• 제목/요약/키워드: Treatment Grade

검색결과 2,121건 처리시간 0.034초

Dietary effects of protected fat, glycerol, and soybean meal on performance, physiological parameters, carcass characteristics, and behavioral measurements of late-fattening Hanwoo steers under heat stress conditions

  • Jun Sik Woo;Gyeong Rim Ryu;Jeong Hoon Kim;Sun Sik Jang;Hong Gu Lee;Keun Kyu Park
    • Animal Bioscience
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    • 제37권7호
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    • pp.1303-1315
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    • 2024
  • Objective: This study aimed to determine the effects of increasing energy and protein levels in diets by including protected fat (PF), glycerol (GL), and soybean meal (SBM) on growth performance, physiological parameters, carcass characteristics, and behavioral measurements of late-fattening Hanwoo steers under heat stress conditions. Methods: Thirty-six steers (initial body weight, 724.9±58.3 kg; age, 25.5±0.4 month) were assigned into control (total digestible nutrient [TDN] 76%, crude protein [CP] 15%), PF (TDN 83.6%, CP 15%), PF+GL (TDN 83.6%, CP 15%) and PF+GL+SBM (TDN 83.6%, CP 16.5%) by randomized complete block design for a total of 16 weeks with division of 4-week periods. The average temperature-humidity index was 87.0 (1st period; severe), 82.8 (2nd; moderate), 71.4 (3rd; comfort), and 68.1 (4th; comfort). Results: The dry matter intake (DMI) showed no treatments differences during the whole experiment. However, DMI in 1st and 2nd period decreased by approximately 30% and 10% compared to 4th period, respectively. Higher average daily gain and feed conversion ratio were noted for treatments compared to control at both 1st and 2nd period (p<0.05). There were no treatment effects on rectal temperature (RT), cortisol, and behaviors during the entire experiment. However, both RT and cortisol in 0, 1st and 2nd period were higher than those of 3rd and 4th period (p<0.05). Carcass yield and grade remained unaffected by increasing TDN and CP levels. Behavioral changes in the hot season (1st period) included reduced lying (43%), increased standing (48%), decreased walking (62%), and decreased eating (38%) (p<0.05), with an increase in drinking by 54%. Rumination during standing was 53% higher, while rumination during lying was about 33% lower compared to the post-hot season (3rd period) (p<0.05). Conclusion: Dietary supplementation of protected fat in late-fattening Hanwoo steers under heat stress had a positive effect on preventing a reduction in performance.

Surgical outcome and risk scoring to predict survival after hepatic resection for hepatocellular carcinoma with portal vein tumor thrombosis

  • Tae-Seok Kim;Kwangho Yang;Gi Hong Choi;Hye Yeon Yang;Dong-Sik Kim;Hye-Sung Jo;Gyu-Seong Choi;Kwan Woo Kim;Young Chul Yoon;Jaryung Han;Doo Jin Kim;Shin Hwang;Koo Jeong Kang
    • 한국간담췌외과학회지
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    • 제28권2호
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    • pp.134-143
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    • 2024
  • Backgrounds/Aims: The hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is classified as the advanced stage (BCLC stage C) with extremely poor prognosis, and in current guidelines is recommended for systemic therapy. This study aimed to evaluate the surgical outcomes and long-term prognosis after hepatic resection (HR) for patients who have HCC combined with PVTT. Methods: We retrospectively analyzed 332 patients who underwent HR for HCC with PVTT at ten tertiary referral hospitals in South Korea. Results: The median overall and recurrence-free survival after HR were 32.4 and 8.6 months, while the 1-, 3-, and 5-year overall survival rates were 75%, 48%, and 39%, respectively. In multivariate analysis, tumor number, tumor size, AFP, PIVKA-II, neutrophil-to-lymphocyte ratio, and albumin-bilirubin (ALBI) grade were significant prognostic factors. The risk scoring was developed using these seven factors-tumor, inflammation and hepatic function (TIF), to predict patient prognosis. The prognosis of the patients was well stratified according to the scores (log-rank test, p < 0.001). Conclusions: HR for patients who have HCC combined with PVTT provided favorable survival outcomes. The risk scoring was useful in predicting prognosis, and determining the appropriate treatment strategy for those patients who have HCC with PVTT.

