• 대한방사선기술학회지:방사선기술과학
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• 제15권2호
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• pp.25-30
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• 1992

With transmitted dose through chest which has the problem of wide variations in absorption, simple film/screen combination method makes it diffucult to image lung field, mediastinum and retrocardiac areas. In order to overcome this, it is very common to use the high kilovoltage technique in diminishing the differences between high and low contrast. We have been adopting this method at department of diagnostic radiology, Seoul National University Hospital. To compare the image of it with that of low kilovoltage technique, we did radiographic tests using beans on the skin. We marked off into three anatomical categories such as lungs, mediastinum and near diaphragm, then attached a bean on a marked area at random. In order to compare with high and low, we took a radiography of high($120{\sim}140\;kVp$) and low($70{\sim}90\;kVp$) kilovoltage tehchniques, respectively at the same time. We have done experiments 320 cases. We evaluated the results of test in response to sensitivity(true positive) and specificity(true negative). In evaluating, we gave them points from 1 to 5 according to true or false. With given points by a radiologist having much experiences, we could acquire the percentage of sensitivity and specificity. The percentage made us to get the schematic table of ROC curve of those two methods. Consequently, high kilovoltage technique appeared 18% better than low kilovoltage technique for detecting beans with our apparatus.

• Applied Microscopy
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• 제38권3호
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• pp.185-193
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• 2008

전자 빔 조사 민감 물질인 gibbsite(${\gamma}-Al(OH)_3$)의 전자 빔 조사 상전이 연구에서 전자회절 자료의 기록에 대한 imaging plate와 필름의 기록 특성을 실험적으로 비교하였다. Imaging plate는 극단적으로 낮은 전자 강도와 높은 전자 강도를 동시 기록하기에 충분한 선형 dynamic range를 갖기 때문에, 매우 낮은 전자 조사 조건(${\leq}0.1\;e^-/{\mu}m^2$)에서 전자 회절 자료를 기록할 때 필름에 비해 회절 자료의 spatial frequency 범위가 두 배 이상 확장되었다. 심지어 이미 기록 포화된 투과 빔 주위의 신호 정보 레벨을 세분화하는 데에도 훨씬 우수한 분해 성능을 나타내었다. 따라서 본 연구 결과는 imaging plate가 극단적으로 낮은 전자 강도 기록이 필요한 전자 빔 조사 민감 물질이나 cryo-biological 시편들의 구조 연구 관점에서 가장 적절한 기록 매체임을 나타낸다.

• Journal of Microbiology
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• 제40권3호
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• pp.199-204
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• 2002

A microsporidium, from cabbage white bntteflies, Pieris rapae, collected in Korea, was purified and characterized according to its gene structure, spore morphology and pathogenicity. From the observation of the isolate by SEM and TEM, the endospores, exospores and nuclei, about 12 polar filament coils of the polar tube and posterior vacuoles were all identified. The nucleotide sequence was determined for a portion of genomic DNA which spans the V4 variable region of the small subunit rRNA gene. Comparison with the GenBank database for 15 other microsporidia species suggests that this isolate is most closely related to Nosema species. The pathogenicity against cabbage white butterflies was quantified by inoculating variable doses of spores to the second instar larvae. Peroral inoculation at a dosage of 10$\^$8/ spores/ml resulted in the death of all larvae prior to adult eclosion, but at lower spore dosages of 10$\^$4/-10$\^$5/ spores/ml, many adults successfully emerged. The median lethal dose (LD$\_$50/) was deter-mined to be 4.6$\times$10$\^$6/ spores/ml and the isolate also transmitted transovarially to the progeny eggs at a frequency of 92%.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제31권1호
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• pp.81-85
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• 2009

As panfacial fractures are involved multiple fracture, there are possibility of many pre-operative & postoperative complications. It is necessary to do exact pre-operative evaluation, appropriate operation and care, for preventing and treating these complications, especially related to optic nerve injury. The complication occurs rarely after periorbital facial bone fracture, and indirect injuries may occur as a result of impact shearing force transmitted into the optic nerve axons or to the nutrient vessels of the optic nerve. Also indirect injuries may occur after the force of impact because of vasospasm and swelling of the optic nerve within the confines of the nonexpansile optic canal. It is necessary to active evaluation and treatments involving decompression of the orbit surgically and high dose steroid therapy in relation to panfacial fracture. But sometimes this treatments are limited due to severe swelling of the face and related multiple bone fractures in the body. This case showed the delayed neuropathy, at last visual loss, in spite of megadose methylprednisolone administration. The purpose of this article is to present indirect traumatic optic neuropathy that is one of many complications in panfacial bone fracture.

