• Tuberculosis and Respiratory Diseases
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• v.85 no.4
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• pp.341-348
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• 2022

Background: An accurate diagnosis in patients with interstitial lung diseases (ILDs) by multidisciplinary discussion (MDD) based on histopathologic information is essential for optimal treatment. Transbronchial lung cryobiopsy (TBLC) has increasingly been used as a diagnostic alternative to surgical lung biopsy. This study aimed to evaluate the appropriate methods of TBLC in patients with ILD in Korea. Methods: A total of 27 patients who underwent TBLC were included. TBLC procedure details and clinical MDD diagnosis using TBLC histopathologic information were retrospectively analyzed. Results: All procedures were performed under general anesthesia with the fluoroscopic guidance in the operation room using flexible bronchoscopy and endobronchial balloon blocker. The median procedure duration was less than 30 minutes, and the median number of biopsies per participant was 2. Most of the bleeding after TBLC was not severe, and the rate of pneumothorax was 25.9%. The most common histopathologic pattern was alternative (48.2%), followed by indeterminate (33.3%) and usual interstitial pneumonia (UIP)/probable UIP (18.5%). In the MDD after TBLC, the most common diagnosis was idiopathic pulmonary fibrosis (33.3%), followed by smoking-related ILD (25.9%), nonspecific interstitial pneumonia (18.6%), unclassifiable-ILD (14.8%), and others (7.4%). Conclusion: This first single-center experience showed that TBLC using a flexible bronchoscopy and endobronchial balloon blocker with the fluoroscopic guidance under general anesthesia may be a safe and adequate diagnostic method for ILD patients in Korea. The diagnostic yield of MDD was 85.2%. Further studies are needed to evaluate the diagnostic yield and confidence of TBLC.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.224-224
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• 2019

국제기상기구의 Global Framework for Climate Services (GFCS)의 관점에서 살펴보면 국내의 기상 기후 정보는 기상청을 중심으로 관측 자료와 중장기 예측 및 기후변화 시나리오 정보 등의 다양한 시간규모로 생산되고 있다. 하지만 사용자가 직접적으로 다양한 기후정보를 상세화하여 활용하기 위해서는 기후정보의 구축 및 전처리를 수행해야하는 어려움이 있다. 따라서 APEC Climate Center (APCC)에서 다학제 융합 기반 기후정보 서비스를 중심으로 사용자 인터페이스 플랫폼 (User Interface Platform: UIP)의 기술적 플랫폼으로 APCC Integrated Modeling Solution (AIMS)를 개발하였다. AIMS는 사용자의 관점으로 상세화를 수행할 수 있고, 다양한 응용 분야에 적용하기 쉽게 데이터를 생성하여 연구에 도움을 주고 있다. 본 연구는 AIMS에서 제공하고 있는 기존의 국가별로 제공하는 제 5차 결합 기후모델 비교사업 (The $5^{th}$ phase of the coupled model intercomparision project, CMIP5)에서 해석한 전구기후모델 (General Circulation Model, GCM)의 통계적 상세화 방법인 Simple Quantile Mapping (SQM)과 Spatial Disaggregation Quantile Delta Mapping (SDQDM)를 포함하여 AIMS에 새롭게 추가 된 통계적 상세화 방법인 Bias Correction and Stochastic Analog (BCSA) 방법을 소개하고자 한다. 또한 60개의 종관기상관측 (Automated Surface Observing System, ASOS)자료를 중심으로 생성한 세 가지 통계적 상세화방법의 과거재현성과 RCP4.5, RCP8.5 시나리오를 활용한 미래 불확실성 평가 결과를 이용하여 연구자들의 맞춤형 자료를 생산하고 평가하는데 도움을 줌으로써 다양한 기후자료의 효과적인 활용이 가능할 것으로 기대된다.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.10
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• pp.1395-1399
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• 2004

The objective of this study was to evaluate the effect of dietary fat inclusion on nutrient intake, body weight, milk production, return to estrus, pregnancy and lambing of winter-lambing, postpartum Awassi ewes. Thirty multiparous, winter-lambing Awassi ewes (body weight=51${\pm}$7.0 kg) were randomly assigned to three dietary treatments (n=10) for 62 days using a completely randomized design. Experimental diets were isonitrogenous, and were formulated to contain 0 (CON), 2.5 (MF), and 5% (HF) added fat, and 33% of the dietary crude protein (CP) as undegradable intake protein (UIP). On day 26 postpartum (day 0=parturition), ewes and their lambs were housed in individual pens for 28 days. Feed offered and refused was recorded daily. At the end of this period, ewes and their lambs within each treatment were combined into one group and fed their respective diet ad libitum. One fertile Awassi ram fitted with a marking harness was allowed with each group for 34 days. No significant (p>0.05) differences in dry matter intake, organic matter intake, and crude protein intake were observed for ewes fed the three experimental diets. No difference was observed in metabolizable energy intake (MEI) for ewes fed the CON and the MF diets (average 8.3 Mcal/d) diet. However, ewes fed the HF diet had greater(p<0.05) MEI compared with the rest of the treatments. Ewe body weights increased throughout the study, unaffected by the experimental diets. No significant differences in milk production were found among ewes fed the three experimental diets. No significant differences were observed in pregnancy rate (6/10, 5/10, 6/10 for CON, MF and HF diets, respectively), lambing rate and the number of lambs per ewe among the three treatments. postpartum reproductive performance of well-fed, winter-lambing Awassi ewes.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.5C
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• pp.469-477
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• 2007

