• 농촌의학ㆍ지역보건
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• 제35권2호
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• pp.151-164
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• 2010

우리나라의 섬에는 18만 8천여 명의 주민이 거주하고 있다. 의료서비스에 대한 지리적 접근성문제와 의료서비스 공급부족 문제는 섬 지역에서 아직까지 큰 문제점으로 남아 있고, 섬 지역에는 고령인구와 같은 건강 문제가 발생하기 쉬운 취약한 사람이 많이 거주하고 있어 미충족 의료가 발생할 가능성이 크며, 이 같은 미충족 의료는 섬 지역주민의 건강을 위협할 수 있다. 이 연구의 목적은 일개 섬의 미충족 의료의 수준과 이와 관련된 요인을 조사함으로써 섬 지역의 의료문제 개선을 위한 하나의 기초 자료를 마련하는 것이다. 조사는 2008년 7월 30일에서 8월 1일까지 3일 동안 자원봉사 대학생에 의하여 전라남도 완도군 노화도에서 실시되었고 주민의 의료이용 수준, 일반적인 특성, 사회경제적 특성 및 일반적인 미충족 의료와 육지의 의료기관 이용과 관련한 미충족 의료를 조사하였다. 324명의 주민이 조사되었으며, 일반적인 미충족보건의료를 경험한 주민의 비율은 26.5%로 조사되었다. 단변량 분석에서는 여성과 독거하는 사람이 통계적으로 유의하게 미충족 의료를 많이 경험하는 것으로 조사되었고, 다변량 분석에서는 독거하는 사람만이 통계적으로 유의하게 미충족 의료를 많이 경험하는 것으로 분석되었다. 육지의 의료기관 이용과 관련한 미충족 의료를 경험한 주민의 비율은 13.2%였으며 단변량 분석결과 상대적으로 젊은 연령층과 직업이 상업인 주민에서 미충족 의료가 통계적으로 유의하게 증가하였고, 다변량 분석에서는 통계적으로 유의하게 육지의 의료기관 이용과 관련한 미충족 의료를 증가시키는 요인은 없는 것으로 조사되었다. 노화도에는 고령인 주민과 사회 경제적으로 취약한 주민들이 많이 거주하고 있으며, 상당한 수준의 미충족 의료 문제가 있는 것으로 조사되었다. 이후 섬 지역의 미충족 의료문제 해결을 위한 추가적인 연구와 사회적 지원이 필요할 것으로 판단된다.

• 한국환경복원기술학회지
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• 제6권3호
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• pp.35-45
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• 2003

This study was performed to suggest growth status data of the large old trees as the natural monuments of Korea. Field investigation of 70 large old trees as the natural monuments of Korea was carried out in Seoul, Inchon, Kyungki, Chungbuk, Chungnam, Chonbuk, Chonnam. The main field of this study is classified into the growth condition, soil state and management situation. The results of this study are below : The age distribution of the large old trees as the natural monuments of Korea is as follows : above l00years in 5.9%, above 200years in 8.9%, above 300 years in 11.8%, above 400 years in 16.2%, above 500 years in 16.2% and above 600years in 41.1%. Location types of the large old trees as the natural monuments of Korea are found in 11 types; the types are hill side(22.9%), historical monument area(15.7%), field(l4.3%) and building area(12.9%), etc. Also, growth type of the trees is individually placed. In the aspect of soil environment, the acidification of soils has been appearing in all surveyed areas, and the soil of Seoul area has much acidum phosphoricum because of excessive fertilizer. Finally, in management situation. major factors inhibiting growth of the large old trees as the natural monuments of Korea are soil covering of protruded root above ground, soil hardening by human, embankments, small area that has been surrounded fence. Continuous monitoring and accumulation of status data are necessary to preserve the large old trees as the natural monuments of Korea.

• Journal of Chest Surgery
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• 제21권5호
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• pp.828-841
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• 1988