Pancreaticoduodenectomy with superior mesenteric artery first-approach combined total meso-pancreas excision for periampullary malignancies: A high-volume single-center experience with short-term outcomes

  • Thanh Khiem Nguyen;Ham Hoi Nguyen;Tuan Hiep Luong;Kim Khue Dang;Van Duy Le;Duc Dung Tran;Van Minh Do;Hong Quang Pham;Hoan My Pham;Thi Lan Tran;Cuong Thinh Nguyen;Hong Son Trinh;Yosuke Inoue
    • 한국간담췌외과학회지
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    • 제28권1호
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    • pp.59-69
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    • 2024
  • Backgrounds/Aims: Pancreaticoduodenectomy (PD) is the only radical treatment for periampullary malignancies. Superior mesenteric artery (SMA) first approach combined with total meso-pancreas (MP) excision was conducted to improve the oncological results. There has not been any previous research of a technique that combines the SMA first approach and total MP excision with a detailed description of the MP macroscopical shape. Methods: We prospectively assessed 77 patients with periampullary malignancies between October 2020 and March 2022 (18 months). All patients had undergone PD with SMA first approach combined total MP excision. The perioperative indications, clinical data, intra-operative index, R0 resection rate of postoperative pathological specimens (especially mesopancreatic margin), postoperative complications, and follow-up results were evaluated. Results: The median operative time was 289.6 min (178-540 min), the median intraoperative blood loss was 209 mL (30-1,600 mL). Microscopically, there were 19 (24.7%) cases with metastatic MP, and five cases (6.5%) with R1-resection of the MP. The number of lymph nodes (LNs) harvested and metastatic LNs were 27.2 (maximum was 74) and 1.8 (maximum was 16), respectively. Some (46.8%) patients had pancreatic fistula, but mostly in grade A, with 7 patients (9.1%) who required re-operations. Some 18.2% of cases developed postoperative refractory diarrhea. The rate of in-hospital mortality was 1.3%. Conclusions: The PD with SMA first approach combined TMpE for periampullary malignancies was effective in achieving superior oncological statistics (rate of MP R0-resection and number of total resected LNs) with non-inferior short-term outcomes. It is necessary to evaluate survival outcomes with long-term follow-up.

국소적으로 진행된 비소세포 폐암에 대한 과분할 방사선 치료의 성적 (The Results of Hyperfractionated Radiotherapy on Locally Advanced Non-Small Cell Lung Cancer)

