• Clinical and Experimental Pediatrics
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• v.64 no.6
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• pp.293-300
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• 2021

Background: Understanding the epidemiology and prevalence of febrile urinary tract infection (fUTI) in children is important for risk stratification and selecting appropriate urine sample collection candidates to aid in its diagnosis and treatment. Purpose: This study aimed to analyze the epidemiology, etiology, and changes in antibiotic susceptibility patterns of the first fUTI in children. Methods: This retrospective observational cohort study included children younger than 19 years of age who were diagnosed and treated for their first fUTI in 2006-2016. Electronic medical records were analyzed and radiologic images were evaluated. Results: A total of 359 patients (median age, 5.1 months; interquartile range, 3.0-10.5 months) fit the inclusion criteria; of them, 78.0% (n=280) were younger than 12 months old. The male to female ratio was 5.3:1 for patients aged 0-2 months, 2.1:1 for those 3-5 months, and 1.6:1 for those 6-11 months. Beyond 12 months of age, there was a female predominance. Escherichia coli was the leading cause (83.8%), followed by Enterococcus species (6.7%), and Klebsiella pneumoniae (3.6%). Significant yearly increases in the proportions of multidrug-resistant strains (P<0.001) and extended-spectrum beta-lactamase (ESBL) producers (P<0.001) were observed. In patients with vesicoureteral reflux (VUR), the overall recurrence rate was 53.6% (n=15). A significantly higher recurrence rate was observed when the fUTI was caused by an ESBL versus non-ESBL producer (75.0% vs. 30.0%, P=0.03). Conclusion: fUTI was most prevalent in children younger than 12 months of age and showed a female predominance in patients older than 12 months of age. The proportion of ESBL producers causing fUTI is increasing. Carbapenems, rather than noncarbapenems, should be considered for treating fUTI caused by ESBL-producing enteric gram-negative rods to reduce short-term recurrence rates in children with VUR.

• Childhood Kidney Diseases
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• v.12 no.2
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• pp.194-201
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• 2008

Purpose : Voiding cystourethrography(VCUG) is required to detect vesicoureteral reflux(VUR), which may manifest as urinary tract infection(UTI) in children. It is well known that VCUG can cause UTI(post-VCUG UTI). In this study, risk factors for post-VCUG UTI and the preventive effect of antibiotics against this complication of VCUG were explored. Methods : Medical records of 284 patients who underwent VCUG at our hospital in 2007 were reviewed retrospectively. The incidence of post-VCUG UTI and risk factors for post-VCUG UTI, and the impact of antibiotic use on prevention of post-VCUG UTI were evaluated. According to antibiotics usage, we divided the enrolled patients into 4 groups of noantibiotics group, prophylactic antibiotics group(prophylactic antibiotics having been used before), antibiotics-for-VCUG group(antibiotics added for VCUG) and antibiotics-for-treatment group(treatment dose of antibiotics). Results : Seven of 284 children(2.5%) developed UTI after they underwent VCUG. Highgrade(grade$\geq$III) VUR was the only statistically significant risk factor(odds ratio[OR] 6.266, P=0.026) for post-VCUG UTI, while sex, age, and other anomalies of urinary system were not significant. Five post-VCUG UTI cases belonged to prophylactic antibiotics group. Antibiotics use (three groups using antibiotics vs. no-antibiotics group) or addition of antibiotics for VCUG (antibiotics-for-VCUG vs. other groups) did not have any effect on prevention of post-VCUG UTI. Conclusion : The risk factor for post-VCUG UTI was high-grade VUR. Antibiotics use did not prevent post-VCUG UTI in this study.

• Childhood Kidney Diseases
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• v.5 no.1
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• pp.15-21
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• 2001

Purpose : Urinary tract infections (UTIs) of children require prompt and correct diagnosis and treatment to reduce the risk of renal damage. As a first step to improve the outcome of UTI in Korea, we investigated the practical variations in the methods of diagnosis, treatment, and evaluation of children with UTI and UTI prevention. Method :A questionnaire related to the individual policy on UTI diagnosis. treatment, imaging test, and prevention was submitted to 26 experts. Result Majority of the experts used bag-collected urine specimen for infants and mid-stream urine specimen for children for urinary culture. With a negative result of culture study, they diagnosed UTI when there was pyuria, positive results of the nitrite test, or bacteriuria. 80 $\%$ of experts prescribed prophylactic antibiotics after upper tract UTI. Operative treatment of vesicoureteral reflux (VUR) was indicated for children older than one or two years old with high-grade VUR, refractory breakthrough infections, or recurrent UTIs. Most of them performed kidney ultrasonography on the diagnosis of UTI and more than half of them evaluated children treated of UTI with vesicocystourethrogram and/or DMSA scintigraphy. Majority did not recommend circumcision. Half of the experts were screening siblings of VUR patients. Conclusion : Considering the variations exposed through this study systematic guidelines for management of children with UTI in Korean would be necessary. (J. Korean Soc Pediatr Nephrol 5 : 15-21, 2001)

• Biomolecules & Therapeutics
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• v.5 no.2
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• pp.158-164
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• 1997

To investigate the effects of trypsin inhibitors, aprotinin and urinary trypsin inhibitor (UTI), on the cute pancreatitis, this study was carried out in dogs of acute pancreatitis induced by oleic acid (0.28 mg/kg). Administration with aprotinin and UTI seemed to have a therapeutic effect on the clinical sign, ultrasonographic finding, histopathologic finding. But in amylase and lipase activity, there were no significant differences among three groups.

• The Pure and Applied Mathematics
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• v.5 no.1
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• pp.45-54
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• 1998

We study the space-times that have a unique terminal indecomposable past set or a unique terminal indecomposable future set and examine their causal boundary, and we investigate some conditions for the warped product space-times of the form (a, b) ${\times}_fF$ to have a unique terminal indecomposable past set or a unique terminal indecomposable future set.

