• 제목/요약/키워드: U87

검색결과 687건 처리시간 0.048초

시험관내 폐암(肺癌), 위암(胃癌) 및 신경교종(神經膠腫) 세포(細胞)에 대한 석웅황(石雄黃)의 항암효과(抗癌效果) (Induction of Apoptosis by Realgar on Lung Cancer Cells(A549), Stomach Center Cells(KATO) and Neuroglioma Cells(SNU-1118, U-87MG, U-373MG))

  • 방대건;김진성;류봉하
    • 대한한방내과학회지
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    • 제28권2호
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    • pp.294-303
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    • 2007

  • Objectives : We are aimed to identify anti-tumor effects of realgar on some kinds of cancer cells through molecular biologic methods. Materials & Methods : We used 5 kinds of cancer cell lines: lung cancer cells(A549). stomach cancer cells(KATO) and neuroglioma cells(SUN-1118. U-87MG, U-373MG). We injected the boiled extracts of realgar $50{\mu}g$. $100{\mu}g$ to cultural media( ml )for 24 hours. We measured the killing effects on 5 kinds of cancer cells through inverted and fluorescence microscope, the suppressive effects on viability of those cells via XTT assay and the effects on the revelation of Bax and Bcl-2 proteins related to apoptosis by western blotting. Results : In the changes of morphology, the extracts of realgar showed more significant killing effects on all cancer cells. especially KATO, SNU-1118, U-87MG, U-373MG, than the control group with dose dependence, which was statistically significant. In XTT assay, the extracts of realgar showed more suppressive effects on viability of all cancer cells, especially KATO and U-373MG, than the control group with dose dependence, which was statistically significant. In the revelation of proteins related to apoptosis, the extracts of realgar increased the level of Bax and decreased that of Bcl-2 in all cancer cells with dose dependence. Conclusions : We identified that realgar had more anti-tumor effects on stomach cancer and neuroglioma than on lung cancer in the experiments above. However, these basic experiments were performed in vitro. We hope the anti-tumor effects of realgar will be practically identified through more progressive research.

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U-CDS의 자연환기를 위한 AirDam시스템의 효과에 대한 연구 (System Effectiveness of AirDam for Natural Ventilation by U-CDS)

  • 김승철;신부현;오기대
    • KEPCO Journal on Electric Power and Energy
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    • 제8권2호
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    • pp.87-92
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    • 2022

  • Recently, there has been an increasing demand for electric equipment installed on the ground to be installed in an underground space. Accordingly, U-CDS (Underground-Compact Distribution Station) installed in the underground is supplied, and to improve its weak ventilation performance, an Airdam-type structure was applied and the effect was analyzed. As a result, the temperature around the transformer was reduced by up to 9.5 degrees, and the air flow increased by up to 1.17 m/s. Airdam structure can be supplied in the form of various sculptures because it is possible to design freely while maintaining its principle.

  • https://doi.org/10.18770/KEPCO.2022.08.02.87 인용 PDF KSCI