• Journal of the Computational Structural Engineering Institute of Korea
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• v.29 no.2
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• pp.179-185
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• 2016

In this paper numerical stability of CSS and ISS schemes in axisymmetric fluid-structure-burning simulation for solid rocket motors are studied. The implemented CSS and ISS algorithms for two-dimensional axisymmetric FSI problems are used to analyze ACM and BCM solid rocket motors. Numerical results from CSS and ISS schemes are compared to investigate the efficacy of ISS scheme over CSS scheme in stabilizing the numerical solution. The ACM and BCM simulation results show that ISS scheme gives stable and converged numerical solutions with appropriately small system time step size, while CSS scheme fails to converge after generating rapidly amplified oscillatory solutions. It is concluded that ISS scheme can be useful in improving the numerical stability of FSI analysis for ACM and BCM solid rocket motor simulations, which is not successfully obtained with CSS scheme.

• Journal of the Earthquake Engineering Society of Korea
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• v.8 no.4
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• pp.21-32
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• 2004

A Seismic analysis procedure of bi-directional brideg motions is developed by using mechanical bridge model. A three-dimensional mechanical model can consider major phenomena under bi-directional seismic excitations, such as nonlinear pier motion under biaxial bending, pounding and bearing damage due to the rotaion of the superstructure, etc. The analyses utilizing the uni-directional and the bi-directional bridge model for the 3-span simply supported bridge are then performed. The seismic responses in two cases are examined and compared by investigating the relative displacements of each superstructure to both ground and adjacent superstructures and the restoring forces of RC pier. The analysis using either the uni-directional model or bi-directional model is acceptable for estimating the displacement responses of a bridge, but the bi-directional analysis is found to give more conservative results for resisting forces of RC piers. To make general conclusions, therefore, the analysis using the bi-directional bridge model should be performed in evaluating the seismic safety of bridges.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7039-7044
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• 2015

Background: Many functional molecules controlling diverse cellular function are included in low-molecular weight proteins and peptides. Materials and Methods: To identify proteins controlling function in lung adenocarcinomas (AC), we performed two-dimensional gel electrophoresis employing tricine-SDS polyacrylamide in the second dimension (tricine 2-DE). This system was able to detect proteins under 1 kDa even with post-translational modifications. To confirm the utility of detected proteins as novel tumor markers for AC, we performed immunohistochemical analysis using 170 formalin-fixed and paraffin-embedded lung AC tissues. Results: Tricine 2-DE revealed that five proteins including S100A16 were overexpressed in lung AC-derived cells compared with lung squamous cell carcinoma, small cell carcinoma, and large cell neuroendocrine carcinoma-derived cells. Immunohistochemically, S100A16 showed various subcellular localization in lung cancer tissues and a membranous staining status was correlated with the T-factor (P=0.0008), pathological stage (P=0.0015), differentiation extent (P=0.0001), lymphatic invasion (P=0.0007), vascular invasion (P=0.0001), pleural invasion (P=0.0087), and gender (P=0.039), but not with the age or smoking history. More importantly, membranous staining of S100A16 was significantly correlated with a poorer overall survival of either stage I (P=0.0088) or stage II / III (P=0.0003) lung AC patients, and multivariate analysis confirmed that membranous expression of S100A16 was an independent adverse prognostic indicator (P=0.0001). Conclusions: The present results suggest that S100A16 protein is a novel prognostic marker for lung AC.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3653-3661
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• 2013

Along with rapid economic growth and enhanced agricultural productivity, particulate matter emissions in the northern cities of Thailand have been increasing for the past two decades. This trend is expected to continue in the coming decade. Emissions of particulate matter have brought about a series of public health concerns, particularly chronic respiratory diseases. It is well known that lung cancer incidence among northern Thai women is one of the highest in Asia (an annual age-adjusted incidence rate of 37.4 per 100,000). This fact has aroused serious concern among the public and the government and has drawn much attention and interest from the scientific community. To investigate the potential causes of this relatively high lung cancer incidence, this study employed Fourier transform infrared spectroscopy (FTIR) transmission spectroscopy to identify the chemical composition of the $PM_{2.5}$ collected using Quartz Fibre Filters (QFFs) coupled with MiniVol$^{TM}$ portable air samplers (Airmetrics). $PM_{2.5}$ samples collected in nine administrative provinces in northern Thailand before and after the "Haze Episode" in 2013 were categorised based on three-dimensional plots of a principal component analysis (PCA) with Varimax rotation. In addition, the incremental lifetime exposure to $PM_{2.5}$ of both genders was calculated, and the first derivative of the FTIR spectrum of individual samples is here discussed.

