• 기술혁신학회지
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• 제8권3호
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• pp.932-954
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• 2005

The purpose of this paper is to evaluate of The University of Science and Technology (UST) as field-oriented graduate school model. The UST is unique in world-wide because of its operating system through the synergy effect of research and education and its interdisciplinary major system differentiated from the traditional graduate school, It first deals with measuring the users satisfaction by using a five-point Likert scale to analyze the general and special factors of UST, through which some findings are pointed out as follows; the education aims and visions are highly satisfied while essential factors in field-oriented education such as curriculum composition, apprentice and tailored education system, field training are not so high level. Finally it points out some suggestions for the UST development.

• Asian-Australasian Journal of Animal Sciences
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• 제33권7호
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• pp.1138-1147
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• 2020

Objective: A study was made investigate factors affecting body surface temperature changes after weaning in sows, whether these can be used to aid detection of natural estrus and how they relate to subsequent reproductive performance. Methods: A total of 132 sows were selected during summer from a breeding farm, with mean parity of 3.6±2.3 and 28.5±0.9 days lactation length. Four daily measurements (6:00, 8:00, 16:00, and 18:00) of vulva (VST), udder (UST), ear base and central back skin temperatures for individual sows were taken by an infrared thermometer, continuing up to 8 days post weaning. Results: The VST obtained from sows showing estrus at 4 days post-weaning (4DPW), 5DPW, and 6DPW showed a peak at the fourth day post-weaning, but then started to decrease. The VST of sows not detected in standing heat (NDPW) remained at a lower level during the experiment, but UST was increased soon after weaning. The VST-UST temperature differences during daytime of sows that were showing behavioural standing heat on 4DPW, 5DPW, 6DPW, and 7DPW were 0.46℃±0.123℃, 0.71℃±0.124℃, 0.66℃ ±0.171℃, and 0.58℃±0.223℃, respectively. The NDPW sows had the highest UST observed, but also the lowest VST so that a more negative value of temperature difference (-0.31℃) was seen during first few days post-weaning. A total of 119 sows were observed to show standing heat and were bred. The later the estrus, the smaller the litter size (p = 0.005). Conclusion: Sows which did not show behavior indicative of stable standing heat after weaning had a VST which remained at a lower level, but the UST increased soon after weaning. Therefore, for sow heat detection under field conditions, the changes of VST and UST and difference between the two should be considered together to increase the accuracy of detection.

• Molecules and Cells
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• 제38권10호
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• pp.843-850
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• 2015

The1hepatic cell death induced by acetaminophen (APAP) is closely related to cellular adenosine triphosphate (ATP) depletion, which is mainly caused by mitochondrial dysfunction. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of low energy status. AMPK regulates metabolic homeostasis by stimulating catabolic metabolism and suppressing anabolic pathways to increase cellular energy levels. We found that the decrease in active phosphorylation of AMPK in response to APAP correlates with decreased ATP levels, in vivo. Therefore, we hypothesized that the enhanced production of ATP via AMPK stimulation can lead to amelioration of APAP-induced liver failure. A769662, an allosteric activator of AMPK, produced a strong synergistic effect on AMPK Thr172 phosphorylation with APAP in primary hepatocytes and liver tissue. Interestingly, activation of AMPK by A769662 ameliorated the APAP-induced hepatotoxicity in C57BL/6N mice treated with APAP at a dose of 400 mg/kg intraperitoneally. However, mice treated with APAP alone developed massive centrilobular necrosis, and APAP increased their serum alanine aminotransferase and aspartate aminotransferase levels. Furthermore, A769662 administration prevented the loss of intracellular ATP without interfering with the APAP-mediated reduction of mitochondrial dysfunction. In contrast, inhibition of glycolysis by 2-deoxy-glucose eliminated the beneficial effects of A769662 on APAP-mediated liver injury. In conclusion, A769662 can effectively protect mice against APAP-induced liver injury through ATP synthesis by anaerobic glycolysis. Furthermore, stimulation of AMPK may have potential therapeutic application for APAP overdose.

• 한국기술혁신학회:학술대회논문집
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• 한국기술혁신학회 2016년도 춘계학술대회 논문집
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• pp.451-462
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• 2016

• 한국레이저가공학회지
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• 제17권2호
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• pp.19-25
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• 2014

Optical embedded diffraction gratings with the bulk modification in BK-7 glass plates excited by tightly focused high-intensity femtosecond (130fs) Ti: sapphire laser (peak wavelength = 790nm) were demonstrated. The structural modifications with diameters ranging from 400nm to $4{\mu}m$ were photo-induced after plasma formation occurred upon irradiation with peak intensities of more than $1{\times}1013W/cm^2$. The graded refractive index profile was fabricated to be a symmetric around from the center of the point at which low-density plasma occurred. The maximum refractive index change was estimated to be $1.5{\times}10^{-2}$. The two optical embedded gratings in BK-7 glass plate were demonstrated with refractive index modification induced by the scanning of low-density plasma formation.