  • 허원주;이형식;김정기;최영민;이호준;윤선민;김재석;김효진;우종수;최필조;이기남
    • Radiation Oncology Journal
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    • 제16권3호
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    • pp.275-282
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    • 1998
  • 목적 : 국소적으로 진행된 병기 IIIA, IIIB 비소세포 폐암에서 과분할 방사선 치료의 효과를 알아보고자 하였다. 방법 : 1992년 10월부터 1995년 10원까지 병기결정과 병리조직 검사상 절제 불가능한 비소세포 폐암으로 확진된 환자 중 전신상태가 양호한 (ECOG score 2 이하) 61명을 대상으로 분석하였다. 방사선치료는 확진 후 2주내 시행하였으며 15 MV x-ray를 이용하여 일일 2회 (매 치료당 120 cGy) 주 5회 치료하였으며 방사선 총량은 6400-7080 cGy (중앙값 6934 cGy)가 되도록 조사하였다. 결과 : 치료후 종양의 완전관해 (CR)는 전체 61명 중 22명이었고 부분관해 (PH)가 32명에서 관찰되었으며 무반응 (NR)의 경우도 7명에서 관찰되었다. 완전관해의 경우 중앙 생존기간이 19.5개월로 부분관해의 11.7개월, 무반응의 6.3개월에 비해 높아 통계적 유의성이 있었으며 (p=0.0003), 1년 및 2년 생존율도 완전 관해군에서 70.0$\%$, 22.7$\%$로 부분관해의 46.8$\%$ 및 3.3$\%$보다 높았다. 전체 61명 환자 중 IIIA군이 29명 1110군이 32명이었고 완전 관해는 IIIA군에서 11명, IIIB군에서도 11명이었다. 각 병기에 따른 1년 및 2년 생존율은 IIIA군이 각각 63.3$\%$, 16.8$\%$이고 IIIB군이 43.3$\%$, 3.5$\%$ 로 통계적 유의성이 있었고 (p=0.043), 중앙 생존기간은 IIIA가 16.7개월, IIIB가 11.4개월이었다. 국소 치료 실패율은 양군에서 유사한 정도로 관찰되었으나 (IIIA 74.4$\%$, IIIB 75$\%$), 원격전이는 IIIB 환자가 높게 나타났다 (IIIA 24.1$\%$, IIIB 43.8$\%$). 조직학적으로도 편평상피암과 선암의 경우 국소치료 실패율은 비슷하였으나 (편평상피암 74.5$\%$, 선암71.4$\%$), 원격전이는 선암이 많았다 (편평상피암 29.8$\%$, 선암 50.0$\%$). 과분할 방사선 치료에 대한 합병증은 전체 61명 환자 중 43명에서 Grade I-II의 방사선 식도염이 관찰되었고 치료 종결후 2개월 내에 2명의 환자에서 급성 방사선 폐렴이 나타났고, 만성 방사선 폐렴은 1명에서 나타났으며 13개월만에 만성 방사선 폐렴에서 폐 섬유화가 진행되어 사망하였다. 결론 : 국소적으로 진행되어 수술 불가능한 비소세포성 폐암중 특히 IIIA의 경우 치료에 대한 독성을 감안하더라도 과분할 방사선 치료를 시도하여 완전 관해율을 향상시킴으로써 생존율 향상에 많은 도움을 줄 수 있을 것으로 사료된다.

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기능적 전기 자극과 유산소 운동이 복부비만의 피하지방과 내장지방에 미치는 효과 (The Change of The Effect on The Subcutaneous Fat Area and Visceral Fat Area by The Functional Electrical Stimulation and Aerobic Exercise)

