• Investigative Magnetic Resonance Imaging
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• v.14 no.2
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• pp.95-102
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• 2010

Purpose : To evaluate the magnetic resonance imaging (MRI) and clinicopathological features of triple negative breast cancer, and compare them with those of non-triple negative breast cancer. Materials and Methods : This study included 231 pathologically confirmed breast cancers from January 2007 to May 2008. We retrospectively reviewed the MRI findings according to the Breast Imaging Reporting and Data System (BI-RADS) lexicon: mass or non-mass type, mass shape, mass margin, non-mass distribution, and enhancement pattern. Histologic type, histologic grade, and the results for epidermal growth factor receptor, p53, and Ki 67 were reviewed. Results : Of 231 patients, 43(18.6%) were triple negative breast cancer. Forty triple negative breast cancers (93.0%) were mass-type lesion on MRI. A round or oval or lobular shape (p=0.006) and rim enhancement (p=0.004) were significantly more in triple negative breast cancer than non- triple negative breast cancer. In contrast, irregular shape (p=0.006) and spiculated margins (p=0.032) were significantly more in non-triple negative breast cancer. Old age (p=0.019), high histologic grade (p<0.0001), EGFR positivity (p<0.0001), p53 overexpression (p=0.038), and Ki 67 expression (<0.0001) were significantly associated with the triple negative breast cancer. Conclusion : MRI finding may be helpful for differentiation between triple negative and non-triple negative breast cancer.

• Journal of the Korean Magnetic Resonance Society
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• v.10 no.2
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• pp.175-187
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• 2006

Binding interactions between a positively charged porphyrin derivative TMAP(meso-tetra(p-trimethylanilinium-4-yl)porphyrin) and triple helical $(dT)_{12}{\cdot}(dA)_{12}{\cdot}(dT)_{12}$, as well as double helical $(dA)_{12}{\cdot}(dT)_{12}$ have been studied with NMR, UV and CD spectroscopy to obtain the detailed information about the binding mode and binding site. UV melting studies showed both DNA duplex and triple helix represented very similar UV absorption patterns upon binding TMAP, but the presence of third strand of triple helical $(dT)_{12}{\cdot}(dA)_{12}{\cdot}(dT)_{12}$, inhibited improvement in thermal stability in terms of melting temperature, $T_m$. In addition, the TMAP molecule is thought to bind to the major groove, according to CD and NMR data. But absence of the clear isosbestic point in UV absorption spectra represented that binding of TMAP to DNA duplex as well as DNA triplex did not show a single binding mode, rather complex binding modes.

• World Technopolis Review
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• v.6 no.2
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• pp.90-101
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• 2017

This paper defines the role of the Science Park and makes policy recommendations for the "Era of $4^{th}$ Industrial Revolution" from a Triple Helix viewpoint. The role of traditional science parks, and theory of Triple Helix and the $4^{th}$ Industrial Revolution are reviewed, and strategies to cope with the $4^{th}$ Industrial Revolution in a few advanced countries are analyzed. This paper finishes by suggesting strategies such as acceleration of networking, education to foster creative and innovative manpower and initiating capacity building projects for the advancement of Science Parks in the $4^{th}$ Industrial Revolution.

• Journal of the Korean Society for Precision Engineering
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• v.5 no.3
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• pp.48-62
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• 1988

A triple hot-wire probe has an essential potentiality for the measure- ment of an instantaneous velocity vector in a three dimensional unsteady flow with large amplitude of velocity fluctuations, the key problems asso- ciated with this instrument are the directional range of applicability and the accuracy. This present paper is concerned with a new method of the techniques of calibration and data processing to estimate the three dimensional flow field using an arbitrary shaped triple hot-wire probe. The method is not based on the assumptions of orthogonality or symmetry and it is especially useful for applications to a hand-made probe where probe geometry is not accurately known. The test application is made to evaluate the effect of cone angles of symmetric non-orthogonal probe.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.33A no.11
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• pp.70-77
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• 1996

In this paper, a modifed TE$_{113}$/TM$_{012}$ triple-mode bandpass filter is implemented by using a modified inter-cavity iris in which the number of slots are reduced upto 50%. In a coventioanl iris two prirs of slot apertures are used to independently couple three resonant modes between two adjacent cavities. However, if transverse magnetic polarizability of a pair of veritcal slot apertures is used to control weak horizontal TE$_{h}$-TE$_{h}$ mode coupling, the width of novel iris slots would substitute for the slot length of the conventional iris, causing to eliminate the horizontal slot apertures. The measured data of two filters, which are the modified filter and ocnventional one, are compared. Experimental result shows that the characteristics of the novel triple-mode filter matches well that of the conventional filter.

