• Bulletin of the Korean Chemical Society
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• v.20 no.3
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• pp.301-306
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• 1999

Hepatitis C virus (HCV) has been known to be an enveloped virus with a positive strand RNA genome and the major agent of the vast majority of transfusion associated cases of hepatitis. For viral replication, HCV structural proteins are first processed by host cell signal peptidases and NS2/NS3 site of the nonstructural protein is cleaved by a zinc-dependent protease NS2 with N-terminal NS3. The four remaining junctions are cleaved by a separate NS3 protease. The solution conformations of NS4B/5A, NS5A/5B substrates and NS5A/5B inhibitor have been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. NMR data suggested that the both NS5A/5B substrate and inhibitor appeared to have a folded tum-like conformation not only between P1 and P6 position but also C-terminal region, whereas the NS4B/5A substrate exhibited mostly extended conformation. In addition, we have found that the conformation of the NS5A/5B inhibitor slightly differs from that of NS5A/5B substrate peptide, suggesting different binding mode for NS3 protease. These findings will be of importance for designing efficient inhibitor to suppress HCV processing.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.2
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• pp.40.3-40.3
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• 2019

Our recent observations of the Sun through strong spectral lines have revealed several important properties of the three-minute umbral oscillations inside sunspots -- the oscillations of intensity and Doppler velocity with periods of 2 to 3 minutes. The oscillations usually occur in the form of a time series of oscillation packets each of which lasts 10 to 20 minutes, not as continuous trains. Each oscillation packet is characterized by a singly peaked power spectrum of velocity oscillation. The oscillations propagate in the vertical direction from the photosphere to the corona. In the upper chromosphere, they develop into shocks that eventually collide with the transition region. When shocks propagate along a highly inclined direction, the merging of two successive shocks can take place. Once they enter the corona, they change to linear compressional waves. In the image plane, the three-minute oscillations propagate with high speeds in the transverse direction as well, usually propagating radially outwards from a point, and sometimes accompanying spiraling patterns of Doppler velocity. These observational properties can be theoretically explained by postulating the spatio-temporally localized source of fast MHD waves at a depth of about 2000 km below the surface, the excitation of slow MHD waves via mode conversion near the photosphere, and the resonance of the slow waves in the photospheric layer below the temperature minimum, and the nonlinear development of slow waves in the chromosphere.

• Journal of the Optical Society of Korea
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• v.13 no.4
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• pp.428-433
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• 2009

A photonic crystal fiber with two large air holes outside the holey cladding region is fabricated to induce an effective long periodic grating (LPG) in the core by an electric arc discharge. We believe that the two large air holes lead to the asymmetric perturbation in the core under the electric arc discharge, thereby introducing the coupling to the first higher-order mode. The transmission characteristics of the PCF with the LPG for the external perturbation such as strain, curvature, and temperature are also investigated. It was found that the shift of resonance peak in the transmission spectrum depends on the bending direction. The curvature of 8.55 $m^{-1}$ results in the center wavelength shifts of 1.8, 4.3, and 11 nm for a vertical, diagonal, and horizontal direction of the curvature to the large air-hole alignment, respectively.

• Journal of the Korean Society for Railway
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• v.15 no.5
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• pp.485-497
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• 2012

Recently, with increasing social interests on noise and vibration induced by railway traffic, the application of floating slab track that can efficiently reduce the railway vibration is increasing. In this study, to more accurately understand the dynamic behavior of the floating slab track, a laboratory mock-up test has been performed, and the static and dynamic behaviors at frequency range near the system resonance frequency were explored. Based on the test results, the design of the floating slab track and the structural analysis model used in the design have been verified. The analytic and test results demonstrate that the dominant frequency of the floating slab track occurs at the frequencies between vertical rigid body mode natural frequency and bending mode natural frequency, and the dominant deformation mode is close to the bending mode. This suggests that in the design of the floating slab track, the bending rigidity of the slab and the boundary conditions at slab joints and slab ends should be taken into consideration. Also, the analytic results by the two-dimensional finite element analysis model using Kelvin-Voigt model, such as static and dynamic deflections and force transmissibility, are found in good agreement with the test results, and thus the model used in this study has shown the reliability suitable to be utilized in the design of the floating slab track.