To predict the postoperative hemodynamic status of right ventricle preoperatively, a retrospective analysis was undertaken to determine the influence of pulmonary artery size on postoperative right ventricular pressure in 32 consecutive patients with tetralogy of Fallot who underwent total correction between July, 1987 to June, 1988 at the Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital. We have related the ratio of the postrepair peak systolic pressure in the right ventricle and the systemic systolic arterial pressure[PRV/Ao] to the preoperative cineangiographic measurement of pulmonary arterial tree, expressed as pulmonary artery index[PAI], the ratio of diameter of the right pulmonary artery to diameter of ascending aorta[r.PA/A.Ao], the ratio of right and left pulmonary artery to diameter of descending aorta[r.I.PA/D.Ao] There was tendency that the postrepair PRV/Ao seems to be related to the preoperative diameter of right and left pulmonary artery, but there were no statistically significant correlation with PAI, r.PA/A.Ao, r.l.PA/D. Ao to the ratio of the postoperative peak systolic right ventricular pressure and systemic systolic arterial pressure[PRV/Ao]. There was tendency to decrease the postoperative right ventricular pressure[PRV/Ao] about 11.2%[P < 0.025] within several hours than immediately after repair, but after then, there was no change of right ventricular pressure[PRV/Ao] significantly. There was good correlation of pressure change between the immediate and late postrepair right ventricular pressure[48 hour], and the derived linear regression line was; y=0.68534 0.1994[r=0.57294, P < 0.001]. There was no operative death due to residual high right ventricular pressure[PRV/Ao >0.75] related to hypoplastic pulmonary arterial development, thus we expect, for symptomatic patients even infants, that complete repair can be attempted when the pulmonary artery index[PAI] is over 108mm2/BSA, RPA/AAo is over 0.35, RPA LPA/D. Ao is over 1.36.

• 한국멀티미디어학회논문지
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• 제11권3호
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• pp.386-397
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• 2008

본 연구는 HL7 버전 3의 객체지향 분석 및 개발 방법론인 HL7 개발 프레임워크(HDF)를 이용하여 투약관리의 임상문서구조의 개발을 통해 임상활동의 표준화 데이터 모델을 구현하는 것을 제안한다. 투약관리는 의료현장에서 임상전문가가 행하는 가장 중요한 업무이다. 표준화 된 데이터 모델 및 구조화된 병원정보시스템은 근거기반 임상 활동을 이루기 위해 상당히 중요한 과제이다. 임상문서구조를 생성하기 위해서 HDF와 제공된 도구들을 사용하였다. 본 연구자들은 투약관리활동에서 HDF의 각 단계의 다이어그램을 생성할 수 있었다. 그 결과, 임상 활동 중 하나인 투약관리에 대한 표준화 정보모델을 생성하였다. 이 모델은 보건의료정보시스템을 모델링하기 위한 정보통신개발자들에게 국제 표준방법론을 이해하기 위한 기본적 개념모델이 될 것이다.

• 대한의생명과학회지
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• 제12권1호
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• pp.9-16
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• 2006

We investigated the effects of 835-MHz electromagnetic field (EMF), one of the most popular communication frequency band in Korean code-division multiple-access (CDMA) mobile phone system, on cellular signal transduction. For this, we examined the change of intracellular calcium $([Ca^{2+}]_i)$, reactive oxygen species (ROS) and F-actin polymerization after exposure to 835-MHz EMF followed by the treatment of agonists in Rat-2 fibroblast cells. Culture cells were pretreated with serum-tree medium and concomitantly exposed to 835-MHz at specific absorption rate (SAR) of 4.0 W/kg for 24 hr in a specialized designed apparatus based on Transverse Electro Magnetics (TEM) wave theory. Intracellular $Ca^{2+}$ responses to lysophosphatidic acid (LPA) and epidermal growth factor (EGF) in Rat-2 fibroblast after exposure to 835-MHz EMF were shown to be similar pattern as observed in normal cultured cells. However, the LPA-induced calcium spiking was slightly delayed to 7 sec and sustained thereafter to a little higher ground level under 835-MHz EMF radiation compared to unexposed cells. ROS production level by LPA in the exposed cells was not different from that in control. Furthermore, LPA induced the production of stress fibers with no significant difference in the exposed and unexposed cells. These results suggest that mobile phone radiation (835-MHz, SAR 4.0 W/kg) may not be directly related to signal transduction in Rat-2 fibroblasts except the slight effect of calcium spiking in LPA-induced cells but remain to be further elucidated for possible indirect intervention.

• Journal of Korean Neurosurgical Society
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• 제48권1호
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• pp.73-78
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• 2010

Objective : Streptococcus pyogenes is a beta-hemolytic bacterium that belongs to Lancefield serogroup A, also known as group A streptococci (GAS). There have been five reported case in terms of PubMed-based search but no reported case of brain abscess caused by Streptococcus pyogenes as a result of penetrating skull injury. We present a patient who suffered from penetrating skull injury that resulted in a brain abscess caused by Streptococcus pyogenes. Methods : The patient was a 12-year-old boy who fell down from his bicycle while cycling and ran into a tree. A wooden stick penetrated his skin below the right lower eyelid and advanced to the cranium. He lost consciousness on the fifth day of the incident and his body temperature was measured as $40^{\circ}C$. While being admitted to our hospital, a cranial computed tomography revealed a frontal cystic mass with a perilesional hypodense zone of edema. There was no capsule formation around the lesion after intravenous contrast injection. Paranasal CT showed a bone defect located between the ethmoidal sinus and lamina cribrosa. Results : Bifrontal craniotomy was performed. The abscess located at the left frontal lobe was drained and the bone defect was repaired. Conclusion : Any penetrating lesion showing a connection between the lamina cribrosa and ethmoidal sinus may result in brain abscess caused by Streptococcus pyogenes. These patients should be treated urgently to repair the defect and drain the abscess with appropriate antibiotic therapy started due to the fulminant course of the brain abscess caused by this microorganism.

