• 한국가금학회지
• /
• 제40권3호
• /
• pp.223-234
• /
• 2013

Poultry industry is abounding day by day as it engrosses less cost of investment per bird as compared to large animals. Poultry have the most copious genomic tool box amongst domestic animals for the detection of quantitative trait loci (QTL) and marker assisted selection (MAS). Use of multiple markers and least square techniques for mapping of QTL affecting quality and production traits in poultry is in vogue. Examples of genetic tests that are available to or used in industry programs are documented and classified into causative mutations (direct markers), linked markers in population-wide linkage disequilibrium (LD) with the QTL (LD markers), and linked markers in population wide equilibrium with the QTL (LE markers). Development of genome-wide SNP assays, role of 42 K, 60 K (Illumina) and 600 K (Affymetrix$^{(R)}$ Axim$^{(R)}$) SNP chip with next generation sequencing for identification of single nucleotide polymorphism (SNP) has been documented. Hybridization based, PCR based, DNA chip and sequencing based are the major segments of DNA markers which help in conducting of MAS in poultry. Economic index-marker assisted selection (EI-MAS) provides platform for simultaneous selection for production traits while giving due weightage to their marginal economic values by calculating predicted breeding value, using information on DNA markers which are normally associated with relevant QTL. Understanding of linkage equilibrium, linkage dis-equilibrium, relation between the markers and gene of interest are quite important for success of MAS. This kind of selection is the most useful tool in enhancing disease resistance by identifying candidate genes to improve the immune response. The application of marker assisted selection in selection procedures would help in improvement of economic traits in poultry.

• 한국항행학회논문지
• /
• 제18권5호
• /
• pp.494-500
• /
• 2014

최근 대량의 개인정보 유출 사고가 잇따라 발생하고 있으며, 외부 해킹과 더불어 내부직원 및 외주업체 직원에 의한 개인정보 유출사고가 증가하고 있다. 이에 따라 기업에서는 내부 보안을 강화하고, 개인정보 처리 업무를 위탁한 수탁사를 대상으로 개인정보의 분실, 도난, 유출 위험을 최소화하기 위해 정기적인 조사 및 점검을 통한 개인정보 감사를 진행하고 있다. 그러나 수탁사의 다양한 업무환경으로 인해 한정된 시간 동안 모든 개인정보 취급 PC를 정밀 조사하는데 어려움이 있다. 따라서 개인정보의 유출 위험성이 높은 고위험군을 식별하여 점검 대상을 효과적으로 선정하는 것이 필요하다. 본 논문에서는 디지털 포렌식 기법을 활용하여 사용자 행위 기반의 고위험군 선정 방안을 제안한다. 또한, 이를 활용하기 위한 도구를 설계 및 구현하였고, 실험 결과를 통해 효과를 입증한다.

• Computers and Concrete
• /
• 제15권5호
• /
• pp.771-794
• /
• 2015

This paper proposes an innovative method for selection of measurement sets in static parameter identification of concrete or steel bridges. This method is proved as a systematic tool to address the first steps of Structural System Identification procedures by observability techniques: the selection of adequate measurement sets. The observability trees show graphically how the unknown estimates are successively calculated throughout the recursive process of the observability analysis. The observability trees can be proved as an intuitive and powerful tool for measurement selection in beam bridges that can also be applied in complex structures, such as cable-stayed bridges. Nevertheless, in these structures, the strong link among structural parameters advises to assume a set of simplifications to increase the tree intuitiveness. In addition, a set of guidelines are provided to facilitate the representation of the observability trees in this kind of structures. These guidelines are applied in bridges of growing complexity to explain how the characteristics of the geometry of the structure (e.g. deck inclination, type of pylon-deck connection, or the existence of stay cables) affect the observability trees. The importance of the observability trees is justified by a statistical analysis of measurement sets randomly selected. This study shows that, in the analyzed structure, the probability of selecting an adequate measurement set with a minimum number of measurements at random is practically negligible. Furthermore, even bigger measurement sets might not provide adequate SSI of the unknown parameters. Finally, to show the potential of the observability trees, a large-scale concrete cable-stayed bridge is also analyzed. The comparison with the number of measurements required in the literature shows again the advantages of using the proposed method.

