• The Korean Journal of Physiology and Pharmacology
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• v.17 no.5
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• pp.375-383
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• 2013

Hepatocellular carcinoma (HCC) related to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections is thought to account for more than 80% of primary liver cancers. Both HBV and HCV can establish chronic liver inflammatory infections, altering hepatocyte and liver physiology with potential liver disease progression and HCC development. Cyclophilin A (CypA) has been identified as an essential host factor for the HCV replication by physically interacting with the HCV non structural protein NS5A that in turn interacts with RNA-dependent RNA polymerase NS5B. CypA, a cytosolic binding protein of the immunosuppressive drug cyclosporine A, is overexpressed in many cancer types and often associated with malignant transformation. Therefore, CypA can be a good target for molecular cancer therapy. Because of antiviral activity, the CypA inhibitors have been tested for the treatment of chronic hepatitis C. Nonimmunosuppressive Cyp inhibitors such as NIM811, SCY-635, and Alisporivir have attracted more interests for appropriating CypA for antiviral chemotherapeutic target on HCV infection. This review describes CypA inhibitors as a potential HCC treatment tool that is contrived by their obstructing chronic HCV infection and summarizes roles of CypA in cancer development.

• Quality Improvement in Health Care
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• v.5 no.2
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• pp.296-310
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• 1998

Background : Performance evaluation of medical care providers has become more important than before in Korea. Especially in university hospitals, job contents of medical staffs are so complicated that evaluation is not easily performed. In addition, in order that the feedback of evaluation be successful, acceptance of staffs to be evaluated is essential. This study is aimed at the development of items for evaluation and weighting of each item in one university hospital, and clustering departments by different weight given by medical staffs. Methods : Through resource group meeting. performance items were listed up by categories of education, research, medical services, and other activities in and out of the hospital. For each item, all the medical staffs were asked how important they thought, compared with publishing one original article. By factor analysis, the items in each category were grouped into a few subgroups. In turn, cluster analysis was done for the purpose of grouping departments by priority the medical staffs gave. Results and Conclusion : Among five major categories, medical staffs regard education, research, and medical services more important than other activities in and out of the hospital. Five categories consisted of two or three components. Departments in hospital were grouped into three. However, characteristics of each group was not clearly delineated. This result suggests that more comprehensive tool should be developed and applied in the process of performance evaluation in university hospitals.

• Asian Journal for Public Opinion Research
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• v.8 no.3
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• pp.180-196
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• 2020

This paper considers Japanese political interviews to integrate conversation and facial expression analysis. The behaviors of political leaders will be disclosed by analyzing questions and responses by using the turn-taking system in conversation analysis. Additionally, audiences who cannot understand verbal expressions alone will understand the psychology of political leaders by analyzing their facial expressions. Integral analyses promote understanding of the types of facial and verbal expressions of politicians and their effect on public opinion. Politicians have unique techniques to convince people. If people do not know these techniques and ways of various expressions, they will become confused, and politics may fall into populism as a result. To avoid this, a complete understanding of verbal and non-verbal behaviors is needed. This paper presents two analyses. The first analysis is a qualitative analysis that deals with Prime Minister Shinzō Abe and shows that differences between words and happy facial expressions occur. That result indicates that Abe expresses disgusted facial expressions when faced with the same question from an interviewer. The second is a quantitative multiple regression analysis where the dependent variables are six facial expressions: happy, sad, angry, surprised, scared, and disgusted. The independent variable is when politicians have a threat to face. Political interviews that directly inform audiences are used as a tool by politicians. Those interviews play an important role in modelling public opinion. The audience watches political interviews, and these mold support to the party. Watching political interviews contributes to the decision to support the political party when they vote in a coming election.

• Korean Journal of Agricultural Science
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• v.42 no.3
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• pp.269-276
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• 2015

Unmanned Aerial Vehicle (UAV) has several advantages over conventional remote sensing techniques. They can acquire high-resolution images quickly and repeatedly. And with a comparatively lower flight altitude, they can obtain good quality images even in cloudy weather. In this paper, we discussed the state-of-the-art of the domestic and international use of UAV in agricultural sector as well as assessed its utilization and applicability for agricultural environment in Korea. Association of robotic, computer vision and geomatic technologies have established a new paradigm of low-altitude aerial remote sensing that has now been receiving attention from researchers all over the world. In a field study, it has been found that use of UAV imagery in an agricultural subsidy program can reduce the farmers' complain and provide objective evidence. UAV high resolution photography can also be helpful in monitoring the disposal zone for animal carcasses. Due to its expeditiousness and accuracy, UAV imagery can be a very useful tool to evaluate the damage in case of an agricultural disaster for both parties insurance companies and the farmers. Also high spatial and temporal resolution in UAV system can increase the prediction accuracy which in turn help to maintain the agricultural supply and demand chain.

