• Archives of Pharmacal Research
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• 제3권1호
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• pp.17-21
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• 1980

A sensitive spectrophotofluorometric method was developed for the analysis of 2[[3-(trifluoromethyl)phenyl]amino]-3-phridine carboxylic acid (I) in urine. The method is based on the fluoroscence behavior of the I-aluminum complex in absolute ethanol. This fluorophore has activation and emission wavelengths of 355 and 450 nm, respectively. Optimum conditions for the reaction were investigated. The fluorescence was linear in the range of 0.25 3.0 ug of I/ml. Replicate studies of spiked urine samples, each containing 2.5 ug of I/ml showed good precision with a relative standard deviation of 0.019. Overall recovery percent from five spiked urine samples was 99.4 $\pm$1.32%.

• Bulletin of the Korean Chemical Society
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• 제31권6호
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• pp.1515-1518
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• 2010

Regio- and diastereoselective 1,3-dipolar cycloaddition reactions of nitrones {(Z)-${\alpha}$-phenyl-N-methylnitrone (1a) and (Z)-${\alpha}$-propyl-N-butylnitrone (1b)} with electron-deficient perfluoro-2-methyl-2-pentene (2) lead to novel isoxazolidines {5-fluoro-5-pentafluoroethyl-4,4-bis-trifluoromethyl-2-methyl-3-phenyl-isoxazolidine (3a) and 2-butyl-5-fluoro-5-pentafluoroethyl-4,4-bis-trifluoromethyl-3-propyl-isoxazolidines (3b) respectively} as major constituents. These derivatives were characterized by IR, $^1H$ and $^{19}F$ NMR, GC-MS and NOE measurements, and the absolute structure of 3a was confirmed by X-ray crystallography.

• Bulletin of the Korean Chemical Society
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• 제17권5호
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• pp.461-463
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• 1996

The laser-induced fluorescence excitation spectrum of 7-amino-4-(trifluoromethyl)coumarin in a supersonic jet has been recorded in the 340-352 nm region. The electronic band origin was observed at 28622.8 cm-1. Vibrational assignments for the three fundamental low-frequency modes and eight combination bands have been made for the S1 electronic excited state. The out-of-plane vibrations of this molecule have been characterized from the low-frequency assignments of the spectrum. The periodic potential energy function for the CF3 torsion, which satisfactorily fits the observed data, were also determined to be V(Φ)=95X(1-cos3Φ)-32X(1-cos6Φ) where Φ is the torsional angle. The relatively low torsional barrier of 99 cm-1 in S1 state could be explained by the small steric interactions between the functional groups attached to a bicyclic ring.

• Bulletin of the Korean Chemical Society
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• 제20권10호
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• pp.1218-1220
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• 1999

• Bulletin of the Korean Chemical Society
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• 제11권4호
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• pp.258-260
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• 1990

• 농약과학회지
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• 제2권3호
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• pp.117-125
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• 1998

Flupyrazofos [O,O-diethyl-O-(1-phenyl-3-trifluoromethyl-5-pyrazoyl)thiophosphoric acid ester]는 trifluoromethyl기가 존재하는 피라졸계통의 유기인계 살충제이다. 이 화합물은 배추좀나방에 대해서 탁월한 살충활성을 나타내었으며, 또한 작은각시들명나방과 멸강나방에 대해서도 우수한 살충활성을 나타내었다. 배추좀나방의 알, 번데기, 성충에 대해서는 살충효과가 떨어지지만, 유충은 발육 단계에 관계없이 강한 살충효과를 나타내었으며, 살충효과의 발현속도는 매우 빨랐다($LT_{50}$=0.9 hrs, $LT_{95}$=4.5 hrs). 침투이행성 효과는 없었지만, 잔효성은 있었다. 유기인계, 피레스로이드계 및 IGR계 저항성계통에 대해서 비교차저항성을 나타내었다. 채집지역별 살충제 감수성은 실내계통(S)과 큰차이가 없었다. 따라서 flupyrazofos는 야외에서 배추좀나방, 멸강나방, 작은각시들명나방을 효과적으로 방제할 수 있을 것으로 판단된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7687-7692
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• 2014

