• Biomolecules & Therapeutics
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• 제24권5호
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• pp.523-528
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• 2016

Urotensin II (UII) is a potent vasoactive peptide and mitogenic agent to induce proliferation of various cells including vascular smooth muscle cells (VSMCs). In this study, we examined the effects of a novel UII receptor (UT) antagonist, KR-36676, on vasoconstriction of aorta and proliferation of aortic SMCs. In rat aorta, UII-induced vasoconstriction was significantly inhibited by KR-36676 in a concentration-dependent manner. In primary human aortic SMCs (hAoSMCs), UII-induced cell proliferation was significantly inhibited by KR-36676 in a concentration-dependent manner. In addition, KR-36676 decreased UII-induced phosphorylation of ERK, and UII-induced cell proliferation was also significantly inhibited by a known ERK inhibitor U0126. In mouse carotid ligation model, intimal thickening of carotid artery was dramatically suppressed by oral treatment with KR-36676 (30 mg/kg/day) for 4 weeks compared to vehicle-treated group. From these results, it is indicated that KR-36676 suppress UII-induced proliferation of VSMCs at least partially through inhibition of ERK activation, and that it also attenuates UII-induced vasoconstriction and vascular neointima formation. Our study suggest that KR-36676 may be an attractive candidate for the pharmacological management of vascular dysfunction.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권1호
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• pp.110-114
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• 2020

Gastric xanthoma is frequently an incidental finding on upper endoscopy in adults. Gastric xanthomas (GX) can be mistaken for malignancies and warrant prompt histologic diagnosis. The underlying etiology is not fully understood; however, it has been linked to Helicobacter pylori gastritis and gastric cancer. GX in the pediatric population is largely unreported in the literature. Because of the relative rarity, documentation with case reports are essential to provide as much data as possible to see if there is a correlation between GX and malignant potential in the pediatric population. Our group is reporting two cases, a 10-year-old male and a 7-year-old male, both who presented with chronic dysphagia, upper abdominal pain, nausea, vomiting, and loss of appetite. Upper endoscopies for both patients revealed small polypoid lesions located in the antrum with foamy histiocytes on histology, leading to the diagnosis of gastric xanthoma.

• 한국정밀공학회지
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• 제26권1호
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• pp.97-104
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• 2009

There is a many kinds with nondestructive testing such as RT and UT representatively. Referred before two testing methods there is a limit which is spatial such as nuclear pipe, small vessel, sealing up vessel. So a new technique needs to overcome the limit which is spatial. shearography will be able to overcome the limit which is spatial. This paper introducing shearography which was known as non-contact full-field testing method and It is an interferometric technique for measurement of surface deformation such as displacement or displacement gradient. Also, a research about internal defect of the flange welding zone was accomplished. About variation with method pressurized with the Gaseous Nitrogen. Phase map where is various were measured according to changing a sheared direction, size of crack and loaded pressure. Consequently, crack quantitatively to be detected qualitatively was measured by using shearography.

• 한국소음진동공학회논문집
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• 제14권2호
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• pp.111-118
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• 2004

A number of researchers have attempted to measure the reverberation time of a passenger car, ut the reverberation time of passenger car is too short to measure with the traditional band pass filter. And if the reverberation time is very short, the product of the reverberation time (T) and the bandwidth (B) of the traditional band pass fitter becomes small. The low limit of BT product required for the measurement of reverberation time with the traditional band pass filter is 16. In order to overcome this problem, the wavelet filter bank was developed. In this study, this new wavelet filter was employed to measure the reverberation times of five different classes of passenger cars. The low limit of BT product required for the measurement of reverberation time with the wavelet filter is 4. The reverberation times of five passenger cars were measured successfully with the new wavelet filter bank. The reverberation times measured in most passenger cars was found to be around 0.04. Compared with general acoustic rooms like concert halls, this is a very short reverberation time

• 한국운동역학회지
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• 제25권3호
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• pp.301-309
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• 2015

Objective : The purpose of this study was to describe the correlation between the activity of the muscles of upper and lower limbs of a golf driver swing according to shoulder injury. Method : The subjects were 18 professional golfers (7 male in KPGA and 11 female in KLPGA). Using surface electromyography, we evaluated muscle activities during the golf drive swing. Surface electrodes were used to record the level of muscle activity in the left Deltoid(MD), Triceps Brachii(TB), Pectoralis(PM), Trapezius(UT), Rectus Femoris(RF), Vastus Medialis Obilique(VMO), Biceps Femoris(BF), Gastrocnemius(GCM) muscles during the golfer's swing. The golf swing was divided into five phases: take away, forward swing, acceleration, early follow through, late follow through. Results : The results can be summarized as follows: MD, VMO had statistically significant difference in take away phases, GCM had statistically significant difference in acceleration phases, MD, PM, VMO had statistically significant difference in early follow through phases, PM had statistically significant difference in late follow through phases, Conclusion : Muscle activity of the 8 muscles(Deltoid, Triceps Brachii, Pectoralis, Trapezius, Rectus Femoris, Vastus Medialis Obilique, Biceps Femoris, Gastrocnemius) along the shoulder damage or absence of has shown that they are organically connected to each of the phases.

