• Wind and Structures
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• 제20권5호
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• pp.643-660
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• 2015

The wind tunnel test of large-scale sectional model and computational fluid dynamics (CFD) are employed for the purpose of studying the aerodynamic appendices and mechanism on suppression for the vortex-induced vibration (VIV). This paper takes the HongKong-Zhuhai-Macao Bridge as an example to conduct the wind tunnel test of large-scale sectional model. The results of wind tunnel test show that it is the crash barrier that induces the vertical VIV. CFD numerical simulation results show that the distance between the curb and crash barrier is not long enough to accelerate the flow velocity between them, resulting in an approximate stagnation region forming behind those two, where the continuous vortex-shedding occurs, giving rise to the vertical VIV in the end. According to the above, 3 types of wind fairing (trapezoidal, airfoil and smaller airfoil) are proposed to accelerate the flow velocity between the crash barrier and curb in order to avoid the continuous vortex-shedding. Both of the CFD numerical simulation and the velocity field measurement show that the flow velocity of all the measuring points in case of the section with airfoil wind fairing, can be increased greatly compared to the results of original section, and the energy is reduced considerably at the natural frequency, indicating that the wind fairing do accelerate the flow velocity behind the crash barrier. Wind tunnel tests in case of the sections with three different countermeasures mentioned above are conducted and the results compared with the original section show that all the three different countermeasures can be used to control VIV to varying degrees.

• 약학회지
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• 제45권2호
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• pp.220-226
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• 2001

A bioequivalence study of Lovastati $n^{TM}$ tablets (Dong Sung Pharmaceutical Co., Korea) to Mevaco $r^{TM}$ tablets (Choong Wae Pharmaceutical Co., Korea) was conducted according to the guidelines (No. 98-56) of Korea Food and Drug Administration (KFDA). Each tablet contained 20 mg of lovastatin. Eighteen healthy Korean male subjects received each formulation at a lovastatin dose of 80 mg (i.e., four tablets) in a 2 $\times$ 2 crossover study. There was a washout period of a week between the dose of the two formulations. Plasma concentrations of lovastatin acid were monitored by a GC/MS method for over a period of 12hr after each administration. The area under the plasma concentration-time curve from time zero to 12hr (AUC) was calculated by a linear trapezoidal method. The maximum plasma drug concentration ( $C_{max}$) and the time to reach $C_{max}$ ( $T_{max}$) were compiled from the plasma drug concentration-time data. Analysis of variance (ANOVA) of these parameters revealed that there are no differences in AUC and $C_{max}$ between the formulations. The apparent differences between the formulations in these parameters were 4.87 and 8.03% for AUC and $C_{max}$, respectively. Minimum detectable differences (%) at $\alpha$=0.1 and 1-$\beta$=0.8 were 17.84 and 15.36% for AUC and $C_{max}$ respectively. The 90% confidence intervals were -15.30~5.56 and -17.02-0.95% for AUC and $C_{max}$, respective1y. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Mevaco $r^{TM}$ tablets and Dong Sung Lovastati $n^{TM}$ tablets are bioequivalent.ivalent.ent.alent.ent.

• Journal of Pharmaceutical Investigation
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• 제37권1호
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• pp.57-62
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• 2007

The purpose of the present study was to evaluate the bioequivalence of two donepezil tablets, $Aricept^{TM}$ tablet (Dae Woong Pharm. Co., Ltd., Korea, reference drug) and $Donpezil^{TM}$ tablet (Dong Wha Pharm. Ind. Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four healthy male Korean volunteers received one tablet containing donepezil hydorchloride 10 mg in a $2{\times}2$ crossover study. There was a three-week washout period between the doses. Plasma concentrations of donepezil were monitored by an LC-MS/MS far over a period of 240 hr after the administration. $AUC_t$, (the area under the plasma concentration-time curve from time zero to 240 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$)were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$, No significant sequence effects were found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ and $C_{max}$ were log 0.95${\sim}$log 1.03 and log 0.94${\sim}$log 1.08, respectively. These values were within the acceptable bioequivalence intervals of log 0.80${\sim}$log 1.25. Taken together, our study demonstrated the bioequivalence of $Aricept^{TM}$ and $Donpezil^{TM}$ with respect to the rate and extent of absorption.

