• BMB Reports
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• v.44 no.6
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• pp.369-374
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• 2011

MHC-I molecules play a critical role in immune surveillance against viruses by presenting peptides to cytotoxic T lymphocytes. Although the mechanisms by which MHC-I molecules assemble and acquire peptides in the ER are well characterized, how MHC-I molecules traffic to the cell surface remains poorly understood. To identify novel proteins that regulate the intracellular transport of MHC-I molecules, MHC-I-interacting proteins were isolated by affinity purification, and their identity was determined by mass spectrometry. Among the identified MHC-I-associated proteins was Tmp21, the human ortholog of yeast Emp24p, which mediates the ER-Golgi trafficking of a subset of proteins. Here, we show that Tmp21 binds to human classical and non-classical MHC-I molecules. The Tmp21-MHC-I complex lacks ${\beta}_2$-microglobulin, and the number of the complexes is increased when free MHC-I heavy chains are more abundant. Taken together, these results suggest that Tmp21 is a novel protein that preferentially binds to ${\beta}_2$-microglobulin-free MHC-I heavy chains.

• Geomechanics and Engineering
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• v.12 no.2
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• pp.257-267
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• 2017

This paper presents laboratory investigation of stabilization of subgrade soil. One type of soil and three types of stabilizers i.e., hydrated lime, class F fly ash and polypropylene fibres are selected in the study. Atterberg limit, compaction, california bearing ratio (CBR), unconfined compressive strength and triaxial shear strength tests are conducted on unstabilized and stabilized soil for varying percentage of stabilizers to analyze the effect of stabilizers on the properties of soil. Vertical compressive strains at the top of unstabilized and stabilized subgrade soil were found out by elasto-plastic finite element analysis using commercial software ANSYS. Strategy for design of optimum pavement section was based on extension in service life (TBR) and reduction in layer thickness (LTR). Extension in service life of stabilized subgrade soil is 6.49, 4.37 and 3.26 times more due to lime, fly ash and fibre stabilization respectively. For a given service life of the pavement, there is considerable reduction in layer thicknesses due to stabilization. It helps in reduction in construction cost of pavement and saving in natural resources as well.

• Journal of The Geomorphological Association of Korea
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• v.24 no.4
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• pp.75-89
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• 2017

Sinkholes are key karst landforms that primarily evolve through the dissolution of limestone, and it posing a significant threat to roads, buildings, and other man-made structures. This study aims to analyze the area susceptible to sinkhole development using GIS and to identify potential danger area from sinkholes. Eight sinkhole related factors (slope angle, distance to caves, distance to faults, bedrock lithology, soil depth, drainage class, distance to mines, and distance to traffic routes) were constructed as spatial databases with sinkhole inventory. Based on the spatial database, sinkhole susceptibility maps were produced using nearest neighbor distance and frequency ratio models. The maps were verified with prediction rate curve and area under curve. The result indicates that the nearest neighbor distance and frequency ratio models predicted 95.3% and 94.4% of possible sinkhole locations respectively. Furthermore, to identify potential sinkhole danger area, the susceptibility map was compared with population distribution and land use map. It has been found that very highly susceptible areas are along Osipcheon and southeast southwest part of Hajang-myeon and south part of Gagok-myeon of Samcheok-si. Among those areas, it has been identified that potential sinkhole danger areas are Gyo-dong, Seongnae-dong, Jeongna-dong, Namyang-dong and Dogye-eup. These results can be useful in the aspects of land use planning and hazard prevention and management.

• ETRI Journal
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• v.43 no.4
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• pp.630-639
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• 2021

Autonomous driving requires a computerized perception of the environment for safety and machine-learning evaluation. Recognizing semantic information is difficult, as the objective is to instantly recognize and distinguish items in the environment. Training a model with real-time semantic capability and high reliability requires extensive and specialized datasets. However, generalized datasets are unavailable and are typically difficult to construct for specific tasks. Hence, a light detection and ranging semantic dataset suitable for semantic simultaneous localization and mapping and specialized for autonomous driving is proposed. This dataset is provided in a form that can be easily used by users familiar with existing two-dimensional image datasets, and it contains various weather and light conditions collected from a complex and diverse practical setting. An incremental and suggestive annotation routine is proposed to improve annotation efficiency. A model is trained to simultaneously predict segmentation labels and suggest class-representative frames. Experimental results demonstrate that the proposed algorithm yields a more efficient dataset than uniformly sampled datasets.

