• The Korean Journal of Pain
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• 제37권2호
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• pp.132-140
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• 2024

Background: This study aimed to identify exact anatomical landmarks and ideal injection volumes for safe adductor canal blocks (ACB). Methods: Fifty thighs from 25 embalmed adult Korean cadavers were used. The measurement baseline was the line connecting the anterior superior iliac spine (ASIS) to the midpoint of the patellar base. All target points were measured perpendicular to the baseline. The relevant cadaveric structures were observed using ultrasound (US) and confirmed in living individuals. US-guided dye injection was performed to determine the ideal volume. Results: The apex of the femoral triangle was 25.3 ± 2.2 cm distal to the ASIS on the baseline and 5.3 ± 1.0 cm perpendicular to that point. The midpoint of the superior border of the vasto-adductor membrane (VAM) was 27.4 ± 2.0 cm distal to the ASIS on the baseline and 5.0 ± 1.1 cm perpendicular to that point. The VAM had a trapezoidal shape and was connected as an aponeurosis between the medial edge of the vastus medialis muscle and lateral edge of the adductor magnus muscle. The nerve to the vastus medialis penetrated the muscle proximal to the superior border of the VAM in 70% of specimens. The VAM appeared on US as a hyperechoic area connecting the vastus medialis and adductor magnus muscles between the sartorius muscle and femoral artery. Conclusions: Confirming the crucial landmark, the VAM, is beneficial when performing ACB. It is advisable to insert the needle obliquely below the superior VAM border, and a 5 mL injection is considered sufficient.

• 동양고전연구
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• 제34호
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• pp.225-255
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• 2009

본고에서는 정혜(貞惠) 정효(貞孝)공주의 묘지(墓誌)에 대한 분석을 바탕으로 발해 묘지 양식의 형성 배경과 특징 그리고 후대에 끼친 영향을 살펴보았다. 발해의 묘지 양식은 다음과 같은 고고학적인 특징과 역사적인 의의를 지니고 있다. 첫째, 발해의 묘지는 규형(圭形)의 비갈(碑碣) 형태를 띠고 있는데, 규형으로 된 비(碑)는 동한(東漢) 시대에 처음 보이기 시작하였으며, 위진(魏晉) 시대에 이르러 무덤 앞에 묘비 세우는 것을 엄격하게 규제함에 따라 무덤 안에 규모가 작은 비갈 형태의 묘지가 출현하였다. 그러나 출토된 발해의 묘지 2점은 동시대의 당나라나 통일 신라의 그것과는 달리 규형의 비갈 양식을 띠고 있다. 이는 위진 남북조 시기의 비갈 양식이 고구려에 영향을 끼쳤고 다시 고구려의 비갈 양식이 고분벽화와 함께 발해의 묘지 제작 방식에 영향을 주었음을 시사하고 있다. 둘째, 인근 왕조의 영향에도 불구하고, 발해는 스스로의 독특한 묘지 양식을 발전시켜왔다. 발해의 묘지 형태는 전형적인 규형(5각형)에서 뾰족한 윗부분을 다시 반으로 나누고 가로로 윗부분을 잘라 내어 사다리꼴의 변형된 규형(6각형)으로 변화 되었는데, 이는 이전과 동시대의 주변국에서는 찾아 볼 수 없는 고유한 양식이다. 셋째, 정혜공주묘지 정면의 테두리선과 문양도 새롭게 등장하는 양식으로, 발해의 묘지에서는 미학적인 기준이 중요하게 고려되었던 듯하다. 정혜공주의 묘지는 우선 비 몸돌의 정면에 실선을 새겨 넣어 장방형의 몸체와 사다리꼴의 이수(?首) 부분으로 구분하고, 다시 사면의 가장자리에서 두 선을 긋고 그 사이에 식물의 덩굴문양을 새겼으며, 윗부분의 사다리꼴 안에는 꽃문양을 새겨 넣음으로써 한층 화려한 모습을 보인다. 넷째, 발해의 묘지 양식은 인근 지역에 성립된 후대 왕조의 묘지 양식에도 적지 않은 영향을 주었다. 발해의 영향을 받은 고려는 물론 요, 송, 금, 원 등의 묘지에서도 발해묘지 양식의 흔적을 찾아 볼 수 있다.