• Korean Journal of Applied Biomechanics
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• v.27 no.3
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• pp.197-203
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• 2017

Objective: The purpose of this study was to determine how exercise intensity affects muscle activity and kinematic variables during squat. Method: Fifteen trainers with >5 years of experience were recruited. For the electromyography (EMG) measurements, four surface electrodes were attached to both sides of the lower extremity to monitor the rectus femoris (RF) and biceps femoris. Three digital camcorders were used to obtain three-dimensional kinematics of the body. Each subject performed a squat in different conditions (40% one-repetition maximum [40%1RM], 60%1RM, and 80%1RM). For each trial being analyzed, three critical instants and two phases were identified from the video recording. For each dependent variable, one-way analysis of variance with repeated measures was used to determine whether there were significant differences among the three different conditions (p<.05). When a significant difference was found, post hoc analyses were performed using the contrast procedure. Results: The results showed that the average integrated EMG values of the RF were significantly greater in 80%1RM than in 40%1RM during the extension phase. The temporal parameter was significantly longer in 80%1RM than in 40%1RM and 60%1RM during the extension phase. The joint angle of the knee was significantly greater in 80%1RM than in 40%1RM at flexion. The range of motion of the knee was significantly less in 80%1RM than in 40%1RM and 60%1RM during the flexion phase and the extension phase. The angular velocity was significantly less in 80%1RM than in 40%1RM and 60%1RM during the extension phase. Conclusion: Generally, the increase of muscle strength decreases the pace of motion based on the relation between the strength and speed of muscle. In this study, we also found that the increase of exercise intensity may contribute to the increase of the muscle activity of the RF and the running time in the extension phase during squat motion. We observed that increased exercise intensity may hinder the regulation of the range of motion and joint angle. It is suitable to perform consistent movements while controlling the proper range of motion to maximize the benefit of resistance training.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.39 no.6
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• pp.691-702
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• 2019

Flood inundation map has various important roles in terms of municipal planning, timely dam operation, economic levee design, and building flood forecasting systems. Considering that the riparian areas adjacent to national rivers with high potential flood vulnerability conventionally imposed special cares to justify applications of recently available two- or three-dimensional flood inundation numerical models on top of digital elevation models of dense spatial resolution such as LiDAR irrespective of their high costs. On the contrary, local streams usually could not have benefits from recent technological advances, instead they inevitably have relied upon time-consuming manual drawings or have accepted DEMs with poor resolutions or inaccurate 1D numerical models for producing inundation maps due mainly to limited budgets and suitable techniques. In order to efficiently and cost-effectively provide a series of flood inundation maps dedicatedly for the local streams, this study proposed an OpenGIS-based flood mapping tool named Open Flood Mapper (OFM). The spatial accuracy of flood inundation map derived from the OFM was validated throughout comparison with an inundation trace map acquired after typhoon Nari in Hancheon basin located in Jeju Island. Also, a series of inundation maps from the OFM were comprehensively investigated to track the burst of flood in the extreme flood events.

• Journal of the Korean Geotechnical Society
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• v.35 no.12
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• pp.135-145
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• 2019

The slope collapse can be classified into internal and external factors. Internal factors are engineering factors inherent in the formation of slopes such as soil depth, slope angle, shear strength of soil, and external factors are external loading such as earthquakes. The external factor for earthquake can be expressed by various values such as peak ground acceleration (PGA), peak ground velocity (PGV), Arias coefficient (I), natural period (T_p), and spectral acceleration (S_aT=1.0). Specially, PGA is the most typical value that defines the magnitude of the ground motion of an earthquake. However, it is not enough to consider the displacement in the slope which depends on the duration of the earthquake even if the vibration has the same peak ground acceleration. In this study, numerical analysis of two-dimensional plane strain conditions was performed on engineered block, and slope responses due to seismic motion of scaling PGA to 0.2 g various event scenarios was analyzed. As a result, the response of slope is different depending on the presence or absence of sliding block; it is shown that slope response depend on the seismic wave triggering sliding block than the input motion factors.

