• Bulletin of the Korean Chemical Society
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• 제26권9호
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• pp.1366-1368
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• 2005

The first synthesis of a 4'-branched carbocyclic C-nucleoside 11 was achieved via the key intermediate 6, which was prepared using Knovenagel type condensation from ketone derivative 4.

• Bulletin of the Korean Chemical Society
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• 제27권1호
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• pp.153-154
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• 2006

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2008년도 추계학술대회 논문집
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• pp.551-552
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• 2008

• Applied Science and Convergence Technology
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• 제26권6호
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• pp.164-173
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• 2017

Across the most industry, the demand for nanoparticles is increasing. Therefore, many studies have been carried out to synthesize nanoparticles using various methods. The aim of this paper is to introduce an industry-applicable as well as financially and environmentally effective solution plasma process. The solution plasma process involves fewer chemicals than the traditional kit, and can be used to replace many of the chemical agents employed in previous synthesis of nanoparticles into plasma. In this study, this process is compared to the wet-reaction process that has thus far been widely used in the most industry. Furthermore, the solution plasma process has been classified into four different types (in-solution, out of solution, direct type, and remote type), according to its plasma occurrence position and plasma types. Thus, the source of radicals, nanoparticle synthesis, and modification methods are explained for each design. Lastly, unlike nanoparticles with hydrophilic functional groups that are made inside the solution, a nanoparticle synthesis and modification method to create a hydrophobic functional group is also proposed.

• 말소리와 음성과학
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• 제13권3호
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• pp.65-70
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• 2021

This paper proposes a method for designing a large recording script for open domain English speech synthesis. For read-aloud style text, 12 domains and 294 sub-domains were designed using text contained in five different news media publications. For conversational style text, 4 domains and 36 sub-domains were designed using movie subtitles. The final script consists of 43,013 sentences, 27,085 read-aloud style sentences, and 15,928 conversational style sentences, consisting of 549,683 tokens and 38,356 types. The completed script is analyzed using four criteria: word coverage (type coverage and token coverage), high-frequency vocabulary coverage, phonetic coverage (diphone coverage and triphone coverage), and readability. The type coverage of our script reaches 36.86% despite its low token coverage of 2.97%. The high-frequency vocabulary coverage of the script is 73.82%, and the diphone coverage and triphone coverage of the whole script is 86.70% and 38.92%, respectively. The average readability of whole sentences is 9.03. The results of analysis show that the proposed method is effective in producing a large recording script for English speech synthesis, demonstrating good coverage in terms of unique words, high-frequency vocabulary, phonetic units, and readability.

• 약학회지
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• 제23권3_4호
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• pp.159-166
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• 1979

Twelve derivatives of PAS-sulfonamide were synthesized and tested for their antibacterial activity against various bacterial strains. The derivatives XII and XIV showed relatively potent antibacterial activity to INAH-R strains and INAH-PAS-R strains and type XII to streptococcal strains; type IX and type VI to Pseudomonas aeruginosa.

• Bulletin of the Korean Chemical Society
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• 제33권2호
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• pp.620-624
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• 2012

An efficient synthesis of poly-substituted furans, pyrroles, and thiophenes was carried out in a regiocontrolled manner via a three-step process; (i) conjugate addition of methyl cyanoacetate derivatives to ${\alpha}$,${\beta}$-enones, (ii) CuI-mediated aerobic oxidation, and (iii) Paal-Knorr type synthesis of five-membered heterocycles.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.822-826
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• 2008

A linkage mechanism is a device to convert an input motion into a desired output motion. Traditional linkage mechanism designs are based on trial and error approaches so that size or shape changes of an original mechanism often result in improper results. In order to resolve these problems, an improved automatic mechanism synthesis method that determines the linkage type and dimensions by using an optimization method during the synthesis process has been proposed. For the synthesis, a planar linkage is modeled as a set of rigid blocks connected by zero-length translational springs with variable stiffness. In this study, the sizes of rigid blocks were also treated as design variables for more general linkage synthesis. The values of spring stiffness and the size of rigid block yielding a desired output motion at the end-effecter are found by using an optimization method.

• 한국음향학회:학술대회논문집
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• 한국음향학회 1994년도 FIFTH WESTERN PACIFIC REGIONAL ACOUSTICS CONFERENCE SEOUL KOREA
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• pp.949-956
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• 1994

In this paper, we introduce a new speech synthesis method for Japanese and Korean arbitrary sentences using the natural speech data-base. Also, application of this method to a CAI system is discussed. In our synthesis method, a basic sentence and basic accent-phrases are selected from the data-base against a target sentence. Factors for those selections are phrase dependency structure (separation degree), number of morae, type of accent and phonemic labels. The target pitch pattern and phonemic parameter series are generated using those selected basic units. As the pitch pattern is generated using patterns which are directly extracted form real speech, it is expected to be more natural than any other pattern which is estimated by any model. Until now, we have examined this method on Japanese sentence speech and affirmed that the synthetic sound preserves human-like features fairly well. Now we extend this method to Korean sentence speech synthesis. Further more, we are trying to apply this synthesis unit to a CAI system.

• Clinics in Shoulder and Elbow
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• 제21권1호
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• pp.3-14
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• 2018

Background: Platelet-rich plasma (PRP) stimulates cell proliferation and enhances matrix gene expression and synthesis. However, there have been no comparative study of the PRP effect on the normal and degenerative tenocytes. The purpose of this study was to compare the effect of PRP on tenocytes from normal and degenerative tendon. Methods: Tendon tissues were obtained from patients undergoing arthroscopic repair (n=9) and from healthy donors (n=3). Tenocytes were cultured with 10% (vol/vol) platelet-poor plasma, PRP activated with calcium, and PRP activated with calcium and thrombin. The total cell number was assessed at days 7 and 14. The expressions of type I and III collagen, decorin, tenascin-C, and scleraxis were evaluated by quantitative real-time reverse transcriptase polymerase chain reaction. The total collagen and glycosaminoglycan (GAG) synthesis was evaluated at days 7 and 14. Results: No differences were observed between the groups at day 7, but cell proliferation was remarkably increased in tenocytes from the degenerative tendon at day 14. In both tenocyte groups, the gene expressions of type I and III collagen were up-regulated. GAG synthesis was greater in the normal tendon, whereas the expressions of decorin and tenascin-C were increased in tenocytes from the degenerative tendon. Tenocytes from the degenerative tendon had higher fold-change of GAG synthesis and a lower collagen III/I ratio than normal tenocytes. Conclusions: PRP promoted the cell proliferation and enhanced the synthesis of tendon matrix in both groups. PRP has a greater positive effect on cell proliferation, matrix gene expression and synthesis in tenocytes from degenerative tendon.