• 콘크리트학회논문집
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• 제16권6호
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• pp.841-850
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• 2004

전 세계적으로 많은 수의 크고 작은 댐이 사용되고 있으나, 콘크리트 댐의 안전성 평가에 있어서 댐 내에 필연적으로 존재하는 균열을 함께 고려한 실질적 해석은 아직 미진한 실정이다. 따라서 향후 건설될 댐에 대해서는 설계 단계에서부터 이러한 파괴역학적 해석이 뒷받침되어야 댐의 안전성 확보에 매우 유리하다고 볼 수 있다. 특히 댐 제체와 지반이 접하는 경계면은 많은 균열 발생이 예상되는 영역으로써 이 균열 사이에 작용하는 양압력의 모델링은 중력식 콘크리트 댐 해석시 매우 중요한 요소이다. 즉, 콘크리트 댐의 균열 안정성 평가는 정확한 양압력의 모델링이 선행되어야 올바른 예측이 가능하다. 댐에 있어서 양압력의 취급은 단지 댐 체제 안정성 평가를 위한 전형적인 수계산 방법으로 널리 사용되고 있으나, 양압력에 대한 유한요소 모델링 방법은 연구가 부족한 실정이다. 본 연구에서는 중력식 콘크리트 댐과 지반이 접하는 부분에 발생된 균열에 양압력이 작용할 경우, 선형탄성파괴역학의 관점에서 접근하여 양압력이 응력확대계수에 미치는 영향을 비교 분석하였다. 양압력의 분포형상은 현재 등분포로 가정한 간략해석법으로 수행되고 있으나 최근의 연구 결과에 의하면 양압력 분포형상이 균열면에 따라 변화함을 보이고 있어, 본 연구에서는 수압의 형태를 등분포 형상 외에 삼각형 분포, 제형분포 및 포물선 분포 형상에 대해서도 각각 고려하여 각 분포형상별 응력확대계수를 평가하였다. 응력확대계수의 계산은 일반 8절점 등매개변수요소를 사용한 표면적분법을 사용하였으며, 자중의 영향 및 월류 수압의 영향도 함께 고려하여 해석 결과를 나타내었다.

• 한국임상약학회지
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• 제15권1호
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• pp.21-26
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• 2005

A bioequivalence study of CKD $Cefaclor^{(R)}$ capsule (Chong Kun Dang Pharm Co., Ltd) to $Ceclor^{(R)}$ capsule (Lilly Korea Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korean volunteers received each medicine at the cefaclor dose of 250 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. An improved high-performance liquid chromatorgraphy (HPLC) analytical method with UV detection was used to determine plasma cefaclor concentration in human volunteers for 8 hr after oral drug administration. The area under the plasma concentration-time curve from time zero to 8 hr ($AUC_{0-8hr}$) was calculated by the linear trapezoidal rule. the $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_{0-8hr}\;and\;C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the cross-over design was properly performed. The $90{\%}$ confidence intervals of the $AUC_{0-8hr}$ ratio and the $C_{max}$ ratio for CKD $Cefaclor^{(R)}$ and $Ceclor^{(R)}$ were $0.9400{\leq}{\delta}{\leq}1.0345$ and $0.8858{\leq}{\delta}{\leq}1.1021$, respectively. These values were within the acceptable bioequivalence intervals of 0.80-1.25. Thus, our study demonstrated the of CKD $cefaclor^{(R)}$ capsule was bioequivalent to $Cefaclor^{(R)}$ capsule with respect to its bioavailability.