• 지식경영연구
• /
• 제19권2호
• /
• pp.151-162
• /
• 2018

Response surface methodology (RSM) is one of popular tools to support a systematic improvement of quality of design in the product and process development stages. It consists of statistical modeling and optimization tools. RSM can be viewed as a knowledge management tool in that it systemizes knowledge about a manufacturing process through a big data analysis on products and processes. The conventional RSM aims to optimize the mean of a response, whereas dual-response surface optimization (DRSO), a special case of RSM, considers not only the mean of a response but also its variability or standard deviation for optimization. Recently, a posterior preference articulation approach receives attention in the DRSO literature. The posterior approach first seeks all (or most) of the nondominated solutions with no articulation of a decision maker (DM)'s preference. The DM then selects the best one from the set of nondominated solutions a posteriori. This method has a strength that the DM can understand the trade-off between the mean and standard deviation well by looking around the nondominated solutions. A posterior method has been proposed for DRSO. It employs an interval selection strategy for the selection step. This strategy has a limitation increasing inefficiency and complexity due to too many iterations when handling a great number (e.g., thousands ~ tens of thousands) of nondominated solutions. In this paper, a TOPSIS-based method is proposed to support a simple and efficient selection of the most preferred solution. The proposed method is illustrated through a typical DRSO problem and compared with the existing posterior method.

• Geomechanics and Engineering
• /
• 제25권1호
• /
• pp.1-16
• /
• 2021

Machine learning models have been widely used for landslide susceptibility assessment (LSA) in recent years. The large number of inputs or conditioning factors for these models, however, can reduce the computation efficiency and increase the difficulty in collecting data. Feature selection is a good tool to address this problem by selecting the most important features among all factors to reduce the size of the input variables. However, two important questions need to be solved: (1) how do feature selection methods affect the performance of machine learning models? and (2) which feature selection method is the most suitable for a given machine learning model? This paper aims to address these two questions by comparing the predictive performance of 13 feature selection-based machine learning (FS-ML) models and 5 ordinary machine learning models on LSA. First, five commonly used machine learning models (i.e., logistic regression, support vector machine, artificial neural network, Gaussian process and random forest) and six typical feature selection methods in the literature are adopted to constitute the proposed models. Then, fifteen conditioning factors are chosen as input variables and 1,017 landslides are used as recorded data. Next, feature selection methods are used to obtain the importance of the conditioning factors to create feature subsets, based on which 13 FS-ML models are constructed. For each of the machine learning models, a best optimized FS-ML model is selected according to the area under curve value. Finally, five optimal FS-ML models are obtained and applied to the LSA of the studied area. The predictive abilities of the FS-ML models on LSA are verified and compared through the receive operating characteristic curve and statistical indicators such as sensitivity, specificity and accuracy. The results showed that different feature selection methods have different effects on the performance of LSA machine learning models. FS-ML models generally outperform the ordinary machine learning models. The best FS-ML model is the recursive feature elimination (RFE) optimized RF, and RFE is an optimal method for feature selection.

• Interdisciplinary Bio Central
• /
• 제6권1호
• /
• pp.1.1-1.6
• /
• 2014

A growing body of evidence shows that most psychological traits are polygenic, that is they involve the action of many genes with small effects. However, the study of selection has disproportionately been on one or a few genes and their associated sweep signals (rapid and large changes in frequency). If our goal is to study the evolution of psychological variables, such as intelligence, we need a model that explains the evolution of phenotypes governed by many common genetic variants. This study illustrates simple statistical tools to detect signals of recent polygenic selection: a) ANOVA can be used to reveal significant deviation from random distribution of allele frequencies across racial groups. b) Principal component analysis can be used as a tool for finding a factor that represents the strength of recent selection on a phenotype and the underlying genetic variation. c) Method of correlated vectors: the correlation between genetic frequencies and the average phenotypes of different populations is computed; then, the resulting correlation coefficients are correlated with the corresponding alleles' genome-wide significance. This provides a measure of how selection acted on genes with higher signal to noise ratio. Another related test is that alleles with large frequency differences between populations should have a higher genome-wide significance value than alleles with small frequency differences. This paper fruitfully employs these tools and shows that common genetic variants exhibit subtle frequency shifts and that these shifts predict phenotypic differences across populations.

