• Journal of Chest Surgery
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• 제45권5호
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• pp.295-300
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• 2012

Background: With growing attention to the aortopathy associated with aortic valve diseases, the number of candidates for accompanying ascending aorta and/or root replacement is increasing among the patients who require aortic valve replacement (AVR). However, such procedures have been considered more risky than AVR alone. This study aimed to compare the surgical outcome of isolated AVR and AVR combined with aortic procedures. Materials and Methods: A total of 86 patients who underwent elective AVR between 2004 and June 2010 were divided into two groups: complex AVR (n=50, AVR with ascending aorta replacement in 24 and the Bentall procedure in 26) and simple AVR (n=36). Preoperative characteristics, surgical data, intra- and postoperative allogenic blood transfusion requirement, the postoperative clinical course, and major complications were retrospectively reviewed and compared. Results: The preoperative mean logistic European System for Cardiac Operative Risk Evaluation (%) did not differ between the groups: $11.0{\pm}7.8%$ in the complex AVR group and $12.3{\pm}8.0%$ in the simple AVR group. Although complex AVR required longer cardiopulmonary bypass ($152.4{\pm}52.6$ minutes vs. $109.7{\pm}22.7$ minutes, p=0.001), the quantity of allogenic blood products did not differ ($13.4{\pm}14.7$ units vs. $13.9{\pm}11.2$ units). There was no mortality, mechanical circulatory support, stroke, or renal failure requiring hemodialysis/filtration. No difference was found in the incidence of bleeding (40% vs. 33.3%) which was defined as red blood cell transfusion ${\geq}5$ units, reoperation, or intentional delayed closure. The incidence of mediastinitis (2.0% vs. 0%), ventilator ${\geq}24$ hours (4.0% vs. 2.8%), atrial fibrillation (18.0% vs. 25.0%), mean intensive care unit stay (34.5 hours vs. 38.8 hours), and median hospital stay (8 days vs. 7 days) did not differ, either. Conclusion: AVR combined with additional aortic or root replacement showed an excellent outcome and recovery course equivalent to that after isolated AVR.

• 대한소아신경학회지
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• 제26권4호
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• pp.288-291
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• 2018

편마비편두통은 조짐편두통의 드문 아형으로 완전히 회복 가능한 운동 조짐이 동반되며, 가족편마비편두통과 산발편마비편두통으로 나뉘고, 현재까지 가족편마비편두통과 관련된 3가지의 유전자들이 알려져 있다. 전형적인 편마비편두통은 유년기 혹은 청소년기에 시작되며, 20-30분에 걸쳐 점차 진행하는 조짐 증상들이 연속적으로 두통과 동반되어 나타난다. 조짐은 시각, 감각, 운동, 실어성 조짐 등이 흔하고, 종종 기저형편두통의 증상으로도 발생한다. 위약감은 감각 조짐이 나타나는 곳과 관계가 있으며, 감각-운동 조짐은 대개 한쪽 손에서 시작하여 점차 팔과 얼굴 쪽으로 퍼져 간다. 언어 장애는 주로 표현의 장애로 나타나지만, 드물게는 이해의 장애가 동반되기도 한다. 본 증례는 동측 상지의 조짐은 없었고 우측 안면부터 동측 하지로 감각-운동 증상이 진행되었는데 저자가 아는 한 이와 같은 경과를 보인 편마비편두통에 대한 증례 보고는 없었다. 증상 발현 초기 벨 마비로 오인할 수 있는 경과를 보였기에, 편측안면마비를 호소하는 경우 벨 마비 외에 드문 원인으로 뇌졸중 및 편마비편두통 등도 고려해 볼 필요가 있겠다.

• Journal of Korean Neurosurgical Society
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• 제62권5호
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• pp.502-518
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• 2019

Objective : Since less invasive endovascular treatment was introduced to South Korea in 1994, a considerable proportion of endovascular treatments have been performed by neuroradiology doctors, and endovascular treatments by vascular neurosurgeons have recently increased. However, few specific statistics are known regarding how many endovascular treatments are performed by neurosurgeons. Thus, authors compared endovascular treatments collaboratively performed by vascular neurosurgeons with all cases throughout South Korea from 2013 to 2017 to elucidate the role of neurosurgeons in the field of endovascular treatment in South Korea. Methods : The Society of Korean Endovascular Neurosurgeons (SKEN) has issued annual reports every year since 2014. These reports cover statistics on endovascular treatments collaboratively or individually performed by SKEN members from 2013 to 2017. The data was requested and collected from vascular neurosurgeons in various hospitals. The study involved 77 hospitals in its first year, and 100 in its last. National statistics on endovascular treatment from all over South Korea were obtained from the Healthcare Bigdata Hub website of the Health Insurance Review & Assessment Service based on the Electronic Data Interchange (EDI) codes (in the case of intra-arterial (IA) thrombolysis, however, statistics were based on a combination of the EDI and I63 codes, a cerebral infarction disease code) from 2013 to 2017. These two data sets were directly compared and the ratios were obtained. Results : Regionally, during the entire study period, endovascular treatments by SKEN members were most common in Gyeonggido, followed by Seoul and Busan. Among the endovascular treatments, conventional cerebral angiography was the most common, followed by cerebral aneurysmal coiling, endovascular treatments for ischemic stroke, and finally endovascular treatments for vascular malformation and tumor embolization. The number of endovascular treatments performed by SKEN members increased every year. Conclusion : The SKEN members have been responsible for the major role of endovascular treatments in South Korea for the recent 5 years. This was achieved through the perseverance of senior members who started out in the midst of hardship, the establishment of standards for the training/certification of endovascular neurosurgery, and the enthusiasm of current SKEN members who followed. To provide better treatment to patients, we will have to make further progress in SKEN.

