• BMB Reports
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• v.49 no.1
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• pp.63-68
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• 2016

The serine/threonine kinase mTOR is essential for the phosphoinositide 3-kinases (PI3K) signaling pathway, and regulates the development and function of immune cells. Aberrant activation of mTOR signaling pathway is associated with many cancers including leukemia. Here, we report the contributions of mTOR signaling to growth of human leukemic cell lines and mouse T-cell acute leukemia (T-ALL) cells. Torin, an ATP-competitive mTOR inhibitor, was found to have both cytotoxic and cytostatic effects on U-937, THP-1, and RPMI-8226 cells, but not on Jurkat or K-562 cells. All cells were relatively resistant to rapamycin even with suppressed activity of mTOR complex 1. Growth of T-ALL cells induced by Notch1 was profoundly affected by torin partially due to increased expression of Bcl2l11 and Bbc3. Of note, activation of Akt or knockdown of FoxO1 mitigated the effect of mTOR inhibition on T-ALL cells. Our data provide insight on the effect of mTOR inhibitors on the survival and proliferation of leukemic cells, thus further improving our understanding on cell-context-dependent impacts of mTOR signaling. [BMB Reports 2016; 49(1): 63-68]

• Magazine of the Korean Society of Agricultural Engineers
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• v.32 no.E
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• pp.1-19
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• 1990

Abstract Over the last several decades, crop production in the United States increased largely due to the extensive use of animal waste and fertilizers as plant nutrient supplements, and pesticides for crops pests and weed control. Without the application of animal waste best management, the use of animal waste can result in nonpoint source pollution from agricultural land area. In order to increase nutrient levels and decrease contamination from agricultural lands, nonpoint source pollution is responsible for water quality degradation. Nonpoint source pollutants such as animal waste, ferilizers, and pesticides are transported primarily through runoff from agricultural areas. Nutrients, primarily nitrogen and phosphorus, can be a major water quality problem because they cause eutrophic algae growth. In 1985, it was presented that Watershed/Water Quality Monitoring for Evaluation BMP Effectiveness was implemented for Nomini Creek Watershed, located in Westmoreland County, Virginia. The watershed is predominantly agricultural and has an aerial extent of 1505 ha of land, with 43% under cropland, 54% under woodland, and 3% as homestead and roads. Rainfall data was collected at the watershed from raingages located at sites PNI through PN 7. Streams at stations QN I and QN2 were being measured with V-notch weirs. Water levels at the stream was measured using an FW-l Belfort (Friez FWl). The water quality monitoring system was designed to provide comprehensive assessment of the quality of storm runoff and baseflow as influenced by changes in landuse, agronomic, and cultural practices ill the watershed. As this study was concerned with the Nomini Creek Watershed, the separation of storm runoff and baseflow measured at QNI and QN2 was given by the master depletion curve method, and the loadings of baseflow and storm runoff for TN (Total Nitrogen) and TP (Total Phosphorus) were analyzed from 1987 through 1989. The results were studied for the best management practices to reduce contamination and loss of nutrients, (e.g., total nitrogen and total phosphorus) by nonpoint source pollution from agricultural lands.

• Journal of Advanced Navigation Technology
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• v.21 no.2
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• pp.193-199
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• 2017

In the paper, a dual band-notched monopole antenna is proposed for 2.4 GHz WLAN (2.4 ~ 2.484 GHz) and UWB (3.1 ~ 10.6 GHz) applications. The 3.5 GHz WiMAX band notched characteristic is achived by a pair of L-shaped slots instead of the previous U-shaped slot on the center of the radiating patch, whereas the 7.5 GHz band notched characteristic is achived by C-shaped strip resonator placed near to the microstrip feed line. The measured impedance bandwidth (${\mid}S_{11}{\mid}{\leq}-10dB$) is 8.62 GHz (2.38 ~ 11 GHz) which is sufficient to cover 2.4 GHz WLAN and UWB band, while measured band-notched bandwidths for 3.5 GHz WiMAX and 7.5 GHz bnad are 1.13 GHz (3.15 ~ 4.28 GHz) and 800 MHz (7.2 ~ 8 GHz) respectively. In particular, it has been observed that antenna has a good omnidirectional radiation patterns and higher gain of 2.51 ~ 6.81 dBi over the entire frequency band of interest.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2009.06a
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• pp.475-486
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• 2009

