• Parasites, Hosts and Diseases
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• 제58권1호
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• pp.61-65
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• 2020

Majority of the imported malaria cases in Korea is attributed to Plasmodium falciparum and P. vivax infections, whereas P. malariae and P. ovale infections are very rare. Falciparum and ovale malaria are mostly imported from Africa, while most of the vivax malaria cases are imported from Southeast Asia. Here, we report 6 Korean imported ovale malaria cases (4 males and 2 females) who had visited in Africa during 2013-2016. These subjects were diagnosed with P. ovale based on microscopic findings, Plasmodium species-specific nested-PCR, and phylogenetic clade using 18S rRNA gene sequences. We identified 2 P. ovale subtypes, 1 P. ovale curtisi (classic type) and 5 P. ovale wallikeri (variant type). All patients were treated with chloroquine and primaquine, and no relapse or recrudescence was reported for 1 year after treatment. With increase of travelers to the countries where existing Plasmodium species, the risk of Plasmodium infection is also increasing. Molecular monitoring for imported malaria parasites should be rigorously and continuously performed to enable diagnosis and certification of Plasmodium spp.

• 식물병연구
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• 제10권2호
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• pp.105-111
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• 2004

마늘흑색썩음균핵병에 대한 국내재배 마늘의 품종저항성을 구명하기 위하여 발병에 관여하는 Sclerotium cepivorum과 대균핵을 형성하는 Sclerotium sp.에 대한 invitro clove inoculation법에 의한 균사생장과 균핵형성소요 일수 그리고 이병포장에서의 품종별 발병정도를 조사하였다. 마늘인편 절편상에서의 병원균의 생장과 균핵형성은 품종 또는 병원균간에 차이를 보였다. 대서종에서는 두 가지 병원균 모두 가장 높은 균사생장을 보였다. S. cepivorum과 Sclerotium sp.의 균핵은 고당종에서 가장 빠르게 형성되었고, 남도종에서 가장 늦게 형성되었다. 포장에서의 품종별 병 저항성에 있어서는 S. cepivorum에 대해서는 모든 마늘에서 이병주율이 50% 이상으로 시험 품종 모두 감수성인 것으로 판명되었으며, 난지형마늘에 비해 한지형마늘에서 발병이 적었다. Sclerotium sp.에 대해서는 난지형 마늘 모두 고도의 감수성이었고, 한지형마늘은 서산종, 단양종 그리고 예천종이 중도저항성이었으며 의성종은 저항성인 것으로 나타났다. 마늘의 품종저항성을 정량적으로 평가하기 위하여 병진전곡선을 1차 회귀직선화하여 얻은 초기발병치(intercept), 병진전속도 및 병진전곡선하면적(AUDPC)을 비교한 결과 초기발병과 병진전이 함께 고려된 AUDPC가 품종별 병저항성을 평가하는데 적당한 것으로 나타났다. In vitro 조건하에서의 균사생장 및 균핵형성과 포장에서의 역학지수(초기발병치, 최종발병치, 병진전속도, AUDPC)와의 상관관계를 조사한 결과, S. cepivorum에 대하여 균사생장과 최종발병치, 균사생장과 병진전속도간에는 정의상관을, 그리고 균핵형성과 역학지수간에는 부의 상관을 보였으나 5％ 수준에서 유의성은 없었다.

• 대한한의학원전학회지
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• 제20권1호
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• pp.1-10
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• 2007

"The Essence of the Synopsis of the Golden Chamber" is an annotated book on the "Synopsis of the Golden Chamber" written by You-Yi(尤怡) of the Qing Dynasty (1729). Chapter 3 of this annotated book contains explanations of BaiheDisease(百合病). You-Yi(尤怡) maintained that the cause of Baihe-Disease(百合病) is a deficient-type fever(虛熱) induced by lung-fluid deficiency(肺陰不足). Generally, a higher fever led to a worse prognosis, and this disease was mainly treated by supplement methods(補法). In his pharmacological explanations, You-Yi(尤怡) often used the analogical inference of the five evolutive phases(五行歸類), and he frequently quoted "The Yellow Emperor's Canon of Internal Medicine(黃帝內經)" and "The Medical Secret of an Official(外臺秘要)" to explain the texts.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권6호
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• pp.451-455
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• 2022

Glycogen storage disease (GSD) is a group of inherited disorders, which result in the deficiency of enzymes involved in glycogen metabolism, leading to an accumulation of glycogen in various organs. Deficiency of amylo-1-6-glicosidase (debranching enzyme) causes glycogen storage disease type III (GSD III). The main problems that anesthesiologists face in patients with GSD III include hypoglycemia, muscle weakness, delayed awakening due to abnormal liver function, possible difficulty in airway, and cardiomyopathy. In the face of these difficulties, airway preparation and appropriate glucose monitoring and support during the fasting period are important. The doses of the drugs to be used should be calculated considering the increased volume of distribution and decreased metabolic activity of the liver. We present the case of a child with GSD IIIa who underwent dental prosedation under general anesthesia. She was also being prepared for liver transplantation. This case was additionally complicated by the patient's serious allergic reaction to eggs and milk.

• Journal of Yeungnam Medical Science
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• 제16권1호
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• pp.125-130
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• 1999

저자들은 최근 25세 여자 환자로 뚜렷한 가족력이 없으면서 3-4세경부터 발생한 근육의 강직현상과 현저한 근비대소견이 있는 환자를 경험하였다. 임상적으로 타진성 근긴장증을 보이고 전기생리적 검사로 새끼손가락 외향근에서의 운동과 반복신경자극에서 복합근육활동전위의 감소를 보였으며, 이두박근의 근생검 소견상 용적이 증가된 근섬유와 중심핵화현상이 관찰되었다. 환자는 mexiletin 경구 투여후 근육의 강직현상이 다소 호전되었다. 이에 문헌고찰과 함께 Becker형 선천성 근긴장증 1례를 보고하는 바이다.

