• Journal of Pharmaceutical Investigation
• /
• v.36 no.4
• /
• pp.223-229
• /
• 2006

[ $PGE_1$ ]-ethyl ester intraurethral solutions were prepared in ethanol/propylene glycol mixture with penetration enhancer and viscosity-enhancing agent. The stability of $PGE_1$-ethyl ester in intraurethral solution was investigated at various temperature. Simultaneous determination of $PGE_1$-ethyl ester and $PGE_1$ was performed using a validated HPLC technique. In pentobarbital anesthetized cats, increase in intracavernous pressure(ICP), increase in penile length and duration of erectile response were determined after intraurethral application of $PGE_1$-ethyl ester solutions. $PGE_1$-ethyl ester solutions, when instilled into the eyes of rabbits, produces no noticeable irritation, or slight transient conjunctival irritation. From these results, ocular irritation of this solutions was judged as practically non-irritating. The stability study indicates that the therapeutically effective content in solution is well maintained for 46 weeks or longer when they are stored at $4^{\circ}C$. After intraurethral application of $PGE_1$-ethyl ester, ICP was increased and penile erection was induced. $PGE_1$-ethyl ester intraurethral solutions for erectile dysfunction could be developed and evaluated by employing feline erection model.

• Applied Biological Chemistry
• /
• v.39 no.4
• /
• pp.260-264
• /
• 1996

Process of particle bombardment for efficient transformation of Cymbidium virescence rhizome microcross sections was investigated using Biolistic particle delivery system with pBI121 harboring the ${\beta}-glucuronidase$(GUS) and the neomycin phosphotransferaseII(nptII). The best result was obtained from the combination of $1.11{\;}{\mu}m$ tungsten particles coated with pBl121, $77.33kg/cm^2$ helium pressure, 6.35 mm gap distance, and 7.0 cm target distance. Transient expression of the reporter gene, GUS, bombarded into the rhizome microsections was observed by the histochemical assay. The marker gene, nptII, delivered by bombarding the tungsten particles coated with the plasmid DNA was identified in the transformed rhizome by polymerase chain reaction.

• Proceedings of the Korea Society for Energy Engineering kosee Conference
• /
• 1995.05a
• /
• pp.185-198
• /
• 1995

This is an experimental study conducted to visualize the nucleate boiling phenomena and flow regimes occurring inside the liquid pool in a closed two-phase thermosyphon. To meet this purpose, an annular-type thermosyphon was designed and manufactured using a glass tube and a stainless steel tube, being assembled axisymmetrically. The heat to be supplied to the working fluid is generated within a very thin layer of stainless steel tube wall by applying a high frequency electromagnetic field through the induction coil, axisymmetrically set around the evaporator zone. Some important results were as follows ; 1) Considering the structural complexity of the tested thermosyphon, it showed good performance for the range of heat flux 2＜ q" ＜25kW/$m^2$ and saturation vapor pressure, 0.1＜Pv＜1.1bar 2) different type of nucleating boiling regimes were observed as described below, -Pulse boiling regime : Flow pattern changed cyclically with time during 1 cycle of pulse boiling process. The onset of Nucleation was followed by expulsive growing of vapor bubble, resulting in the so called blow-up phenomenon, massive expulsion of large amount of liquid around the bubble. -Transient : Some spherical vapor bobbles were observed growing out from 2~3 nucleating sites, that was dispersed at the lower part of the heated tube wall in the liquid pool. But the rest upper region above the nucleating sites were filled with churns or bubbles of vapor. -Continuous nucleate boiling regime : The whole zone of evaporator was filled with lots of spherical vapor bubbles, and the bubbles showed tendency to decrease in diameter as the heat flux increased.ased.