  • 오성태;이문환;박래준
    • The Journal of Korean Physical Therapy
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    • 제16권1호
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    • pp.85-123
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    • 2004
  • Back ground : Subcutaneous fat area is the main factor involved in replacement disease and arteriosclerosis. Simple weight control is the appropriate medical treatment. It's understood that weight reduction does not only reduce the fat concentrations in blood but also reduces blood pressure, improves glucose levels in diabetes patients and reduces incidents of heart disease. there are several methods for reducing fat in the abdominal region but their effectiveness is not folly understood. one method is electrical stimulation of the problem areas. Method : From May 1st 2002 to October 31st. The 15 subjects who received medical examination were aged between 25 and 53 and were of mixed gender. The subjects were divided into two groups one to received functional electrical stimulation and the other a control group. Using Broca's criterion for judging fat grades. I analysed the differences between the two groups before and after the treatment. Subjects received functional electrical stimulation on the abdominal muscle intensity 50Hz. They received this treatment 4 days a week for 40 minutes a day. In the case of aerobic exercise, at the Treadmill, we used it with the intensity of $75\%$ maximum heart rate (220-age). Result 1)After functional electrical stimulation in the case of male subjects, the weight was reduced 1.93kg, obesity $2.60\%$, fat mass 2.73kg, Percent body fat $4.40\%$, waist circumference 6.53cm, circumference of hips 5.53cm. On the other side, the quality of muscle was increased at the rate of 1.03kg, but it's not attentional level. The subcutaneous fat area was reduced by $26.63cm^2$, the visceral fat area was reduced by $43.00cm^2$, In the female subjects, we can see the reduction of fat grade by $26.63cm^2$, the quantity of body fat by 1.5kg, percent body fat by $1.77\%$, circumference of waist by 4.02cm, circumference of hips by 3.67cm, weight by 1.40kg but was increased 0.72kg at the quantity of muscles. We can see the reduction also in the subcutaneous fat area $24.03cm^2$, the visceral fat area by $25.36cm^2$. 2)After aerobic exercise, on the male subjects, we can see reduction of weight by 3.36kg, obesity by $4.00\%$, fat mass by 2.83kg and we can see increase at the soft lean mass by 2.96kg, but we can see reduction, the percent body fat by $3.03\%$, fat distribution by $0.023\%$, circumference of waist by 3.10cm, circumference of hips by 2.23cm. The female subjects show a reduction in the weight by 2.48kg, percent body fat by $2.20\%$, show an increase in the soft lean mass by 1.54kg. We can see a reduction in the quantity of fat mass by 2.32kg, the percent body fat by $2.80\%$, the circumference of waist by 2.16cm, the circumference of hips by 2.68cm, the fat distribution by $0.016\%$, the subcutaneous fat area by $15.25cm^2$ the visceral fat area by $11.52cm^2$. After aerobic exercise, we can't see the attentional change at the total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol. 3)After the application of functional electrical stimulation and aerobic exercise, in result of measurement on the body ingredient, we could see the weight reduction and increase the quantity of muscle with the male group who exercised aerobic. We can see the attentional rate on the electrical stimulation about abdominal fat rate, circumference of waist, circumference of hips. The other hand, I couldn't see the attentional differences between the two groups in the rate of fatness and quantity of body fat and the rate of body fat. There isn't any attentional difference in the area of fat under skin, on the contrary, There is attentional difference in the fat in the internal organs area at the electrical stimulation site. We can't see the attentional change of total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol between electrical stimulation and aerobic exercise. 4)After execution of functional electrical stimulation and aerobic exercise, in result of measurement on change of body ingredient among female objects, We could see weight reduction, increase at muscle quantity in the aerobic exercise group. We could see the attentional differences in the rate of fatness, the rate of abdominal region, the circumference which received electrical stimulation. But, we couldn't see the attentional differences between two groups in the quantity of body fatness, the circumference of hips. The subcutaneous fat area doesn't show the attentional differences. On the Contrary, we could see lots of differences in the visceral fat area of the electrical stimulation group. Conclusion The results show that functional electrical stimulation and aerobic exercise have insignificant differences when if comes to total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol. Though there is affirmative change in body ingredient after both electrical stimulation and aerobic exercise. Functional electrical stimulation is more effective on the subcutaneous fat area and in changing visceral fat area. There fore. It is concluded that the physical therapy is more effective in the treatment of abdominal fatness.

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국소진행성 비소세포폐암에서 Paclitaxel 매주투여 및 방사선치료 동시요법 (Concurrent Chemoradiation with Weekly Paclitaxel in Locally Advanced Non-small Cell Lung Cancer)

  • 배강우;송탁호;양주연;김윤섭;박재석;지영구;이계영
    • Tuberculosis and Respiratory Diseases
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    • 제57권4호
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    • pp.351-357
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    • 2004
  • 연구배경 : 최근 항암화학요법과 방사선요법의 병용치료는 국소진행성 비소세포폐암 치료에 있어서 표준치료방법으로 자리잡고 있으며 동시요법이 순차적요법에 비해 치료반응율에 있어서 우수하다고 알려져 있다. 본 연구는 비소세포폐암 치료에 있어서 우수한 효과를 보이고 방사선감작 효과가 있다고 알려진 paclitaxel (60 $mg/m^2$) 매주투여와 동시 방사선요법의 III병기 비소세포폐암 환자에서의 치료효과와 독성을 조사하기 위하여 시행하였다. 방 법 : III병기 비소세포폐암 환자 22명 (IIIA:6, IIIB:16)을 대상으로 paclitaxel (60 $mg/m^2$)을 제 1, 8, 15, 22, 29, and 36일째에 매주 투여하고 동시에 54 Gy의 방사선 치료를 시행하였다. 초기 동시치료를 종료하고 paclitaxel (175 $mg/m^2$)/cisplatin (75 $mg/m^2$) 혹은 paclitaxel (175 $mg/m^2$)/carboplatin (6AUC) regimen 으로 보강화학요법을 3주 간격으로 2주기 시행하였다. 결 과 : 전반적 치료반응율은 81.8% (18/22)로서 완전관해가 9.1% (2/22), 부분관해가 72.7% (16/22)의 결과를 보였다. 두명의 (9.1%) 환자가 치료종료 후 방사선폐장염의 합병증으로 사망하였다. 3도 이상의 독성 반응은 방사선폐장염 (22.7%), 식도염 (22.7%), 신경병증 (13.6%), 및 백혈구감소증 (13.6%)의 결과를 나타내었다. 중앙생존기간은 15개월이었고 1년 및 2년 생존율은 각각 63.6%와 31.8%였다. 결 론 : 국소진행성 비소세포폐암 환자에서 paclitaxel 매주 투여에 의한 동시 방사선요법은 우수한 종양반응율을 나타내지만 치명적인 방사선폐장염의 발생 위험이 있으므로 향후 보완연구가 필요할 것으로 사료된다.