• 한국강구조학회 논문집
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• 제26권6호
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• pp.605-615
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• 2014

본 연구의 목적은 파형 복부판과 허니컴 샌드위치 패널에 사용된 강판 보강 방법을 강바닥판에 적용하고, 새로운 리브와 기존 개단면 및 폐단면 리브와의 비교를 통하여 경제적인 새로운 형태의 리브를 제안하는데 있다. 새로운 리브 형태로 사다리꼴 파형, ㄹ형, 벌집형, ㅁ형 리브를 고려하고, 개단면 및 폐단면 리브와 리브 강재량을 비교한 결과, 경제성 측면에서 벌집형과 ㅁ형 리브가 좋은 결과를 나타내었으며, ㅁ형 리브가 벌집형보다 좀 더 좋음을 알 수 있었다. 실제 강바닥판에 적용 가능한 ㅁ형 리브를 만들기 위하여, 민감도 분석과 매개변수 연구를 수행하였으며, 특정 응력 조건하에서 적정한 단면을 선택할 수 있는 시스템을 구축하였다. 실 교량의 폐단면 리브와 제안한 시스템의 ㅁ형 리브의 강재량을 비교한 결과, 새로운 형태의 리브가 더 경제적임을 알 수 있었다. 따라서, ㅁ형 리브를 갖는 보강판에 대하여 본 연구에서 제안한 시스템을 이용하면 보다 더 경제적인 강바닥판을 얻을 수 있을 것으로 판단된다.

• Journal of Pharmaceutical Investigation
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• 제33권3호
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• pp.215-221
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• 2003

A bioequivalence study of $Ambrect^{TM}$ tablets (Dong Wha Pharm. Ind. Co., Ltd.) to $Mucopect^{TM}$ tablets (Boehringer Ingelheim Korea, Ltd.) was conducted according to the guideline of Korea Food and Drug Administration (KFDA). Twenty four healthy male Korea volunteers received each medicine at the ambroxol hydrochloride dose of 30 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of ambroxol were monitored by a high-performance liquid chromatography for over a period of 24 hours after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 24 hr) was calulated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}\;(time\;to\;reach\;C_{max})$ were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t\;and\;C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Ambrect^{TM}/Mucopect^{TM}$ were 0.89-1.01 and 0.89-1.02, respectively. These values were within the acceptable bioequivalence intervals of 0.80-1.25. Thus, our study demonstrated the bioequivalence of $Ambrect^{TM}\;and\;Mucopect^{TM}$ with respect to the rate and extent of absorption.

• Journal of Pharmaceutical Investigation
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• 제35권2호
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• pp.117-122
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• 2005

After establishing improved HPLC analytical method of cefaclor in human plasma samples, a bioavailability study of cefaclor capsules was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). The standard calibration curve using an HPLC with UV detector was constructed in a range of $0.0324{\sim}16\;{\mu}g/ml$. The 6% perchloric acid instead of 6% trichloroacetic acid was used to precipitate plasma protein. The HPLC chromatograms were precisely and accurately resolved when spiked with human plasma spiked with cefaclor and cephalexin (internal standard). Twenty healthy male Korean volunteers received two commercial cefaclor capsules, $Neocef^{\circledR}$ capsule (Jinyang Pharm. Co., Ltd) or $Ceclor^{\circledR}$ capsule (Lilly Korea. Co., Ltd.) at the 250 mg cefaclor in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of cefaclor were monitored for 8 hours after oral drug administration. $AUC_t$ the area under the plasma concentration-time curve from time zero to 8 hr (13 points), was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the cross-over design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Neocef^{\circledR}/Ceclor^{\circledR}$ were $0.9049{\leq}{\delta}{\leq}1.226$, respectively. These values were within the acceptable bioequivalence intervals of 0.80-1.25. Thus, our study demonstrated the bioequivalence of $Neocef^{\circledR}/Ceclor^{\circledR}$ with respect to the extent of absorption.