• 한국기술혁신학회:학술대회논문집
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• 한국기술혁신학회 2017년도 춘계학술대회 논문집
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• pp.473-487
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• 2017

본 논문은 대한민국의 제19대 대통령 선거와 관련하여 각 후보들의 과학기술정책 공약이 과학자들의 여론을 반영하였는지 알아본다. 이를 위해서, 주요 정당(더불어민주당, 국민의당, 바른정당, 정의당)의 후보들이 과학 언론인 동아사이언스로부터 받은 과학기술정책 공약에 대한 문의에 대해 답변한 내용과 사단법인 과학자 단체인 '변화를 꿈꾸는 과학기술인 네트워크(ESC)'가 발간한 '2017 대선 과학기술지원정책 타운미팅 - 우리는 대통령 후보에게 무엇을 묻고 요구할 것인가'라는 자료집에 대해 답변한 내용을 중심으로 하였다. ESC의 해당 자료집은 ESC 소속 회원들이 주관한 타운미팅에서 참가자들이 소속 및 직위에 의한 제한 없이 반대 의견에 부딪히지 않고 자유롭게 의견을 개진함으로써 발간된 것이기 때문에, 과학기술계의 여론을 가감 없이 반영했다고 볼 수 있다. 분석을 해본 결과, 국민의당 안철수 후보의 과학기술정책 공약이 과학기술계 여론을 가장 많이 반영하였으나, 과학기술 일자리 확충 및 과학기술인재 등용과 관련해서는 더불어민주당 문재인 대통령이, 과학문화 정책과 관련해서는 바른정당 유승민 후보 및 정의당 심상정 후보가 과학기술계 여론을 잘 반영한 것으로 나타났기에, 문재인 대통령이 세부 정책별로 다른 후보의 공약을 참고할 필요가 있는 것으로 파악되었다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권11호
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• pp.5209-5228
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• 2016

Device-to-device (D2D) communication underlaying cellular networks can bring significate benefits for improving the performance of mobile services. However, it hinges on elaborate resource sharing scheme to coordinate interference between cellular users and D2D pairs. We formulate a joint mode selection, link allocation and power control optimization problem for D2D communication sharing uplink resources in a multi-user cellular network and consider the efficiency and the fairness simultaneously. Due to the non-convex difficulty, we propose a three-step scheme: firstly, we conduct mode selection for D2D pairs based on a minimum distance metric after an admission control and obtain some cellular candidates for them. And then, a cellular candidate will be paired to each D2D pair based on fairness. Finally, we use Lagrangian Algorithm to formulate a joint power control strategy for D2D pairs and their reused cellular users and a closed-form of solution is derived. Simulation results demonstrate that our proposed algorithms converge in a short time. Moreover, both the sum rate of D2D pairs and the energy efficiency of cellular users are improved.

• 한국전자파학회논문지
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• 제22권10호
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• pp.999-1004
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• 2011

본 논문에서는 무선 전력 전송 시스템에서 널리 사용되는 원형 코일 사이의 상호 인덕턴스 계산 방법과 이를 이용한 해석 결과를 제시한다. 두 원형 코일은 수직으로 배열되었다. 상호 인덕턴스 계산을 위해 수직 배열된 수전부 원형 코일의 면적을 일정한 높이의 단위 셀로 나누고, 각 단위 셀에 쇄교하는 자속 밀도를 구하여 상호인덕턴스를 계산하였다. 이를 위해 두 원형 코일을 필라멘트 코일로 모델링하였고, 각 코일에서의 전류는 균일 하다고 하였다. 검증을 위해 헬리컬, 스파이럴 형태로 두 원형 코일을 제작하였고, z 방향의 간격이 50~100 cm인 구간에서 상호 인덕턴스를 측정한 결과, 본 논문에서 제시한 이론값과 일치하였다.

• 한국환경농학회지
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• 제29권3호
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• pp.232-238
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• 2010

본 연구에서는 UST-AF 시스템에 전(前)응집 후(後)생물학적 처리 공정을 도입하여 질소와 인을 동시에 제거하고자 하였다. 연속공정은 유기물 및 SS의 제거 효율이 90%이상으로 균등화 효과와 질산화 효율이 높았다. 호기성 여과조에서 질산화 효율이 95% 이상이었으며, 반송을 통한 탈질화 효율은 80% 이상이었다. 하수원수에 화학적 처리 공정을 도입하여 총인을 90% 이상 제거하였으며, 후속공정의 생물반응에 영향을 주지 않은 alum 주입량은 40 mg/L이었다. 그러나 하수원수에 포함된 응집제에 의한 생물반응의 저해는 관찰되지 않았으나, 향후 장기간 운전하였을 경우 공정내 축적된 응집 슬러지의 영향에 대한 고찰이 필요할 것으로 예상된다.

• BMB Reports
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• 제55권10호
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• pp.506-511
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• 2022

Advanced hepatocellular carcinoma (HCC) is among the most challenging cancers to overcome, and there is a need for better therapeutic strategies. Among the different cancer drugs that have been used in clinics, sorafenib is considered the standard first-line drug for advanced HCC. Here, to identify a chemical compound displaying a synergistic effect with sorafenib in HCC, we screened a focused chemical library and found that MG149, a histone acetyltransferase inhibitor targeting the MYST family, exhibited the most synergistic anticancer effect with sorafenib on HCC cells. The combination of sorafenib and MG149 exerted a synergistic anti-proliferation effect on HCC cells by inducing apoptotic cell death. We revealed that cotreatment with sorafenib and MG149 aggravated endoplasmic reticulum (ER) stress to promote the death of HCC cells rather than adaptive cell survival. In addition, combined treatment with sorafenib and MG149 significantly increased the intracellular levels of unfolded proteins and reactive oxygen species, which upregulated ER stress. Collectively, these results suggest that MG149 has the potential to improve the efficacy of sorafenib in advanced HCC via the upregulation of cytotoxic ER stress.