• 한국산학기술학회논문지
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• 제15권9호
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• pp.5602-5609
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• 2014

본 연구는 카제인포스포펩타이드-아모르포우스칼슘포스포페이트(CPP-ACP)에 불소이온을 결합시킨 불화 카제인포스포펩타이드-아모르포우스칼슘포스페이트(CPP-ACFP)제제의 법랑질 재광화 정도를 알아보기 위한 실험으로 법랑질 표면에 산부식 시간을 달리한 후 CPP-ACFP제제를 같은 횟수로 도포했을 때의 재광화 정도와 CPP-ACFP제제의 도포 횟수가 법랑질의 재광화에 미치는 영향을 알아보고자 건전한 치아 64개를 대상으로 미세경도측정, 주사전자현미경 관찰 실험을 하였다. 그 결과 산부식 시간이 길어질수록, CPP-ACFP제제의 도포 횟수를 증가시킬수록 법랑질의 재광화가 더 잘 일어나는 것을 관찰할 수 있었다. 그러므로 CPP-ACP에 불소이온을 결합시켜 치아에 무기질 공급과 불소도포를 한 번에 할 수 있는 CPP-ACFP제제는 법랑질 재광화 물질로 권장할 만하다고 하겠다.

• 한국재료학회지
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• 제14권1호
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• pp.52-58
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• 2004

The surface property and formation behavior of a boride layer formed on Ni-Cr-Mo steel in a plasma paste boronizing treatment were investigated. The plasma paste boronizing treatment was carried out at 973～1273 K for 1-7 hrs under the gas ratio of Ar:H$_2$ (2:1). The thickness of the boride layer increased with increasing temperature and time in the boronizing treatment. The cross-section of the boride layer was a tooth structure and the hardness was Hv 2000～2500. XRD analysis revealed that the compound was identified as FeB, $Fe_2$B, and mixed phase of FeB/$Fe_2$B in the boride layer formed at 973～1073 K, 1173K, and 1273K, respectively. The Ni-Cr-Mo alloy boronized at 1173-1273 K showed the best excellent wear resistance against the sand. As a results of corrosion test in 1 M $H_2$$SO_4$ solution, $Fe_2$B formed on the matrix alloy exhibited higher corrosion resistance than FeB.

• 대한소아치과학회지
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• 제41권4호
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• pp.335-343
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• 2014

재생적 근관치료는 치수 괴사를 보이는 미성숙 영구치 치료에 있어서 괴사된 치수를 치유하고 계속되는 치근의 발달을 유도할 수 있다. 그러나 여기에는 몇 가지 단점과 불리한 결과들이 있다. 이 중 재생적 근관치료에 가장 큰 임상적 부작용은 minocycline과 MTA에 의한 변색이다. 본 증례에서는 재생적 근관치료 후에 나타나는 치관 변색을 방지하기 위해 minocycline을 clindamycin으로 대체한 triple antibiotics와 칼슘 지르코늄 알루민산염 시멘트인 Retro MTA를 사용하였다. 치수 괴사된 미성숙 영구치에서 근관 와동 형성 및 근관 세척 후 수정된 triple antibiotics를 적용하고, 혈병 또는 콜라겐 스펀지를 스캐폴드(scaffold)로 하여 Retro MTA로 근관을 폐쇄하였다. 정기적인 검진 결과 미성숙 영구치의 치근 성장 및 정상적인 치아 주위 조직들이 관찰되었으며, 치관 변색 없이 모두 양호한 치유 결과를 얻었다.

• 대한소아치과학회지
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• 제35권1호
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• pp.159-166
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• 2008