• Structural Engineering and Mechanics
• /
• v.66 no.2
• /
• pp.273-283
• /
• 2018

Currently, the dynamic amplification effect of suction is described using the wind vibration coefficient (WVC) of external loads. In other words, it is proposed that the fluctuating characteristics of suction are equivalent to external loads. This is, however, not generally valid. Meanwhile, the effects of the ventilation rate of louver on suction and its WV are considered. To systematically analyze the effects of the ventilation rate of louver on the multi-dimensional WVC of ultra-large cooling towers under suctions, the 210 m ultra-large cooling tower under construction was studied. First, simultaneous rigid pressure measurement wind tunnel tests were executed to obtain the time history of fluctuating wind loads on the external surface and the internal surface of the cooling tower at different ventilation rates (0%, 15%, 30%, and 100%). Based on that, the average values and distributions of fluctuating wind pressures on external and internal surfaces were obtained and compared with each other; a tower/pillar/circular foundation integrated simulation model was developed using the finite element method and complete transient time domain dynamics of external loads and four different suctions of this cooling tower were calculated. Moreover, 1D, 2D, and 3D distributions of WVCs under external loads and suctions at different ventilation rates were obtained and compared with each other. The WVCs of the cooling tower corresponding to four typical response targets (i.e., radial displacement, meridional force, Von Mises stress, and circumferential bending moment) were discussed. Value determination and 2D evaluation of the WVCs of external loads and suctions of this large cooling tower at different ventilation rates were proposed. This study provides references to precise prediction and value determination of WVC of ultra-large cooling towers.

• Journal of Power System Engineering
• /
• v.12 no.1
• /
• pp.13-19
• /
• 2008

In this study, a variable induction and exhaust system is applied to turbocharged diesel engine to improve the volumetric efficiency, especially, in a low and transient engine speed range where much of the pollutant matters are expelled out. The volumetric efficiency is known as one of the most important factor which affects significantly engine performance, fuel economy and further emission and noise level. As the torque increase with the engine speed up, the gas flow in an exhaust pipe become pulsating and then has an effect on boost up capacity of air charging into the cylinder and expelling capacity to atmosphere simultaneously. But at a low and idling speed, the pulsation effect was not so significant. Accordingly, resonator was employed to compensate their loss. The variable induction system consists of the secondary pipe, resonator, intercooler, and torque variance were examined with extended operating conditions. In the mean time, for interpretation and well understanding for the phenomena of wave action that arising during intake and exhaust process between turbocharger and variable intake system, the concept of the combined supercharging was introduced. Some of results are depicted which deal with a pressure history during valve events of induction process. Consequently, by the governing of these phase and amplitude of pulsating wave, it enables us to estimate and evaluate for the intake system performance and also, designing stage of the system layout.

• Nuclear Engineering and Technology
• /
• v.48 no.4
• /
• pp.941-951
• /
• 2016

The aim of this work is to simulate the thermohydraulic consequences of a main steam line break and to compare the obtained results with Rossendorf Coolant Mixing Model (ROCOM) 1.1 experimental results. The objective is to utilize data from steady-state mixing experiments and computational fluid dynamics (CFD) calculations to determine the flow distribution and the effect of thermal mixing phenomena in the primary loops for the improvement of normal operation conditions and structural integrity assessment of pressurized water reactors. The numerical model of ROCOM was developed using the FLUENT code. The positions of the inlet and outlet boundary conditions and the distribution of detailed velocity/turbulence parameters were determined by preliminary calculations. The temperature fields of transient calculation were averaged in time and compared with time-averaged experimental data. The perforated barrel under the core inlet homogenizes the flow, and therefore, a uniform temperature distribution is formed in the pressure vessel bottom. The calculated and measured values of lowest temperature were equal. The inlet temperature is an essential parameter for safety assessment. The calculation predicts precisely the experimental results at the core inlet central region. CFD results showed a good agreement (both qualitatively and quantitatively) with experimental results.

• The Korean Journal of Physiology and Pharmacology
• /
• v.3 no.3
• /
• pp.321-328
• /
• 1999

