• 한국결정성장학회지
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• 제27권4호
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• pp.196-205
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• 2017

오늘날 의료분야의 서비스 디자인은 유 무형의 서비스 요소를 통합적으로 가시화하고 혁신적 해결책을 도출, 고객이 해당 서비스를 더 중요한 가치로 느낄 수 있도록 지원하는 실용적 서비스 연구개발로 발전하고 있는 상황이다. 개인의 소득수준이 향상되면서 의료복지와 웰빙에 대한 관심이 날로 높아지고 있어, 의료분야의 초점도 과거의 질병 질환에 대한 치료의 개념에서 예방 의료로 구심점이 이동하고 있다. 이런 추세에 맞추어 최근 의료복지에 유비쿼터스 개념을 접목하여 건강진단 및 건강관리의 시간과 공간 제약을 대폭 줄인 홈헬스케어 시스템의 연구개발이 활발히 진행되고 있고 헬스케어3.0 시대에 따른 사용자 중심의 의료 서비스와 사용자 니즈를 기반으로 한 제품 및 의료 환경 개선 요구가 증대하고 있어 그에 따라 사용자 중심 니즈와 요구가 반영된 현장 의료진단 제품 개발이 필요하다. 본 연구는 현장 의료진단 제품 중 하나인 '무선 X-ray 디텍터'를 연구 개발함에 있어 현장진단 제품에 적합한 소재와 외형을 적용하여 사용자의 요구가 충분히 반영된 제품을 개발 연구하는 것을 목표로 두고 있다.

• Asian-Australasian Journal of Animal Sciences
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• 제14권4호
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• pp.515-524
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• 2001

Two experiments using growing and finishing pigs (Landrace$\times$Duroc$\times$Yorkshire) were conducted to determine the effects of different levels of vitamins and trace minerals (VTM) on growth performance, nutrient digestibility, carcass characteristics and meat quality of growing-finishing pigs, and to evaluate the suitability of vitamin-mineral levels commonly used in the swine industry in Korea. A total of 120 three crossbred (Landrace$\times$Duroc$\times$Yorkshire) growing (Experiment I: 20.90 0.44 kg average initial body weight) and finishing (Experiment II: 53.55 0.97 kg average initial body weight) were used in 6 and 9 weeks feeding trials, respectively. Pigs were allotted on the basis of sex and weight to 5 treatments with 6 replications per treatment with 4 pigs per pen in a completely randomized block design. Treatments were: 1) control, 2) fat soluble vitamin 200% vs. control, 3) water soluble vitamin 200% vs. control, 4) trace mineral 50% vs. control, 5) trace mineral 200% vs. control. In experiment I, during the overall experimental period (0 to 6 weeks, 21 to 54 kg body weight), ADG of the 200% trace mineral supplemented group was significantly higher than that of the 50% trace mineral supplemented group. There were no significant differences among other the treatments. Digestibility of crude protein was lowest in mineral 50% supplemented group (p<0.05). Calcium digestibility was significantly higher in the 200% fat soluble vitamin supplemented group than in the other treatments (p<0.05). In experiment II, during the overall experimental period (0 to 9 weeks, 54 to 106 kg body weight), growth performance was not significantly affected by dietary vitamin and trace mineral levels. However, increasing level of water soluble vitamins at the level of 200% compared to control had a tendency to improve the overall growth performance. Overall carcass characteristics except for carcass length did not differ among pigs fed the dietary treatments. Loin eye area, pH, drip loss and shear force of meat were not affected by dietary vitamin and trace mineral levels. There was a trend for less fat content (%) in pork when the level of vitamin and trace mineral was increased, but the difference was not significant. Flavor score was the lowest in control and highest in the 200% fat soluble vitamin supplemented group (p<0.05). Juiciness of muscle was lower in the 200% fat soluble vitamin supplemented group than other dietary treatments, except for trace mineral 50% supplemented group (p<0.05). Based on these results, it is suggested that "typical" commercial levels of vitamin and trace minerals used by feed companies in Korea are sufficient to meet requirement for the maximum growth of growing-finishing pigs. Our results suggests that a reduction in trace mineral levels in commercial diets could be considered to reduce feed cost and nutrient excretion with economic and environmental benefits.