• 한국농공학회지
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• 제38권3호
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• pp.50-57
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• 1996

A numerical method is presented to obtain the natural frequencies and mode shapes of the arbitrary tapered beams with static deflection due to arbitrary distributed dead loads. The differential equation governing free vibration of such beams is derived and solved numerically. The double integration method using the trapezoidal rule is used to solve the static behaviour of beams loaded arbitrary distributed dead load. Also, the Improved Euler method and the determinant search method are used to integrate the differential equation subjected to the boundary conditions and to determine the natural frequencies of the beams, respectively. In the numerical examples, the various geometries of the beams are considered : (1) linearly tapered beams as the arbitrary variable cross-section, (2) the triangular, sinusoidal and uniform loads as the arbitrary distributed dead loads and (3) the hinged-hinged, clamped-clamped and hinged-clamped ends as the end constraints. All numerical results are shown as the non-dimensional forms of the system parameters. The lowest three natural frequencies versus load parameter, slenderness ratio and section ratio are reported in figures. And for the comparison purpose, the typical mode shapes with and without the effects of static deflection are presented in the figure. According to the numerical results obtained in this analysis, the following conclusions may be drawn : (1) the natural frequencies increase when the effects of static deflections are included, (2) the effects are larger at the lower modes than the higher ones and (3) it should be betteF to include the effect of static deflection for calculating the frequencies when the beams are supported by both hinged ends or one hinged end.

• 한국임상약학회지
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• 제10권1호
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• pp.25-29
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• 2000

Bioequivalence of cisapride-containing $Cisaplus^{(R)}$ tablets (Daewoong Co.) to reference $Prepulsid^{(R)}$ tablets (Janssen Co.) was evaluated according to the guidelines of Korea Food and Drug Administration (KFDA). Sixteen healthy volunteers were divided randomly into two groups and administered orally at a cisapride dose of 10 mg in a $2\times2$ crossover design. There was a 1-week washout period between the treatments. Blood samples were taken at predetermined time intervals for 48 hr and the plasma cisapride concentrations were determined by an HPLC with UV detector. The area under the plasma drug concentration-time curve (AUC) was caltulated from time zero to the last sampling time by a linear trapezoidal method. The maximum observed plasma drug concentration ($C_{max}$) and the time to $C_{max}\;(T_{max})$ were estimated directly from the drug concentration-time data. Analysis of variance (ANOVA) showed that the apparent differences for AUC, $C_{max}\;and\;T_{max}$ were $-7.52\%,\;-8.91\%\;and\;-15.55\%$, respectively. The minimum detectable differences for AUC, $C_{max}\;and\;T_{max}$ between formulations were $14.52\%,\;11.57\%\;and\;28.00\%$ respectively, at $\alpha=0.05\;and\;1-\beta=0.8\;levels.\;The\;90\%$ confidence intervals for AUC, $C_{max}\;and\;T_{max}\;were\;-16.00\sim0.97\%,\;-15.67\sim-2.15\%\;and\;-31.88\%\sim0.84\%$, respectively. These results satisfy the bioequivalence criteria of KFDA guidelines, indicating that the two formulations of cisapride are bioequivalent.

• 한국임상약학회지
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• 제8권2호
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• pp.101-106
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• 1998

A bioequivalence study of the Kerola tablets (Dongkwang Pharmaceutical Co., Korea) to the Tarasyn tablets (Roche Co., Korea), formulations of ketorolac trometamine(KTR), was conducted. Sixteen healthy Korean male subjects received each formulation at the dose of 10 mg as KTR in a $2\times2$ crossover study. There was a 1-week washout period between the dose. Plasma concentrations of KTR were monitored by an HPLC method for over a period of 12 hr after each administration. AUC (area under the plasma concentration-time curve) was calculated by the linear trapezoidal method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma drug concentration-time data. Analysis of variance (ANOVA) revealed that there are no differences in AUC, $C_{max}\;and\;T_{max}$ between the formulations. The apparent differences between the formulations in these parameters were all far less than $20\%$ (i.e., 2.31, 8.19 and $0\%$ for AUC, $C_{max}\;and\;T_{max}$, respectively). Minimum detectable differences $(\%)\;at\;\alpha=0.1\;and\;1-\beta=0.8$ were all less than $20\%$ difference in these parameters between the formulations were all over 0.8. The $90\%$ confidence intervals for these parameters were also within $20\%$. These results satisfy the bioequivalence criteria of the Korea Food and Drug Administration (KFDA) guidelines (No. 1998-86). Therefore, these results indicate that the 2 formulations of KTR are bioequivalent and, thus, may be prescribed interchangeably.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 춘계 학술발표회 제20권1호
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• pp.985-988
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• 2008

