• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2003년도 제8차 학술대회 초록집
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• pp.38-39
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• 2003

To evaluate the clinical characteristics and outcome of the patients with disseminated pilocytic astrocytoma compared to non-disseminated disease and to discuss treatment options for disseminated disease. We Identified patients with disseminated pilocytic astrocytoma from our Tumor Registry over 21 years of period and reviewed medical records and neuroimages to determine location of the tumor, pattern of dissemination, clinical characteristics, treatment, and outcome. 24 controls without dissemination, matched for age at diagnosis, tumor histology, and primary location were selected from the same registry and case/control comparison was done using Kaplan-Meier survival analysis.

• Journal of Korean Neurosurgical Society
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• 제54권4호
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• pp.340-343
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• 2013

Intracerebral schwannomas are rare and there have been none reported in Korea. We present the case of a 25-year-old man with newly developed right-side weakness and recent seizure aggravation. His seizures started approximately 9 years prior to admission. At that time, a 1 cm diameter intra-axial enhancing mass at the left precentral gyrus was found on magnetic resonance image (MRI). After 9 years of observation and treatment with antiepileptic medication, an MRI taken due to symptom aggravation revealed peri-tumoral cyst formation with tumor enlargement. The tumor was surgically removed. Subsequently, right-side weakness diminished and there was good seizure control. Pathologic diagnosis was schwannoma. Schwannoma is a very rare tumor and there are no pathognomonic findings on radiologic images; thus, it is challenging to make a correct diagnosis. However, considering the natural course and excellent prognosis after surgical treatment of this kind of intra-axial mass with benign features, early surgery for diagnosis and proper treatment is highly recommended.

• 대한두경부종양학회지
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• 제35권2호
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• pp.57-60
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• 2019

Warthin's tumor (WT) is second most common neoplasm in the parotid gland and it can be accompanied by inflammation and necrosis. The chest wall inflammation may present a rapid and fatal clinical course and secondary to parotid abscess is extremely rare. An 81-year-old man came to emergency room complained of rapidly enlarged left parotid mass and inflammatory symptoms and signs around the upper lateral neck. We performed incision and drainage with adequate infection control. He was pathologically diagnosed as abscess. We report the unique and instructive clinical case with a literature review.

• 대한방사선치료학회지
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• 제7권1호
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• pp.176-184
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• 1995

It is very useful benefits to use the megavoltage photon beams in deep site tumor radiotherapy for skin sparing effects. But, In some cases of head and mock tumors, it is often necessary to use spoiler for rapid buildup on skin region. A spoiler with tissue equivalent material to be moved between the patients and the collimator can increase or control the skin dose and buildup region due to position and thickness of the spoiler was measured. Then, the effect of spoiler on skin dose and build up region in protruded tumor of head and neck was evaluated quantitatively. The measurements were abtained with PTW 2334 chamber (Markus type) on a polystylene phantom for 6MV x-ray from an accelerator.

• 대한골관절종양학회지
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• 제1권2호
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• pp.249-253
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• 1995

The fibrous dysplasia is a progressive and disabling condition that lead to deformity, especially weight bearing bones. The morbidity that is associated with the polyostotic fibrous dysplasia is the recurrent fracture and deformity. Various methods of treatment had been failed to control this problem. We used osteotomy and reconstruction nailing for polyostotic fibrous dysplasia occured in the proximal part of right femur with varus deformity and reconstruction nailing in left femur without osteotomy, and interlocking intramedullary nailing in right tibia to prevent pathologic fracture. These methods brought a good result of bone union and full weight bearing ambulation after 1 year and 6 month follow up. We think these methods are useful methods to control refracture and deformity, so we reported this case with bibliographic reviews.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1769-1772
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• 2013

A case-control study of the association of miR-499A>G rs3746444 with risk of hepatocellular carcinoma (HCC)was conducted. Patients with HCC and healthy control subjects were recruited for genotyping of miR-499A>G using duplex polymerase-chain-reaction with confronting-two-pair primer(PCR-RFLP) analysis. The MiR-499 GG genotype was associated with a decreased risk of HCC as compared with the miR-499 AA genotype (adjusted OR=0.74, 95%CI=0.24-0.96). Similarly, the GG genotype showed a 0.45-fold decreased HCC risk in a recessive model. The MiR-499 G allele was significantly associated with decreased risk of HCC among patients infected with HBV in a dominant model (OR=0.09, 95%CI= 0.02-0.29). In conclusion, the MiR-499A>G rs3746444 polymorphism is associated with HCC risk in the Chinese population, and may be useful predictive marker for CAD susceptibility.