• Journal of the Korean Magnetic Resonance Society
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• v.4 no.1
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• pp.19-28
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• 2000

Authors evaluated alterations of observable metabolite ratios between the cerebral lesion and the contralateral region related to the clinical symptomatic side in levodopa-treated Parkinson's disease (PD) and investigated correlation between age in patients with PD and metabolite ratios of the lesion. Patients with levodopa-treated PD (n = 54) and age-matched normal controls (n = 15) underwent magnetic resonance spectroscopy (MRS) examinations using a stimulated echo acquisition mode (STEAM) pulse sequence that provided 2$\times$2$\times$2 cm3 volume of interest in the selected regions of substantia nigra (SN) and putamed-globus pallidus (PG). To evaluate dependence of metabolite ratios on age, we divided into two groups (i.e., younger and older age). We quantitatively measured N-acetylaspartate (NAA), creatine (Cr), choline-containing compounds (Cho), inositols (Ins), and the sum of glutamate (Glx) and GABA levels and obtained proton metabolite ratios relative to Cr using a Marquart algorithm. Compared with the contralateral region, a significant neuronal laterality of the NAA/Cr ratio in the lesion of SN related to the clinical symptomatic side was established (P = 0.01), but was not established in the lesion of PG (P = 0.24). Also, Cho/Cr ratio tended toward significance in the lesion of SN (P = 0.07) and was statistically significant in the lesion of PG(P = 0.01). Compared with that in the younger age group, NAA/Cr ratio in the older age was decreased in the lesion of SN (P = 0.02), while NAA/Cr ratio was not statistically significant in the lesion of PG ( P = 0.21). Significant metabolic alterations of NAA/Cr and Cho/Cr ratios might be closely related with functional changes of neuropathological process in SN and PG of levodopa treated PD and could be a valuable finding for evaluation of the PD. A trend of NAA/Cr reduction, being statistically significant in older patients, could be indicative of more pronounced neuronal damage in the SN of the progressive PD.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.38 no.5
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• pp.456-466
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• 2010

Typical combustion instability such as DC-Shift found in the hybrid rocket motor is characterized by non-linearity. DC-Shift can occur in two different realizations. One is so-called a positive shift of measured DC voltage where the pressure increase suddenly. The other is a negative shift where the pressure drops abruptly. In the present work, specifically the negative DC-Shift was investigated to analyze the effect of oxidizer flow condition and the resonance between fundamental frequency and other ones, such as Helmholtz frequency, and acoustic frequency. Results show a peak frequency of several hundreds HZ shifts as combustion proceeds. A negative DC-shift was found as the result of phase cancellation between two dominant frequency, combustion frequency and flow related frequency. Still is it required to study further to identify the change of dominance of frequency during the combustion.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.23 no.2
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• pp.57-62
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• 2012

Objectives : Characteristic symptoms, including hyperactivity and easy distractibility, in children with attention-deficit hyperactivity disorder (ADHD) suggest that their brain status, even at rest, might differ from that of healthy children. This study was conducted in order to determine whether resting state brain activity is compromised in medication-naive children with ADHD. Methods : Twenty medication-naive children with ADHD (mean age $10.3{\pm}2.5$) and 28 age- and gender-matched healthy volunteers (mean age $10.3{\pm}2.0$) underwent measurements for resting state brain activity using functional magnetic resonance imaging (fMRI). Among resting state related-independent components (RSICs) extracted from fMRI data using independent component analysis, a significant difference in RSICs was observed between groups, using a mixed Gaussian/gamma model. Results : Except for IQ, which was higher in the healthy control group, no demographic difference was observed between the two groups (p<.001). Significantly less activation of one RSIC, which includes the bilateral precuneus/posterior cingulate cortex, occipito-temporal junction, and anterior cingulate cortex, was observed in the ADHD group, compared with the control group (p<.05). Conclusion : An abnormal RSIC, posterior default mode network (DMN), was observed in the medication-naive ADHD group. Results of our study suggest that abnormality of posterior DMN is one of the main pathophysiologies of ADHD.

