• The Korea Swine Journal
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• v.6 no.6 s.58
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• pp.106-109
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• 1984

• 대학교육
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• s.24
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• pp.94-98
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• 1986

• Korean Architects
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• no.8 s.79
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• pp.29-37
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• 1975

• Korean Architects
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• no.12 s.118
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• pp.47-55
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• 1978

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.4
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• pp.231-236
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• 2019

In drug discovery or preclinical stages of development, potency parameters such as $IC_{50}$, $K_i$, or $K_d$ in vitro have been routinely used to predict the parameters of efficacious exposure (AUC, $C_{min}$, etc.) in humans. However, to our knowledge, the fundamental assumption that the potency in vitro is correlated with the efficacious concentration in vivo in humans has not been investigated extensively. Thus, the present review examined this assumption by comparing a wide range of published pharmacokinetic (PK) and potency data. If the drug potency in vitro and its in vivo effectiveness in humans are well correlated, the steady-state average unbound concentrations in humans [$C_{u_-ss.avg}=f_u{\cdot}F{\cdot}Dose/(CL{\cdot}{\tau})=f_u{\cdot}AUCss/{\tau}$] after treatment with approved dosage regimens should be higher than, or at least comparable to, the potency parameters assessed in vitro. We reviewed the ratios of $C_{u_-ss.avg}$/potency in vitro for a total of 54 drug entities (13 major therapeutic classes) using the dosage, PK, and in vitro potency reported in the published literature. For 54 drugs, the $C_{u_-ss.avg}$/in vitro potency ratios were < 1 for 38 (69%) and < 0.1 for 22 (34%) drugs. When the ratios were plotted against $f_u$ (unbound fraction), "ratio < 1" was predominant for drugs with high protein binding (90% of drugs with $f_u{\leq}5%$; i.e., 28 of 31 drugs). Thus, predicting the in vivo efficacious unbound concentrations in humans using only in vitro potency data and $f_u$ should be avoided, especially for molecules with high protein binding.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.2
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• pp.721-727
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• 2013

This study sought to compare the difference of Phonation Threshold Pressure and Nasalance according to vowels. We tested 28 normal females(20~30age) who be in attendance at a school from May to August 2012. We measured Phonation Threshold Pressure through PAS(Phonatory aerodynamic system, model 6600, KAY electronics, Inc) that aero-mechanical instrument called. Phonation Threshold Pressure was measured by using the consonant /p/ and the three vowels /a, i, u/ and was analyzed the three times of Phonation the five times. Also We measured Nasalance through the Nasometer${\Pi}$(model 6450, KAY electronics, Inc). The vowel's phonation was recored by using the three vowels /a, i, u/. the nasalance score was measured via Nasometer. As a Result, Phonation Threshold Pressure according to three vowels show significantly difference. Also, Nasalance according to three vowels show significantly difference. Finally, Correlation coefficient of Phonation Threshold Pressure and Nasalance according to three vowels show positive relation ship. Therefore Phonation Threshold Pressure and Nasalance according to three vowels have closely relationship.

• The Journal of the Korea Contents Association
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• v.15 no.4
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• pp.263-276
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• 2015

This study aimed to examine the relationship between lifestyle in early recollections and life position of adolescence. The data was collected from 409(male 201, female 208) middle school students. To analyze the data, factor analysis, Pearson correlation coefficient, MANOVA and multiple regression were used. The major results of this study were as follows: First, it was proved that the correlation coefficient of those variables between lifestyle and life position were statistically significant. In particular, to BSI & WR were positively associated with I+ & U+, while GA & BC were positively associated with I- & U-. Second, U- had greatest influence on GA, I+ & U+ had greatest influence on WR, I- had greatest influence on BC. Based on the finding results, discussion and implication for further research were suggested.

• Journal of Haehwa Medicine
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• v.20 no.1
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• pp.39-50
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• 2011

In western, aromatherapy uses essential oils to prevent and treat disease, and is one of the ways to stay healthy. In oriental medicine, there was also a similar medical treatment using aromatic herbs for a long ago. The exisiting research of oriental medical herbs is mainly focused on the theory of qi and flavor(氣味論). But on aromatherapy used with aromatic herbs, it is necessary to study the aromatic herbs by aroma. So "xi$\bar{a}$ng p$\check{u}$, 香譜" and "b$\check{e}$n c$\check{a}$o g$\bar{a}$ng m$\grave{u}$, 本草綱目" mainly contain the study about clinical effects of aromatic herbs. And "b$\check{e}$n c$\check{a}$o p$\check{i}$n hu$\grave{i}$ j$\bar{i}$ng y$\grave{a}$o, 本草品彙精要"mainly explains the effects of medical herbs with five aroma classification of x$\bar{i}$ng(腥), sh$\bar{a}$n(膻), xi$\bar{a}$ng(香), ch$\grave{o}$u(臭), xi$\check{u}$(朽). The former one makes more clinical uses of medical herbs, and the latter one grows up the theory of medical herbs. This study is expected to have a good influence on aromatherapy and classification of oriental medical herbs.

• Korean Journal of Environment and Ecology
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• v.8 no.1
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• pp.1-10
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• 1994

Present problems of the Korean rare and endangered plant species evaluations are discussed. It is proposed that the evaluation criteria for Korean rare and endangered are urgently needed in the future. The translation of new proposed criteria into Korean should be discussed in order to avoid confusion in the future. The draft of a new criteria system for rare and endangered plant species. prepared by the S. S. C. (Species Survival Commission) of I. U. C. N (International Union of Conservation of Nature) are introduced. The proposed draft for the criteria being developed by the S. S. C. of I. U. C. N. are Extinct, Extinct in the Wild, Critical, Endangered, Vulnerable, Susceptible, Safe /Low Risk, Insufficiently Known, and Not Evaluated. It is expected to take the more time to be technically developed further and also officially recognized by the I. U. C. N. for the practical use in the future.

• Electrical & Electronic Materials
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• v.3 no.2
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• pp.90-98
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• 1990

Y-Bi-Ba-Cu-O계 초전도체를 보통의 ceramic방법과 screen printing과 소결법으로 원판형과 후막형으로 제작하였다. B $i_{2}$ $O_{3}$를 첨가하여 소결한 $Y_{1}$B $a_{2}$C $u_{3}$ $O_{7-y}$의 초전도 성질은 전기저항측정과 자석위에 부상 유무로 조사하였다. 또한 B $i_{2}$ $O_{3}$를 첨가함에 따라 소결된 시편의 미세구조에 어떠한 영향을 주었는지 알아보았다. 전기저항 측정시 Yttrium 대신에 Bi로 부분적으로 치환한 경우인 $Y_{0.85}$B $i_{0.15}$B $a_{2}$C $u_{3}$ $O_{7-y}$의 상온 저항치가 기본조성인 $Y_{1}$B $a_{2}$C $u_{3}$ $O_{7-y}$의 그것보다 향상된 미세구조로 인해 더 작은 값을 나타낸다. 반면 $Y_{1}$B $a_{2}$C $u_{3}$ $O_{7-y}$에다가 초과로 B $i_{2}$ $O_{3}$를 첨가한 경우 오히려 미세구조는 불량하고 상온저항치도 더 높다. 이러한 사실은 입계에 잔류하는 이차상은 전기적 성질에는 크게 영향을 주나 자기적 성질에는 거의 영향을 주지않는 것으로 보인다. 후막으로 Y-Bi-Ba-Cu-O를 제작시 기판에 의해 좌우되는데 단지 magnesia 기판에서 소결시 bulk시편과 유사한 성질을 나타냈다.질을 나타냈다.다.