• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2008.11a
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• pp.201-201
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• 2008

박형초음파모터의 구조는 그림 1(a) 와 같이 크로스형태의 앓은 스테이터에 윗면과 아랫면에 각각 8 개의 압전세라믹이 부착된 형태이다. 압전세라믹의 분극방향은 로터와 접촉하는 스테이터의 A, B, C, D 네 개의 타점에서 순차적인 타원변위가 생성되도록 결정된다. 유한요소해석프로그램인 ATILA 5.2.4를 사용하여 최적설계를 한 결과 폭 3[mm], 길이 18[mm], 두께 1.8[mm], Brass 재질, Mid surface clamp 조건에서 입력전압 18[Vrms] 일 때 0.3[${\mu}m$]의 변위를 보였다. 최적설계된 모델을 제작하였고, 정확한 실험결과를 얻기 위해서 푸쉬풀게이지, x-y스테이지, rpm 메타, 토크게이지를 이용하여 실험테이블을 구성하였다. 그림 1(b) 는 마이크로컨트롤러를 이용한 구동 드라이버를 보여준다. 한 주기에서 1/4분주의 순차적인 네 개의 구형파를 생성하고, 이를 push-pull회로를 동하여 90도의 위상차가 나는 정현파를 생성하여 초음파 모터의 구동전원으로 사용한다. 엔코더와 AD 컨버터를 이용하여 정속도 운전을 위한 피드백 제어가 된다. 제안된 구동드라이버를 이용하여 측정한 결과, 구동 주파수 88.6[kHz], 입력전압 [40Vrms], preload 0.2 [N]에서 130 [rmp] 의 속도와 25 [gfcm] 의 토크특성을 보였다. 압력전압을 증가시킬수록 속도는 선형적인 증가를 보였고, 토크는 이와 반대로 감소하는 특성을 보였다. 피드백 제어회로가 없는 경우에는 preload 변화에 따른 극심한 속도 변화를 보였고, 피드백 제어를 하였을 경우에는 0.2~0.4[N]의 범위에서 정속도 운전이 가능함을 확인하였다. 기존의 주파수발생기와 파워 엠프를 이용한 구동장비와의 특성비교에서도 큰 차이를 보이지 않았으며, 장시간의 운전에도 안정적인 구동이 가능함을 확인하였다.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.04b
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• pp.51-51
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• 2009

Thin Cross 초음파모터의 구조는 그림 1(a)와 같이 크로스형태의 얇은 스테이터에 윗면과 아랫면에 각각 8개의 압전세라믹이 부착된 형태이다. 압전세라믹의 분극방향은 로터와 접촉하는 스테이터의 중심부인 네 개의 타 점에서 순차적인 타원변위가 생성되도록 결정된다. 유한요소해석프로그램인 ATILA 5.2.4를 사용하여 최적설계된 모델을 제작하였고, 푸쉬풀 게이지, x-y 스테이지, rpm 메타, 토크 게이지를 이용하여 구동시스템을 구성하였다. 그림 1(b)는 마이크로컨트롤러(ATmega)를 이용한 구동 드라이버를 보여준다. 한 주기에서 1/4분주의 순차적인 네 개 의 구형파를 생성하고, 이를 push-pull회로를 통하여 90도의 위상차가 나는 정현파를 생성하여 초음파 모터의 구동 전원으로 사용한다. 피드백 회로인 맨코더와 AD 컨버터는 정속도 운전을 위해서 사용되었다. 제안된 구동드라이버를 이용하여 측정한 결과, 기존의 제품화된 드라이버와 비교하여도 특성의 큰 차이를 보이지 않았으며 피드백 회로를 통하여 부하변화에 따른 속도의 극심한 변화를 비교적 안정화 시킬 수 있었다. 입력전압을 증가시킬수록 속도는 선형적인 증가를 보였고 토크는 이와 반대로 감소하는 특성을 보였다. 피드백 제어회로가 없는 경우에는 프리로드 변화에 따른 극심한 속도 변화를 보였고, 피드백 제어를 하였을 경우에는 0.2~0.4[N]의 범위에서 정속도 운전이 가능함을 확인하였으며, 장시간의 운전에도 온도 및 속도특성이 안정적인 특성을 보였다.

• Advances in environmental research
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• v.6 no.3
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• pp.173-187
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• 2017

Heavy metals, such as vanadium, are some of the most toxic types of water contaminants. In this study, vanadium was removed using a new composite adsorbent called BAZLSC. The impacts of pH and initial concentration of vanadium(V) on the elimination effectiveness of this metal by using BAZLSC were investigated in the first step of the study. Vanadium removal increased as pH increased to 3-3.5, and initial concentration increased to 60-70 mg/L. The removal efficiency then decreased. Central composite design and response surface methodology were employed to examine experimental data. Initial concentration of V ($mg.L^{-1}$), pH, and dosage of adsorbent (g/L) were the independent factors. Based on RSM, the removal effectiveness of vanadium was 86.36% at the optimum of initial concentration (52.69 mg/L), pH (3.49), and adsorbent dosage (1.71 g/L). Also adsorption isotherm investigations displayed that the Freundlich isotherm could explain vanadium adsorption by BAZLSC better than the Langmuir isotherm. Beside them, desorption studies showed sorption was slightly diminished after six continuous cycles.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.4869-4872
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• 2015