성장단계별 사료급여 방법이 육성-비육돈의 성장과 육질 그리고 생산비에 미치는 영향 (The Influence of Phase Feeding Methods on Growth Performance, Meat Quality, and Production Cost in Growing-Finishing Pigs)

  • 정태삼;허필승;이근영;김동혁;주원석;김유용
    • Journal of Animal Science and Technology
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    • 제52권1호
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    • pp.29-36
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    • 2010
  • 본 연구는 사료급여 방법에 있어서 사양 단계별 영양소 요구량을 충족하는 사료급여와 요구량보다 높은 수준의 영양소 사료 급여간 육성-비육돈의 사양성적과 경제성, 도체등급 그리고 육질특성에 미치는 영향을 규명하기 위해 수행되었다. 실험결과 성장성적에 있어서 전 기간(13주) 동안 자돈사료를 급여한 실험처리구의 사료효율(G:F ratio)이 높았지만(P<0.01) 일당증체량(ADG)과 일당사료 섭취량(ADFI) 그리고 총 증체량(body weight gain)에 있어서는 통계적인 유의차가 발견되지 않았으며, 도체등급(육질)과 육질등급에 있어서도 처리구간 통계적 유의차가 보이지 않았다. 출하체중을 110 kg 기준으로 볼 때 경제성분석에 있어서 처리구간 110 kg 도달 일령의 차이는 D 리구를 제외하고 나타나지 않았지만 비육돈 두당 총 사료 비용은 자돈사료만을 급여한 처리구(A), 육성기에 자돈사료를 그리고 비육기에 육성사료를 급여한 처리구(B), 전기간 육성사료만 급여한 처리구(C), 육성기에 육성사료를 그리고 비육전후기에 비육전기사료를 급여한 처리구(D)의 순으로 육성기-비육전기-비육후기의 각 성장단계에 적합한 사료를 급여한 처리구(E)에 비해 각각 51,240원(54.22%), 35,134원(37.19%), 17,172원(18.18%), 7,275원(7.7%)이 추가적으로 소요되었다. 혈중요소태질소(BUN)를 통한 단백질 이용효율에서도 적정수준 보다 높은 단백질 수준의 사료를 급여한 처리구들(A, B, C, D)의 단백질 이용효율이 성장단계에 적합한 수준의 단백질 사료를 급여한 E 처리구보다 유의적으로 낮게 나타났다(P<0.05). 본 실험결과를 종합해 보면 성장단계별 영양소요구량보다 높은 수준의 영양소 함량을 가진 사료를 급여할 경우가 성장단계별 요구량에 맞는 사료를 급여하였을 경우 보다 사양성적에 있어서 사료효율은 소폭 증가 하지만, 성장능력, 출하일령 및 돈육품질은 뚜렷하게 개선되지 않았다. 또한, 육성-비육돈에게 성장단계별 사료급여 방법대신 고영양소 사료를 급여한 처리구에서는 사료비가 적게는 7.7%에서 많게는 54.2%까지 증가하여 양돈농가들에게는 많은 경영부담이 되는 것으로 나타났다. 따라서 우리나라 양돈장에서 육성-비육돈을 사육할 때에는 성장단계별로 사료를 급여하는 것이 경제적으로 가장 효과적인 사료급여방법인 것을 제시할 수 있다.