Pulmonary blood vessels with diameters of $200{\sim}400\;{\mu}m$ produce considerably more force in response to vasoconstrictor drugs than those which are either smaller or larger. We have therefore investigated whether or not hypoxic pulmonary vasoconstriction (HPV) is more powerful in vessels of these diameters. We have also looked at the possibility that vessels from different regions of the lung respond differently. To do this we have grouped vessels according to their location within the lung as well as by size. We used a small vessel myograph (Cambustion AM10, Cambridge, UK) to study 208 preconstricted $(1\;{\mu}M\;PGF_{2{\alpha}})$ small pulmonary arteries $(300{\sim}800\;{\mu}m$ diameter when stretched to a tension equivalent to 25 mmHg transmural pressure) from 39 rats anaesthetized with 2% inspired halothane. A biphasic contraction was observed in response to hypoxia (ca. 25 mmHg $Po_2).$ The magnitudes of both the first, transient, phase (PT, peak tension) and of the second, sustained, phase (SST, steady state tension) were measured. The latter was measured 40 min after the start of hypoxia. The first phase was most pronounced in vessels with an average diameter of 423 ${\mu}m$ while the second phase was most pronounced in larger vessels (mean diameter 505 ${\mu}m).$ These maximal responses were all seen in vessels somewhat larger than reported by others. The responses of smaller vessels $(400{\sim}500\;{\mu}m)$ did not depend upon their location within the lung, but those of larger vessels $(600{\sim}700\;{\mu}m)$ showed regional differences. Those from the right lobe and those from the base of the lung gave the largest responses. It was especially noticeable that large vessels (631 ${\mu}m$ diameter) from the base of the right lung gave the biggest responses. Thus HPV seems to occur not in a uniform manner, dependent solely to the size of vessels, but it also depends to some degree on the region of the lung from which vessels have been taken. Furthermore, our results suggest that larger vessels, as well as smaller ones, may contribute significantly to HPV.

• Journal of the Korean institute of surface engineering
• /
• v.48 no.6
• /
• pp.297-302
• /
• 2015

Nanocrystalline diamond(NCD) coated aluminium plates were prepared and applied as heat sinks for LED modules. NCD films were deposited on 1 mm thick Al plates for times of 2 - 10 h in a microwave plasma chemical vapor deposition reactor. Deposition parameters were the microwave power of 1.2 kW, the working pressure of 90 Torr, the $CH_4/Ar$ gas ratio of 2/200 sccm. In order to enhance diamond nucleation, DC bias voltage of -90 V was applied to the substrate during deposition without external heating. NCD film was identified by X-ray diffraction and Raman spectroscopy. The Al plates with about 300 nm thick NCD film were attached to LED modules and thermal analysis was carried out using Thermal Transient Tester (T3ster) in a still air box. Thermal resistance of the module with NCD/Al plate was 3.88 K/W while that with Al plate was 5.55 K/W. The smaller the thermal resistance, the better the heat emission. From structure function analysis, the differences between junction and ambient temperatures were $12.1^{\circ}C$ for NCD/Al plate and $15.5^{\circ}C$ for Al plate. The hot spot size of infrared images was larger on NCD/Al than Al plate for a given period of LED operation. In conclusion, NCD coated Al plate exhibited better thermal spreading performance than conventional Al heat sink.

• Journal of the Korea Society for Simulation
• /
• v.25 no.1
• /
• pp.1-9
• /
• 2016

This study focuses on the air to air missile control fin planform optimization for the minimizing hinge moment with the considering phenomena of fluid and structure simultaneously. The fluid-structure interaction method is applied for the fluid and structure phenomena simulation of the control fins. A transient-loosely coupled method is used for the fluid-structure interaction simulation because it is suited for using each fluid and structure dedicated simulation software. Searching global optimization point is required many re-calculation therefore in this study, a mathematical model is applied for rapidly calculation. The face centered central composite method is used for generating design points and the 2nd polynomial response surface is sued for generating mathematical model. Global optimization is performed by using the generic algorithm. An objective function is the minimizing travel distance of the center of pressure between Mach 0.7 and 2.0 condition. Finally, the objective function of optimized planform is reduced 7.5% than the baseline planform with satisfying constrained conditions.

• Nuclear Engineering and Technology
• /
• v.15 no.4
• /
• pp.236-247
• /
• 1983

Analyzed are the the DNBR(Departure from Nucleate Boiling Ratio) sensitivities to variations in various PWR operating parameters utilizing the Korea Nuclear Unit 1(KNU-1) design and operating data. Studied parameters in the analysis are core power level, system pressure, core inlet flow rate, core inlet temperature, enthalpy rise hot channel factor, and axial power peaking factor and axial offset. The calculations are performed using the steady state and transient thermal-hydraulics computer program, COBRA-IV-K, which is the revised version of COBRA-IV-i that has been adapted, partially modified and verified at KAERI. A reference case is established based on the design and operating condition of the KNU-1 reactor core, and this provides a basis for the subsequent sensitivity analysis. From the calculation results it is concluded that the most sensitive parameter in the DNBR thermal design is the coolant core inlet temperature while the axial power peaking factor is the least sensitive.