• 복식
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• 제44권
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• pp.181-199
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• 1999

The industry of modern clothing has deviated from the overflow of commercialism and the standardization and nowadays is going toward pursuing art, creativity, and high added value. This trend brings the return of the natural materials from the synthetic textiles and increases the value of old and handmade fabrics. Finally, the handmade-paper, which is a natural material, comes to be reconsidered as a new material for the clothing. Therefore, as the natural materials and the manufacture of handmade clothing are rising again, the qualitative improvement and globalization of clothing industry should be first realized through the developments of creative and various clothing materials and new expressing techniques. The above investigation and study have been synthesized and analyzed as follows: First, through the study on the origin of the paper clothing, its historical background and the process of its development, we've learned these two facts following : the paper clothing of the East in the past mostly had practiced meanings. On the other hand, in the West it had meanings which were raised the artist's emotions and beauty-consciousness to the artistic level by the various kinds of expressing methods. Second, handmade-paper was manufactured by the embedding method, which mixed mulberry pulp, gauze, corn, hair, sisal, silk and so on. It was found that handmade-paper had the affluent and proper texture as the clothing material and was be able to control the clarity through the variation of thickness. It was also confirmed that the creative and original texture with hand-worked molding beauty was obtained by the use of handmade-paper. Third, when the handmade-paper is used, the molding beauty of plane, relievo, and solid can be freely pursued, and various and effective molding conformation can be constructed by the effect of superposition and repetition. Also, because the maximum discretion from the various optional manufacturing methods is allowed, the molding beauty can be maximized when the clothes are manufactured with handmade-paper. Fourth, the gauze with strong drape was combined to overcome the stiffness and the tearing of the paper. As a result, the durability and the wearability of the paper were strengthened and thus the thus the applications as the clothing material were enlarged. In conclusion, in order to enhance the value, creativity, practicality, and artistic sense of the design for modern clothing, the clothes made of handmade-paper should be more studied. Moreover, for the generalization of paper clothes, the studies on the development of practical paper with paper with water resistance, post-treatment after dyeing, flexibility, and durability should be done. I really hope that this study will be the motive to provoke the possibility of handmade-paper as new clothing material in not only practical sense but also artistic sense.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1603-1609
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• 2014

Background: The response to treatment and overall survival (OS) of patients with acute myeloid leukemia (AML) is variable, with a median ranging from 6 months to 11.5 years. TP53 is associated with old age, chemotherapy resistance, and worse OS. Using genetic sequencing, we set out to look at our own experience with AML, and hypothesized that both TP53 mutations and SNPs at codon 72 would mimic the literature by occurring in a minority of patients, and conferring a worse OS. Materials and Methods: We performed a pilot study of randomly selected, newly diagnosed AML patients at Mount Sinai Medical Center, diagnosed from 2005-2008 (n=10). TP53 PCR sequencing was performed using DNA from bone marrow smears. Analysis was accomplished using Mutation Surveyor software with confirmation of the variants using the COSMIC and dbSNP databases. Results: Fewer than half of the patients harbored TP53 mutations (40%). There was no significant difference in OS based on gender, AML history, risk-stratified karyotype, or TP53 mutation. There were possible trends toward improved survival among patients less than 60 (11 vs 4 months, p=0.09), Hispanics (8 vs 1 months, p=0.11), and those not harboring SNP P72R (8 vs 2 months, p=0.10). There was a significant improvement in survival among patients with better performance status (28 vs 4 months, p=0.01) and those who did not have a complex karyotype (8 vs 1 months, p=0.03). The most commonly observed TP53 mutation was a missense N310K (40%) and the most commonly observed SNP was P72R (100.0%). Conclusions: Our study confirms previous reports that poor PS and the presence of a complex karyotype are associated with a decreased OS. In our cohort, TP53 mutations were relatively common, occurring more frequently in male patients with an adverse karyotype. Although there was no significant difference in survival between TP53 mutated and un-mutated patients, there was a possible trend toward worse OS among patients with SNP P72R. Larger studies are needed to validate these findings.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.362-362
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• 2017