타이타늄의 표면개질에 따른 도재 결합 특성 (THE BOND CHARACTERISTICS OF PORCELAIN FUSED BY TITANIUM SURFACE MODIFICATION)

  • 최택휴;박상원;방몽숙;양홍서;박하옥;임현필;오계정;김현승;이광민;이경구
    • 대한치과보철학회지
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    • 제45권2호
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    • pp.169-181
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    • 2007
  • Statement of problem: Titanium is well known as a proper metal for the dental restorations, because it has an excellent biocompatibility, resistance to corrosion, and mechanical property. However, adhesion between titanium and dental porcelains is related to the diffusion of oxygen to the reaction layers formed on cast-titanium surfaces during porcelain firing and those oxidized layers make the adhesion difficult to be formed. Many studies using mechanical, chemical and physical methods to enhance the titanium-ceramic adhesion have been actively performed. Purpose: This study meant to comparatively analyse the adhesion characteristics depending on different titanium surface coatings after coating the casts and wrought titanium surfaces with Au and TiN. Material and method: In this study, the titanium specimens (CP-Ti, Grade 2, Kobe still Co. Japan) were categorized into cast and wrought titanium. The wrought titanium was cast by using the MgO-based investment(Selevest CB, Selec). The cast and wrought titanium were treated with Au coating($ParaOne^{(R)}$., Gold Ion Sputter, Model PS-1200) and TiN coating(ATEC system, Korea) and the ultra low fusing dental porcelain was fused and fired onto the samples. Biaxial flection test was done on the fired samples and the porcelain was separated. The adhesion characteristics of porcelain and titanium after firing and the specimen surfaces before and after the porcelain fracture test were observed with SEM. The atomic percent of Si on all sample surfaces was comparatively analysed by EDS. In addition, the constituents of specimen surface layers after the porcelain fracture and the formed compound were evaluated by X-ray diffraction diagnosis. Result: The results of this study were obtained as follows : 1. The surface characteristics of cast and wrought titanium after surface treatment(Au, TiN, $Al_2O_3$ sandblasting) were similar and each cast and wrought titanium showed similar bonding characteristics. 2. Before and after the biaxial flection test, the highest atomic weight change of Si component was found in $Al_2O_3$ sandblasted wrought titanium(28.6at.% $\rightarrow$ 8.3at.%). On the other hand, the least change was seen in Au-Pd-In alloy(24.5at.% $\rightarrow$ 9.1at.%). 3. Much amount of Si components was uniformly distributed in Au and TiN coated titanium, but less amount of Si's was unevenly dispersed on Al2O3 sandblasting surfaces. 4. In X-ray diffraction diagnosis after porcelain debonding, we could see $Au_2Ti$ compound and TiN coating layers on Au and TiN coated surfaces and $TiO_2$, typical oxide of titanium, on all titanium surfaces. 5. Debonding of porcelain on cast and wrought titanium surface after the biaxial flection is considered as a result of adhesion deterioration between coating layers and titanium surfaces. We found that there are both adhesive failure and cohesive failure at the same time. Conclusion: These results showed that the titanium-ceramic adhesion could be improved by coating cast and wrought titanium surfaces with Au and TiN when making porcelain fused to metal crowns. In order to use porcelain fused to titanium clinically, it is considered that coating technique to enhance the bonding strength between coating kKlayers and titanium surfaces should be developed first.

4기 비소세포폐암 환자에서 복합화학요법군과 보존적치료군의 생존율 비교연구 (Survival Difference of Combination Chemotherapy versus Supportive Care in the Patients with Stage Ⅳ Non-Small Cell Lung Cancer)