• International conference on construction engineering and project management
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• 2022.06a
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• pp.1017-1023
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• 2022

Past research shows that the construction of new infrastructure accelerates economic growth in the region by attracting more people and commodities. However, the previous studies only considered large-scale infrastructures such as sea-cross bridges and channel tunnels. There is a paucity of literature on regional infrastructure and its impact on socio-economic indicators. This paper explores the impact of new bridge construction on the human population, particularly focusing on regional bridges constructed during the 2000s in the state of Georgia. The human population at a county level was selected as a single socio-economic factor to be evaluated. A total of 124 cases were investigated as to whether the emergence of a new bridge affected the population change. The interrupted time series analysis was used to statistically examine the significance of population change due to the construction by treating each new bridge as an intervention event. The results show that, out of the 124 cases, the population of 67 cases significantly increased after the bridge construction, while the population of 57 cases was not affected by the construction at a significance level of 0.05. The 124 cases were also analyzed by route type, functional class, and traffic volume, but the results revealed, unlike large-scale infrastructure, that no clear evidence was found that a new bridge would bring an increase in the human population at a county level.

• Geomechanics and Engineering
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• v.34 no.1
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• pp.69-86
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• 2023

To overcome the dilemma of the [BQ] method's inability to predict mountain tunnel support loads, this study is based on the Hoek-Brown criterion and previous results to obtain the connection equations from GSI scores to each parameter of the Hoek-Brown criterion and the link between the [BQ] scores and the GSI system. The equations were embedded in the Hoek-Brown criterion of FLAC6.0 software to obtain tunnel construction forecasts without destroying the in-situ stratigraphy. The feasibility of the secondary development of the Hoek-Brown criterion was verified through comparative analysis with field engineering measurements. If GSI > 45 with a confining pressure of less than 10 MPa, GSI has little effect on the critical softening factor while we should pay attention to the parameter of confining pressure when GSI < 45. The design values for each parameter are closer to the FLAC3D simulation results and the secondary development of the Hoek-Brown criterion meets the design objectives. If the Class V surrounding rock is thinned with shotcrete or the secondary lining is installed earlier, the secondary lining may act as the main load-bearing structure. The study may provide ideas for rapid prediction of mountainous tunnels in China.

• Steel and Composite Structures
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• v.48 no.2
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• pp.191-206
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• 2023

The present research investigates how micromechanical models affect the behavior of Functionally Graded (FG) plates under different boundary conditions. The study employs diverse micromechanical models to assess the effective material properties of a two-phase particle composite featuring a volume fraction of particles that continuously varies throughout the thickness of the plate. Specifically, the research examines the vibrational response of the plate on a Winkler-Pasternak elastic foundation, considering different boundary conditions. To achieve this, the governing differential equations and boundary conditions are derived using Hamilton's principle, which is based on a four-variable shear deformation refined plate theory. Additionally, the Galerkin method is utilized to compute the plate's natural frequencies. The study explores how the plate's natural frequencies are influenced by various micromechanical models, such as Voigt, Reuss, Hashin-Shtrikman bounds, and Tamura, as well as factors such as boundary conditions, elastic foundation parameters, length-to-thickness ratio, and aspect ratio. The research results can provide valuable insights for future analyses of FG plates with different boundaries, utilizing different micromechanical models.

• Journal of KIISE:Information Networking
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• v.31 no.4
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• pp.414-428
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• 2004

Many portable devices are coming to be commercially successful and provide useful services to mobile users. Mobile devices may request a variety of data types, including text and multimedia data, thanks to the rich content of the Internet. Different types of data and/or different classes of users may need to be treated with different qualities of service. The implementation of service differentiation in wireless networks is very difficult because of device mobility and wireless channel contention when the backoff algorithm is used to resolve contention. Modification of the t)mary exponential backoff algorithm is one possibility to allow the design of several classes of data traffic flows. We present a study of modifications to the backoff algorithm to support three classes of flows: sold, silver, and bronze. For example, the gold c]ass flows are the highest priority and should satisfy their required target bandwidth, whereas the silver class flows should receive reasonably high bandwidth compared to the bronze class flows. The mixture of the two different transport protocols, UDP and TCP, in ad hoc networks raises significant challenges when defining backoff algorithm modifications. Due to the different characteristics of UDP and TCP, different backoff algorithm modifications are applied to each class of packets from the two transport protocols. Nevertheless, we show by means of simulation that our approach of backoff algorithm modification clearly differentiates service between different flows of classes regardless of the type of transport protocol.

