• 한국콘텐츠학회논문지
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• 제11권12호
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• pp.250-257
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• 2011

사법의 민주적 정당성을 강화하고 투명성을 높임으로써 국민의 신뢰확보를 위하여 마련된 국민참여재판이 시행된지 벌써 3년 10개월이 지났다. 형사사법절차에 국민이 참여하는 절차적 민주주의와 공정하고 신중한 재판이 실현되고 있다는 점에서 긍정적 평가를 받을 수 있다. 그러나 국민참여재판은 극소수의 사건을 재판대상으로 하여 배심원의 평결에 권고적 효력만 인정하고 구속력을 인정하지 않는 한계가 있다. 뿐만 아니라 대상사건의 한정, 피고인의 선택제, 배제결정제도, 법관의 평의관여 및 배심원의 다수결평결 등의 문제점을 여전히 갖고 있다. 따라서 본고는 국민참여재판에 대한 몇 가지 쟁점과 문제점을 검토한 후 이에 대한 대안을 제시하는 것을 연구의 초점으로 한다.

• 한방안이비인후피부과학회지
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• 제26권1호
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• pp.104-117
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• 2013

Objective : The aim of this review is to development of clinical trial protocol for against cosmetics as a treatment of dry skin condition. Methods : We searched the literature from 2002 through April 2012 using 5 databases. We included randomized controlled trials(RCTs) in which human participants with dry skin condition as chief complaint were treated with cosmetics. The methodological quality of all RCTs was using the Jadad score. Results : Nine RCTs met the inclusion criteria. Cosmetic types included cream (7 trials), lotion (1 trial), oil (1 trial) and body wash (1 trial). The methodological quality of the trials was generally low (Jadad score: mean 1.78; range, 1 to 3). Conclusions : The evidence for cosmetics as an effective treatment for dry skin condition(xerosis) is currently scarce and of poor quality, and is therefore inconclusive. More rigorous studies are warranted.

• Fisheries and Aquatic Sciences
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• 제21권10호
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• pp.30.1-30.6
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• 2018

A study of three feeding trials was conducted to investigate the dietary protein requirements of Pacific white shrimp (Litopenaeus vannamei) at three different growth stages. Six experimental diets were formulated to include increasing protein levels of 25, 30, 35, 40, 45, and 50% (designated as P25, P30, P35, P40, P45, and P50, respectively) for three feeding trials. The three feeding trials were conducted in different-sized shrimp at 0.65 g (trial 1), 4.80 g (trial 2), and 10.5 g (trial 3). Triplicate groups of shrimp were fed one of the experimental diets for 36, 42, and 48 days in trials 1, 2, and 3, respectively. In trial 1, the growth performance was not affected by the dietary protein levels. However, protein efficiency ratio was significantly higher in P30 diet compared to P40, P45, and P50 diets. In trial 2, growth rate was significantly higher in P35 diet than in P25 diet. In trial 3, the lowest growth performance was obtained in P25 diet which significantly differed from that of other experimental diets. Broken line analysis of growth data indicates that the optimal dietary level of crude protein is 34.5, 35.6, and 32.2% for small-, medium-, and large-sized (juvenile, sub-adult, and adult stages) Pacific white shrimp, respectively.

• 한국항해항만학회지
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• 제33권9호
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• pp.623-628
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• 2009

The objective of this paper is to make clear the difference of maneuvering characteristics of a VLCC in standstill from those of her in running. The authors made mathematic models to calculate maneuvering motions of a VLCC in standstill using various ahead engine with full rudder angle and calculated their motions in each case and compared the calculated values with those of the same vessel running in sea trial tests. The difference of motions between them is great. For example, a VLCC in standstill can achieve a great alteration of heading over 90 degrees within the distance of 0.2L advance while she advances 3.0L for 90 degrees turning in full running sea trial turning test. Therefore whenever a VLCC in standstill meets a vessel approaching in collision course situation in near distance, it is better and recommendable that she should use her ahead engine with full rudder to avoid collision. So "maneuvering trial tests in standstill conditions" should be added to the content of sea trial tests when a newly built VLCC commence to take sea trials, that has not been included until now.

• 대한조선학회논문집
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• 제56권2호
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• pp.117-127
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• 2019

Vessel's ice speed performances will be verified in ice sea trial but environmental conditions of ice fields are changeable according to the weather condition of ice trial area. Speed performance has to correct in the no wind, wave and current etc. after sea trial. Especially finding ice fields which is exact the same as owner's ice thickness and strength requirements is not easy. Therefore speed correction according to environment condition has to be done after sea trial measurements. Correction methods for ice thickness, ice strength, wave, wind and ship draft, trim, ice drift etc. are checked in ice sea trial based on literature review such as ISO standard, ITTC recommendation, journal papers and proceedings of conferences. Possibility of application for current and ice drift correction in ice field are discussed and measuring schemes and procedures of correction methods are described in this paper. All of correction schemes are calculated for 'Araon' which is ice breaking research vessel with Arctic and Antarctic ice field test results. Analyzed results shows that Araon is satisfied with her official ice speed performance of 3 knots with 10MW power at 1m ice thickness, 570kPa ice flexural strength.

