• Asian Pacific Journal of Cancer Prevention
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• v.16 no.4
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• pp.1397-1401
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• 2015

Background: To determine the expressions of Tbx3, a member of subgroup belonging to T-box family, and its prognostic value in pancreatic carcinoma. Materials and Methods: We determined the expression levels of Tbx3 on both mRNA and protein levels in 30 pairs of fresh tumor tissues and paratumor tissues by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting, respectively. In addition, protein level of Tbx3 were identified using immunochemistry in 80 pairs of paraffin-embedded specimen. The correlations between Tbx3 expression and various clinicopathological parameters as well as overall survival were evaluated. Results: Tbx3 mRNA and protein levels in tumor tissues were significantly higher than in the paratumor tissues by qRT-PCR ($0.05{\pm}0.007$ vs. $0.087{\pm}0.001$, p<0.001) and western blotting ($1.134{\pm}0.043$ vs. $0.287{\pm}0.017$, p<0.001). The statistical analysis based on immunohistochemical evaluation suggested that Tbx3 aberrant expression was significantly associated with several conventional clinicopathological variables, such as gender, age, tumor position, preoperative CA19-9 level, pathological T staging and N staging. Univariate and multivariate analyses revealed that Tbx3 expression was an independent prognostic factor for overall survival (<0.001). Conclusions: Our results suggest that overexpression of Tbx3 is associated with poor prognosis of pancreatic cancer patients. However, additional clinical trials are needed to accurately validate this observation.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2013.05a
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• pp.862-865
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• 2013

The smartphone digs deep into our lives, is changing our life. With increases the penetration of smart phones, it getting better performance. In recent years, tend to increase its utilization by an increase in the prevalence of smart phones equipped with NFC short-range wireless communication technology based on RFID in a number of areas, including e-cards, tagging. In this paper, we implement a system that can operate the system by traditional saddlecloth way of waiting waiting waiting standby system more efficient by applying NFC.

• International Journal of Naval Architecture and Ocean Engineering
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• v.10 no.6
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• pp.692-710
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• 2018

The Three-dimensional (3-D) dynamical behaviors of a fluid-conveying pipe subjected to vortex-induced vibration are investigated with different internal flow velocity ${\nu}$. The values of the internal flow velocity are considered in both subcritical and supercritical regimes. During the study, the 3-D nonlinear equations are discretized by the Galerkin method and solved by a fourth-order Runge-Kutta method. The results indicate that for a constant internal flow velocity ${\nu}$ in the subcritical regime, the peak Cross-flow (CF) amplitude increases firstly and then decrease accompanied by amplitude jumps with the increase of the external reduced velocity. While two response bands are observed in the In-line (IL) direction. For the dynamics in the lock-in condition, 3-D periodic, quasi-periodic and chaotic vibrations are observed. A variety of CF and IL responses can be detected for different modes with the increase of ${\nu}$. For the cases studied in the supercritical regime, the dynamics shows a great diversity with that in the subcritical regime. Various dynamical responses, which include 3-D periodic, quasi-periodic as well as chaotic motions, are found while both CF and IL responses are coupled while ${\nu}$ is beyond the critical value. Besides, the responses corresponding to different couples of ${\mu}_1$ and ${\mu}_2$ are obviously distinct from each other.

• Journal of the Korea Convergence Society
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• v.11 no.5
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• pp.299-307
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• 2020

The purpose of this study was to explore what chiefs of tong/ri' experiences in suicide prevention activities are and what their changes are. The study participants are three chiefs of tong/ri who have participated in suicide prevention activities for more than two years in the community. In order to gain a deeper understanding of their respective experiences, used a qualitative method of narrative study. Chiefs of tong/ri' experiences experience in participating in suicide prevention activities consisted of start, experience, change and growth. The meaning is as follows. They did a "light start" with the idea that they could do it easily in their original activities. "Escape from the burden" of learning and maintaining each of own ways in the difficult problem of suicide prevention, "Responsibility as a chief" was the driving force behind suicide prevention activities. They were able to find "change of their own" because of the activity naturally.

• Journal of Microbiology and Biotechnology
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• v.29 no.4
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• pp.633-644
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• 2019

An advanced anaerobic expanded granular sludge bed (AnaEG) and an internal circulation (IC) reactor, which were adopted to treat starch processing wastewater (SPW) and ethanol processing wastewater (EPW), were comprehensively analyzed to determine the key factors that affected the granules and microbial communities in the bioreactors. The granule size of $900{\mu}m$ in the AnaEG reactor was smaller than that in the IC reactor, and the internal and external morphological structures of the granular sludge were also significantly different between the two types of reactors. The biodiversity, which was higher in the AnaEG reactor, was mainly affected by reactor type. However, the specific microbial community structure was determined by the type of wastewater. Furthermore, the dominant methanogens of EPW were mainly Methanosaeta and Methanobacterium, but only Methanosaeta was a major constituent in SPW. Compared with the IC reactor, characteristics common to the AnaEG reactor were smaller granules, higher biodiversity and larger proportion of unknown species. The comparison of characteristics between these two reactors not only aids in understanding the novel AnaEG reactor type, but also elucidates the effects of reactor type and wastewater type on the microbial community and sludge structure. This information would be helpful in the application of the novel AnaEG reactor.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.10a
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• pp.693-695
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• 2014

Radioactive isotopes for radiation diagnosis is production by using Cyclotron like a PET. Radioactive isotopes is influenced product yield according to shape and size of the proton beam and target irradiation position by cyclotron. And to develop a device for measuring the distribution of the beam to increase the loss of the beam. Beam measuring device is measured vertically beam current according move the two wires. In this way, by using the beam current value in each position you are able to know the cross section and location information of the beam. By scanning cross-section for X-axis Y-axis of beam acquires data of beam. Print this into 2D graph, and analyze the result. You can save this result by documentation process.

