• Title/Summary/Keyword: Topical Association

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Retrospective Study about the Effectiveness of a Korean Medicine Treatment on 69 Infant and Young Child Atopic Dermatitis Patients (영유아 아토피피부염 환자 69명의 한의학적 치료효과에 대한 후향적 연구)

  • Min, Deul Le;Han, Myeong Hwa;Park, Gun;Seo, San;Han, Su Ryun
    • The Journal of Pediatrics of Korean Medicine
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    • v.28 no.3
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    • pp.17-30
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    • 2014
  • Objectives The purpose of this study is to report the effectiveness of Korean medicine treatment on 69 infant and young child atopic dermatitis patients. Methods 69 infants and young child atopic dermatitis patients who had visited oriental medical clinics from 2011.1.9 to 2012.1.31 were studied. All of them were continually treated for 3 to 9 months, and were analyzed by Objective SCORAD Index (OSI). A detailed analysis of OSI was done according to gender, age, using of topical steroid ointment, family history of atopic disease, treatment period, and intensity. Results 1. Male and female percentage of the study group was 56.5%: 43.5%. The average period of treatment was 6.09 months. 71.0% used topical steroid ointment, and 65.2% had family history of atopic disease. 2. The average period of treatment was significantly longer in patients who used topical steroid ointment, or who had family history of atopic disease. 3. 95.7% of total patients reported decrease in OSI score at the final visit. OSI was significantly lowered after 3, 6, and 9 months of treatment. The longer period of treatment, the lower average post-treatment OSI. 4. 85.5% of the study group had severe dermatitis, and 14.5% was moderate case based on the OSI intensity assessment at initial visit. These percentages got changed at the final visit as 34.8% of severe, 58.0% of moderate, and 7.2% of mild cases. The average treatment period of patients who were diagnosed as severe at the initial visit was 6.18 months, and their final OSI improvement rate was 39.58%. 58% of them were improved to be mild or moderate at the final visit. Conclusion The Korean medicine treatment is effective in treating infant and young child atopic dermatitis patients. There was significant decrease in OSI score after 3, 6, and 9 months of treatment. The difference increase with the treatment period.

EFFECTS OF LOCAL APPLICATION OF HEPARIN AND VASCULAR FREEZING ON THROMBOSIS OF MICROVASCULAR ANASTOMOSES IN THE RABBIT FEMORAL VEIN (가토 대퇴정맥에서 헤파린 국소 적용과 혈관냉동이 미세혈관문합부 혈전 형성에 미치는 영향)

  • Kim, Ji-Young;Oh, Hee-Kyun;Ryu, Sun-Youl;Kim, Sun-Hun
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.23 no.2
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    • pp.137-143
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    • 2001
  • The effect of topical heparin application and vascular freezing on thrombosis was evaluated in the femoral vein of rabbits. The femoral veins were crushed, incised transversely and treated by 4 different ways; 1) group 1, heparin treated only, 2) group 2, frozen only, 3) group 3, heparin treated and frozen, 4) group 4, treated with saline as control. The patency was evaluated by empty-and-refill test and thrombus formation was judged by stereoscopic and SEM observation. The results obtained were as follows: 1. Thirty minutes after suture, the patency was more improved in the three groups than the control, but there was no significant difference among groups. 2. Three days after suture, the patency was more improved in the three groups than the control, and was prominent in group 1 and group 3 (P<0.05). 3. Significantly reduced thrombus could be seen in most case of group 3. These results suggest that topical application of heparin and vascular freezing is effective in reducing thrombus formation in microsurgery of vein.

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A Randomized Active Controlled Clinical Trial to Evaluate Safety and Efficacy of a Topical Unani Formulation Marham Kharish Jadeed in the Management of Qūbā (Tinea Corporis)

  • Aaliya, Aaliya;Nawab, Mohammad;Kazmi, M.H.;Ayyub, Sana
    • CELLMED
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    • v.10 no.3
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    • pp.22.1-22.7
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    • 2020
  • Introduction: Qūbā (Tinea Corporis) is a very common disease widely prevalent worldwide. 20 - 25 % individuals suffer for this stubborn disease. Unani System of Medicine offers its treatment. There are many pharmacopoeial formulations indicated for various types of dermatophytic infections. In this study clinical efficacy and safety of the topical Unani formulation Marham Kharish Jadeed (a compound drug in the dosage form of an ointment) was assessed and compared with a standard conventional medicine. Materials and methods: A clinical study was conducted on 60 participants of qūbā randomized into test and control groups (n=30 in each group). The participants were clinically diagnosed and confirmed by microscopy of skin scrapings. The efficacy of the Unani formulation was assessed in terms of TSS score and elimination of fungal elements from the skin lesions. The data collected were analyzed statistically. Results and discussion: The study showed that the Unani formulation had comparatively better efficacy clinically than conventional medicine Terbinafine hydrochloride 1% cream in terms of reduction of itching, erythema, scaling, peripheral raised margins of the lesion comparing to baseline. In this study, 27 participants in test group and 18 participants in control group were completely cured (≥75% reduction in TSS Score with Mycological Cure) after 4 weeks of treatment. The efficacy of the Unani formulation was found significant statistically. The individual drugs of the formulations having analgesic (Musakkin), blood purifier (Muṣaffi-i-Dam), demulcent (Mulaṭṭif), antifungal (Qātil-i-fafūndῑ), detergent (Jālῑ), refrigerant (Mubarrid) and antiseptic (Dāfi'-i-'Ufūnat) properties might be responsible for the efficacy of Unani formulation. Conclusion: The findings of the study suggested that the Unani formulation was found effective and safe in the management of qūbā. No local and systemic adverse effect was reported during the study.