• Child Health Nursing Research
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• v.15 no.4
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• pp.350-358
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• 2009

Purpose: This study was done to better understand how sick children and their families define chronic illness; what behaviors they used for managing chronic illness; and how they perceived the socio-cultural context of Korea. Methods: This study was a secondary analysis of qualitative studies. Articles on children with a chronic illness and their families located in electronic databases were selected for review. Twenty one qualitative studies were reviewed. Qualitative studies that had used an analysis tool, the Family Management Style Framework were reviewed. Results: Children with chronic illness and their families tended to accept illness as a negative outcome and thought that they were deprived of the context of normality. In the traditional Korean family style, parents-in-law demand absolute obedience from their daughter-in-law, leading to a conflict between the two parties, which, in turn, may have negatively affected their perceptions of chronic illness. Western and oriental medical treatments were used, and participants sought an array of folk remedies. Conclusion: Culturally specific findings can help to better understand the difficulties faced by children with a chronic illness and their families and can provide invaluable input into the development of culturally appropriate and sensitive nursing interventions.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2003.04a
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• pp.255-259
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• 2003

Moire topography method isa well-known non-contacting 3-D measurement method as afast non-contact test for three-dimension shape measuring method. Recently, it's important to study the automatic three-dimension measurement by moire topography because it is frequently applied to the reverse engineering , the medical , the entertainment fields. Three-dimension measurement using projection of moire topography is very attractive because of its high measuring speed and high sensitivity. In this paper, the classical moire method is computerized-so called digital moire when a virtual grating pattern is projected on a surface, the captured image by the CCD camera has three-dimension information of the objects. The moire image can be obtained through a simple image processing and a reference grating pattern. and it provides similar results without physical grating pattern. digital projection moire topography turn out to be very effective for the three-dimension measurement of objects. Using different N-bucket algorithm method of digital projection moire topography is tested to measuring object with the 2-ambiguity problem. Experimental results prove that the proposed scheme is capable of finding measurement errors that decreased more by using the four-three step algorithm method instead of the same step in the phase shifting of different pitch.

• Nuclear Engineering and Technology
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• v.44 no.8
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• pp.889-896
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• 2012

Recent progress in the computational fluid dynamics methods of two- and multiphase phase flows has already started opening up new exciting possibilities for using complete multidimensional models to simulate boiling systems. Combining this new theoretical and computational approach with novel experimental methods should dramatically improve both our understanding of the physics of boiling and the predictive capabilities of models at various scale levels. However, for the multidimensional modeling framework to become an effective predictive tool, it must be complemented with accurate mechanistic closure laws of local boiling mechanisms. Boiling heat transfer has been studied quite extensively before. However, it turns out that the prevailing approach to the analysis of experimental data for both pool boiling and forced-convection boiling has been associated with formulating correlations which normally included several adjustable coefficients rather than based on first principle models of the underlying physical phenomena. One reason for this has been the tendency (driven by practical applications and industrial needs) to formulate single expressions which encompass a broad range of conditions and fluids. This, in turn, makes it difficult to identify various specific factors which can be independently modeled for different situations. The objective of this paper is to present a mechanistic modeling concept for both pool boiling and forced-convection boiling. The proposed approach is based on theoretical first-principle concepts, and uses a minimal number of coefficients which require calibration against experimental data. The proposed models have been validated against experimental data for water and parametrically tested. Model predictions are shown for a broad range of conditions.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.33 no.2
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• pp.109-113
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• 2020

A power device is a component used as a switch or rectifier in power electronics to control high voltages. Consequently, power devices are used to improve the efficiency of electric-vehicle (EV) chargers, new energy generators, welders, and switched-mode power supplies (SMPS). Power device designs, which require high voltage, high efficiency, and high reliability, are typically based on MOSFET (metal-oxide-semiconductor field-effect transistor) and IGBT (insulated-gate bipolar transistor) structures. As a unipolar device, a MOSFET has the advantage of relatively fast switching and low tail current at turn-off compared to IGBT-based devices, which are built on bipolar structures. A superjunction structure adds a p-base region to allow a higher yield voltage due to lower R_DS (on) and field dispersion than previous p-base components, significantly reducing the total gate charge. To verify the basic characteristics of the superjunction, we worked with a planar type MOSFET and Synopsys' process simulation T-CAD tool. A basic structure of the superjunction MOSFET was produced and its changing electrical characteristics, tested under a number of environmental variables, were analyzed.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2004.10a
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• pp.225-232
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• 2004

Recently, there has been a rapid development in computer technology, which has in turn led to develop the automated welding system using Artificial Intelligence (AI). However, the automated welding system has not been achieved duo to difficulties of the control and sensor technologies. In this paper, the classification of the optimized bead geometry such as bead width, height penetration and bead area in the Gas Metal Arc (GMA) welding with fuzzy logic is presented. The fuzzy C-Means algorithm (FCM), which is best known an unsupervised fuzzy clustering algorithm is employed here to analysis the specimen of the bead geometry. Then the quality of the GMA welding can be classified by this fuzzy clustering technique and the choice for obtaining the optimal bead geometry can also be determined.

• Asian-Australasian Journal of Animal Sciences
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• v.27 no.3
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• pp.447-456
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• 2014

The use of electrical stimulation (ES) as a management tool to improve meat quality and efficiency of meat processing is reviewed. The basis of the efficacy of ES is its ability to fast track postmortem glycolysis, which in turn stimulates myriad histological, physical, biochemical, biophysical and physiological changes in the postmortem muscle. Electrical stimulation hastens the onset and resolution of rigor mortis thereby reducing processing time and labor and plays a vital role in improving meat tenderness and other meat quality traits. However, ES may have negative impacts on some meat quality traits such as color stability and water holding capacity in some animals. Electrical stimulation is not an end in itself. In order to achieve the desired benefits from its application, the technique must be properly used in conjunction with various intricate antemortem, perimortem and postmortem management practices. Despite extensive research on ES, the fundamental mechanisms and the appropriate commercial applications remained obscured. In addition, muscles differ in their response to ES. Thus, elementary knowledge of the various alterations with respect to muscle type is needed in order to optimize the effectiveness of ES in the improvement of meat quality.