Aim: To observe the effects of a novel all-trans retinoid acid (ATRA) derivative, N-(3-trifluoromethyl-phenyl)-retinamide (ATPR), on lung adenocarcinoma A549 cells and to explore the potential mechanism of ATPR inhibiting of A549 cell migration. Materials and Methods: The cytotoxicity of ATRA and ATPR on A549 cells was assessed using MTT assay. Wound healing assays were used to analyze the influences of ATRA, ATPR, ML-7 (a highly selective inhibitor of myosin light chain kinase (MLCK)), PMA (an activator of MAPKs) and PD98059 (a selective inhibitor of ERK1/2) on the migration of A549 cells. Expression of MLCK and phosphorylation of myosin light chain (MLC) were assessed by Western blotting. Results: ATRA and ATPR inhibited the proliferation of A549 cells in a dose- and time-dependent manner, and the effect of ATPR was much more remarkable compared with ATRA. Relative migration rate and migration distance of A549 cells both decreased significantly after treatment with ATPR or ML-7. The effect on cell migration of PD98059 combining ATPR treatment was more notable than that of ATPR alone. Moreover, compared with control groups, the expression levels of MLCK and phosphorylated MLC in A549 cells were both clearly reduced in ATRA and ATPR groups. Conclusions: ATPR could suppress the migration and invasion of A549 cells, and the mechanism might be concerned with down-regulating the expression of MLCK in the ERK-MAPK signaling pathway, pointing to therapeutic prospects in lung cancer.

• Elastomers and Composites
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• 제47권4호
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• pp.355-363
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• 2012

2,2-Bis(3-amino-4-hydroxyphenyl)hexafluoropropane 와 방향족 디이미드-디카르복실산을 thionyl chloride, triethyl amine 및 NMP 하에서 직접 중축합하여 trifluoromethyl group을 포함하는 일련의 poly(hydroxyamide)s(PHAs)를 제조 하였다. PHAs은 $35^{\circ}C$ DMAc 용액에서 0.54-0.96 dL/g의 고유점도를 보였다. 모든 PHAs은 여러 종류의 유기용매에 쉽게 용해되었으나, PBOs은 황산에 부분적으로 용해되는 것을 제외하고, 전혀 용해되지 않았다. PHAs은 열적고리화 반응에 의해서 흡열과 함께 PBOs로 전환되었다. PHAs의 최대 중량손실온도는 $559-567^{\circ}C$의 영역을 보였고, poly(benzoxazole imide)s(PBOs)은 47-59%의 비교적 높은 char 수득율을 보였다. PBOs의 Pyrolysis Combustion Flow Calorimeter(PCFC) 결과에서 12-19 W/g의 HRR 과 2.7-3.6 kJ/g의 total HR을 보였다. PBO 1의 HRR은 PBO 3 의 HRR (19 W/g)보다 37 % 낮은 12 W/g의 가장 낮은 값을 보였다.

• Bulletin of the Korean Chemical Society
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• 제4권5호
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• pp.200-203
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• 1983

1,1,1-Trifluoro-4-substituted-3-buten-2-ols and 1,1,1-trifluoro-5-phenyl-4-penten-2-ol were prepared by hydromagnesation and palladium catalyzed phenylation in high stereoselectivity.

• Bulletin of the Korean Chemical Society
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• 제10권2호
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• pp.158-161
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• 1989

The hydrophobic interaction occurring between rhodamine 6G and tetraphenylborate anions has been investigated with surfactants by absorption and fluorescence studies. In the order of tetraphenylborate, tetrakis(4-fluorophenyl)borate, and tetrakis[3,5-bis(trifluoromethyl)phenyl]borate the hydrophobicity is found to be increased.