Therapeutic Effect of Majoon Mundi and Qairooti Karnab in Dā al-Ṣadaf (Psoriasis): A Case Series

  • Siddiqui, Gulnaz Fatima;Siddiqui, Shahid Akhtar;Jabeen, Arzeena;Qamaruddin, Qamaruddin;Kazmi, Munawwar Husain
    • CELLMED
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    • v.9 no.4
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    • pp.8.1-8.5
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    • 2019
  • Introduction: Psoriasis is a major health concern around the world. Physicians of the Unani system of medicine have been treating psoriasis for centuries. Aim: The purpose of our study was to assess the effect of Majoon Mundi (a semisolid Unani medication intended for oral intake used as blood purifier) and Qairooti Karnab (a Unani medication in paste form intended for topical application used as emollient) in the treatment $na{\ddot{i}}ve$ psoriasis cases and to collect data to warrant further clinical trials. Material and Methods: Psoriasis cases were diagnosed clinically. Data were collected during treatment of five patients of psoriasis treated with the Majoon Mundi (oral intake of 5 gm twice daily with 200 ml of water for 12 weeks) and Qairooti Karnab (topical application on affected sites twice a day for 12 weeks). Patients were treated for 12 weeks. Treatment response was seen with clinical improvement in skin lesions and measurement of Psoriasis Area and Severity Index (PASI Scoring) before and after treatment. Results: Reduced PASI Score was observed in all five patients after 12 weeks of treatment [PASI before and after treatment was (mean${\pm}$SD) $20.7{\pm}4.6$ vs. $3.2{\pm}1.8$; p-value <0.05.]. Clinical improvement was noticed within an average of 4 weeks of treatment. Conclusion: Preliminary findings indicate the potential therapeutic role of Majoon Mundi and Qairooti Karnab in the treatment of psoriasis. Clinical trials based on this Unani pharmacopeial formulation should be conducted to explore the therapeutic potential of this formulation in psoriasis

The Therapeutic Efficacy of Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis (항암화학요법 유발 말초신경병증에 대한 한약의 치료 효과: 체계적 문헌고찰 및 메타 분석)

  • Kim, Eun Hye;Yoon, Jee-hyun;Lee, Jee Young;Yoon, Seong Woo
    • Journal of Korean Traditional Oncology
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    • v.25 no.2
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    • pp.23-36
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    • 2020
  • Objective: This study was aimed to report the therapeutic effects of herbal medicine on chemotherapy-induced peripheral neuropathy (CIPN). Methods: The prior studies were searched from the databases included PubMed, Cochrane Library, EMBASE, CNKi, CiNii, KISS, NDSL, KMBASE, and OASIS until September 2020. The main search keywords were chemotherapy, peripheral neuropathy, and herbal medicine, and only randomized controlled trials that analyzed the therapeutic efficacy of herbal medicine were included. The Cochrane's Risk of Bias was used for assessment of the risk of bias and the Review Manager 5.3 program was used for meta-analysis. Meta-analyses were grouped by the administration routes of herbal medicines (oral administration or topical use). Results: Nine studies with a total of 563 participants were included. Compared with usual care, the effective rate was higher in oral administrated herbal medicine (RR 1.67, 95% CI 1.25 to 2.23; p<0.001, I2=31%). In addition, topical herbal medicine showed an significantly higher effective rate than placebo (RR 2.20, 95% CI 1.52 to 3.18; p<0.001, I2=0%) and usual care (RR 2.24, 95% CI 1.74 to 2.89; p<0.001, I2=66%). There was no severe adverse effect in all participants. Conclusions: Herbal medicine appears to improve neuropathy caused by chemotherapy in cancer patients more than conventional therapy of CIPN. However, as there is heterogeneity between the included studies and a lack of blinding, further well-designed researches are more needed.