• 대한유전성대사질환학회지
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• 제14권2호
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• pp.182-185
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• 2014

GM1 gangliosidosis is a rare autosomal recessively inherited metabolic disease due to deficiency of ${\beta}$-galactosidase caused by mutations in the GLB1 gene. There have been three clinical subgroups in GM1 gangliosidosis, however it is difficult to differentiate because there is considerable overlap between classical phenotypes and clinical and imaging findings among the subgroups. Here, we report a Korean girl with type 2 GM1 gangliosidosis, who showed dysostosis multiplex and progressive neurological deterioration. Developmental regression was first noted at the age of 9 months, and she was diagnosed as GM1 gangliosidosis by ${\beta}$-galactosidase enzyme analysis and GLB1 mutation analysis at the age of 16 months.

• The Journal of Advanced Prosthodontics
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• 제8권4호
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• pp.321-328
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• 2016

PURPOSE. This study was designed to investigate the maintenance of teeth and implants in patients with viral liver disease. MATERIALS AND METHODS. 316 patients without any significant systemic disease were selected as a control group. Liver disease group was consisted of 230 patients. Necessary data were collected using clinical records and panoramic radiographs. Then, the patients were subdivided into 2 groups based on the type of active dental therapy received before maintenance period (Pre-Tx). Analysis for finding statistically significant difference was performed based on the need for re-treatment of active dental therapy (Re-Tx) and change in the number of teeth (N-teeth) and implants (N-implants). RESULTS. Comparing to control group, the patients with liver disease showed higher value on N-teeth, N-implants, and Re-Tx. Statistically significant differences were found on N-teeth (P=.000) and Re-Tx (P=.000) in patients with non-surgical Pre-Tx. Analysis based on severity of liver disease showed that N-teeth and Re-Tx were directly related to severity of liver disease regardless of received type of Pre-Tx. Significant differences were found on N-teeth (P=.003) and Re-Tx (P=.044) in patients with non-surgical Pre-Tx. CONCLUSION. In this study, it was concluded that liver disease might influence the loss of teeth and cause the relapse of dental disease during maintenance period in patients. A significant positive relationship between tooth and implant loss and severity of liver disease seems to exist.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제22권5호
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• pp.487-492
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• 2019

Waardenburg syndrome (WS) type IV is characterized by pigmentary abnormalities, deafness and Hirschsprung's disease. This syndrome can be triggered by dysregulation of the SOX10 gene, which belongs to the SOX (SRY-related high-mobility group-box) family of genes. We discuss the first known case of a SOX10 frameshift mutation variant defined as c.895delC causing WS type IV without Hirschsprung's disease. This female patient of unrelated Kuwaiti parents, who tested negative for cystic fibrosis and Hirschsprung's disease, was born with meconium ileus and malrotation and had multiple surgical complications likely due to chronic intestinal pseudo-obstruction. These complications included small intestinal necrosis requiring resection, development of a spontaneous fistula between the duodenum and jejunum after being left in discontinuity, and short gut syndrome. This case and previously reported cases demonstrate that SOX10 gene sequencing is a consideration in WS patients without aganglionosis but with intestinal dysfunction.

• 대한유전성대사질환학회지
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• 제14권1호
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• pp.42-47
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• 2014

Gaucher disease is a multisystemic disorder arising from a deficient activity of the lysosomal enzyme glucocerebrosidase, which leads to accumulation of glycosylceraide and other glycolipids in the regiculoendothelial system. The characteristics of Gaucher disease are anemia, thrombocytopenia, hepatosplenomegaly, and skeletal disease. Enzyme replacement therapy (ERT) has been proven to prevent progressive manifestations of Gaucher disease and effective in improving anemia, thrombocytopenia, bone markers and biomarkers. However, some patient needs still remain unmet because of the inaccessibility of certain sites including brain, bone and various organs. ERT could not Improve the irreversible lesion such as liver fibrosis, hepatopulmonary syndrome, and necrosis or infarction of bone and other organs. Adult patients with Gaucher disease should be screened for longterm complication such as bone disease, pulmonary hypertension, gallstone, and cancer, especially in patients with splenectomy. Parkinsonism and polyneuropathy was also reported among patients with type 1 Gaucher disease, but ERT does not improve neurological function. We need to review the benefits and unmet needs of ERT in Gaucher disease.

• 대한간호학회지
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• 제40권4호
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• pp.580-588
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• 2010

Purpose: The purpose of this study was to examine effects of decreased locomotor activity on mass, Type I and II fiber cross-sectional areas of ipsilateral and contralateral hindlimb muscles 21 days after establishing the Parkinson's disease rat model. Methods: The rat model was established by direct injection of 6-hydroxydopamine (6-OHDA, 50 ${mu}g$) into the left substantia nigra after stereotaxic surgery. Adult male Sprague-Dawley rats were assigned to one of two groups; the Parkinson's disease group (PD; n=17) and a sham group (S; n=8). Locomotor activity was assessed before and 21 days after the experiment. At 22 days after establishing the rat model, all rats were anesthetized and soleus and plantaris muscles were dissected from both ipsilateral and contralateral sides. The brain was dissected to identify dopaminergic neuronal death of substantia nigra in the PD group. Results: The PD group at 21 days after establishing the Parkinson's disease rat model showed significant decrease in locomotor activity compared with the S group. Weights and Type I and II fiber cross-sectional areas of the contralateral soleus muscle of the PD group were significantly lower than those of the S group. Conclusion: Contralateral soleus muscle atrophy occurs 21 days after establishing the Parkinson's disease rat model.