, and pigmentation. Recently, increasing efforts are being made to understand the relationship between foods and skin health. Ginsenosides are present in ginseng (Ginseng Radix Rubra) extract, and are known to have biomedical properties, such as, anti-oxidant and anti-inflammatory effects. In this study, we investigated whether KTNG0345 prepared from red ginseng extracts delivered orally reduces skin wrinkling and ultraviolet B (UVB)-induced wrinkle formation in hairless mouse skin. KTNG0345 was administrated orally to the mice (5 times a week) during the period of UVB-irradiation (3 times a week) for 8 weeks at three different doses of 300 mg/kg, 500 mg/kg and 1000 mg/kg (w/v). UV doses were increased weekly by 1 MED (1MED = 75 $mJ/cm^2)$ up to 4 MED and then maintained at this level. After the 8-week administration period, it was found that orally administered KTNG0345 significantly inhibited UVB-induced wrinkle formation in a dose-dependent manner. Increases in skin thickness caused by UVB were prevented by KTNG0345. Moreover, it also significantly inhibited matrix metalloproteinases (MMP) -13 and MMP-9 expressional inductions by UVB. In addition, KTNG0345 was observed to prevent UVB-induced water loss of epidermis in hairless mouse skin. Our results demonstrate that orally administered KTNG0345 has anti-wrinkling effects in hairless mouse skin, and suggest that dietary red ginseng and herbal mixture may be considered a functional beauty food for preventing UVB-induced skin wrinkles.

• Environmental Analysis Health and Toxicology
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• v.11 no.1_2
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• pp.1-10
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• 1996

A decrease in stratospheric ozone probably caused by chloroflurocarbons (CFCs) emissions, has been observed large parts of-the globe. It is generally accepted that if ozone levels in the stratosphere are depleted, greater amounts of shortwave ultraviolet radiationB (UVB) will reach the earth's surface, resulting in increased incidence of nonmelanoma skin cancer. In this study, we evaluated several mathematical models, such as a power and an exponential model, and a geometric model considering the surface area of a human body part and ages for the prediction of Skin cancer incidence caused by exposure to the UVB radiation. These models basically estimated the risk of skin cancer based on those measurements of the local ozone in stratosphere and UVB. Both were measured at a part of Seoul with a Dobson ozone spectrometer and Robertson-Berger UV Biometer for 1995. As a result, we calculated the point estimation applying a biological amplification factor (BAF), UVB radiation and other factors. We used a Monte-Carlo simulation technique with assumption on the distribution of each considered factor. The sensitivity analysis of model by there components conducted using Gaussian sensitivity method. The annual integral of UVB radiation was 2275 MED (minimal erythema dose)/yr. Also, an estimate of the annual amount of UVB reaching the earth's surface at a korea's latitude and altitude was 3328 MED/yr. The values of the radiation amplification factor (RAF) were ranged from 0.9 to 1.5 in Seoul. To give the effective factors required to model the prediction of skin cancer incidence caused by exposure to the UVB radiation in Korea, we studied the pros and cons of above mentioned models with the application of those parameters measured in Seoul, Korea.

• Journal of Environmental Science International
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• v.11 no.12
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• pp.1195-1204
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• 2002

We calculated dose rate using radiative transfer equations to consider radiative processes distinctly. The dose rate at Pohang(36°02'N, 129°23'E) was calculated using measured ozone and meteorological data and two-stream approximations(quadrature, Eddington, delta Eddington, PIFM(practical improved flux method), discrete ordinate, delta discrete ordinate) are used in solving equation. The purpose of this study is to determine the most compatible radiative transfer approximation for simulating the radiative and photochemical processes of atmosphere through comparision between calculated and measured values. Dose rate of the biologically effective irradiance in the region 0.28-0.32 U m showed the highest value when quadrature and Eddington was used and lower value on condition that delta scaling was applied. Correlation coefficient between dose rate at surface using radiation transfer equation and measured UV-B at Pohang was 0.78, 0.79 and 0.81 when delta Eddington, PIFM and delta discrete ordinate were used. Also, in case of above approximations were used, MBE(Mean Bias Error) was within -0.3MED/30min and RMBE(Relative Mean Bias Error) was below 10% between 1200 LST and 1400 LST Approximations which are compatible in estimating radiative process are delta Eddington, PIFM and delta discrete ordinate. Especially, in case that radiative process is considered more detail, delta discrete ordinate increased the number of stream is proper.