Dissemination of IPB3S rice variety combined with cultivation technology named IPB Prima was aimed to introduce IPB research product particularly for IPB rice variety with high-yield character that is IPB3S. The rice variety IPB3S and IPB Prima cultivation technology was expected to be one of solution to improve rice productivity and accelerate to food self-sufficiency in Indonesia. Research sctivity was consist of three main research unit i.e. (1) Dissemination of IPB3S rice variety and IPB Prima production technology; (2) The development of Information and management web-based system (IMS) for planning and monitoring IPB3S and IPB Prima application distribution; and (3) The development of High-capacity grain drying system in Fluidized-bed drying ang in-store drying system. The objective of main research i.e. to introduce IPB high-yield rice variety, to accelerate rice productivity to support self-sufficiency, to develop integrated system model through fluidized and in-store drying, and to develop web-based management-information system in result analyzing IPB3S and IPB Prima distribution and technology application. The dissemination activities was arranged in two location. The first location was in Banyuwangi, East Java with total area 10.87 ha, consist of 8.91 ha planting area for IPB3S and 1.96 ha planting area for Ciherang. The second location is in Tegal, Middle Java with total planting area in 5 ha. The experiment was arranged in different treatment of varieties and cultivation method. The experiment consist of (1) rice variety Ciherang with conventional cultivation technology (P0); (2) rice variety Ciherang with IPB Prima cultivation technology (P1); (3) rice variety IPB3S with conventional cultivation technology (P2); (4) rice variety IPB3S with IPB Prima cultivation technology (P3). Planting distance for twin rows system is $50cm{\times}25cm{\times}12.5cm$. Planting distance for single row system is $25cm{\times}25cm$. The research result elucidated that productivity result in two location has different grades in similar trend. Experiment in Tegal resulted P0 result is $6.18ton\;ha^{-1}$, P1 result is $6.30ton\;ha^{-1}$, P2 result is $6.82ton\;ha^{-1}$, P3 result is $7.31ton\;ha^{-1}$. Experiment in Banyuwangi resulted optimum production of IPB3S variety productivity number are $7.29ton\;ha^{-1}$, while Ciherang are $6.73ton\;ha^{-1}$.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.203-203
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• 2017

The Earth's climate is rapidly changing because of increasing carbon dioxide content in atmosphere so, climate prediction models anticipate that earth surface temperature will rise by 3 to $5^{\circ}C$ in next 50 to 100 years. Therefore, frequency of un-expected weather events such as drought, salinity, low or high temperature and flooding etc. will be increasing worldwide. Furthermore, increased atmosphere temperature can influence pests and pathogens spread as well. Therefore, to protect enormous grain loss from unexpected weather conditions, studies related with combine stress conditions like abiotic plus biotic stress condition are really required. Thus, our research focused on physiological responses under combined abiotic and biotic stress condition in rice plant. To induce uniform stress condition, we used NaCl (100 mM) and salicylic acid (0.5 and 1.0 mM SA) as each stress a stimulator. Each artificial abiotic and biotic stress inducer was applied to hydroponically grown rice seedlings alone or together for four day. The data were collected in a time-dependent manner [1, 2, 3 and 4 day(s) after treatment (DAT)] and were matched with our anticipation that shoot length and shoot fresh weight was decreased in solo and combined abiotic and biotic stress condition. The lipid peroxidation content was significantly increased ($1.5{\pm}0.2$ to $2.7{\pm}0.1mg$ mg of $MDA\;g^{-1}FW$) in the first two days in both stress exposed plants, and showed the opposite trend ($0.5{\pm}0.01$ to $0.1{\pm}0.001mg$ of $MDA\;g^{-1}FW$) in last two days under multi stress condition. Superoxide dismutase (SOD) activity did not showed difference in only biotic stress condition (alone 0.5 and 1.0 mM SA) as compared to control however, it was significantly increased in multi stress condition or solo abiotic stress condition whereas, catalase (CAT), and ascorbate peroxidase (APX) activities were significantly decreased in solo biotic and combined abiotic and biotic condition. In particular, both enzymes activities were more decreased in multi stress condition as compared to solo biotic stress condition. The results for relative mRNA expression level of CAT and APX enzymes were in agreement with results of spectrophotometric values. Correlation value between each stress condition and phenotypic data showed that biotic stress condition showed high correlation with activity of CAT and APX whilst, abiotic stress condition revealed significant correlation with SOD activity.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.61-61
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• 2017

