• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.6
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• pp.1108-1112
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• 2011

Voice can be widely used to classify the four constitution types and to recognize one's health condition from extracting meaningful features as physical quantity in traditional Korean medicine or Western medicine. In this paper, we proposed the method to update the standard operating procedure (SOP) to acquire and record voices for extracting stable vocal features since they are sensitive to the variation of a subject's utterance. At first, we obtained pitch frequencies from vowels and the sentence and intensity form the sentence as features with voices acquired under subjects' utterance conditions and then the deviation ratios of features from median values according to the utterance conditions were obtained and the condition to minimize the ratio was selected as a new SOP. As a result, we decided the SOP for a subject to utter vowels with the length of 2s~1s and sentences with over 2s interval between them after practice, in consideration of the deviation and qualitative requirements. Stable voice features obtained from updated SOP produce accurate diagnosis, which will be developed and simplified for using in the u-Healthcare system of personalized medicine.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.3 no.1
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• pp.1-12
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• 2005

This study aimed at examining the maximal isometric contraction caused by voluntary exercise and at comparing its aspects of decrease and restoration in their different repeated application, as to the quadriceps muscles of thigh in the subjects composed of patients with spastic hemiplegia and normal adults. Using isokinetic exercise analyser(Biodex Medical Systems Inc., Biodex System 3PRO, U.S.A.), experiment was conducted as to the normal group composed of fifteen adults and the patient group composed of fifteen patients with spastic hemiplegia. As to each group, MVIC(maximal voluntary isometric contraction) of the quadriceps muscle of thigh caused by voluntary exercise and the aspects of decrease and restoration of the isometric contraction were examined with the method to induce isometric exercise, and their SDI(strength decrement index) and SRI(strength recovery index) were also calculated. The results can be summarized as follows: 1. As for decrease of maximal isometric contraction, both groups showed slow decrease in voluntary exercise, but the normal group showed rapid decrease later phase. 2. As for SDI, no significant differences could be observed in comparison between groups. 3. As for restoration of maximal isometric contraction, both groups showed slow restoration in voluntary exercise, but the normal group showed rapid restoration early phase. 4. As for SRI, comparison between groups showed significant differences in voluntary exercise. These results lead us to the conclusions that spastic muscle is characterized by slow decrease and restoration of MVIC in comparison with normal muscle in voluntary exercise.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.4
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• pp.371-376
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• 2017

The caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn; MDH) receives direct inputs from small diameter primary afferent fibers that predominantly transmit nociceptive information in the orofacial region. Recent studies indicate that reactive oxygen species (ROS) is involved in persistent pain, primarily through spinal mechanisms. In this study, we aimed to investigate the role of xanthine/xanthine oxidase (X/XO) system, a known generator of superoxide anion ($O_2{^-}$), on membrane excitability in the rat MDH neurons. For this, we used patch clamp recording and confocal imaging. An application of X/XO ($300{\mu}M/30mU$) induced membrane depolarization and inward currents. When slices were pretreated with ROS scavengers, such as phenyl N-tert-butylnitrone (PBN), superoxide dismutase (SOD), and catalase, X/XO-induced responses decreased. Fluorescence intensity in the DCF-DA and DHE-loaded MDH cells increased on the application of X/XO. An anion channel blocker, 4,4-diisothiocyanatostilbene-2,2-disulfonic acid (DIDS), significantly decreased X/XO-induced depolarization. X/XO elicited an inward current associated with a linear current-voltage relationship that reversed near -40 mV. X/XO-induced depolarization reduced in the presence of $La^{3+}$, a nonselective cation channel (NSCC) blocker, and by lowering the external sodium concentration, indicating that membrane depolarization and inward current are induced by influx of $Na^+$ ions. In conclusion, X/XO-induced ROS modulate the membrane excitability of MDH neurons, which was related to the activation of NSCC.