• Journal of the Korean Data and Information Science Society
• /
• 제25권4호
• /
• pp.881-891
• /
• 2014

그래프모형(graphical model)은 확률 변수들간의 조건부 독립성(conditional independence)을 시각적인 네트워크형태로 표현할 수 있기 때문에, 정보학 (bioinformatics)이나 사회관계망 (social network) 등 수많은 변수들이 서로 연결되어 있는 복잡한 확률 시스템에 대한 직관적인 도구로 활용될 수 있다. 그래프 LASSO (graphical least absolute shrinkage and selection operator)는 고차원의 자료에 대한 가우스 그래프 모형 (Gaussian graphical model)의 추정에서 과대적합 (overfitting)을 방지하는데에 효과적인 것으로 알려진 방법이다. 본 논문에서는 그래프 LASSO 추정에서 매우 중요한 문제인 모형선택에 대하여 고려한다. 특히 여러가지 모형선택기준을 모의실험을 통해 비교하며 실제 금융 자료를 분석한다.

• 무역상무연구
• /
• 제64권
• /
• pp.187-210
• /
• 2014

As port functions change to act as an economic catalyst and take on a central position in industries engaged in international trade, port hinterland has become a significant component in international shipping. The success of port hinterland as a strategic base of logistic activities critically depends on location selection factor for international distribution center that links elements of global supply chain management. By examining multi-measurement items empirically, this paper analyzed location selection factor for international logistics distribution center in port hinterland, and evaluated Busan new port hinterland from the user's perspective. Employing exploratory factor analysis, the results revealed that the model structured around five factors incorporating geo-location and accessibility, availability, political supports, cost factors, and quality of business environment is valid and reliable in the context of the location selection factors for logistics distribution center in the context of port hinterland operations. The evaluation of Busan new port hinterland provides useful insights for strategic improvement to accommodate the users' expectation. Further, the model offers both a descriptive and diagnostic strategic management tool for port hinterland development and operations, to guide future improvement.

• 한국공작기계학회논문집
• /
• 제18권1호
• /
• pp.59-67
• /
• 2009

The purpose of this study is to provide a decision support to select an appropriate layered manufacturing(LM) machine that suits the application of a part. Selection factors include concept model, form/fit/functional model, pattern model far molding, material property, build time and part cost that greatly affect the performance of LM machines. However, the selection of a LM is not an easy decision because they are uncertain and vague. For this reason, the aim of this research is to propose hybrid multiple attribute decision making approaches to effectively evaluate LM machines. In addition, because subjective considerations are relevant to selection decision, a fuzzy logic approach is adopted. The proposed selection procedure consists of several steps. First, we identify LM machines that the users consider After constructing the evaluation criteria, we calculate the weights of the criteria by applying the fuzzy Analytic Hierarchy Process(AHP) method. Finally, we construct the fuzzy Technique of Order Preference by Similarity to Ideal Solution(TOPSIS) method to achieve the ranking order of all machines providing the decision information for the selection of LM machines.

• Genomics & Informatics
• /
• 제21권3호
• /
• pp.28.1-28.13
• /
• 2023

Mild cognitive impairment (MCI) is a clinical syndrome characterized by the onset and evolution of cognitive impairments, often considered a transitional stage to Alzheimer's disease (AD). The genetic traits of MCI patients who experience a rapid progression to AD can enhance early diagnosis capabilities and facilitate drug discovery for AD. While a genome-wide association study (GWAS) is a standard tool for identifying single nucleotide polymorphisms (SNPs) related to a disease, it fails to detect SNPs with small effect sizes due to stringent control for multiple testing. Additionally, the method does not consider the group structures of SNPs, such as genes or linkage disequilibrium blocks, which can provide valuable insights into the genetic architecture. To address the limitations, we propose a Bayesian bi-level variable selection method that detects SNPs associated with time of conversion from MCI to AD. Our approach integrates group inclusion indicators into an accelerated failure time model to identify important SNP groups. Additionally, we employ data augmentation techniques to impute censored time values using a predictive posterior. We adapt Dirichlet-Laplace shrinkage priors to incorporate the group structure for SNP-level variable selection. In the simulation study, our method outperformed other competing methods regarding variable selection. The analysis of Alzheimer's Disease Neuroimaging Initiative (ADNI) data revealed several genes directly or indirectly related to AD, whereas a classical GWAS did not identify any significant SNPs.