• Journal of Korean Neurosurgical Society
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• 제64권5호
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• pp.791-798
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• 2021

Objective : The period of mechanical ventilator (MV)-dependent respiratory failure after cervical spinal cord injury (CSCI) varies from patient to patient. This study aimed to identify predictors of MV at hospital discharge (MVDC) due to prolonged respiratory failure among patients with MV after CSCI. Methods : Two hundred forty-three patients with CSCI were admitted to our institution between May 2006 and April 2018. Their medical records and radiographic data were retrospectively reviewed. Level and completeness of injury were defined according to the American Spinal Injury Association (ASIA) standards. Respiratory failure was defined as the requirement for definitive airway and assistance of MV. We also evaluated magnetic resonance imaging characteristics of the cervical spine. These characteristics included : maximum canal compromise (MCC); intramedullary hematoma or cord transection; and integrity of the disco-ligamentous complex for assessment of the Subaxial Cervical Spine Injury Classification (SLIC) scoring. The inclusion criteria were patients with CSCI who underwent decompression surgery within 48 hours after trauma with respiratory failure during hospital stay. Patients with Glasgow coma scale 12 or lower, major fatal trauma of vital organs, or stroke caused by vertebral artery injury were excluded from the study. Results : Out of 243 patients with CSCI, 30 required MV during their hospital stay, and 27 met the inclusion criteria. Among them, 48.1% (13/27) of patients had MVDC with greater than 30 days MV or death caused by aspiration pneumonia. In total, 51.9% (14/27) of patients could be weaned from MV during 30 days or less of hospital stay (MV days : MVDC 38.23±20.79 vs. MV weaning, 13.57±8.40; p<0.001). Vital signs at hospital arrival, smoking, the American Society of Anesthesiologists classification, Associated injury with Injury Severity Score, SLIC score, and length of cord edema did not differ between the MVDC and MV weaning groups. The ASIA impairment scale, level of injury within C3 to C6, and MCC significantly affected MVDC. The MCC significantly correlated with MVDC, and the optimal cutoff value was 51.40%, with 76.9% sensitivity and 78.6% specificity. In multivariate logistic regression analysis, MCC >51.4% was a significant risk factor for MVDC (odds ratio, 7.574; p=0.039). Conclusion : As a method of predicting which patients would be able to undergo weaning from MV early, the MCC is a valid factor. If the MCC exceeds 51.4%, prognosis of respiratory function becomes poor and the probability of MVDC is increased.

• 재활치료과학
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• 제12권2호
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• pp.9-23
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• 2023

목적 : 작업치료 분야에서 편측무시 중재를 사용한 연구 중 단일대상연구를 적용한 문헌들의 내용과 특성을 확인하고, 중재 효과 및 질적 수준을 분석하기 위해 실시하였다. 연구방법 : 본 연구는 체계적 고찰이며, 2012년부터 2022년까지 최근 10년간 국내 학회지에 게재된 단일대상연구로 진행된 논문을 대상으로 하였다. 결과 : 논문 분석 결과 뇌졸중 환자를 대상으로 시행하였으며 중재제거설계가 7편으로 가장 많은 비율을 차지했고 2편이 복수 기초선 설계였다. 중재제거설계 중 4편이 ABA설계를 사용하였다. 편측무시에 적용한 중재 효과 크기를 분석한 결과 중재 효과 크기는 '매우 효과적인 중재'는 7회, '효과적인 중재'는 18회, '의심스러운 중재'는 5회, '비효과적인 중재'는 6회로 나타났다. 논문들의 질적 수준을 분석한 결과 높은 수준이 6편, 중간 수준이 3편으로 낮은 수준의 연구는 한 편도 없었다. 결론 : 연구 결과 편측무시 중재들은 불빛 자극, 로봇 보조 능동운동, 진동 자극 등 다양한 방법을 적용하고 있었다. 본 연구의 분석을 통해 임상에서 편측무시 환자에게 중재를 적용할 수 있을 것으로 생각된다.

