• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.42-42
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• 2003

Large-conductance $Ca^{2+}$-activated potassium channels ($BK_{Ca}$ are a widely distributed and play key roles in various cell functions. In nerve cells, $BK_{Ca}$ channels shorten the duration of action potentials and block $Ca^{2+}$ entry thereby repolarizing excitable cells after excitation. $BK_{Ca}$ channel opening has been postulated to confer neuroprotection during stroke, and has attracted attention as a means for therapeutic intervention in asthma, hypertension, convulsions, and traumatic brain injury. Several natural and synthetic compounds including a steroid hormone, $\beta$-estradiol, have been identified as the activators of $BK_{Ca}$ channels. Based on the structural features of the previously reported activators of $BK_{Ca}$ channels, we designed several lead compounds, synthesized chemically, and tested their functional activity on cloned $BK_{Ca}$ channels. The $\alpha$ subunit of rat $BK_{Ca}$ channel was expressed alone or with different $\beta$ subunits in Xenopus oocytes and the effects of the compounds were tested electrophysiological means. One of the lead compounds affected the activity of the $\alpha$ subunit of $BK_{Ca}$ channel in a $\beta$ subunit-specific manner. While the activity of B $K_{ca}$ channel $\alpha$ subunit was Potentiated, the channel composed of $\alpha$ and $\beta$1 subunits were inhibited by this compound. We are currently investigating the mechanism of the $\beta$ subunit-dependent effects and planning to localize the receptor site of the lead compound.f the lead compound.

• Journal of Acupuncture Research
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• 제27권1호
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• pp.21-29
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• 2010

Objectives : This study aims to evaluate current clinical evidence of acupuncture treatment for rehabilitation in patients with traffic accident in South Korea. Methods : Seven Korean databases were searched for prospective clinical trials for acupuncture on rehabilitation in patients with traffic accident from their inception to June, 2009. Only studies conducted in Korean language were searched. Risk of bias in included randomized controlled trials were assessed by Cochrane Handbook procedure. Results : Fifteen clinical trials were included among 31 studies searched. Eight were observational studies, five were non-randomizedcontrolled trials, and two were randomized controlled trials. In all of included studies, acupuncture were conducted with other concomitant treatment. Included studies dealt with such conditions as neck pain, low back pain tinnitus after traffic accident, post-traumatic stress, oculomotor nerve palsy, diplopia and insomnia. All of included studies reported favorable effects of acupuncture group compared to baseline or control group. All of included studies lacked the occurrence of adverse events. High risk of bias were observed in two randomized controlled trials. Conclusions : There is no evidence that acupuncture is effective for rehabilitation of traffic accident. All of included studies lacked appropriate methodological qualities and internal validity. Future welldesigned clinical trials that evaluate the effects and safety of acupuncture treatment for rehabilitation in patients with traffic accident is needed.

• 대한족부족관절학회지
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• 제17권4호
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• pp.288-293
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• 2013

Purpose: Number of arthroscopic surgery is gradually increasing with development of its equipment and technique. Arthroscopic ankle surgery performed with the traction device has various complications and need more time for preparation. We investigated whether the complication rate increased when surgery was performed without the traction device, and compared the complication rate of arthroscopic surgery with the traction device. Materials and Methods: From January 2009 to June 2012, arthroscopic ankle surgery was performed without the traction device in four hundred eleven cases. There were two hundred sixty-one males and one hundred fifty females. The average age at operation was 35 years (range, 17-56), and the average follow up period was 28 months (range, 12-41). Postoperative symptoms and complications were checked. Results: There were difficulties performing arthroscopic surgery without the traction device in five cases with severe traumatic osteoarthritis. However, after burring and shaving, we had enough space to work on. Superficial peroneal nerve symptom was found in two cases, grooving of talus was found in 11, and saphenous vein injury was found in five. Since preparing for the traction device was unnecessary, we were able to save time with the mean duration of surgery of 50 minutes (range, 30-120). Conclusion: With only manual traction, we could explore the entire ankle joint without damage on cartilage. Yet, skilled arthroscopic technique will be necessary for arthroscopic surgery without the traction device.