• 한국수산과학회지
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• 제52권3호
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• pp.268-273
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• 2019

This study evaluated acute nitrate nitrogen ($NO_3-N$) toxicity in juvenile blackhead seabream Acanthopagrus schlegelii. Seventy juveniles (Trial A, $7.1{\pm}0.6g$) and nine juveniles (Trial B, $71.3{\pm}3.5g$) per 70 L tank were exposed to $NO_3-N$ concentrations of 0, 500, 1500, 2500, 3500, and 4500 mg/L and 0, 600, 1200, 1800, 2400, and 3000 mg/L, respectively, in triplicate for 7 days. In Trial A, all fish exposed to 3500 and $4500mg\;NO_3-N/L$ died within 48 h; in Trial B, all fish exposed to $3000\;NO_3-N/L$ died after 120 h. The $96\;LC_{50}$ and $168\;LC_{50}$ were 2505 and $1806mg\;NO_3-N/L$, respectively, in Trial A, and 2663 and $2377mg\;NO_3-N/L$ in Trial B. Large juveniles were more resistant to $NO_3-N$ than small juveniles. The results of acute $NO_3-N$ toxicity studies provide important data for subsequent chronic toxicity studies.

• 한국운동역학회지
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• 제26권2호
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• pp.175-181
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• 2016

Objective: The aim of this study was to investigate age-related changes of multi-finger synergy during a constant force production task with and without an additional mechanical constraint. Method: Fourteen elderly subjects (age: $78.50{\pm}4.63yrs$, height: $157.29{\pm}8.97cm$, weight: $65.13{\pm}6.93kg$) and 14 young subjects (age: $21.13{\pm}1.35yrs$, height: $171.57{\pm}8.43cm$, weight: $70.29{\pm}16.77kg$) participated in this study. The subjects were asked to place their index and middle fingers on two force transducers fixed on a small non-moving teeterboard and produce 10 N by pressing the sensors while watching force feedback on a computer screen under the no additional constraint condition (NAC). The subjects also performed the same task with an additional mechanical constraint (AC) where the subjects were asked to balance a teeterboard that could be rotated by finger forces. An uncontrolled manifold approach was used to calculate within-trial and between-trial multi-finger synergy indices, variance in uncontrolled subspace ($V_{UCM}$), and variance in subspace orthogonal to UCM subspace ($V_{ORT}$). Two-way repeated measured ANOVA was performed with the within-factor of task condition (with and without an additional constraint) and the between factor of groups (elderly and young). Results: The elderly group showed significantly increased within-trial $V_{ORT}$ in AC compared with NAC (p < .05) while the young group showed no significant difference between AC and NAC. There was no significant group difference for within-trial $V_{UCM}$. Between-trial $V_{ORT}$ remained unchanged between groups and conditions. However, between-trial $V_{UCM}$ for the elderly group significantly decreased in AC as compared to NAC, along with no significant difference for the young group. For multi-finger synergy, there was no significant group difference of within-trial synergy. However, between-trial synergy for the elderly group significantly decreased in AC as compared to NAC (p < .05). Conclusion: Our results indicate that aging decreased consistency (i.e., ability to perform the task on a moment-to-moment basis) with an additional mechanical constraint. In addition, aging was associated with decreased multi-finger synergy on a trial-to-trial basis.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3977-3980
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• 2015

Background: To investigate the effects of preemptive analgesia with parecoxib sodium on haemodynamics and plasma stress hormones in surgical patients with thyroid carcinoma. Materials and Methods: Fifty-seven patients with thyroid carcinoma who underwent thyroidectomy selectively in Laiwu Hospital Affiliated to Taishan Medical University and Binzhou People's Hospital were selected and randomly divided into three groups, 19 cases in each group. The control group was intravenously injected 0.9% sodium chloride injection before anesthesia induction; trial group I was intravenously injected with parecoxib sodium 20 min before anesthesia induction; based on trial group I, trial group II was injected with parecoxib sodium again 12 h after surgery. The levels of plasma norepinephrine (NE), cortisol (Cor) and blood glucose before, 12 and 24 h after surgery and changes of haemodynamics before surgery, at the end of surgery and 12, 24 and 48 h after surgery were compared in the three groups. Besides, visual analogue scale (VAS) scores were recorded 4, 8, 12 and 24 h after surgery. Results: 12 and 24 h after surgery, the levels of plasma NE and Cor in three groups rose dramatically (P<0.05 or (P<0.01); The levels of plasma NE and Cor in trial groups I and II were evidently lower than in control group (P<0.05 or P<0.01), and those in trial group II slightly lower than in trial group I. 12 h after surgery, the heart rates (HR) and systolic pressures (SBP) in trial groups I and II increased obviously by comparison to surgery before (P<0.05 or P<0.01), but gradually returned to the preoperative level. HR, SBP and diastolic pressures (DBP) in trial groups I and II at the end of surgery and 12 h after surgery were all lower than in the control group, and significant differences were present (P<0.05 or (P<0.01). At 4, 8, 12 and 24 h after surgery, VAS scores in trial groups I and II were markedly lower than in the control group (P<0.05 or (P<0.01), the scores in trial group II being the lowest. Conclusions: Combined application of parecoxib sodium for preemptive analgesia before anesthesia and after surgery can effectively reduce the levels of plasma stress hormones and improve analgesic effects in surgical patients with thyroid carcinoma, and without conspicuous impact on haemodynamics.