• 대한유전성대사질환학회지
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• 제23권1호
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• pp.17-24
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• 2023

목적: 과거에는 혈장 아미노산 및 소변 유기산의 대사 이상 검출이 멜라스 증후군과 같은 임상적인 미토콘드리아 질환을 진단하는 데 널리 사용되었다. 본 연구에서는 혈장 아미노산 및 소변 유기산의 진단적 가치를 고찰하고, 멜라스 증후군 진단에 있어 이들의 유효성을 후향적으로 살펴보았다. 방법: 임상적으로 진단된 모든 멜라스 증후군 환자(n=31)로부터, 진단 당시의 혈액 및 소변 검체를 채취하여 혈장 아미노산 및 소변 유기산 검사를 시행하였다. 모든 샘플은 결과의 인위적 오류를 최소화하기 위해 금식 상태에서 수집되었습니다. 유전자로 진단된 멜라스 증후군 환자(n=19, m.3243A>G 돌연변이)와 유전자로 진단되지 않은 멜라스 증후군 환자(n=12) 그룹 간에 초기 진단 시 혈장 아미노산 및 소변 유기산의 비정상 대사물질 비율의 차이를 통계적으로 비교하였다. 유전자로 진단되지 않은 멜라스 증후군 환자군을 대조군으로 사용하였다. 결과: 두 그룹 간의 혈장 아미노산과 소변 유기산을 비교한 결과, 유전자로 진단된 멜라스 증후군 환자와 유전자로 진단되지 않은 멜라스 증후군 환자 간에 특징적인 차이를 보이는 비정상적인 대사 산물이 없는 것으로 나타났다. 결론: 혈장 아미노산 또는 소변 유기산의 비정상적인 대사물질 값은 멜라스 증후군의 진단에 있어서 선별 검사로 유용할 수 있지만 진단하기에는 충분하지 않다.

• 문화기술의 융합
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• 제9권3호
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• pp.57-65
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• 2023

현대 서예의 유파가 많은데 '추서(醜書)'가 하나의 유파로 봐야 할지에 대해 학자들의 의견이 분분하다. '추서'를 인정받지 않은 사람은 '추서'에서 전통적인 결자 규범이 없다고 본다. 그리고 문제의 식별성도 사라진다고 주장한다. 그러나 '추서'가 존재하고 발전을 이루는 것은 현대 서예가의 끊임없은 탐색과 개혁과 관련된다. 뿐만 아니라 서예들의 미적 인식 능력이 늘어나고 미적 표준도 시대와 함께 변화한다. 이에 따라 '추서'를 인정하는 사람도 많아질 것이다. 시대에 앞장선 서예가들이 전통적인 서예 사상을 줄곧 견지하면서 전인을 배우고 경험을 쌓는다. 그 중에서 전통적인 중용(中庸)사상을 저버리고 '추(醜)'를 세인에게 보이는 서예가들이 있다. 옥흥화(沃興華)와 증상(曾翔) 등 서예가들이 바로 여기에 해당한다. 옥흥화와 증상은 모두 고대 비첩을 골자로, 민간 서예를 혈액으로 하여 나름의 풍격을 창출했다. 본고는 옥흥화와 증상의 작품을 분석함으로써 '추서'의 정의와 형성 과정을 탐색, 연구하고자 한다. 이와 동시에 '추서'의 특징 및 '추서'의 미감을 정리하도록 한다.

• 한국구조물진단유지관리공학회 논문집
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• 제28권3호
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• pp.91-99
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• 2024

배관시스템은 다양한 산업 분야에서 이용되는 중요한 설비이며 생활 및 안전과 관련된 영역에서 사용되고 있다. 배관시스템은 건축물 및 시설의 주요 구조부에 고정되어 있으나 외부 하중을 지지하지 않으며 주어진 고유기능을 수행하는 비구조요소이다. 지진하중으로 인한 배관시스템은 두 지지점 사이의 서로 다른 거동으로 발생하는 위상차로 인한 상대 변위의 영향을 받으며 변위 지배적인 반복거동 때문에 손상이 발생할 가능성이 있다. 배관시스템에서 피팅과 조인트는 지진하중에 취약한 대표적인 요소이다. 배관시스템의 피팅과 조인트에 대한 내진성능과 한계상태를 평가하고자 한다면 상대변위를 모사하기 위한 높은 스트로크를 가지는 엑츄에이터가 필요하나 실험을 수행할 수 있는 설비가 많지 않아 어려움이 있다. 따라서 피팅과 조인트로 연결된 배관시스템의 내진성능과 한계상태를 평가하기 위해서는 요소 단위의 실험이 필요하다. 이 연구에서는 수직배관시스템에서 지진하중에 취약한 요소인 피팅과 조인트를 포함하는 엘보 시험체에 대하여 내진성능을 평가하는 방법을 제시하였다. 엘보 시험체는 90° 배관 엘보의 양단에 직관부를 유동식 그루브 조인트를 이용하여 연결하였다. 엘보 시험체에 대하여 변형각에 기반을 둔 주기하중 프로토콜을 이용하여 내진성능을 평가하였다. 평가된 내진성능에 대한 여유도를 확인하기 위하여 일정한 진폭에 대한 주기하중을 적용하여 한계상태를 평가하였다.