• Journal of Astronomy and Space Sciences
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• v.16 no.2
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• pp.159-166
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• 1999

As the spatial resolution of remote sensing satellites becomes higher, very accurate determination of the position of a LEO (Low Earth Orbit) satellite is demanding more than ever. Non-symmetric Earth gravity is the major perturbation force to LEO satellites. Since the orbit propagation is performed in the celestial frame while Earth gravity is defined in the terrestrial frame, it is required to convert the coordinates of the satellite from one to the other accurately. Unless the coordinate conversion between the two frames is performed accurately the orbit propagation calculates incorrect Earth gravitational force at a specific time instant, and hence, causes errors in orbit prediction. The coordinate conversion between the two frames involves precession, nutation, Earth rotation and polar motion. Among these factors, unpredictability and uncertainty of Earth rotation, called UTI-UTC, is the largest error source. In this paper, the effect of UTI-UTC on the accuracy of the LEO propagation is introduced, tested and analzed. Considering the maximum unpredictability of UTI-UTC, 0.9 seconds, the meaningful order of non-spherical Earth harmonic functions is derived.

• Biomolecules & Therapeutics
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• v.4 no.3
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• pp.257-264
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• 1996

The protective effect of human urinary trypsin inhibitor (UTI) on acute pancreatitis was studied in beagle model. After pancreatitis was experimentally induced in beagle dogs by infusing trypsin and sodium taurocholate into the accessory pancreatic ducts under laprotomy, effects of UTI were compared to those of aprotinin. Routine physical examination, hematology and blood chemistry values were used as parameters and checked on a periodical basis during the experiment. At the end of experiment, surviving animals were sacrificed and liver, kidney, and pancreas were histologically examined. The results of this study warrant the development of UTI as new therapeutics for acute pancreatitis.

• Childhood Kidney Diseases
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• v.20 no.1
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• pp.1-5
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• 2016

Since many years, continuous low dose antibiotic prophylaxis (CAP) has been used for children at a risk for recurrent urinary tract infection (UTI), especially those with vesicoureteral reflux (VUR). The incidence of recurrent UTI has been shown to be higher in children with VUR with bladder and bowel dysfunction (BBD) than in those with VUR without BBD. Therefore, CAP has been recommended for children with BBD and VUR because of the increased risk of UTI. However, the use of CAP has become highly controversial because of bacterial resistance developed due to antibiotic over-usage. The preventive effects of probiotics have been proved in various adult urogenital infections, and the antimicrobial activities of lactobacilli against uropathogens have been demonstrated in previous in vitro studies. However, a critical assessment of their efficacy in children with UTI is lacking. The importance of the use of urogenital probiotics is that it is a natural approach that replenishes the depleted normal flora to create a better environment to fight off uropathogens. Probiotics have a great potential, particularly today with the increasing threat of antibiotic-resistant microorganisms.

• Proceedings of the KOR-KST Conference
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• 2007.05a
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• pp.159-168
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• 2007

• Proceedings of the Korean Information Science Society Conference
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• 2006.06d
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• pp.316-318
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• 2006

본 논문에서는 차세대 지능형 교통시스템인 UTIS(Urban Traffic Information System)의 빠른 접속 요구 조건을 만족하기 위한 DLC(Dynamic Limited Contention) 알고리즘을 제안한다. UTIS 네트워크는 고속으로 이동하는 차량에 설치된 모바일 노드와 도로 변에 설치된 노변 기지국으로 구성되며, 이 네트워크를 통해서 IP 데이터 그램의 전송 서비스, 방송 데이터를 실시간으로 전송하는 실시간 전송 서비스 그리고 차량의 위치를 계속적으로 알려 주는 위치 탐색 서비스를 지원한다. 이러한 전송 서비스를 지원하기 위해서 UTIS는 물리 계층과 MAC 계층으로 구성된다. 그러나 UTIS에서는 차량의 고속 이동으로 인해서 셀(cell)간의 핸드오프가 빈번히 발생하고 또한 위치 추적과 방송 서비스와 같은 실시간 전송 서비스를 지원해야 하기 때문에 기존의 802.11 MAC을 사용할 수 없다. 즉 UTIS에서의 빠른 등록 요구 조건을 충족시키기 위해 기존의 802.11에서 사용하는 경쟁(contention) 방식은 비효율적이다. 본 논문에서는 셀 내에 도착하는 노드 수에 따라 경쟁을 하는 그룹의 크기를 동적으로 조절하는 DLC 알고리즘을 제안한다. 기존의 UTIS에서는 그룹 크기를 정적으로 결정하고 모바일 노드는 자신의 주소에 이 정적 그룹 크기로 modulo하여 자신의 속한 그룹을 초기에 계산한다. 기지국이 접속해야하는 그룹을 폴링 메시지로 지정할 때 그 그룹에 속한 모바일 노드들만이 제한적으로 경쟁하게 된다. 이러한 정적인 그룹 크기는 셀 내에의 노드의 숫자와 그룹 크기의 분포를 고려하지 않는 방식으로 비효율적이다. 본 DLC 알고리즘에서는 전 폴링 주기 동안에 경쟁하는 노드의 빈도수를 계속적으로 추적하여 등록 시점에 경쟁하는 그룹의 개수를 동적으로 조절하게 된다. 이러한 방식은 UTIS와 같이 접속 시간이 제한적이고 접속하려는 노드 수가 빠르게 변화하는 환경 하에서 기존의 802.11 MAC 프로토콜과 정적인 그룹 크기 방식에 비해 효율적이다.