• Journal of Pharmaceutical Investigation
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• 제37권3호
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• pp.197-203
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• 2007

A bioequivalence study of $Dilast^{TM}$ Capsule (Chong Kun Dang Pharma. Co., Ltd.) to $Ketas^{(R)}$ Capsule (Han Dok Pharma. Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty eight healthy male Korean volunteers received each medicine at the ibudilast dose of 20 mg in a $2{\times}2$ crossover study. There was one week wash-out period between the doses. Plasma concentrations of ibudilast were monitored by a liquid chromatography-tandem mass spectrometry (LC-MS/MS) for over a period of 36 hours after drug administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 36 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t\;and\;C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Dilast^{TM}$ $Capsule/Ketas^{(R)}$ Capsule were $log0.93{\sim}log1.06$ and $log0.93{\sim}log1.11$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80{\sim}log1.25$. Thus, our study demonstrated the bioequivalence of $Dilast^{TM}$ Capsule and $Ketas^{(R)}$ Capsule with respect to the rate and extent of absorption.

• Journal of Pharmaceutical Investigation
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• 제39권1호
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• pp.65-71
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• 2009

The aim of the present study was to evaluate the bioequivalence of two domperidone maleate tablets, Motilium-$M^{(R)}$ Tablet (Janssen Korea Ltd., reference product) and $Toriem^{(R)}$ Tablet (Daewon Pharm. Co., Ltd., test product). Domperidone was extracted by liquid-liquid extraction using tert-butyl methyl ether and separated in less than 3 min on $C_{18}$ reverse-phase column using an isocratic elution. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z $426.1{\rightarrow}119.1$ and the m/z $837.4{\rightarrow}158.2$ transitions for domperidone and the internal standard (roxithromycin), respectively. Calibration curves, from $0.05{\sim}50$ ng/mL of domperidone, showed correlation coefficients (r) higher than 0.9941. Intra day and inter day precision (C.V. %) for quality control were ranged from 10.04 to 16.09% and from 10.87 to 18.69%, respectively. The lower limit of quantification (LLOQ) of domperidone was 0.05 ng/mL. The method described is precise and sensitive and has been successfully applied to the study of bioequivalence of domperidone in 24 healthy Korean volunteers. Twenty-four healthy male Korean volunteers received a single dose of each medicine ($2{\times}12.72\;mg$ domperidone maleate) in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of domperidone were monitored for over a period of 24 hr after the administration. $AUC_{0-t}$ (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. The 90% confidence intervals for the log transformed data were within acceptable range of log 0.8 to log 1.25 (e.g., $log\;0.92{\sim}log\;1.05$ for $AUC_{0-t}$, $log\;0.81{\sim}log\;1.05$ for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of KFDA for bioequivalence indicating that $Toriem^{(R)}$ tablet is bioequivalent to Motilium-$M^{(R)}$ tablet.

• 한국안전학회지
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• 제32권4호
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• pp.34-39
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• 2017

Typical flow regime of overflow at barrier or weir constructed in mid and small streams becomes as the submerged flow during most flood events. One of major causes of barrier failure has been reported as the levee-scour near the conjuction node between barrier and levee. However, most related design guidelines in Korea have not mentioned about the protection of levee around barrier or weir in detail. Furthermore, most previous researches have focused on the flow characteristics of overflow around several types of weirs but they did not have considered the material properties of levee itself. In this study, local scour near barrier was investigated with different material properties of levee under the submerged overflow condition which is assumed to reenact a flood event. Based on results from Fritz et al. and Mavis et al., a theoretical formula was also proposed in initial stage of laboratory experiments. And hydraulic experiments were carried out for the verification of the proposed formula. Levee was installed in the prismetic trapezoidal open channel and most parts were made of concrete except for movable section in which scour was expected to occur for the efficiency of experimental procedure. Each compaction of movable section in levee was followed by the basis of the KS F 2312. Further, after performing the experiments to find the optimum water content for each sediment, the specific amount of water was injected before flowing water. The difference between the proposed theoretical formula and experiment results was not much but considerable, which might be caused by the effect of compaction. For theoretical approach, it seemed that the formula did not take into account the compaction of levee, thus the correction coefficient for levee compaction determined in the literature was considered. Finally, the formula for the length of scour around barrier or weir was proposed, which can be useful to predict a levee in the reference design of revetment in mid and small streams. As shortly future study, scour length of levee around barrier or weir under different flow conditions such as perfect overflow condition will be studied and it will be able to contribute to suggest the design formula or criteria under all overflow conditions near barrier or weir.