• Korean Journal of Radiology
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• 제23권10호
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• pp.939-948
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• 2022

Objective: Evidence supports the efficacy of coronary computed tomography angiography (CCTA)-based risk scores in cardiovascular risk stratification of patients with suspected coronary artery disease (CAD). We aimed to compare two CCTA-based risk score algorithms, Leiden and Confirm scores, in patients with diabetes mellitus (DM) and suspected CAD. Materials and Methods: This single-center prospective cohort study consecutively included 1241 DM patients (54.1% male, 60.2 ± 10.4 years) referred for CCTA for suspected CAD in 2015-2017. Leiden and Confirm scores were calculated and stratified as < 5 (reference), 5-20, and > 20 for Leiden and < 14.3 (reference), 14.3-19.5, and > 19.5 for Confirm. Major adverse cardiovascular events (MACE) were defined as the composite outcomes of cardiovascular death, nonfatal myocardial infarction (MI), stroke, and unstable angina requiring hospitalization. The Cox model and Kaplan-Meier method were used to evaluate the effect size of the risk scores on MACE. The area under the curve (AUC) at the median follow-up time was also compared between score algorithms. Results: During a median follow-up of 31 months (interquartile range, 27.6-37.3 months), 131 of MACE were recorded, including 17 cardiovascular deaths, 28 nonfatal MIs, 64 unstable anginas requiring hospitalization, and 22 strokes. An incremental incidence of MACE was observed in both Leiden and Confirm scores, with an increase in the scores (log-rank p < 0.001). In the multivariable analysis, compared with Leiden score < 5, the hazard ratios for Leiden scores of 5-20 and > 20 were 2.37 (95% confidence interval [CI]: 1.53-3.69; p < 0.001) and 4.39 (95% CI: 2.40-8.01; p < 0.001), respectively, while the Confirm score did not demonstrate a statistically significant association with the risk of MACE. The Leiden score showed a greater AUC of 0.840 compared to 0.777 for the Confirm score (p < 0.001). Conclusion: CCTA-based risk score algorithms could be used as reliable cardiovascular risk predictors in patients with DM and suspected CAD, among which the Leiden score outperformed the Confirm score in predicting MACE.

• Korean Journal of Radiology
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• 제23권3호
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• pp.333-342
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• 2022

Objective: Intracranial atherosclerotic stroke occurs through various mechanisms, mainly by artery-to-artery embolism (AA) or branch occlusive disease (BOD). This study evaluated the spatial relationship between middle cerebral artery (MCA) plaques and perforating arteries among different MCA territory infarction types using vessel wall magnetic resonance imaging (VW-MRI). Materials and Methods: We retrospectively enrolled patients with acute MCA infarction who underwent VW-MRI. Thirty-four patients were divided into three groups according to infarction pattern: 1) BOD, 2) both BOD and AA (BOD-AA), and 3) AA. To determine the factors related to BOD, the BOD and BOD-AA groups were combined into one group (with striatocapsular infarction [BOD+]) and compared with the AA group. To determine the factors related to AA, the BOD-AA and AA groups were combined into another group (with cortical infarction [AA+]) and compared with the BOD group. Plaque morphology and the spatial relationship between the perforating artery orifice and plaque were evaluated both quantitatively and qualitatively. Results: The plaque margin in the BOD+ group was closer to the perforating artery orifice than that in the AA group (p = 0.011), with less enhancing plaque (p = 0.030). In the BOD group, plaques were mainly located on the dorsal (41.2%) and superior (41.2%) sides where the perforating arteries mainly arose. No patient in the AA group had overlapping plaques with perforating arteries at the cross-section where the perforator arose. Perforating arteries associated with culprit plaques were most frequently located in the middle two-thirds of the M1 segment (41.4%). The AA+ group had more stenosis (%) than the BOD group (39.73 ± 24.52 vs. 14.42 ± 20.96; p = 0.003). Conclusion: The spatial relationship between the perforating artery orifice and plaque varied among different types of MCA territory infarctions. In patients with BOD, the plaque margin was closer and blocked the perforating artery orifice, and stenosis degree and enhancement were less than those in patients with AA.