• Journal of Microbiology and Biotechnology
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• 제30권12호
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• pp.1801-1809
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• 2020

Chikungunya virus (CHIKV) was first identified in 1952 as a causative agent of outbreaks. CHIKV is transmitted by two mosquito species, Aedes aegypti and A. albopictus. Symptoms after CHIKV infection in human are typically fever and joint pain, but can also include headache, muscle pain, joint swelling, polyarthralgia, and rash. CHIKV is an enveloped single-stranded, positive-sense RNA virus with a diameter of approximately 70 nm. The pathogenesis of CHIKV infection and the mechanism by which the virus evades the innate immune system remain poorly understood. Moreover, little is known about the roles of CHIKV-encoded genes in the viral evasion of host immune responses, especially type I interferon (IFN) responses. Therefore, in the present study, we screened CHIKV-encoded genes for their regulatory effect on the activation of nuclear factor kappa B (NF-κB), a critical transcription factor for the optimal activation of IFN-β. Among others, non-structural protein 2 (nsP2) strongly inhibited melanoma differentiation-associated protein 5 (MDA5)-mediated induction of the NF-κB pathway in a dose-dependent manner. Elucidation of the detailed mechanisms of nsP2-mediated inhibition of the MDA5/RIG-I signaling pathway is anticipated to contribute to the development of virus-specific therapeutics against CHIKV infection.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권2호
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• pp.129-143
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• 2022

Background: Patient-controlled analgesia (PCA) has been widely used as an effective medical treatment for pain and for postoperative analgesia. However, improper dose errors in intravenous (IV) administration of narcotic analgesics from a PCA infusion pump can cause patient harm. Furthermore, opioid overdose is considered one of the highest risk factors for patients receiving pain medications. Therefore, accurate delivery of opioid analgesics is a critical function of PCA infusion pumps. Methods: We designed a microbalance method that consisted of a closed acrylic chamber containing a layer and an oil layer with an electronic balance. A commercially available infusion analyzer (IDA-5, Fluke Co., Everett, WA, USA) was used to measure the accuracy of the infusion flow rate from a commercially available smart PCA infusion pump (PS-1000, UNIMEDICS, Co., Ltd., Seoul, Korea) and compared with the results of the microbalance method. We evaluated the uncertainty of the flow rate measurement using the ISO guide (GUM:1995 part3). The battery life, delay time of the occlusion alarm, and bolus function of the PCA pump were also tested. Results: The microbalance method was good in the short-term 2 h measurement, and IDA-5 was good in the long-term 24 h measurement. The two measurement systems can complement each other in the case of the measurement time. Regarding battery performance, PS-1000 lasted approximately 5 days in a 1 ml/hr flow rate condition without recharging the battery. The occlusion pressure alarm delays of PS-1000 satisfied the conventional alarm threshold of occlusion pressure (300-800 mmHg). Average accuracy bolus volume was measured as 63%, 95%, and 98.5% with 0.1 ml, 1 ml, and 2 ml bolus volume presets, respectively. A 1 ml/hr flow rate measurement was evaluated as 2.08% of expanded uncertainty, with a 95% confidence level. Conclusion: PS-1000 showed a flow accuracy to be within the infusion pump standard, which is ± 5% of flow accuracy. Occlusion alarm of PS-1000 was quickly transmitted, resulting in better safety for patients receiving IV infusion of opioids. PS-1000 is sufficient for a portable smart PCA infusion pump.

• 한국음향학회지
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• 제41권1호
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• pp.16-29
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• 2022

본 논문에서는 수중통신 장치가 수중에서 이동시 발생하는 도플러(Doppler) 편이를 극복하기 위한 도플러 편이 추정방법과 직접수열 확산대역 전송의 신호처리 방법을 제시한다. 제안한 방법은 도플러 편이에 강인하고, 자기 상관 특성이 우수한 64길이의 Frank 신호열을 두 번 반복하는 프리앰블을 사용하여 2단계로 도플러 편이를 추정한다. 또한, 제안한 방법을 직접수열 대역확산 전송을 사용하는 수중통신방식에 적용하여 수중이동통신용 패킷 설계와 RAKE 수신기를 설계한다. 설계한 확산대역 수중이동통신 변조방식은 데이터 심볼을 Differential-Quadrature Phase Shift Keying(DQPSK) 변조하여 수신시 위상추적이 필요 없고, RAKE 수신기에서 동위상 결합이 용이하게 할 수 있는 장점이 있다. 제안한 도플러 편이 추정방법을 포함하는 RAKE 수신방법은 약 17.5 m/s의 이동속도까지 가상으로 이동하는 송신기로부터 수신한 직접수열 대역 확산 신호를 성공적으로 수신한다.