• Proceedings of the Korean Vacuum Society Conference
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• 2016.02a
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• pp.286-286
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• 2016

Hexagonal boron nitride (hBN) is a dielectric insulator with a two-dimensional (2D) layered structure. It is an appealing substrate dielectric for many applications due to its favorable properties, such as a wide band gap energy, chemical inertness and high thermal conductivity[1]. Furthermore, its remarkable mechanical strength renders few-layered hBN a flexible and transparent substrate, ideal for next-generation electronics and optoelectronics in applications. However, the difficulty of preparing high quality large-area hBN films has hindered their widespread use. Generally, large-area hBN layers prepared by chemical vapor deposition (CVD) usually exhibit polycrystalline structures with a typical average grain size of several microns. It has been reported that grain boundaries or dislocations in hBN can degrade its electronic or mechanical properties. Accordingly, large-area single crystalline hBN layers are desired to fully realize the potential advantages of hBN in device applications. In this presentation, we report the growth and transfer of centimeter-sized, nearly single crystal hexagonal boron nitride (hBN) few-layer films using Ni(111) single crystal substrates. The hBN films were grown on Ni(111) substrates using atmospheric pressure chemical vapor deposition (APCVD). The grown films were transferred to arbitrary substrates via an electrochemical delamination technique, and remaining Ni(111) substrates were repeatedly re-used. The crystallinity of the grown films from the atomic to centimeter scale was confirmed based on transmission electron microscopy (TEM) and reflection high energy electron diffraction (RHEED). Careful study of the growth parameters was also carried out. Moreover, various characterizations confirmed that the grown films exhibited typical characteristics of hexagonal boron nitride layers over the entire area. Our results suggest that hBN can be widely used in various applications where large-area, high quality, and single crystalline 2D insulating layers are required.

• Journal of the Korean Geotechnical Society
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• v.31 no.7
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• pp.29-39
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• 2015

The vertical load imposed on the bucket foundation is transferred from the soil inside the bucket to the bottom of the foundation, and also to the outer surface of the skirt. For the design of a bucket foundation installed in sand, the vertical load transfer characteristics have to be clearly identified. However, the response of bucket foundations in sand subjected to a vertical load has not been investigated. In this study, we performed two-dimensional axisymmetric finite element analyses and investigated the vertical load transfer mechanism of bucket foundation installed in sand. The end bearing capacity of bucket foundation is shown to be larger than that of the shallow foundation, whereas the frictional resistance is smaller than that for a pile. The end bearing capacity of the bucket foundation is larger than the shallow foundation because the shear stress acting on the skirt pushes down and enlarges the failure surface. The skin friction is smaller than the pile because the settlement induces horizontal movement of the soil below the tip of the foundation and reduces the normal stress acting at the bottom part of the skirt. The calculated bearing capacity of the bucket foundation is larger than the sum of end bearing capacity of shallow foundation and skin friction of pile. This is because the increment of the end bearing capacity is larger than the reduction in the skin friction.

• Journal of Embryo Transfer
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• v.31 no.3
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• pp.169-177
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• 2016

There is a growing interest in the application of primary hepatocytes for treatment of liver diseases in humans and for drug development. Several studies have focused on long-term survival and di-differentiation blocking of primary hepatocytes in an in vitro culture system. Therefore, the present study also aimed to optimize an in vitro culture system using primary rat hepatocytes. Primary rat hepatocytes from 6-week-old male Crl:CD rats were isolated using a modified two-step collagenase perfusion. Healthy $3.5{\times}10^6$ primary rat hepatocytes were seeded into a 2 dimensional (2D) culture in a 25T culture flask coated with collagen type I or into a 3D culture in a 125-ml spinner flask for 7 days. Production of plasma protein (ALB and TF), apoptosis (BAX and BCL2), and CYP (CYP3A1) related genes were compared between the 2D and 3D culture systems. The 3D culture system had an advantage over the 2D system because of the relatively high expression of ALB and low expression of BAX in the 3D system. However, the level of CYP3A1 did not improve in the 3D culture with and without the presence of a dexamethasone inducer. Therefore, 3D culture has an advantage for albumin production and primary rat hepatocyte survivability, but a low expression of CYP3A1 indicated that primary rat hepatocytes require a high-density culture for stress reduction by continuous flow.