Most multimedia source coders exhibit unequal bit error sensitivity. Efficient transmission system design should therefore incorporate the use of matching unequal error protection (UEP). In this paper, we present and evaluate a flexible space-time coding system with unequal error protection. Multiple transmit and receive antennas and bit-interleaved coded modulation techniques are used combined with rate compatible punctured convolutional codes. A near optimum iterative receiver is employed with a multiple-in multiple-out inverse mapper and a MAP decoder as component decoders. We illustrate how the UEP system gain can be achieved either as a power or bandwidth gain compared to the equal error protection system (EEP) for the identical source and equal overall quality for both the UEP and EEP systems. An example with two/three transmit and two receive antennas using BPSK modulation is given for the block fading channel.

• The Research Journal of the Costume Culture
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• v.20 no.1
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• pp.83-98
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• 2012

In 2009, two national universities were integrated into one and the following was newly named Gangneung- Wonju National University. Therefore, this university requires consolidation and promotion of UI(University Identity) as a college brand in order to secure and enhance its competitiveness. The purpose of this study was to design and develop campus-wear, ultimately, it can be used as a part of the Gangeung-Wonju University's UIP policy. A qualitative approach of searching==incorporating books, dissertations, and web-based information==was taken to investigate theoretical backgrounds. The campus-wears were collected from the selected universities in Korea and abroad for the distinct design development. The result of the research are as follows. The concept for the design planning was "wit, exciting & challenge for campus life". The developed UI had focused on expressing positive images of the University. Six items were chosen for the campus-wear design. The goal was to demonstrate practicality and fashion trend. The color arrangement primarily focused on the University's official color and pursued a bright, breeze look. The detailed techniques used for the actual production were printing, embroidery, and accessories. The UI products may not only instill the members of the university with the spirit and pride by strengthening the sense of belonging, but also create a synergistic effect in education by boosting the university promotion and by newly establishing standing as the integrated university.

• Journal of the Korean Society of Radiology
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• v.82 no.4
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• pp.770-790
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• 2021

Idiopathic pulmonary fibrosis (IPF), based on the 2018 international clinical practice guidelines, can be diagnosed with a usual interstitial pneumonia (UIP) pattern on high-resolution computed tomography (HRCT) and compatible clinical findings. Given that imaging is pivotal for IPF evaluation and diagnosis, more emphasis should be placed on the integration of clinical, radiological, and pathologic findings for multidisciplinary diagnosis. Interstitial lung abnormality (ILA), on the other hand, has a purely radiological definition based on the incidental identification of CT abnormalities. Taken together, differentiation between ILA and clinically significant interstitial lung disease (ILD) must be based on proper clinical evaluation. With this review, the recent updates in IPF diagnosis and the radiologic considerations for ILA can be well understood, which can be helpful for the proper diagnosis and management of patients with diffuse interstitial pulmonary fibrosis.

• Tuberculosis and Respiratory Diseases
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• v.51 no.3
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• pp.201-210
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• 2001

Background : Approximately 10-13% of patients with interstitial lung disease(ILD) die of lung cancer, and patients with ILD have been reported to have a 7 fold higher incidence of lung cancer compared to the normal population. Recently, overexpression of the p53 and p21 proteins were observed in the epithelial cells from pathologic specimens of ILD. Overexpression of these proteins may result from chronic or recurrent DNA damage by unknown causes of inflammation. However, these proteins may also contribute to oncogenesis if other genetic alterations such as K-ras are superimposed. Methods : Immunohistochemical stains for p53 and K-ras proteins were performed with pathologic specimens from 38 cases with ILD(M/F : 27/11, mean agea : $54{\pm}10$ years) and from 10 control subjects. Results : The p53 protein was expressed in 21.1% (8/38 ILD cases) and K-ras protein expression was observed in 65.8% (25/38 ILD cases). However, neither p53 nor the K-ras protein staining was observed in the control subjects. Conclusion : A significant proportion of cases with ILD expressed the p53 and K-ras proteins in their bronchial epithelial cells. These proteins may be potentially oncogenic with the addition of further genetic alterations. However, to clarify the significance of these findings, further studies looking for correlations with the incidence of lung cancer and other genetic changes are needed.