Dissemination of IPB3S rice variety combined with cultivation technology named IPB Prima was aimed to introduce IPB research product particularly for IPB rice variety with high-yield character that is IPB3S. The rice variety IPB3S and IPB Prima cultivation technology was expected to be one of solution to improve rice productivity and accelerate to food self-sufficiency in Indonesia. Research sctivity was consist of three main research unit i.e. (1) Dissemination of IPB3S rice variety and IPB Prima production technology; (2) The development of Information and management web-based system (IMS) for planning and monitoring IPB3S and IPB Prima application distribution; and (3) The development of High-capacity grain drying system in Fluidized-bed drying ang in-store drying system. The objective of main research i.e. to introduce IPB high-yield rice variety, to accelerate rice productivity to support self-sufficiency, to develop integrated system model through fluidized and in-store drying, and to develop web-based management-information system in result analyzing IPB3S and IPB Prima distribution and technology application. The dissemination activities was arranged in two location. The first location was in Banyuwangi, East Java with total area 10.87 ha, consist of 8.91 ha planting area for IPB3S and 1.96 ha planting area for Ciherang. The second location is in Tegal, Middle Java with total planting area in 5 ha. The experiment was arranged in different treatment of varieties and cultivation method. The experiment consist of (1) rice variety Ciherang with conventional cultivation technology (P0); (2) rice variety Ciherang with IPB Prima cultivation technology (P1); (3) rice variety IPB3S with conventional cultivation technology (P2); (4) rice variety IPB3S with IPB Prima cultivation technology (P3). Planting distance for twin rows system is $50cm{\times}25cm{\times}12.5cm$. Planting distance for single row system is $25cm{\times}25{\times}cm$. The research result elucidated that productivity result in two location has different grades in similar trend. Experiment in Tegal resulted P0 result is $6.18ton\;ha^{-1}$, P1 result is $630ton\;ha^{-1}$, P2 result is $6.82ton\;ha^{-1}$, P3 result is $7.31ton\;ha^{-1}$. Experiment in Banyuwangi resulted optimum production of IPB3S variety productivity number are 7.29 ton ha-1, while Ciherang are $6.73ton\;ha^{-1}$.

• 식물병연구
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• 제7권1호
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• pp.25-30
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• 2001

인삼 뿌리썩음병의 발생을 경감시키기 위한 효과적인 담수조건을 확립하기 위해, 실험실 조건에서 인삼 재작지토양을 공시하여 인위적으로 담수처리하고, 담수전 유기물의 첨가 여부 및 담수후 처리온도가 토양내 Fusarium 을 비롯한 사상균과 세균 밀도에 미치는 영향을 조사하였다. 담수처리를 하였을 때 토양내 Fusarium 및 총사상균 밀도는 시일이 경과할수록 감소하였고, 담수에 의한 균밀도 감소효과는 온도가 높을수록 증가하였고, 또한 동일 온도조건에서 유기물을 첨가하였을 경우에는 그 효과가 더욱 증대하였다. 즉, 3$0^{\circ}C$ 조건에서 유기물을 첨가하지 않았을 경우 처리 60일후의 균밀도가 무담수 토양의 1/10 수준으로 감소하였던 반면, 유기물을 첨가하였을 경우에는 1/100 수준으로 감소하였다. 유기물 종류별로는 볏짚 처리효과가 청초에 비해 더 높았다. 한편 담수토양에서 총세균의 밀도변화 경향은 사상균의 경향과 유사하였으나, 담수에 의한 세균밀도 감소효과는 사상균에 비해 낮았다. 이상의 결과에서 인삼재작지 토양에 유기물을 첨가하고 포화상태로 담수한 후 3개월 이상 수온을 3$0^{\circ}C$이상 유지할 경우 뿌리썩음병 발생을 보다 경감시킬 수 있을 것으로 사료된다.