• Korean Journal of Health Education and Promotion
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• v.22 no.2
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• pp.19-32
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• 2005

Objectives: The purpose of this study was to examine teachers' safety education activities to determine the significant educational diagnosis variables and to identify their needs of safety education in early-child care centers based on the PRECEDE model. Methods: A total of 304 teachers in early-child care centers participated in this study selected by a multi-stage stratified sampling method considering 11 regions in Seoul, Korea. Self-report type questionnaires were posted to all teachers in 220 early-child care centers by ground mailing service and the 304 teachers completed the questionnaires. The participants' responses were anonymously coded into and analyzed in SPSS program. Results: 'Scratch or bite' was the most frequent accident type(78.3%) and the frequent accident places were 'classroom(88.8%)' and 'playground(67.8%)'. The most frequently conducted safety education activities were 'reminding children their safe behaviors at the beginning and the end of daily class' and the next was 'saving a special time for safety education.' For educational diagnosis factors, related to safety education activities, teachers' safety education activity was more frequent when teachers' safety knowledge was high(p<.001), when teachers had good application skills of their knowledge to their teaching activities(p<.001), when they had strong needs on safety training opportunities(p<.05), and their interests on safety education(p<.001). For enabling factors, class preparation by safety education guide-book review(p<.001), by development of educational materials(p<.001), and by search for the related reference (p<.001), and by participation to safety education training programs for teachers(p<.01) were the significant enabling factors on teachers' safety class activities. For the reinforcing factors, the center-wide support of safety education brochures to children (p<.001), the concerns of centers utilizing safety education specialists(p<.001), and the concerns about safety information collection out of centers(p<.001) were significant factors related with teachers' safety education activities. Conclusions: The significant educational and institutional factors on teachers' safety education activities were teachers' concerns on safety education, their interests on safety knowledge, and the strong concerns on child safety education from the centers.

• The Korean Journal of Emergency Medical Services
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• v.12 no.3
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• pp.55-69
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• 2008

Purpose : The purpose of this study was to analyze the prehospital care report prepared by EMS squads of 119 center in Gyeonggi area and to identify the status of prehospital care activities, problems and improvement possibilities of the emergency care. Method : Five hundred copies of prehospital care report prepared by EMS squads in thirty-eight 119 centers under 18 fire stations in Gyeonggi area from March to April in 2008 were randomly chosen for the analysis. Data abstracted according to the purpose of the study were input and the analysis of prehospital care activities were performed using SPSS-WIN(ver. 16) statistics package. Results : 1. Total 500 cases of prehospital emergency care activities were reviewed. By sex, females were 219 (43.8%) and males were 281 (56.2%). The places of reporting were home (57.8%). According to the type of emergency, 281 cases (56.2%) were caused by disease and 291 (43.8%) were from other causes such as traffic accidents or incidental injuries. 2 The average time needed for the 119 EMS squad to arrive at the scene after being reported was 7.29 minutes. The time used at the scene for the emergency care was 7.3 minutes in average and the time to arrive at the hospital was 25.4 minutes in average. 3. In patient evaluation, in 68% of the cases more than two vital signs were measured at one time and emergency patients were 31%, and non-emergency patients were 69%. 4. In one EMS activity, average 2.15 cases of emergency care were provided to a patient. The cases where two kinds of emergency care were given were 14.4%, which is the most frequent cases. When reviewing the details of the emergency cares given to the patient including multiple cares, trivial cards (taking it easy and giving comfort) were the most frequent one as 40.6% and the medical direction of the doctor was given in only one case out of 500 cases. 5. In patient evaluation and emergency care, vital signs were provided to emergency patients at significantly higher rate comparing to the non-emergency patients. The number of emergency care performance was significantly higher in emergency cases. In emergency dispatch, the cases that EMT (1st class) was on board was 86.2%. When comparing the cases when the 1st class EMT was on board and otherwise, the cases with the presence of 1st class EMT showed more vital signs were detected but there was no significant difference in the number of emergency cares provided. Conclusion : It seemed that the on-scene emergency care did not satisfy the expectations. So it is necessary to enforce the cooperation between the elements, the qualifications of the 119 EMS squads and to improve the prehospital working environment in order to provide the better medical service at any time.