• Journal of Korean Neurosurgical Society
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• 제53권1호
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• pp.1-5
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• 2013

Objective : The purpose of this study was to evaluate the characteristics and surgical outcomes of familial hemifacial spasm (HFS) and to discuss the role of genetic susceptibility. Methods : Between 2001 and 2011, 20 familial HFS patients with ten different pedigrees visited our hospital. The data from comprehensive evaluation of these patients, including clinical, radiological and electrophysiological data and surgical outcomes were reviewed to characterize familial HFS and to compare the characteristics between familial HFS and sporadic HFS. Results : According to the family tree, the inheritance pattern was difficult to define clearly using these data. Radiologic findings suggested that the vertebral artery (VA) was a more frequent offender in familial HFS than in sporadic cases (35.0% vs. 10.0%, p<0.001). Chi-square test showed that there were no correlation between VA tortuosity and underlying morbidity such as diabetes or hypertension (p=0.391). Eighteen out of 19 patients who underwent microvascular decompression showed no residual spasm. Other features of familial HFS overlap with sporadic cases. These findings suggest that certain genetic susceptibilities rather than hypertension or diabetes may influence vascular tortuosity and HFS development. Conclusion : In this study, familial HFS seems not so different from sporadic cases. Authors thought familial HFS could have heterogeneous etiology. Further study of familial HFS including clinical, anatomic, genetic, and molecular information may help identify a gene or trait that can provide insight into the mechanisms of sporadic and familial HFS.

• Tuberculosis and Respiratory Diseases
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• 제41권5호
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• pp.574-578
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• 1994

저자들은 폐쇄성 흉부외상 1년 후, 경미한 호흡 곤란으로 내원한 환자에서 단순 흉부X-선상 폐실질에는 이상이 없고 기관지 내시경 검사상 기관지 web형태로 발현한 외상성 기관지 파열을 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 생물정신의학
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• 제15권4호
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• pp.303-309
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• 2008

Objectives : Some reports have suggested that 5-HT5A polymorphism allelic association was associated with depression, however, there has been no report about relationship between the 5-HT5A gene and antidepressant response. We conducted the association study of the 5-HT5A receptor gene polymorphisms (-19G/C,12A/T) and response to citalopram in Korean patients with major depressive disorder(MDD). Methods : A total of 106 patients with major depressive disorder were included in this study. The patient's symptoms were measured by 21-item Hamilton Depression Rating Scale(HAMD) at baseline, week 1, week 2, week 4 and week 8 during citalopram treatment. A Responder to citalopram was defined by 50% reduction of total HAMD scores. To analyze genetic polymorphisms, a polymerase chain reaction based method was used. Results : At week 8, responders were 62, non-responders were 44. No significant differences of genotypes or allelic association in 19G/C and 12A/T polymorphisms were observed between responsive and non-responsive patients. Conclusion : These results do not support the hypothesis that this polymorphism of the HT5A receptor gene is involved in the therapeutic response to citalopram.

• Journal of Species Research
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• 제9권4호
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• pp.346-361
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• 2020

In the project of a comprehensive investigation of indigenous prokaryotic species in Korea, a total of 39 bacterial strains phylogenetically belonging to the classes Betaproteobacteria and Gammaproteobacteria were isolated from various environmental sources such as soil, cultivated soil, sludge, seawater, marine sediment, algae, human, tree, moss, tidal flat, beach sand and lagoon. Phylogenetic analysis based on 16S rRNA gene sequences revealed that 39 strains showed the high sequence similarities (≥98.7%) to the closest type strains and formed robust phylogenetic clades with closely related species in the classes Betaproteobacteria and Gammaproteobacteria. In the present study, we report 14 species of 9 genera of four families of two orders in the class Betaproteobacteria and 25 species of 21 genera of 15 families of eight orders in the class Gammaproteobacteria, which have not been reported in Korea. Morphological, biochemical, and physiological characteristics, isolation sources, and NIBR deposit numbers are described in the species descriptions.