• 한국방사선학회논문지
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• 제14권5호
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• pp.517-522
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• 2020

전자선은 선량분포에 영향을 주는 인자가 많아 동일 설정이라도 사용 장비마다 그 특성을 파악하여 방사선 치료에 이용해야 하며, 체내 구조물에 영향이 민감하여 종양에 균일한 선량분포를 조사하기가 까다롭다. 본 연구에서는 광도전체인 PbI₂를 사용하여 선량계를 제작하였고, 선형가속기에서 6, 9, 12 MeV 전자선에 대한 전기적 특성을 분석하였다. 재현성 평가결과, RSD는 6, 9, 12 MeV 에너지에서 각각 1.1215%, 1.0160%, 0.5137%로 나타나 출력 신호가 안정적인 것을 나타내었다. 선형성 평가결과, 직선형 추세선의 신뢰도 지표 R²값은 6, 9, 12 MeV에서 각각 0.9999, 0.9999, 0.9994로 나타나 선량이 증가함에 따라 PbI₂에 출력 신호가 비례한 것을 확인할 수 있었다. 본 연구의 PbI₂ 선량계는 전자선 측정 적용가능성이 매우 높은 것으로 판단되며, 광도전체 물질을 통한 전자선 선량계의 기초연구로 활용될 수 있을 것으로 사료된다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제14권1호
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• pp.45-51
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• 2011

목 적: Helicobacter pylori (H. pylori) 제균 치료의 적절한 항균제 선택의 기반이 되기 위해 소아에서 H. pylori 항균제 내성률을 알아보고자 하였다. 방 법: 2003년 7월부터 2009년 4월까지 상복부 통증으로 본원을 방문한 환자 중 위 문부 생검 조직 배양에서 H. pylori 가 동정된 균주를 대상으로 항균제 감수성 검사를 시행하였다. 감수성 검사는 clarithromycin과 amoxicillin은 디스크 확산법으로, tetracycline과 metronidazole은 E-test를 시행하였다. 치료 원칙은 감수성 결과가 확인 된 환자는 감수성 결과에 따라 항균제를 선택 하였고, BAM (bismuth subsalicylate, amoxicillin, metronidazole) 또는 OAC (omeprazole, amoxicillin, clarithromycin)를 바탕으로 한 경험적 삼제요법을 택하였다. 치료 실패 시에는 bismuth (또는 bismuth subsalicylate)를 포함한 사제요법을 선택하였다. 결 과: 33명의 환자가 배양검사 양성을 보였고 28명의 환자에서 감수성 검사를 시행하였다. 이 중 항균제 내성을 보인 환아는 9명(32.1%)으로 그 중 7명(25%)이 clarithromycin 내성 균주를 보였고 5명(17.8%)이 metronidazole 내성 균주를 보였다. 대상이 적어 통계적인 분석을 하지 못하였으나 Clarithromycin과 metronidazole의 내성률이 시기적으로 감소하는 추세를 보였다. 결 론: 본 연구는 단일 병원에서 소수의 환아를 대상으로 이루어진 연구로 한계가 있으나, 간접적으로 국내소아 환아에서 분리된 H. pylori의 균주에서도 높은 항균제 내성과 시기적으로 내성률이 변하는 것을 알 수있었다. 따라서 소아 환자에서 적절한 항균제 선택을 제시하기 위한 보다 광범위한 연구가 필요한 것으로 생각한다.