• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2004.04a
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• pp.186-191
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• 2004

Sorption kinetics of 2-chlorophenol(2-ChP), 2,4-dichlorophenol(2,4-DChP) and 2,4,5-trichlorophenol (2,4,5-TChP), onto montmorillonite modified with hexadecyltrimethyl ammonium cations(HDTMA-mont) were investigated. One-site mass transfer model(OSMTM) and two compartment first-order kinetic model(TCFOKM) were used to analyze kinetics. As expected from the number of model parameters involved, the three-parameter TCFOKM was better than the two-parameter OSMTM in describing sorption and desorption kinetics of chlorophenols in HDTMA-mont. For all chlorophenols, the results of OSMTM analysis indicate that the predominant deprotonated speciation(at pH 9.15) exhibited higher mass transfer coefficient( $k_{s}$ ) than the protonated speciation(at pH 4.85). This is because the deprotonated speciation has stronger hydrophobic interaction than protonated speciation. Most sorption completes in three hours. The fraction of the fast sorption and the first-order sorption rate constants for the fast and slow compartments in TCFOKM were determined by fitting experimental data to the TCFOKM. The results of kinetics reveal that the fraction of the fast sorption( $f_1$) and the sorption rate constants in the fast compartments( $k_1$) were in the order 2,4,5-TChP > 2,4-DChP > 2-ChP, which agrees with the magnitude of the $K_{ow}$ . The first-order sorption rate constants in the fast compartment(10$^{0.8}$ - 10$^{1.22}$ h $r^{-1}$ ) were much larger than those in the slow compartment(10$^{-1}$.74/ - 10$^{-2}$.622/ h $r^{-1}$ ).> ).).

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.271-272
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• 1998

Contrast-enhanced CT has an important role in the assessment of liver lesions. However, the optimal protocol to get most effective result is not clear. The main principle for deciding injection protocol is to optimize lesion detectability by rapid scanning when lesion-to-liver contrast is maximum. For this purpose, we developed a physiological model of contrast medium enhancement based on the compartment modeling and pharmacokinetics. Blood supply to liver was modeled in two paths. This dual supply character distinguishes the CT enhancement of liver from that of the other organs. The first path is by hepatic artery and the second is by portal vein. It is assumed that only hepatic artery can supply blood to hepatocellular carcinoma (HCC) compartment. It is known that this causes the difference of contrast enhancement between normal liver tissue and hepatic tumor. By solving differential equations for each compartment simultaneously using computer program Matlab, CT contrast-enhancement curves were simulated. Simulated enhancement curves for aortic, hepatic, portal vein, and HCC compartments were compared with mean enhancement curves from 24 patients exposed to the same protocols as simulation. These enhancement curves were in a good agreement. Furthermore, we simulated lesion-to-liver curves for various injection protocols, and analyzed the effects. These may help to optimize the scanning protocols for good diagnosis.

• Journal of Veterinary Clinics
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• v.14 no.2
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• pp.195-200
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• 1997

In order to compare the pharmacokinetic profiles of enrofloxacin-HCL)ENFLX-HCL) and enrofloxacin-KOH (ENFLX-KOH) after oral administration in broiler chickens, the study was performed. The chickens used in this study weighed $1.82 {\pm}0.2 kg$ and clinically healthy. The dose of intravenous and lral administration was 5 mg per kg of body weight as enrofloxacin. After intravenous injection of enrofloxacin, it showed two-compartment model with the rapid distribution phase and the slow elimination phase. The mean apparent volume of distribution (Vd) was 2.70 l/kg. The mean half-life of elimination and distribution showed 8.26 h and 0.44 h, respectively. The mean area under curve (AUC) was calculated as $19.7 {\mu} g{\cdot} h/ml$. After oral administration of ENFLX-HCL and ENFLX-KOH with a rate of dose 5 mg of enrofloxacin/kg of body weight, Both of the products were showed one-compartment model unlike that of i.v. enrofloxacin standard solution showed the mean bioavailability of 79.64% for the ENFLX-KOG and 86.24% for the ENFLX-HCL. The mean total body clearance of the former was 0.24 l/kg/h and the latter 0.42 l/kg/h. Both enorfloxacin formulations seemed to have good tissue distribution and penetration as indicated by large volume of distribution : 2.72 l/kg for the -KOH and 4.44 l/kg for the -HCL. With the results obtained in this study, ENFLX-HCL could be used in place of its salt form in chickens.

• Current Optics and Photonics
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• v.1 no.5
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• pp.529-537
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• 2017

We explored how changes in blood vessel compliance affected the systolic rise time (SRT) of the maximum blood pressure (BP) peak wave and the diastolic fall time (DFT) of the minimal BP peak wave, compared to photoplethysmograpic (PPG) parameters, using a two-compartment, second-order, arterial Windkessel model. We employed earlier two-compartment Windkessel models and the components thereof to construct equivalent blood vessel circuits, and reproduced BP waveforms using PSpice technology. The SRT and DFT values were obtained via circuit simulation, considering variations in compliance (the dominant influence on blood vessel parameters attributable to BP changes). And then performed regression analysis to identify how compliance affected the SRT and DFT. We compared the SRTs and DFTs of BP waves to the PPG values by reference to BP changes in each subject. We confirmed that the time-shift propensities of BP waves and the PPG data were highly consistent. However, the time shifts differed significantly among subjects. These simulation and experimental results allowed us to construct an initial trend curve of individual BP peak time (measured via wrist PPG evaluations at three arm positions) that facilitated accurate individual BP estimations.