  • 김병훈;이경희;도갑석;이은정;김성목;정진홍;이관호;현명수
    • Tuberculosis and Respiratory Diseases
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    • 제43권4호
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    • pp.536-546
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    • 1996
  • 연구배경 : 복합화학요법이 진행성, 특히 원격전이를 가진 4기 비소세포폐암 환자들의 생존율을 향상시킬 수 있는 지에 대해서는 아직까지 논란의 대상이 되고 있다. 이에 저자들은 원격전이가 증명된 4기 비소세포폐암 환자에서 cis-platin을 근간으로 한 복합화학요법군과 보존적 치료군의 생존율 차이를 평가하고, 생존율에 영향을 미칠 수 있는 예후 인자를 조사하여 보고하고자 한다. 방법 : 대상환자는 1989년 1월부터 1994년 12월까지 5년간 영남대학교 의과대학 부속병원에 내원하여 조직병리학적으로 비소세포폐암으로 진단된 환자 중 원격전이가 증명된 4기 환자, 총 89명에서 평가 가능한 환자 67명을 대상으로 하였고, 67명의 환자를 항암화학요법군과 보존적 치료군으로 나누고 항암화학요법군은 다시 반응군과 비반응군으로 나누어 생존율과 예후인자를 조사하였다. 결과 : 1) 4기 비소세포폐암 환자에서 생존율에 영향을 주는 의미있는 예후인자는 ECOG 기준에 따른 전신수행상태와 조직형이었다. 2) 전체 대상환자의 중앙생존기간은 13.6주였고 복합화학요법군의 중앙생존지간은 20주로써 보존적 치료군의 11.7주에 비해 길었다(p<0.01). 3) 복합화학요법에 반응이 있었던 환자들의 중앙생존기간은 45.5주로써 비반응군의 17.3주에 비해 의미있게 길었다(p<0.05). 4) 복합화학요법군의 1년 생존율은 15%, 보존적 치료군은 8%였다. 5) 복합화학요법의 부작용은 비교적 수용할 만 했다. 결론 : 전신수행상태가 양호하고 젊은 4기 비소세포폐암 환자들에 대해서 보다 적극적인 항암화학치료가 필요할 것으로 사료되며 앞으로 많은 환자를 대상으로 한 전향적 연구가 이루어져야 할 것이다.

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섬유질 배합사료 원료로서 맥주박, 비지박 및 볏짚이 한우 거세우의 사양성적, 혈액성상 및 도체특성에 미치는 영향 (Effects of Brewers Grain, Soybean Curd and Rice Straw as an Ingredient of TMR on Growth Performance, Serum Parameters and Carcass Characteristics of Hanwoo Steers)

  • 장선식;권혁진;이상민;조영무;정기용;최낙진;이성실
    • Journal of Animal Science and Technology
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    • 제55권1호
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    • pp.51-59
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    • 2013
  • 본 연구는 맥주박, 비지박 및 볏짚을 각각 이용하여 배합한 TMR을 한우 거세우에게 급여하였을 때 사양성적, 혈액성상 및 도체특성을 구명하고자 수행되었다. 시험구는 6개월령 한우 거세우 24두(평균체중 168 kg)를 배합사료 볏짚 분리급여구(T1), 맥주박 첨가 TMR 급여구(T2), 비지박 첨가 TMR 급여구(T3) 및 볏짚 첨가 TMR 급여구(T4)에 각각 6두씩 완전임의 배치하여 총 22개월간 사양시험을 실시하여 28개월령에 도축하였다. 시험결과에서 체중은 육성기에서 비육전기까지 처리구들간 유의적인 차이는 없었다. 하지만, 종료시 체중에서 T4 처리구가 T2 처리구에 비해 유의적으로 높았다. 일당증체량은 육성기 및 비육중기에서 TMR 급여구가 T1에 비해 유의적으로 높았지만(p<0.05), 전체평균에서는 차이가 없었다. 건물섭취량은 TMR 급여구(T2, T3, T4)에서 높은 경향을 나타내었다. 사료요구율은 T2 처리구에 비해 T4 처리구가 유의적으로 낮았다(p<0.05). 육량특성에서 도체중은 T1, T2, T3 및 T4 처리구에서 각각 389.0, 368.4 387.5 및 384.3 kg이었다. 등지방두께, 등심단면적 및 육량지수는 처리구들간 유의적 차이는 없었다. 육질특성에서 육색, 지방색, 조직감 및 성숙도에서는 처리 구간 유의적인 차이가 있었으나, 근내지방도와 육질 $1^+$ 등급 이상 출현율에서는 T2와 T3 처리구가 다른 처리구에 비해 높았다. 따라서 본 연구의 결과 맥주박과 비지박을 이용한 TMR 사료는 한우 거세우의 발육 및 도체특성에 있어 적절한 것으로 나타났다.