치아우식증은 치아의 탈회와 재광화가 반복하여 일어나는 동적인 과정으로, 탈회 및 재광화의 속도에 따라 우식이 정지되거나 악화된다. 재광화를 유도하기 위해 불소 제제가 흔히 사용되고 있으나, 개인마다 salivary flow rate이나 타액내 이온 함량 및 타액의 pH 등에 따라 그 효과가 제한될 수 있다. 또한 소아 환자의 경우 과량 섭취로 인한 독성 우려도 배제할 수 없다. 최근 CPP-ACP(Casein Phosphopeptides-Amorphous Calcium Phosphate) 제제를 이용하여 탈회된 법랑질의 재광화를 유도하는 술식이 보고되고 있는 바, 본 증례에서는 법랑질 초기 우식증을 가진 환아에게 국내에서 시판중인 CPP-ACP 제제인 Tooth Mousse를 적용하였다. 제제의 효과를 높이기 위하여 치아미백술 시행시와 동일한 방법으로 제작된 customed tray를 사용하여 매일 도포하도록 하였다. 주기적인 관찰 결과 추가적인 우식의 진행 없이 시술 전과 비교하여 법랑질 병소의 크기가 감소한 양상이 관찰되었다. 발육 장애 증례나 만성적 우식증의 경우에는 그 효과가 크지 않았으나 경도 및 중등도의 초기 우식증을 가진 소아 환자에게 CPP-ACP 제제를 6주간 적용한 결과 치아 삭제 등의 시술 없이 본래 법랑질 밀도를 회복할 수 있었으며 주기적인 점검과 구강위생 교육을 통해 구강 관리 능력을 향상시킬 수 있었다.

• 한국세라믹학회지
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• 제55권2호
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• pp.145-152
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• 2018

Although many bone graft materials have been developed, powder graft materials are somewhat difficult to use in surgery. To solve this problem, a bone graft material in the form of a viscous paste was prepared. Hydroxyapatite was used as a bone graft material, and methyl cellulose was used to impart viscosity. Three cases of samples were prepared, and freeze-dried block type and sintered specimens were made from the paste. The recrystallization of the graft material in a simulated body fluid and the degree of graft adhesion with a tooth were observed by scanning electron microscopy (SEM). The test for cytotoxicity was carried out and the sample was grafted into the back of a mouse to confirm the presence or absence of side effects in the animal's body. Based on these investigations, composites of this type are expected to be applicable for bone grafts.

• Restorative Dentistry and Endodontics
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• 제39권3호
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• pp.230-234
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• 2014

This study describes the treatment of an immature permanent tooth with periapical lesion which was treated with regenerative approach using platelet rich plasma (PRP). The root canal of immature human permanent tooth with periapical lesion was gently debrided of necrotic tissue and disinfected with 2.5% NaOCl, and then medicated with triple antibiotic paste comprised of ciprofloxacin, metronidazole, and tetracycline. When the tooth was asymptomatic, PRP and mineral trioxide aggregate (MTA) were placed into the root canal. Six months after PRP treatment, radiographical examination revealed resolution of the radiolucency and progressive thickening of the root wall and apical closure. Our findings suggest that PRP can be used for the treatment of immature permanent teeth with periapical lesion, as part of a regenerative endodontic treatment procedure.

• Archives of Pharmacal Research
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• 제13권2호
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• pp.211-213
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• 1990

To test flavonoids for antibacterial activity against oral micraorganisms, flavonoids, quercetrin and naringenin, were incorporated into two pharmaceutical preparations in the form of tooth paste. Samplees of dental plaque, the msot accused dental deposit which initiates the gingival and periodental diseases, were collected from the teeth surface of ten dental students at one week interval before and after using placebo, followed by two formulae of tooth paste containing 0.1% of quercetrin and naringenin (formulas I and II, respectively). The amount of dental plaque was assessed by the quigley and Hens index. Then plaque samples were subjected to bacteriological examination of Gram stain and plate counts of microorganisms. The amount of dental plaque was assessed by the Quigley and Hens index. Then plaque samples were subjected to bacteriological examination of Gram stain and plate counts of microorganisms. The results revealed that most of Gram negative cocci and bacilli were highly affected by the two formulae : the number of actinomycetes were decreased after using formula I and disappeared completely by the sue of formula II, while the number of Gram positive streptococci was highly decreased after the treatment with the two formulae. These results indicate a possible use of flavonoids to inhibit dental plaque formation.