자기부상열차는 궤도 위에 부상하여 운행하는 시스템이다. 자기부상열차의 특성상 주행 중 부상공극을 일정하게 유지하는 것이 사용성 및 승객의 승차감 면에서 매우 중요하다. 이 연구는 2006년 출범한 도시형 자기부상열차 실용화 사업단의 3-1 세부과제 선로구축물 성능개선 과제의 협동연구과제로 자 기부상열차교량 상부구조의 급속시공법 개발을 목표로 연구를 수행하였다. 현재 도로교에서 프리캐스트 바닥판은 품질, 공기 면에서 현장타설 바닥판에 비해 우수하며, 널리 사용되고 있다. 따라서, 연구진은 3-1세부과제의 주관기관인 한국철도기술연구원과 협업을 통하여 1차년도에 PSC-U형 거더 및 개구제형 강재 거더에 프리캐스트 바닥판을 적용하여 자기부상열차 가이드웨이의 기본 시스템을 제안한 바 있다. 이 연구에서는 프리캐스트 바닥판과 체일 체결구조의 구조안전성 검토를 목적으로 실대형 요소실험체를 제작, 이들 실험체의 사용하중 상태 및 극한하중 상태의 정적성능평가 실험을 수행하였다.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 춘계 학술발표회 제20권1호
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• pp.57-60
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• 2008

자기부상열차는 궤도 위에 부상하여 운행하는 시스템이다. 자기부상열차의 특성상 주행 중 부상공극을 일정하게 유지하는 것이 사용성 및 승객의 승차감 면에서 매우 중요하다. 이 연구는 2006년 출범한 도시형 자기부상열차 실용화 사업단의 3-1 세부과제 선로구축물 성능개선 과제의 협동연구과제로 자기부상열차교량 상부구조의 급속시공법 개발을 목표로 연구를 수행하였다. 현재 도로교에서 프리캐스트 바닥판은 품질, 공기 면에서 현장타설 바닥판에 비해 우수하며, 널리 사용되고 있다. 따라서, 연구진은 3-1세부과제의 주관기관인 한국철도기술연구원과 협업을 통하여 1차년도에 PSC-U형 거더 및 개구제형 강재 거더에 프리캐스트 바닥판을 적용하여 자기부상열차 가이드웨이의 기본 시스템을 제안한 바 있다. 이 연구에서는 PSC-U형 거더, 프리캐스트 바닥판 및 새로운 형식의 가이드레일 시스템을 적용한 자기부상열차 가이드웨이의 시공성, 사용성, 유지관리성을 평가하고자 거더-바닥판-궤도로 이루어진 목업 실험체를 실대형 크기로 제작하여 실제 시공 환경과 비슷한 모의 시공을 수행하였다.

• 정보처리학회논문지B
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• 제15B권6호
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• pp.603-608
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• 2008

본 논문에서는 주가의 일별 시가, 종가, 최고가, 최저가를 예측하기 위한 퍼지모델을 제안한다. 주가는 시장의 여러 경제 변수에 의존하므로 주가예측 모델의 입력변수를 선택하는 것은 쉽지 않은 일이다. 이와 관련하여 많은 연구가 있지만 정답이 있는 것은 아니다. 본 논문에서는 이를 해결하기 위해 주가 움직임 자체에 주목하는 스틱차트의 기술적 분석에 이용되는 정보를 퍼지규칙의 입력변수로 선택한다. 퍼지규칙은 사다리꼴 멤버쉽함수로 이루어진 전건부와 비선형 수식의 후건부로 구성된다. 최적의 퍼지규칙으로 구성된 퍼지모델을 찾아내기 위해 차분진화가 사용된다. 본 논문에 제안된 방법은 수치 예를 통해 다른 방법과의 비교로 타당성이 검토되며 KOSPI(KOrea composite Stock Price Index) 일별 데이터를 사용, 주가예측 퍼지모델을 구축하고 신경회로망 모델과 비교, 검토된다.

• Wind and Structures
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• 제17권1호
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• pp.87-105
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• 2013

Modeling an equilibrium atmospheric boundary layer (ABL) in an empty computational domain has routinely been performed with the k-${\varepsilon}$ turbulence model. However, the research objects of structural wind engineering are bluff bodies, and the SST k-${\omega}$ turbulence model is more widely used in the numerical simulation of flow around bluff bodies than the k-${\varepsilon}$ turbulence model. Therefore, to simulate an equilibrium ABL based on the SST k-${\omega}$ turbulence model, the inlet profiles of the mean wind speed U, turbulence kinetic energy k, and specific dissipation rate ${\omega}$ are proposed, and the source terms for the U, k and ${\omega}$ are derived by satisfying their corresponding transport equations. Based on the proposed inlet profiles, numerical comparative studies with and without considering the source terms are carried out in an empty computational domain, and an actual numerical simulation with a trapezoidal hill is further conducted. It shows that when the source terms are considered, the profiles of U, k and ${\omega}$ are all maintained well along the empty computational domain and the accuracy of the actual numerical simulation is greatly improved. The present study could provide a new methodology for modeling the equilibrium ABL problem and for further CFD simulations with practical value.