• 한국운동역학회지
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• 제28권3호
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• pp.187-191
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• 2018

Objective: The purpose of the present study is to investigate the effect of a muscle activity by applying the complex exercise method of sling in accordance with the provision of various vibration intensities for paraplegia-spinal cord injury. Method: The subjects of the study were 15 men in their 40s and 50s with lower limb disabilities and low potential risk, who were randomly divided into a sling exercise group (SG n=4), a sling with low frequency vibration group (SLVG n=4), a sling with mid-frequency vibration group (SMVG n=4), and a sling with high frequency group (SHVG n=4) in accordance with the provision of slings and vibration stimuli. The vibratory intensity provided was divided into low frequency (30 Hz), mid-frequency (50 Hz), and high frequency (70 Hz). The anterior deltoid (AD), the posterior deltoid (PD), the pectoralis major (PM), the upper trapezius (UT), the latissimus dorsi (LD), and the multifidus (MF) were measured to compare and analyze muscle activity. Results: The closed kinetic chain (CKC) exercise to the shoulder joint showed higher muscle activity in most muscles for the SMVG, and statistically significant differences in the anterior deltoid (AD), the pectoralis major (PM), and the multifidus (MF) in particular. Conclusion: The intermediate frequency (50 Hz) string vibration was the effective vibration stimuli for Closed kinetic chain (CKC) exercises.

• 천문학회보
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• 제35권2호
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• pp.52.2-52.2
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• 2010

107P/(4015) Wilson-Harrington is one of possible candidates of the dormant or inactive comet nuclei. It was discovered on a photographic plate exposed with the 48-inch Schmidt at Palomar Observatory on 1949 November 19 UT, displaying the faint extended cometary tail. No comet activity has not been after 1949 apparition. Here we present the optical observations of 107P/(4015) Wilson - Harrington during 2009/2010 apparition taken in search of low-level comet activity. Our photometric and spectroscopic data were collected 28 - 86 days after the perihelion passage on 2009 October 22 in a wide range of solar phase angle of 39-68 degree. A disk-integrated phase function was constructed, giving a geometric albedo of 0.055+/-0.012, phase integral of q=0.34, and Bond albedo of A_B=0.019. The photometric property shows profile similar to low albedo asteroids and comet nuclei. Any emission lines were found in our spectrum, giving a flat reflectance similar to low albedo asteroids. Although we could not find any evidence for the comet activity in our photometric and spectroscopic data, we found an upper limit of the fractional active area of 0.001%. We derived the upper limit of the optical depth of the dust trail and tail 7x10^{-10}. We conclude that 107P/(4015)Wilson-Harrington became completely dormant or inactive in 2009/2010 return.

• 천문학회보
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• 제43권1호
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• pp.65.3-66
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• 2018

We present the results of high-resolution optical (R ~ 30,000) and near-infrared (R ~ 45,000) spectroscopic monitoring observations of a new FU Orionis-like young stellar object, 2MASS J06593158-0405277. FU Orionis objects (FUors) are well-studied examples of episodic accretion because of their outburst phenomenon. Recently, 2MASS J06593158-0405277 exhibited an outburst and was identified as a FUor. It provides an important opportunity to investigate the whole FUors phenomenon from its pre-outburst to its post-outburst phase. We monitored 2MASS J06593158-0405277 with the BOES and the IGRINS since Dec 25, 2014 (UT). We detected several wind and disk features and present here our analysis for time variations of those spectral lines.

• 천문학회보
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• 제43권1호
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• pp.59.1-59.1
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• 2018

On 2018 February 5 a gamma ray burst with trigger time 04:25:29.3 UT was detected by Swift BAT and this event was named GRB 180205A. We observed the optical afterglow of GRB 180205A starting from about 1 hour after the burst until February 22 in the optical bands with the 1m telescope of Deokheung Optical Astronomy Observatory (DOAO), the 1m telescope at Mt. Lemmon Optical Astronomy Observatory(LOAO) and the 0.8m and 0.25m telescopes at McDonald Observatory. According to the fireball model, which is a well-accepted and conventional model for the afterglow of the GRB, the mechanism of the afterglow is that the expanding external blast wave of the GRB successively collides with the ambient medium and loses its energy, and as a result emits radiation at wavelengths longer than gamma rays. Here we present optical photometry and light curve of the afterglow in the R band and analyze it to characterize GRB 180205A.

• 한국디지털건축인테리어학회논문집
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• 제10권3호
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• pp.39-46
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• 2010

Recently, in rural areas have been occurred closed school due to reduce children of people who consider educational environment. In July 2009 statistic, Closed school are ut to 3,348; sale process(61%), lease(25%), neglect(14%). Closed school are not only local community education, but also to act as cultural and historical role. First of all, it will be utilized public facilities as well as welfare facilities for local residents. In this study suggests the welfare facility where is remodelled as good case so that it will use as a data when closed school need remodeling. The main contents is as follows; it is set the slope next to the school building, a classroom is remodelled 2 triple rooms which are installed Ondol and a toilet, teacher's room is converted into the canteen, corridors are converted into the kitchen. Having good condition in the area, close school is appropriate to use welfare facility and also effective to convert teacher's space into normal space, canteen, kitchen. Finally, developed 2~5 composition type of elderly facility.