• Title/Summary/Keyword: Trifluoperazine. Thioridazine. Ames test

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Comparative Study on the Mutagenic Activity of Phenothiazines by UV-A Irradiations (UV-A 조사에 의한 Phenothiazines의 돌연변이원성 비교 연구)

  • 김봉희;박영아
    • Journal of Food Hygiene and Safety
    • /
    • v.9 no.1
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    • pp.15-21
    • /
    • 1994
  • The mutagenic activity of four phenothiazine derivatives such as chlorpromazine, perphenazine, trifluoperazine and thioridazine in conjunction with UV-A irradiation or not based on the Ames plate incorporation test in the presence and absence of liver microsomal enzyme(S9 fraction). None of these compounds and their photo-excited were detected as mutagen in the Salmonella microsome assay with TA 98 and TA 100.

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