• Korean Journal of Applied Biomechanics
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• v.15 no.2
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• pp.57-67
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• 2005

The purpose of this study was to analyze the kinetic factors of the golf driver swing using the Inverse Dynamics function. For this purpose, joint force were calculated. In order to test the possibility of Inverse Dynamics function(motion-dependent interaction), a triple segmental system was set for wrist, left shoulder and lumbar and joint force working on the anatomical joint region was estimated. For this study, 7 professional golfers were sampled, and then, their driver swings were recorded with two high-speed digital video cameras (180 frames/sec.) to be synthesized into 3-dimensional images and coordinated. Then, Eular's equation was used to produce some kinematic data, which were used to calculate joint force and torque with Newton's function. All data were calculated using LabVIEW 6.1 graphic program. The results of this study can be summarized as follows; It was found that the joint force was generated on wrist, shoulder and lumbar joints in the direction of the target, and that the joint force was stronger in the direction of target immediately before impact. The joint force was generated towards the target to activate the nodes, and then, it was generated in the reverse direction to increase the speed during impact.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.1
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• pp.68.2-68.2
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• 2010

We present near-infrared (NIR) spectra of 6 young stellar objects (YSOs) around the supernova remnant G54.1+0.3 obtained with TripleSpec, a slit-based NIR cross-dispersion echelle spectrograph on th 5-m Palomar Hale telescope covering the entire NIR atmospheric window of 1-2.4 micron. These YSOs, whose formation was possibly triggered by the progenitor of G54.1+0.3, show significant mid-infrared (MIR) excess and have been proposed to be late O- and early B-type YSOs based on their spectral energy distribution. Our TripleSpec observations reveal the existence of strong H and He I lines, consistent with the previous interpretation of their spectral types, while the absence of Br-gamma emission line indicates that the YSOs do not have a nearby circumstellar disk. We discuss the relation between these YSOs and G54.1+0.3 based on the TripleSpec data and previous photometric data as well.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.1
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• pp.44.2-44.2
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• 2017

Multiple stellar systems composed of triple, double+double or double+triple, etc. are very rare and interesting objects for understanding the star formation and dynamical evolution. However, only six systems have been found to be a doubly eclipsing quadruple, which consists of two eclipsing binaries, and four systems to be a triply eclipsing hierarchical triple. Recently, the 15 doubly eclipsing multiple candidates located in the Large Magellanic Cloud (LMC) have been reported by the OGLE project. In order to examine whether these candidates are real multiple systems with eclipsing features, we performed a high-cadence time-series photometry for the LMC using the KMTNet (Korea Microlensing Telescope Network) 1.6 m telescopes in three site (CTIO, SAAO, and SSO) during 2016-2017. The KMTNet data will help reveal the photometric properties of the multiple-star candidates. In this paper, we present the VI light curves and their preliminarily analyses for 12 of the 15 eclipsing systems in the LMC, based on our KMTNet observations and the OGLE-III survey data from 2001-2009.

• Journal of Contemporary Eastern Asia
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• v.15 no.1
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• pp.1-3
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• 2016

• Genomics & Informatics
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• v.17 no.1
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• pp.3.1-3.4
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• 2019

Intratumor heterogeneity within a single tumor mass is one of the hallmarks of malignancy and has been reported in various tumor types. The molecular characterization of intratumor heterogeneity in breast cancer is a significant challenge for effective treatment. Using single-cell RNA sequencing (RNA-seq) data from a public resource, an ERBB pathway activated triple-negative cell population was identified. The differential expression of three subtyping marker genes (ERBB2, ESR1, and PGR) was not changed in the bulk RNA-seq data, but the single-cell transcriptomes showed intratumor heterogeneity. This result shows that ERBB signaling is activated using an indirect route and that the molecular subtype is changed on a single-cell level. Our data propose a different view on breast cancer subtypes, clarifying much confusion in this field and contributing to precision medicine.