• International Journal of Naval Architecture and Ocean Engineering
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• v.11 no.1
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• pp.624-637
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• 2019

A semi-submersible offshore platform always operates under complex weather conditions, especially wind and waves. It is vital to analyze the structural dynamic responses of the platform in short-term sea states under the combined wind and wave loads, which touches upon three following work. Firstly, a derived relationship between wind and waves reveals a correlation of wind velocity and significant wave height. Then, an Improved Mixture Simulation (IMS) method is proposed to simulate the time series of wind/waves accurately and efficiently. Thus, a wind-wave scatter diagram is expanded from the traditional wave scatter diagram. Finally, the time series of wind/wave pressures on the platform in the short-term sea states are converted by Workbench-AQWA. The numerical results demonstrate that the proposed numerical methods are validated to be applicable for wind and wave simulations in structural analyses. The structural dynamic responses of the platform members increase with the wind and wave strength. In the up-wind and wave state, the stresses on the deck, the connections between deck and columns, and the connection between columns and pontoons are relatively larger under the vertical bending moment. These numerical methods and results are wished to provide some references for structural design and health monitoring of several offshore platforms.

• Molecules and Cells
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• v.46 no.4
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• pp.219-230
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• 2023

Down syndrome (DS) is the most common autosomal aneuploidy caused by trisomy of chromosome 21. Previous studies demonstrated that DS affected mitochondrial functions, which may be associated with the abnormal development of the nervous system in patients with DS. Runt-related transcription factor 1 (RUNX1) is an encoding gene located on chromosome 21. It has been reported that RUNX1 may affect cell apoptosis via the mitochondrial pathway. The present study investigated whether RUNX1 plays a critical role in mitochondrial dysfunction in DS and explored the mechanism by which RUNX1 affects mitochondrial functions. Expression of RUNX1 was detected in induced pluripotent stem cells of patients with DS (DS-iPSCs) and normal iPSCs (N-iPSCs), and the mitochondrial functions were investigated in the current study. Subsequently, RUNX1 was overexpressed in N-iPSCs and inhibited in DS-iPSCs. The mitochondrial functions were investigated thoroughly, including reactive oxygen species levels, mitochondrial membrane potential, ATP content, and lysosomal activity. Finally, RNA-sequencing was used to explore the global expression pattern. It was observed that the expression levels of RUNX1 in DS-iPSCs were significantly higher than those in normal controls. Impaired mitochondrial functions were observed in DS-iPSCs. Of note, overexpression of RUNX1 in N-iPSCs resulted in mitochondrial dysfunction, while inhibition of RUNX1 expression could improve the mitochondrial function in DS-iPSCs. Global gene expression analysis indicated that overexpression of RUNX1 may promote the induction of apoptosis in DS-iPSCs by activating the PI3K/Akt signaling pathway. The present findings indicate that abnormal expression of RUNX1 may play a critical role in mitochondrial dysfunction in DS-iPSCs.

• The korean journal of orthodontics
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• v.53 no.4
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• pp.232-240
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• 2023

Objective: This study aimed to evaluate the zygomaticotemporal suture (ZTS) maturation, analyze the age distribution patterns of ZTS maturation stages, and investigate the relationship between ZTS and cervical vertebral maturation (CVM). Methods: A total of 261 patients who underwent cone-beam computed tomography (112 males, mean age, 13.1 ± 3.3 years; 149 females, mean age, 13.7 ± 3.1 years) were examined to evaluate the ZTS stages. The ZTS stages were defined based on a modified method from previous studies on zygomaticomaxillary sutures. Differences between groups and correlations between indicators were analyzed using the Spearman correlation test, intraclass coefficient of correlation (ICC), one-way analysis of variance and rank sum test. Statistical significance was set at p < 0.05. The diagnostic value of CVM stages in identifying ZTS maturation stages was evaluated using positive likelihood ratios (LRs). Results: A positive relationship was found between the ZTS and CVM stage (r = 0.747, ICC = 0.621, p < 0.01) and between the ZTS stage and chronological age (r = 0.727, ICC = 0.330, p < 0.01). Positive LRs > 10 were found for several cervical stages (CSs), including CS1 and CS2 for the diagnosis of stage B, CS1 to CS3 for the diagnosis of stages B and C, and CS6 for the diagnosis of stages D and E. Conclusions: The ZTS maturation stage may be more relevant to the CVM stage than to the chronological age. The CVM stages can be good indicators for clinical decisions regarding maxillary protraction, except for CS4 and CS5.

• Wind and Structures
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• v.6 no.2
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• pp.151-164
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• 2003

On the basis of the first Lyapunov stability theory, this paper develops a dynamic stability criterion for elastic structural systems under arbitrary dynamic loads, and shows the stability criterion using energy variation. After the dynamic stability criterion is validated through a classic example, it is used for the dynamic stability investigation of practical guyed masts under random wind loads. The criterion is reliable, simple and of advantage for structures with large number of elements and nodes. The slack guys and internal resonance between guys and mast are two main factors which induces the dynamic instability of guyed masts, at the same time, some dynamic stability characteristics of guyed masts are found.