• Tuberculosis and Respiratory Diseases
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• v.52 no.5
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• pp.506-518
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• 2002

Background : There have been several studies showing that angiotensin II and the angiotensin converting enzyme (ACE) contribute to the activation of fibroblast including the pulmonary fibrosis, and apoptosis of the alveolar epithelium in idiopathic intersititial pneumonia. This study was performed to identify the relationship between the serum angiotensin II, ACE and the pulmonary function test (PFT), the dyspnea score, and the cell fraction of the bronchoalveolar lavage fluid(BALF). Materials and Methods : Twenty three patients with idiopathic interstitial pneumonia from March, 1999 to October, 2001 at Gachon medical school were enrolled in this study. They were divided into IPF(UIP) (16) and NSIP (7) groups. Twelve of the idiopathic interstitial pneumonia patients (UIP : 5, NSIP : 7) were diagnosed by an open lung biopsy, 11 of IPF patients were diagnosed by the American Thoracic Society (ATS) diagnostic criteria. The PFT values, dyspnea score, serum ACE and angiotensin II were measured, and a bronchoscopy was performed to obtain the BALF. Results : Of all the patients, 7 were in the normal range and 14 showed an increase in the serum level of angiotensin II. In terms of the serum ACE level, 14 patients had an increased level. The DLCO% of the angiotensin II in increased group was significantly lower than the not-increased group (p=0.021). Other factors did not correlate with the serum ACE or the angiotensin II increased group and not-increased group. Conclusion : These results suggest that an increased angiotensin II serum level may be associated with increase in the of alveolar capillary block in the progression of pulmonary fibrosis in idiopathic interstitial pneumonia.

• Tuberculosis and Respiratory Diseases
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• v.53 no.2
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• pp.136-147
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• 2002

Background : Interstitial lung disease has various manifestations that are differentiated by their pathology, progress and treatment. However, all manifestations eventually progresses to pulmonary fibrosis. Recent studies have shown that apoptosis of pulmonary epithelial cells might be related to pulmonary fibrosis. The correlation of the apoptotic index with the clinical manifestations, pathological findings, HRCT findings and the response to treatment were examined. Materials and Methods : Twenty subjects (14 men, 16 women), who had been diagnosed with interstitial lung disease through an open lung biopsy, were enrolled in this study. The subtypes were one AIP, two NIP, eight BOOP, and seven UIP cases. The apoptotic index was scaled from 0-2 depending on the fraction of positive staining cells by TUNEL method. The clinical severity was assessed by a modification of a previously developed CRP scoring system. The pathologic scores were based on 4 components: fibrosis, cellularity, desquamation, and granulation. In the HRCT study, each lobe was scored by the radiologists on a scale for both fibrosis and ground-glass attenuation. The treatment response was assessed by an increase in more than 10% of the CRP score, and comparing the results 3 months before and after treatment. Results : The apoptotic index showed no correlation with the CRP and HRCT scoring system. The apoptotic index correlated with the pathologic elements including fibrosis, cellularity and the desquamation score (p<0.05). Of the 16 patients who received corticosteroid therapy, 9 patients (56.3%) responded to therapy. There was no correlation between the response to corticosteroid and the apoptotic index. In the case of patients with acute and subacute ILD, the apoptotic index showed a correlation with the cellularity, desquamation, and the total histological score (p<0.05). In the case of patients with chronic ILD, the apoptotic index correlated with the fibrosis and cellularity score (p<0.05). Conclusion : Apoptosis of the pulmonary epithelial cells is implicated in the pathogenesis of interstitial lung disease particularly on a pathological basis.

• Tuberculosis and Respiratory Diseases
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• v.43 no.3
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• pp.388-402
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• 1996

Background : To compare the diagnostic accuracies of High-resolution CT(HRCI) and chest radiography in the diagnosis of diffuse infiltrative lung disease(DILD). Methods : This study included ninety-nine patients with a diagnosis of acute or chronic DILD, representing 20 different diseases. Twelve normal subjects were included as control. The disease state was confirmed either pathologically or clinically. Radiographs and CT scans were evaluated separately by three independent observers without knowledge of clinical and pathologic results. The observers listed three most likely diagnoses and recorded degree of confidence. Results : The sensitivity of HRCT in the detection of DILD was 98.9% compared to 97.9% of chest radiography. Overall, a correct first-choice diagnosis was made in 48% using chest radiographs and in 60% using HRCT images. The correct diagnosis was among the top-three choices in 64% when chest radiographs were used, and in 75% when HRCT images were reviewed. Overally a confident diagnosis was reached more often with HRCT(55%) than with chest radiography(26%). The correct first-choice diagnosis increased remarkably when the HRCT was used in usual interstitial pneumonia, miliary tuberculosis, diffuse panbronchiolitis and lymphangitic carcinomatosis. Conclusion : HRCT is confirmed to be superior to conventional radiography in the detection and accurate diagnosis of DILD. HRCT is especially valuable in the diagnosis of usual interstitial pneumonia, miliary tuberculosis, diffuse panbronchiolitis, and lymphangitic carcinomatosis.