The geological survey of the Mokdo island is for the fist time conduted in Korea history. The island had erupted before $70{\sim}80$ million years as a strato-volcano. The original volcano had been dissected for long periods up to the skeletal stage through the planeze stage. If the island area is surveyed afterwrds in detail, the position of crater is available to be found, either. The coastal terrace is found at 50m level in Mokdo island which is correlated to its fourth plane. The microgeomorphological features as coastal terrace, cliff, sea cave, wave-cut bench, sea stacks, notch, and tafoni, etc. were described. The Mogdo island is located off Molundae at the extension of Nagdong Jeongmaeg(낙동정맥 洛東正脈) showing a "floating turtle". The name of Mogdo island is needed to change to the "Yoo-goo-do" which means the swimming turtle. The Mokdo island is as suitable tourist attraction for if has enough touism sesouccesein sea. The deuelopsment of coartal sightseeing anound lighthoure and uninhabited islands will hare an impontant effect upon construction of the oceanic capitol city of Busan Haabor. The master plan built up an arboretum on the island, a coastal oceanarium, a seaweeds garden under sea coast, and other oceanic culture-spaces is completed in the study.

• Restorative Dentistry and Endodontics
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• v.27 no.2
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• pp.142-149
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• 2002

Low-viscosity composite resins may produce better sealed margins than stiffer compositions (KempScholte and Davidson, 1988: Crim, 1989). Plowable composites have been recommended for use in Class V cavities but it is also controversial because of its high rates of shrinkage. On the other hand, in the study comparing elastic moduli and leakage, the microfill had the least leakage (Rundle et at. 1997) Furthermore, in the 1996 survey of the Reality Editorial Team, microfills were the clear choice for abfraction lesions. The purpose of this study was to evaluate the microleakage of 6 compostite resins (2 hybrids, 2 microfills, and 2 flowable composites) with and without load cycling. Notch-shaped Class V cavities were prepared on buccal surface of 180 extracted human upper premolars on cementum margin. The teeth were randomly divided into non-load cycling group (group 1) and load cycling group (group 2) of 90 teeth each. The experimental teeth of each group were randomly divided into 6 subgroups of 15 samples. All preparations were etched, and Single bond was applied. Preparations were restored with the following materials (n=15) : hybrid composite resin [Z250(3M Dental Products Inc. St. Paul, USA), Denfil(Vericom, Ahnyang, Korea)], microfill [Heliomolar RO(Vivadent, Schaan, Liechtenstein), Micronew(Bisco Inc. Schaumburg, IL, USA)], and flowable composite［AeliteFlo(Bisco Inc. Schaumburg, IL, USA), Revolution(Kerr Corp. Orange, CA, USA)]. Teeth of group 2 were subjected to occlusal load (100N for 50,000 cycles) using chewing simulator(MTS 858 Mini Bionix II system, MTS Systems Corp. Minn. USA). All samples were coated with nail polish 1mm short of the restoration, placed in 2％ methylene blue for 24 hours, and sectioned with a diamond wheel. Enamel and dentin/cementum margins were analyzed for microleakage on a sclale of 0 (no leakage) to 3 (3/3 of wall). Results were statistically analyzed by Kruscal-Wallis One way analysis, Mann-Whitney U-test, and Student-Newmann-Keuls method. (p = 0.05) Results : 1. There was significantly less microleage in enamel margins than dentinal margins of all groups (p＜0.05) 2. There was no significant between six composite resin in enamel margin of group 1. 3. In dentin margin of group 1, flowable composite had more microleakage than others but not of significant differences. 4. there was no significant difference between six composite resin in enamel margin of group 2. 5. In dentin margin of group 2, the microleakage were R＞A =H=M＞D＞Z. But there was no significant differences. 6. In enamel margins, load cycling did not affect the marginal microleakage in significant degree. 7. In enamel margins, load cycling did affect the marginal microleakage only in Revolution. (p＜0.05).