• Restorative Dentistry and Endodontics
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• 제40권4호
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• pp.322-327
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• 2015

A recent treatment option for non-vital immature teeth in young patients is revascularization with triple antibiotic paste (TAP). However, tooth discoloration was reported with the use of conventional minocycline-containing TAP. In this case report, amoxicillin-containing TAP was used for revascularization of non-vital immature teeth to prevent tooth discoloration. At the 1 yr follow up, the teeth were asymptomatic on clinical examination and showed slight discoloration of the crown due to mineral trioxide aggregate (MTA) filling rather than amoxicillin-containing TAP. Radiographic examination revealed complete resolution of the periapical radiolucency, and closed apex with obvious periodontal ligament space. However, the root growth was limited, and the treatment outcome was more like apexification rather than revascularization. These results may be due to unstable blood clot formation which could not resist the condensation force of MTA filling, whether or not a collagen matrix was in place. These cases showed that although revascularization was not successful, apexification could be expected, resulting in the resolution of the periapical radiolucency and the closure of the apex. Therefore, it is worthwhile attempting revascularization of non-vital immature teeth in young patients.

• 지역사회간호학회지
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• 제15권4호
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• pp.618-627
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• 2004

Purpose: To investigate the dental health status of kindergarten children according to their oral health behavior. Method: The subjects were 172 kindergarten children aged 5. A structured questionnaire was used for dental health behavior and oral health status were examined by dentist and bacteria in salivary. Result: 1. Mean score of oral health behavior of children was 4.69 points (SD1.65) with the highest score being 13. No significant differences were observed according to sex, except using tooth paste. A total 71.5% of subjects brushed their tooth twice a day, 9.9% of them once a day, 18.6% of them three times a day, 19.2% of children brushed their teeth after breakfast and lunch, 89.5% of then after dinner, 5.8% of them before going to bed, 18.6% of children brushed correctly, 79.7% of them used tooth paste with fluorine, 3.5% of them regularly examined oral cavity, 84.4% of them took cariogenic food without any restrain, 67.1% of them were observed with oral cavity by their mother. 2. Streptococcus mutans and lactobacilli in the saliva was $3.66({\times}106CFU/m{\ell})\;and\;1.05({\times}103CFU/m{\ell})$, respectively. No significant differences were observed according to sex, while lactobacilli were significantly lower in those children who had regular dental examinations. 3. The index of plaque was 1.56 and the boys were significantly higher than the girls. The mean dft was 4.99. No significant differences were observed according to sex, while the children whose oral cavity was observed regular were significantly lower than those who were not observed. Conclusion: As a whole the practice of oral health behavior of the kindergarten children was poor, and regular dental examinations and oral cavity observations affect their dental health status. These results suggest that intensive dental health education was needed not only for the pre-school children but also their parents and teachers.

• Restorative Dentistry and Endodontics
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• 제46권4호
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• pp.52.1-52.11
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• 2021

Objectives: This study evaluated the effects of low and moderate concentrations of triple antibiotic paste (TAP) and double antibiotic paste (DAP) loaded into a hydrogel system on crown discoloration and explored whether application of an adhesive bonding agent prevented crown discoloration. Materials and Methods: Intact human molars (n = 160) were horizontally sectioned 1 mm apical to the cementoenamel junction. The crowns were randomized into 8 experimental groups (calcium hydroxide, Ca[OH]₂; 1, 10, and 1,000 mg/mL TAP and DAP; and no medicament. The pulp chambers in half of the samples were coated with an adhesive bonding agent before receiving the intracanal medicament. Color changes (ΔE) were detected by spectrophotometry after 1 day, 1 week, and 4 weeks, and after 5,000 thermal cycles, with ΔE = 3.7 as a perceptible threshold. The 1-sample t-test was used to determine the significance of color changes relative to 3.7. Analysis of variance was used to evaluate the effects of treatment, adhesive, and time on color change, and the level of significance was p < 0.05. Results: Ca(OH)₂ and 1 and 10 mg/mL DAP did not cause clinically perceivable tooth discoloration. Adhesive agent use significantly decreased tooth discoloration in the 1,000 mg/mL TAP group up to 4 weeks. However, adhesive use did not significantly improve coronal discoloration after thermocycling when 1,000 mg/mL TAP was used. Conclusions: Ca(OH)₂ and 1 and 10 mg/mL DAP showed no clinical discoloration. Using an adhesive significantly improved coronal discoloration up to 4 weeks with 1,000 mg/mL TAP.