• Journal of East-West Nursing Research
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• v.18 no.2
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• pp.111-119
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• 2012

Purpose: Recently, Neurofeedback training system that based on biofeedback of brain wave was introduced. This study was performed to identify the effects of the improvement of brain function by Neurofeedback training on elders(the 2nd or 3rd grade of long-term care insurance services). Methods: A quasi-experimental design using a nonequivalent control group, pre-post test was used. Total 11 elderly were enrolled in this study (experimental group 5, control group 6). The intervention was conducted 3 times a week for 30 minutes from January to June, 2012 (total 60 times). Chi-square test and Mann-Whitney U-test were used to analyze the data. Results: After the Neurofeedback intervention, attention quotient (AQ), anti-stress quotient (ASQ), emotion quotient (EQ) and brain quotient (BQ) of the experimental group were significantly better than those of the control group. Conclusion: The findings indicate that the Neurofeedback training program was effective in reducing fatigue by AQ, increasing the physical and mental stress resistance by ASQ, emotional balance by EQ and improving of total brain function by BQ. Therefore Neurofeedback training be used as an effective training intervention for the health of elderly in geriatric facility.

• Journal of The Korea Institute of Healthcare Architecture
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• v.24 no.3
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• pp.49-57
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• 2018

Purpose: The increase in patients requiring hemodialysis has resulted in an increase dialysis-associated infections risk. but there are no Renal Dialysis unit design standard meet specified safety and quality standards. Therefore, appropriate Establish standards and legal regulation is important for the provision of initial certification and maintenance of facility, equipment, and human resource quality. Methods: Literature survey on the design guideline and standards of Renal Dialysis unit design in Korea, U.S, Germany, Singapore, Hongkong, Dubai. Results: There are no established standards for facilities in dialysis units in Korea. To prevent infections in dialysis patients, necessary establish standards. Considering the domestic and overseas Health-care facilities standards, the major factors to be considered in the medical environment for Renal Dialysis Unit are as follows. First, planning to separate Clean areas(treatment area) from contaminated areas(medical waste storage area). Second, ensure sufficient space and minimum separation distance. Although there may be differences depending on the circumstances of individual institutions, renal dialysis unit consider the space to prevent droplet transmission. Third, secure infrastructure of infection prevention such as sufficient amount of hand hygiene sinks. Hand washing facilities for staff within the Unit should be readily available. Hand hygiene sinks should be located to prevent water from splashing into the treatment area. Fourth, Heating, ventilation and air conditioning (HVAC) system for Renal Dialysis Unit is all about providing a safer environment for patients and staff. Implications: The results of this paper can be the basic data for the design of the Renal Dialysis Units and relevant regulations.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.295-298
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• 2016

Background: Breast cancer is a very common health problem in Iranian women. The HER2-neu gene is a transmembrane receptor tyrosine kinase with homology to members of the EGF receptor family. The aim of this study was to investigate the association between HER2-neu oncogene status with prognostic factors of breast cancer in Kermanshah province, Iran. Materials and Methods: Relationship between HER2-neu and prognostic factors of 130 cases of breast cancer were evaluated during two years in Imam Reza hospital in Kermanshah, Iran. Data were analyzed using descriptive statistics and the T-test and Mann-Whitney U non-parametric test using SPSS 19. Results: The mean age for the patients was $46.0{\pm}8.0years$, all being female. Among the predictive factors for breast cancer were family history, stage of disease, involvement of the lymphovascular system, number of involved lymph nodes in axillaries, grading and hormone receptor status with HER2-neu oncogene had direct correlation and between factors, tumor location, patient age and histological characteristics and HER2-neu oncogene had no significant relationship. We found significant correlation between HER2 with ER and PR and also HER2 with ER, PR negative. Conclusions: HER2-neu is risk factor that can be a good prognostic and also predictive factor. For these reasons, we recommend that it be evaluated for all types of BC.

• Journal of Korea Game Society
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• v.11 no.6
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• pp.171-180
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• 2011

An interactive wireless-game device based on multi-channel electromyogram has been developed to help rehabilitation of patients with hemiplegia. The device is able to provide a visual feedback and rehabilitation motivations to the patients. The game contents were made according to the number of applied channels and, their level and speed can also be controlled depending on the recovery states of patients. Patient satisfaction survey was conducted to evaluate the necessity and usefulness of the proposed device after playing the game. The results show that the proposed system is expected to give hemiplegia patients exciting and effective rehabilitation chances, if more diverse and specialized rehabilitation games are developed.