• Nuclear Engineering and Technology
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• 제55권10호
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• pp.3854-3859
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• 2023

Background: This study aims to develop an evaluator that can quickly and accurately evaluate the shielding of low-energy industrial radiation generators. Methods: We used PyQt to develop a graphical user interface (GUI)-based program and employed the calculation methodology reported in the National Council on Radiation Protection and Measurements (NCRP)-49 for shielding calculations. We gathered the necessary factors for shielding evaluation using two libraries designed for Python, pandas and NumPy, and processed them into a database. We verified the effectiveness of the proposed program by comparing the results with those from safety reports of six domestic facilities. Results: After verifying the effectiveness of the program using the NCRP-49 example, we obtained an average error rate of 1.73%. When comparing the facility safety report and results obtained using the program, we found that the error rate was between 1.09% and 6.51%. However, facilities that did not use a defined shielding methodology were underestimated by 31.82% compared with the program (the final barrier thickness satisfied the shielding standard). Conclusion: The developed program provides a fast and accurate shielding evaluation that can assist personnel that work in radiation generator facilities and government officials in reviewing safety.

• 대한방사선기술학회지:방사선기술과학
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• 제37권3호
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• pp.187-193
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• 2014

본 연구는 X선 진단장치의 고압정류방식이 그리드 성능을 측정하는 선택도(selectivity)와 대조도 향상능력(contrast improvement ability : K factor)에 미치는 영향을 분석하고자 산란선 함유율을 측정하였다. 정류방식이 서로 다른 X선발생장치를 대상으로 각 장치의 관전압과, 관전류량을 측정하여 출력선량의 정확도를 측정 및 교정한 후 각 장치별 노출조건을 동일하게 설정하고 형광량계를 이용하여 아크릴을 투과한 X선의 산란선 함유율을 측정하였다. Grid 미사용 시 피사체를 투과한 X선의 산란선 함유율 측정 결과는 단상정류방식장치에서 가장 낮은 함유율(34.158%)이 측정되었고, 인버터 정류방식(37.043%)과 삼상24피크 정류방식(37.447%)은 산란선 함유율이 증가하였다. 각 장치들의 산란선 함유율 차이는 최저 0.404%에서 최고 3.289%의 차이를 보였다. 8:1 Gird 사용 시 피사체를 투과한 X선의 산란선 함유율을 측정한 결과는 단상정류방식장치에서 가장 낮은 함유율(18.258%)로 측정되었고, 인버터정류방식(25.502%)과 삼상24피크정류방식에서 산란선 함유율(24.217%)이 증가하였다. 그리드 선택도에 따라 단상정류방식과 정전압(인버터와 삼상24피크)정류방식에서 산란선함유율의 차이는 최저 1.285%에서 최고 7.244%의 차이를 보였다. 통계분석 결과 단상정류방식 및 정전압정류방식에서 대조도 향상계수(K factor)에서도 유의한 차이를 보였다. 결론적으로 그리드 선택도와 대조도 향상계수는 정전압정류방식보다는 단상전파방식에서 모두 증가하여 그리드의 사용으로 선택도 향상과 대조도의 개선효과가 증가함을 알 수 있었다.

• 한국전자파학회논문지
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• 제20권11호
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• pp.1161-1170
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• 2009

본 논문에서는 recursive method를 이용하여 A-Sandwich 레이돔 코어 물질을 유전체, 드루드(Drude) 모델, 이상적인 메타 물질로 각각 가정하고 레이돔의 특성을 비교 분석하였다. 기존의 유전체 레이돔보다 이상적인 메타물질을 사용함으로써 우수한 성능을 얻을 수 있음을 증명하였으며, 분산 메타 물질의 경우 물질 상수 변화가 작은 주파수 대역을 사용함으로써 유전체 레이돔보다 좋은 성능을 얻을 수 있음을 보였다. 또한 레이돔에 메타 물질을 적용하기 위한 스킨과의 관계 및 조건을 제안하였다. Ku band 주파수 대역에서 사용 가능한 레이돔을 분석하였으며, 레이돔의 주요 성능 파라미터인 삽입 손실, 삽입 위상 지연, 편파 부정합에 대해 유전체 레이돔과 메타 물질 레이돔의 전파 특성을 비교하였다. 코어가 주파수 분산 메타 물질일 경우 굴절 지수 -1과 가까운 주파수 대역에서 유전체를 코어로 갖는 레이돔에 비해 우수한 레이돔 성능을 가짐을 알 수 있었으며, 본 논문의 결과로부터 일반적인 유전체 레이돔에 비해 메타 물질 코어를 갖는 레이돔으로부터 개선된 전파 특성을 갖는 레이돔 특성을 얻을 수 있다는 것을 확인하였으며, 레이돔 설계 및 개발에 활용할 수 있다.