A Study on the Topical Associations of Simultaneously Borrowed Books in Public Libraries (공공도서관 동시 대출 도서의 주제 연관성 분석 연구)

  • Woojin Kang;In Yeong Jeong;Jongwook Lee
    • Journal of Korean Library and Information Science Society
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    • v.54 no.3
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    • pp.33-55
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    • 2023
  • There has been research to understand users' information behaviors using book circulation data of public libraries. In this study, we examined the subject areas of books simultaneously borrowed by users of public libraries and aimed to identify the relationships among the subject areas. To accomplish this, we utilized the Korean Decimal Classification codes of 984,790 loaned books in 2019 to transform the lists of concurrently borrowed books, totaling 22,443,699 records, by the same users on the same day, into vectors using the ITEM2VEC technique. Next, we extracted ten highly related classification codes for each classification code, utilizing a total of 522 classification codes to create a network. We identified 15 communities within this network and examined the characteristics of each community. Among the 15 communities, those consisting of two or more main classes allowed us to identify meaningful thematic associations. This study, grounded in users' book usage behaviors, has suggested the topics of books that could be borrowed together. The findings offer valuable insights for library collection development and placement, recommending related subject materials, and revising classification systems.

Chemosis as complication in transconjunctival approach for orbital trauma

  • Olate, Sergio;Palmieri, Celso Jr.;de Moraes, Marcio
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.43 no.1
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    • pp.42-45
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    • 2017
  • The aim of this report was to discuss a complication resulting from a transconjunctival approach to treating an orbital fracture. A 30-year-old male patient presented with a fracture to the zygomatic orbital complex. He was treated with transconjunctival conventional surgical treatment. Two days after surgical treatment, the patient presented with secondary chemosis which was initially slight and then subsequently worsened. The clinical situation was managed with topical and systemic corticosteroids and resolved within one postoperative month. Two-year follow-up showed ptosis of the upper eyelid and limited infraversion in the affected eye. This unusual complication associated with an orbital trauma was resolved with minor functional alterations, although the consequences observed after 2 years were not completely satisfactory.

Topical Features of the Preposed Constituents in English Sentences. (전치되는 구성소의 화제적 속성)

  • 정일병
    • Korean Journal of English Language and Linguistics
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    • v.1 no.4
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    • pp.651-671
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    • 2001
  • There are several English constructions in which a certain constituent appears to the left of its canonical position, typically sentence-initially, leaving its canonical position empty. Such constructions involve Left-dislocation and Y-movement. These operations are called ‘Preposing.’ The preposed constituent of such constructions is generally regarded as the topic of the sentence which involves that constituent. Topics must have at least two features; ‘aboutness’ and ‘givenness.’ The feature ‘aboutness’ defines the range of comment, and the feature ‘givenness’ means ‘informationally old or given.’ The purpose of this paper is to show that the function of Preposing is to reinforce the aboutness of the preposed constituent of a sentence and that most preposed constituents have givenness. We examined Preposing for this purpose. Tough-movement and Passivization were examined also, because they have characteristics informationally similar to those of Preposing.

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English Middles as Categorical Sentences

  • Kim, Sungwook
    • Korean Journal of English Language and Linguistics
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    • v.1 no.4
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    • pp.537-560
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    • 2001
  • Stroik (1992, 1995, 1999) argues for the syntactic approach to English middles. His argumentation is heavily dependent upon the occurrence of a for-phrase in middles. However, many native speakers of English judge middles containing a for-phrase awkward or at best marginal. In addition, some other adverbials show a trait of a very similar nature. These two observational facts seem to justify the Genericity Constraint on Middles (=GCM). Yet a third observational fact that middles in the past tense can be sporadic nullifies GCM. In the present article, based upon several pieces of evidence, I show that the subject of the middle is a topic. In addition, it is argued that the Topical Subject Constraint on Middles can explain away the three observational facts.

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QU'EN EST-IL DE L'INCONSCIENT CHEZ FERDINAND DE SAUSSURE

  • ARRIVE, Michel
    • Lingua Humanitatis
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    • v.8
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    • pp.389-408
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    • 2006
  • This paper is a philological and epistemological study of the concept of the unconscious envisaged in Saussure. The study investigates whether the unconscious in Saussure can be put to question. Most Saussurian specialists have not as of yet raised any questions on this subject. The researches were simply limited to various comparisons between Saussurian concepts with those of Freud. The paper reconstructs the very concept of the unconscious in the Course in General Linguistics, using Lacan as a mediator between Saussure and Freud. Special attention is given to the linguistic subject who is unconscious about the law of langue, which contrasts it to the conscious of other social subjects and can be observed in the semiotic change of a social system. While not suggesting a hasty comparison between Saussure and Freud the paper draws an epistemological point of convergence. In other words, the paper tries to prove that the descriptive unconsciousness operates and intervene in the paradigmatic function of langue and that the topical unconsciousness operates to the syntagmatic function.

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