• Korean Institute of Interior Design Journal
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• v.21 no.6
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• pp.212-223
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• 2012

The "Eco-friendly", "Green" concepts was began around 1992 after the Rio Environmental Summit, and the need for sustainable development globally widespread. The green building certification system was began around 2000 and the concept of green building was started in the late 1990s. The green building, which welcomes a period of radical change, is for the survival of the Earth "climate change" and reducing energy consumption in building sector. In this architecture of eco-friendly concept, the green building is rapidly expanding and existing as a ecological environment preservation. Moreover, the realization of zero energy house is to mandate for new buildings in 2025. The aim of further eco-friendly is through the prior ecosystems to restore and product energy for the 9 Green Building model houses in this paper. Building in the concept of ecology is to show about change into 7R's from the 3R's. The "Reduce", "Reuse", "Recycle" consisting of "3R's" is correlated with the traditional to the present Green Building Design. U.S. NCARB (National Council of Architectural Registration Boards) change into the concept of 7R's as "Receive", "Restore", "Respect" and "Remember", added to "3R's". In this paper, the 9 Green Building model houses do not meet the criteria of 7R's. But, the Green Tomorrow of Samsung C & T Corporation meet the 6 criteria for 7R's. This company is most comfortable at low carbon Green Building model houses. Conclusionally, introduction of eco-friendly technologies and amenities for the health of human and natural community life is to advance eco-friendly construction and enhance brand value of housing. By the way, The problem of eco-friendly architecture is initial investment and maintenance. Therefore, eco-friendly architecture and government has to try solving of this difficulty.

• Korean Journal of Oriental Medicine
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• v.17 no.3
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• pp.97-104
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• 2011

Objectives : In this paper, we proposed a method for selecting reliable variables from various vocal features such as frequency derivative features, frequency band ratios, intensities of 5 vowels and an intensity of a sentence, since some features are sensitive to the variation of a subject's utterance. Methods : To obtain the reliable voice variables, the coefficient of variation (CV) was used as the index to evaluate the level of reliability. Since the distributions of a few features are not Gaussian, but are instead skewed to the right or left, we transformed the features by taking the log or square root. Moreover, the definition of the variables that are suitable to represent the vocal property was explained and analyzed. Results : At first, we recorded the vowels and the sentence five times both in the morning and afternoon of the same day, totally ten recordings from each of six subjects (three males and three females). We then analyzed the CVs of each subject's voice to obtain the stable features with a sufficient repeatability. The features having less than 20% CVs for all six subjects were selected. As a result, 92 stable variables from the 222 features were extracted, which included all the transformed variables. Conclusions : Voice can be widely used to classify the four constitution types and to recognize one's health condition from extracting meaningful features as physical quantity in traditional Korean medicine or Western medicine. Therefore, stable voice variables can be useful in the u-Healthcare system of personalized medicine and for improving diagnostic accuracy.

• Restorative Dentistry and Endodontics
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• v.25 no.2
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• pp.235-242
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• 2000

The purpose of this in vitro study was to evaluate the sealing ability of three sealers(Sealapex, Pulp canal sealer, AH26) used with continuous wave method using an anaerobic bacterial leakage model. 53 extracted human teeth with straight and single canals were prepared with crown-down pressureless technique using .04, .06 taper Profile(Maillefer, Swiss). Master apical file was maintained as #35 K-file. All canals of the experimental teeth were obturated with continuous wave method using System B(Analytic technology, U.S.A.) The teeth were randomly divided into three experimental groups of 15 and two control groups of 4. Experimental group 1 was obturated with Sealapex and group 2 with Pulp canal sealer, and group 3 with AH26. A dual chamber anaerobic bacterial leakage model was assembled. Brain heart infusion with yeast extract, hemin, menadion, and the chromogenic indicator bromocresol purple was used as the culture broth for Fusobacterium nucleatum(VPI 10197), The specimens were incubated in anaerobic chamber at $37^{\circ}C$ and were observed every 2 to 3 clays, The coronal leakage was evaluated through the color change of culture broth in lower chamber for 60 days. The results were as follows: 1. The incidence of bacterial leakage in group 1 (Sealapex group was 80%, 53% in group 2 (Pulp canal sealer), 27% in group 3 (AH26). 2. There were statistically significant differences in leakage scores between group 1 and group 2, and between group 1 and group 3, respectively. (P<0.05) 3. There was no significantly difference in leakage score between group 2 and group 3. (P>0 05)