Background: Mutations of the FMS-like tyrosine kinase-3 (FLT3) receptor gene may promote proliferation via activation of multiple signaling pathways. FLT3-internal tandem duplication (FLT3-ITD) is the most common gene alteration found in patients diagnosed with acute myeloid leukaemia (AML) and has been associated with poor prognosis. Materials and Methods: We performed mutational analysis of exons 14-15 and 20 of the FLT3 gene in 54 AML patients using PCR-CSGE (conformational sensitive gel electrophoresis) followed by sequencing analysis to characterise FLT3 mutations in adult patients diagnosed with AML at Hospital USM, Kelantan, Northeast Peninsular Malaysia. Results: FLT3 exon 14-15 mutations were identified in 7 of 54 patients (13%) whereas no mutation was found in FLT3 exon 20. Six ITDs and one non-ITD mutation were found in exon 14 of the juxtamembrane (JM) domain of FLT3. FLT3-ITD mutations were associated with a significantly higher blast percentage (p-value = 0.008) and white blood cell count (p-value = 0.023) but there was no significant difference in median overall survival time for FLT3-ITD+/FLT3-ITD- within 2 years (p-value = 0.374). Conclusions: The incidence of FLT3-ITD in AML patients in this particular region of Malaysia is low compared to the Western world and has a significant association with WBC and blast percentage.

• CELLMED
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• v.10 no.1
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• pp.7.1-7.6
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• 2020

Plants produce a wide range of active principles, making them a rich source of different types of medicines. Without any knowledge of the phytoconstituents or active principles the medicinal plants itself or in the form of polyherbal formulations, were used by all society of human being from ancient times for prevention and cure of disease, but most of the traditional formulations including the formulation of Ayurveda and Unani have not been scientifically validated in order to establish the pharmacopoeial standards to improve the efficacy. Globally, the people become conscious that uses of synthetic drugs for a long period is not safe; the trend of medical society at large is looking at alternatives from natural, safe sources to combat diseases. Due to this comprehension, it has been increased the demand for plant-derived medicine, and on the other side, it is extremely important to standardize the polyherbal formulations and validate them scientifically to improve their safety and efficacy. The polyherbal Unani formulation Safuf-e-Muallif is widely used and recommended in Unani system of medicine (USM) as a spermatogenic agent, semen thickening agent, etc. to treat sexual disorders viz. premature ejaculation, nocturnal emission, etc. The study mainly deals with phytochemical screening for the detection of nature of phytoconstituents and analytical technique like High-performance thin-layer chromatography (HPTLC) for developing fingerprint of Safuf-e-Muallif revealing specific identities of the drug. The phytochemical screening and HPTLC fingerprint profile for SM reported here may be used as a reference standard for quality control purpose in future.

• CELLMED
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• v.11 no.1
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• pp.2.1-2.8
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• 2021

The clinical condition Amnesia causes difficulty in learning new information and the inability to recall past events. It is primarily concerned with recent memory loss. Majoon-e-Nisyan (MJN) is a polyherbal Unani formulation, present in a semi-solid form. It is widely used potent drug of the Unani System of Medicine (USM) for treating Nisyan (amnesia). In the present study polyherbal Unani formulation, MJN has been studied for its quality control and acute toxicity. Standardization (quality control) of drugs deals with drug identity, drug quality and purity determination. Standardization of MJN had been done as per the Unani pharmacopoeial parameters approved by World Health Organization (WHO) - Pharmacognostical parameters, Physico-chemical parameters, high-performance thin-layer chromatography (HPTLC), microbial load, aflatoxin, and heavy metals. Solvents and chemicals used in the study were of analytical grade and used instrument were calibrated. By conducting an acute oral toxicity study in rats, the safety of MJN was assessed. The limit test method of OECD guideline 425 was followed in the study. Results of standardization and standard operating procedures (SOPs) for preparation of MJN may serve as the standard reference in the future. The data generated in the study for the quality control of MJN proved the quality of formulation and shows that MJN is not toxic in rats following acute dosing up to 2000 mg/kg bw. The data obtained in the paper for MJN may be used as a standard guideline for preparation of the formulation which can save time, cost, and resources for future research endeavours.

• CELLMED
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• v.11 no.4
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• pp.21.1-21.9
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• 2021

Background: Unani System of Medicine (USM) has its origin to Greece. To ensure and develop the quality, authenticity of Unani drugs, standardization on modern analytical parameter is essential requirement for drugs. Objectives: The aimed of the present study was to develop a standard profile of "Qurṣ-e-Mafasil" by systematic study through authenticated ingredients, pharmacognostic identification followed by physicochemical, TLC, HPTLC fingerprinting analysis as per standard protocol. Material and Methods: In this study three batches of "Qurṣ-e-Mafasil" QM were prepared by standard method as per UPI had been followed by organoleptic properties of formulation such as appearance, color, odor, taste. Powder Microscopy and physicochemical studies were carried out such as Uniformity of weight, Friability, Disintegration time, hardness, LOD, ash vales and extractive values in like aqueous, alcohol & hexane. Further qualitative tests such as Thin-Layer Chromatography (TLC), and High-Performance Thin Layer Chromatography (HPTLC) studies were also carried out to develop fingerprint pattern of the alcoholic solvent extract of QM. Phytochemical screening was carried out in different solvent extracts such as alcoholic, aqueous and chloroform extracts to detect the presence phytoconstituents in the formulation QM. Heavy metals, Microbial Load Contamination and pesticidal residues were also determined. Results: Qurṣ-e-Mafasil showed tablet-like appearance, light brown colour, mild pungent odour and acrid taste. Uniformity of weight (mg), friability (rpm), and hardness (kg/cm) and disintegration time was ranged between (500 to 503), (0.0340 to 0.038), (8.40 to 8.67) and (4-5 minutes) respectively for the three batches. Loss in weight on drying at 105℃ was ranged between (8.3425 to 8.7346). Extracted values were calculated in distilled water ranged between (30.9091 to 31.4358), hexane (1.1419 to 1.4281), and alcohol (3.3352 to 3.3962). The ash values recorded were ranged between (3.7336 to 3.8378), and acid insoluble ash (0.5859 to 0.6112).