• Asian-Australasian Journal of Animal Sciences
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• 제14권9호
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• pp.1282-1289
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• 2001

One feeding trial and two metabolic trials were conducted to investigate the effects of lysine to protein ratio in practical swine diets on growth performance and efficiency of nitrogen retention and utilization in different growing phases. In Trial one (the feeding trial), 90 mixed sex pigs weighing $9.1{\pm}1.4kg$ (Duroc ${\times}$ Landrance ${\times}$ Beijing Black) were used to study the effects of concentrations of 5.2, 5.3, 5.8, 6.4 and 7.2 g lysine/100 g CP in diets containing 1.2% lysine on growth performance and serum urea nitrogen. The results showed that feed conversion efficiency and economic efficiency were best for pigs fed the diet containing the lysine concentration of 5.8 g /100 g crude protein. Serum urea nitrogen concentration decreased linearly (p=0.0009) and serum free lysine content increased linearly (p=0.0017) as the lysine to protein ratio in diets increased from 5.2 to 7.2 g/100 g. In Trials two and three (the metabolic trials), five growing barrows (Duroc ${\times}$ Landrance ${\times}$ Beijing black), with initial body weights of approximately $26{\pm}2.4kg$ and $56.3{\pm}3.5kg$, respectively, were allotted to five dietary treatments according to a $5{\times}5$ Latin square design. Trial two contained 5.2, 5.7, 6.1, 6.7 and 6.8 g lysine/100 g CP treatments. Trial three contained 4.6, 5.0, 5.6, 6.1 and 6.6 g lysine/100 g CP treatments. The results showed that nitrogen retention in growing pigs decreased linearly (p=0.0011 in Trial two; p=0.0099 in Trial three) as the lysine to protein ratio in diets increased. The ratio of lysine to protein in diets resulting in maximum nitrogen retention was 5.2 g/100 g and 5.0 g/100 g in Trial two and Trial three, respectively. In Trial two, apparent biological value and gross nitrogen efficiency increased linearly (p=0.0135 and p=0.0192, respectively) as the lysine to protein ratio increased from 5.2 to 6.8 g lysine/100 g CP. In summary, we concluded that the optimal Lysine to Protein Ratios for 8-20 kg and 20-80 kg pigs were 5.8 g/100 g and 5.0 to 5.2 g/100 g, respectively.

• 대한기관윤리심의기구협의회지
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• 제5권1호
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• pp.14-20
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• 2023

Purpose: To obtain fundamental data on selection tools for an internal audit and develop a new guideline. We scored the indicated points from the internal audit, identified the research progress and problems that occurred, and confirmed the validity of the risk factors involved. Methods: Of the 63 internal audits conducted by Keimyung University Dongsan Hospital from 2014 to 2021, we analyzed 55 clinical trials with an inspection checklist. We excluded 8 that failed to transfer data and refused to comply with the internal audit. The statistical summary of the collected data was verified and interpreted by using frequency analysis and a chi-square test. Result: Of total 55 cases included in the internal audit, sponsor-initiated trial (SIT) was 63.6% (vs. investigator-initiated trial [IIT]), clinical trial for investigational drug was 71.0% (vs. nonclinical or clinical trial for investigational device), domestic multicenter trial was 60.0% (vs. single center or multinational multicenter trial), and trial requisition for MFDS approval was 69.1% (vs. exception for MFDS approval). The 10 areas of the clinical trial inspection checklist (reports, protection of subjects, compliance with protocols, records, management of investigational drug and/or device, delegation of duties, qualification of investigators, management of specimen, contract-agreement and approval of protocols, and preservation of recorded documents) were weighted between 2 to 5 points. The average of the total points was 16.09±13.2 and 20 clinical trials were above the average. As a result of comparing the average of the total points weighted by year, the highest score was in 2020. The 4 factors that play significant roles in determining the internal quality were (1) principal subjects that initiated the clinical trials (p=0.049), (2) type (p=0.003), (3) phase of clinical trials (p=0.024), and (4) number of registered subjects reported at the time of continuing deliberation (p=0.019). Of the 10 areas of the clinical trial inspection checklist, 'record' was the most inappropriate and insufficient. We found more indicated points; the quality of performance declined in IIT, nonclinical trials, and other clinical trials that were not in phase I1-IV4, and the study of more than 30 registered subjects at the time of continuing review. Conclusion: If an institution has an internal audit selection tool that reflects the aforementioned risk factors, it will be possible to effectively manage high-risk studies; thereby, contributing to an efficient internal audit and improving the quality of clinical trials.