• The Journal of the Korea institute of electronic communication sciences
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• v.17 no.5
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• pp.775-782
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• 2022

In this paper, a novel small-diameter cylindrical post capacitor inserted into an evanescent-mode rectangular waveguide (EMRWG) is proposed for easier tuning. In order to feed the EMRWG, the proposed structure uses a single ridge rectangular waveguide with the same width and height as the waveguide at the input and output ends. The inserted post capacitor are made up a circular groove formed in the center of the lower part of the broad wall of the EMRWG, and a concentric cylindrical post inserted into the upper part. First, the equivalent circuit model for the proposed structure is presented. When the EMRWG and the single ridge waveguide are combined, the joint susceptance and the turns ratio of the ideal transformer are calculated by two simulations using HFSS (3d fullwave simulator, Ansoft Co.) respectively. The susceptance and resonance characteristics of the inserted post were analyzed by using the obtained parameters and the characteristics of the EMRWG. A 2-post filter with a center frequency of 4.5 GHz and a bandwidth of 170 MHz was designed using a WR-90 waveguide, and the simulation results by using the HFSS and CST, equivalent circuit model were in good agreement.

• Advances in aircraft and spacecraft science
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• v.5 no.2
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• pp.225-237
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• 2018

The difficulties of satellite vibration testing are due to the commonly expressed qualification requirements being incompatible with the limited performance of the entire controlled system (satellite + interface + shaker + controller). Two features cause the problem: firstly, the main satellite modes (i.e., the first structural mode and the high and low tank modes) are very weakly damped; secondly, the controller is just too basic to achieve the expected performance in such cases. The combination of these two issues results in oscillations around the notching levels and high amplitude beating immediately after the mode. The beating overshoots are a major risk source because they can result in the test being aborted if the qualification upper limit is exceeded. Although the abort is, in itself, a safety measure protecting the tested satellite, it increases the risk of structural fatigue, firstly because the abort threshold has been already reached, and secondly, because the test must restart at the same close-resonance frequency and remain there until the qualification level is reached and the sweep frequency can continue. The beat minimum relates only to small successive frequency ranges in which the qualification level is not reached. Although they are less problematic because they do not cause an inadvertent test shutdown, such situations inevitably result in waiver requests from the client. A controlled-system analysis indicates an operating principle that cannot provide sufficient stability: the drive calculation (which controls the process) simply multiplies the frequency reference (usually called cola) and a function of the following setpoint, the ratio between the amplitude already reached and the previous setpoint, and the compression factor. This function value changes at each cola interval, but it never takes into account the sensor signal phase. Because of these limitations, we firstly examined whether it was possible to empirically determine, using a series of tests with a very simple dummy, a controller setting process that significantly improves the results. As the attempt failed, we have performed simulations seeking an optimum adjustment by finding the Least Mean Square of the difference between the reference and response signal. The simulations showed a significant improvement during the notch beat and a small reduction in the beat amplitude. However, the small improvement in this process was not useful because it highlighted the need to change the reference at each cola interval, sometimes with instructions almost twice the qualification level. Another uncertainty regarding the consequences of such an approach involves the impact of differences between the estimated model (used in the simulation) and the actual system. As limitations in the current controller were identified in different approaches, we considered the feasibility of a new controller that takes into account an estimated single-input multi-output (SIMO) model. Its parameters were estimated from a very low-level throughput. Against this backdrop, we analyzed the feasibility of an LQG control in cancelling beating, and this article highlights the relevance of such an approach.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.20 no.10
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• pp.1031-1041
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• 2009

A small microstrip monopole antenna for macro-micro frequency tuning over multiple bands is presented. The meander-shape antenna is fabricated on a conventional printed circuit board(FR-4, $\varepsilon_r=4.4$ and tan $\delta=0.02$). The antenna operates over WiBro(2.3~2.4 GHz) and WLAN a/b(2.4~2.5 GHz/5.15~5.35 GHz) service bands with an essentially constant antenna gain within each service band. Two diodes, a PIN diode and a varactor, are embedded into the antenna for frequency reconfiguration. The PIN diode is used for frequency switching(macro-tuning) between 2 GHz and 5 GHz bands while the varactor is used for frequency tuning(micro-tuning) within the service bands, 2.3~2.5 GHz and 5.15~5.35 GHz. Unwanted resonances between the two frequency bands(2 GHz and 5 GHz) are suppressed by filling up the gaps between the meander lines. The antenna gain is essentially constant and higher than 2 dBi within each service band. The measured performance of the proposed antenna system suggests the macro-micro frequency tuning techniques be useful in reconfigurable wireless communication systems.