• Journal of Pharmaceutical Investigation
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• v.22 no.4
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• pp.289-300
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• 1992

The counter-transport phenomena in the hepatic transport of 1-anilino-8-naphthalene sulfonate (ANS) were kinetically investigated by analyzing the plasma disappearance-time profiles and the transport into the isolated hepatocytes. In vivo "counter transport phenomena" were simulated based on the perfusion model which incorporated the carrier-mediated transport and the saturable intracellular binding. The condition that the mobility of carrier-ligand complex is greater than that of free carrier is not essential for the occurrence of counter-transport phenomenon. To examine the inhibitory effects on the initial uptake of a ligand by the liver, it is necessary to judge whether the true counter-transport mechanism (trans-stimulation) is working or not. The initial plasma disappearance curves of ANS were then kinetically analyzed based on a two-compartment model, in which the ligand is eliminated only from the peripheral compartment (liver compartment). No effects on the initial plasma disappearance rates of ANS were observed after preloading of bromophenol blue (BPB) or rose bengal (RB) in the liver. Inhibitory effect of BPB or RB on the initial uptake (or efflux) rates of ANS by the isolated hepatocytes were not observed, suggesting that the true counter transport mechanism is not working. In conclusion, checking the preloading effects of transstimulation on the initial uptake of a ligand by the liver could be a useful criterion for carrier cycling and common use of the same carrier between two ligands. However, one cannot exclude those possibilities even if the preloading effects cannot be observed.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.19 no.2
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• pp.89-96
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• 2020

In this study, we developed a finite element model for the built-in bottom-freezer type refrigerator and then used the structural analysis method to analyze and evaluate the deflection of the doors. We tested the validity of the developed analytical model by measuring the deflection of the hinge when loads were applied to the upper and lower hinges of the refrigerating compartment and compared these with the analysis results. The comparison of the vertical displacement of the measured result and the analysis result showed an error ratio of up to 12.8%, which indicates that the analytical model is consistent. Using the analytical model composed of the cabinet, hinges and doors, we performed analyses for two cases: both doors closed, and the refrigerating door open. Since the maximum vertical displacement of the refrigerating compartment door (R-door) with the food load is smaller than the gap between the lower surface of the R-door and the upper surface of the freezer compartment door (F-door), it is judged that the R-door and the F-door do not contact when the doors are opened or closed. In addition, the analysis result showed that the difference between the vertical displacement at the hinge on the opposite side and the hinge side of the R-door is favorably smaller than the management criterion of the refrigerator manufacturer.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.31 no.12
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• pp.1024-1032
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• 2007

The flow characteristics with the impinging angles of defrost nozzle jet inside a commercial vehicle passenger compartment were investigated experimentally by using the two-dimensional duct-nozzle model. The shape of the nozzle contraction was designed according to the curved line of cubic equation to the vertical plan of the flow direction. The impinging angles, defined as the angle between nozzle axis and a vertical line to the windshield, were varied from the $0^{\circ}\;to\;80^{\circ}$. The mean velocity distributions, the half-widths, and the momentum distributions with the cases of both the free jet and the impinging jet onto the dummy windshield were measured. The impinging jet flows similarly with wall jet from $X/b_o=20$, and the impinging angle has an effect on the half-width of the impinging jet. The momentum distributions onto the windshield increased with the increase of impinging angle, and then their inflection point was observed around the impinging angle of $60^{\circ}$.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.218-219
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• 2002

In the past, the development of pharmacokinetic/pharmacodynamic (PK/PD) models for quantitating the time course of drug responses was mainly based on two types of models, the empirical effect compartment model that simply accounts for the delay between effect and plasma concentration (hysteresis) and the mechanism-based so-called indirect response model. The first approach traces back to a paper by Segre (1) and its application was popularized by Holford and Sheiner (2); indirect response models were introduced by Jusko's group (3). (omitted)

• Journal of Industrial Technology
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• v.16
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• pp.239-245
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• 1996

Modal parameters determine the frequency response characteristics of vibration system or acoustic system. When the two systems are fully coupled, however, coupling changes the vibrational and acoustic model parameters into those of the coupled system. In this case, it is very difficult to obtain the modified model parameters and response characteristics. In this paper, coupling effect is analytically investigated on the natural frequency, mode and frequency response characteristics. The result can be applied to understand and to design the frequency response characteristics of the vehicle passenger compartment.

• Journal of ILASS-Korea
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• v.13 no.3
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• pp.156-161
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• 2008

The present article reports a numerical study on the fire characteristic change by water-mist in under-ventilated compartments. The natural gas and heptane pool fires are used as fire sources, which are located in the bottom center of the 2/5 reduced-scaled model of the ISO 9705 standard room. The fire modeling using the FDS (Fire Dynamics Simulator) is validated by comparison with previously published experimental results. For temperature and combustion gas concentrations at two positions located in the upper layer of compartment, the predicted results with and without water-mist are compared each other. The results show that under the water-mist operation, the predicted temperature and carbon monoxide concentration reduce as $300{\sim}400^{\circ}C$ and about 20%, respectively, compared to those without water-mist.