• 한국음향학회지
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• 제8권4호
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• pp.5-12
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• 1989

초음파 hyperthermia를 이용한 암 치료는 정상세포에 열적 손상을 주지 않으면서 종양 부위만을 적당한 온도로 가열하여야 하며 따라서 종양세포와 정상세포에 대한 정확한 초음파 세기 조절이 필요하게 된다. 본 연구에서 초음파 hyperthermia용 변환기로써 촛점 거리와 집속 범위를 전자적으로 조절할 수 있는 육각환 변환기를 설계, 제작하였으며 위상조 절회로를 이용하여 초음파 hyperthermia 시스템을 구성, 그 음향 특성을 측정하였으며 모의 생체 실험을 수행하였다. 실험 결과 촛점 부근에서 초음파 에너지가 집속되는 것을 확인하였으며 초음과 hyperthermia 시스템으로써의 유용성을 확인하였다.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.121-122
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• 2002

The main principle of radiation therapy is to deliver optimum dose to tumor to increase tumor cure probability while minimizing dose to critical normal structure to reduce complications. RTP system is required for proper dose plan in radiation therapy treatment. The main goal of this research is to develop dose model for photon, electron, and brachytherapy, and to display dose distribution on patient images with optimum process. The main items developed in this research includes: (l) user requirements and quality control; analysis of user requirement in RTP, networking between RTP and relevant equipment, quality control using phantom for clinical application (2) dose model in RTP; photon, electron, brachytherapy, modifying dose model (3) image processing and 3D visualization; 2D image processing, auto contouring, image reconstruction, 3D visualization (4) object modeling and graphic user interface; development of total software structure, step-by-step planning procedure, window design and user-interface. Our final product show strong capability for routine and advance RTP planning.

• Preventive Nutrition and Food Science
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• 제4권2호
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• pp.117-121
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• 1999

The anititumor and immunologic activities of the glycoproteins extracted from sea cucumber (Stichopus japonicus) on mice bearing sarcoma 180 cells were investigated . Maximum tumor suppression (64%) occurred at the dose of 100mg glycoprotein/kg. The highest prolongation ratio was achieved at the level of 100mg/kg an dincreased by 395 more than that of control. Glycoproteins from sea cucumber exhibited direct cytotoxic effect on the tumor cells. Dose dependent increase of leucocyte, peritoneal exudate cell and weights of immunoorgans revealed the improvement of immunity. When the glycoportein-administered group was compared with the control, a significant difference was not noted in the clinico-chemical values such as S-GOT, S-GPT , alkaline phoshatse activity, total protein, cholesterol, triglyceride, urea nitrogen and glucose levels in blood. These results suggests that the antitumor activity of sea cucumber glycoprotein is associated with activation of cells in the immune system.

• 한국식품영양과학회지
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• 제22권4호
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• pp.398-404
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• 1993

화학적 발암제인 DMBA를 이용하여 챌스터 협낭에 암을 유발시키면서 마늘을 투입시켜 마늘의 유의성있는 항암 효과를 관찰하였다. 햄스터 헙낭에서 DMBA에 의한 발암현상에 대한 마늘의 효과를 병리조직학적으로 관찰한 결과 대조군에 비하여 마늘즙을 복용시킨 실험군에서 암세포의 침윤 증식상이 다소 감소되었다. 그리고 BrdU(bromodeoxy uridine)의 투여후 DMBA 발암현상에 대한 면역 조직 화학적 관찰에서 마늘을 복용시킨 실험군에 비하여 마늘즙을 복용시키지 않은 실험군에서 발암 개시전 기저 세포층의 증식성이 감소되어져 있으나 침윤 증가하는 발암 세포군에서는 서로 거의 유사한 증식상을 보였다. 이것으로 미루어 보아 마늘이 음식물에 적절하게 사용되고 조리하는 방법의 개발에 따라 일상 식생활에서 많이 사용하여 각종 암발생을 예방하는 일환이 되리라고 사료된다.