• Clinics in Shoulder and Elbow
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• 제12권2호
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• pp.236-239
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• 2009

목적: 저자들은 장흉 신경 손상에 의한 전거근 마비로 발생한 진구성 익상 견갑에서 대흉근 이전 술 시행 시 유용성과 임상적 결과를 평가하고자 하였다. 대상 및 방법: 외상 성 탈구로 야기된 견관절 불안정성에 대해 관절경 수술을 시행 후 발생한 진구성 익상 견갑 환자1예를 대상으로 Modified Eden-Lange 술식을 이용한 대흉근 이전술을 시행하였고, 술 전 전방 거상 90도, 외전 70 도에 비해 술 후 전방 거상 170도, 외전 150 도로 술후 향상된 관절운동 범위와 합병증 및 익상 견갑의 재발은 보이지 않았으며, 환자의 술 후 심리적 만족도 또한 높게 나타났다. 결과 및 결론: 장흉 신경에 의한 전거근 마비로 발생한 익상 견갑의 경우 다른 견갑대의 근육, 신경의 이상이 동반되지 않았을 때 대흉근 근육 이전술은 정상적인 견갑흉곽 운동을 제공할 수 있는 만족스러운 치료법 중 하나로 생각된다.

• Journal of Trauma and Injury
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• 제22권1호
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• pp.5-11
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• 2009

Purpose: The mortality and the amputation rates due to vascular trauma remain high despite advanced vascular surgical techniques and supportive management. The clinical features of patients with vascular trauma have not been well studied in the Korean population. The aim of this study was to analyze the clinical characteristics of patients with vascular trauma and to develop a database and guidelines for improving the outcomes of treatment. Methods: The medical records of 37 patients with traumatic vascular injuries who had visited in an emergency center between January 2002 and December 2006 were retrospectively reviewed and statistically analyzed. Results: The mean age was 37.8 years, and the male-to-female ratio was 5.2 : 1. The mechanism of vascular trauma was penetrating in 18 patients and blunt in 19 patients. Upper extremities were most frequently injured (39.4%). The treatment methods were primary repair in 21 patients, exploratory laparotomies in 7, radiological interventions in 3, resections and graft interpositions of the pseudoaneurysm in 3, observations in 3 and a bypass graft in 1. Four out of the 37 patients died, and three of these who died had injuried abdominal vessels. Twenty-five of the patients recovered completely, four expired, seven had neuropathy in the course of treatement, one had his limb amputated, and one experienced wound necrosis. Conclusion: Peripheral vessel injuries are commonly accompanied by nerve, muscle, or tendon injuries. Patients without associated fractures or compartment syndrome had good prognosis. Although the time intervals from hospital arrival to definite treatment were the shortest among patients with blunt abdominal vascular injuries, three expired. Therefore, we offer a 'ritical pathway'to improve the outcomes of patients with blunt abdominal vascular injury.

• 대한물리치료과학회지
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• 제5권3호
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• pp.643-650
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• 1998

저자들은 1996년 3월부터 1997년 3월까지 계명대학교 동산의료원 물리치료실에서 치료를 받은환자 중 안면신경 마비 증세를 나타낸 39례에 대하여 임상적인 고찰을 시행하여 다음과 같은 결과를 얻었다. 1) 연령별로는 30대에서 10례(24.6%)로 가장 많았다. 2) 성별로는 남자 21례(53.8%), 여자 18례(46.2%)였다. 3) 발생부위는 우측 19례(48.7%), 좌측 18례(46.2%)였다. 4) 발생원인별로는 원인불명(Bell's palsy) 19례(48 7%), 염증, 종양 각 6례(15.4%), 외상성 5례(12.9%), 대사성 2례(5.1%), 선천성 1례(2.6%)였다. 5) 병변의 발생에서 최초 치료일까지의 기간은 10일 이내가 26례(66.7%), 11-20일은 8례 (20.5% )였다. 6) 치료기간은 평균 25.21이며, 치료기간과 회복율의 상관관계는 통계학적 유의성은 없었다. 7) 치료 후 치료결과는 상당히 좋은 것으로 나타났다.