• Title/Summary/Keyword: Tolerance level

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Altitude training as a powerful corrective intervention in correctin insulin resistance

  • Chen, Shu-Man;Kuo, Chia-Hua
    • Korean Journal of Exercise Nutrition
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    • v.16 no.2
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    • pp.65-71
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    • 2012
  • Oxygen is the final acceptor of electron transport from fat and carbohydrate oxidation, which is the rate-limiting factor for cellular ATP production. Under altitude hypoxia condition, energy reliance on anaerobic glycolysis increases to compensate for the shortfall caused by reduced fatty acid oxidation [1]. Therefore, training at altitude is expected to strongly influence the human metabolic system, and has the potential to be designed as a non-pharmacological or recreational intervention regimen for correcting diabetes or related metabolic problems. However, most people cannot accommodate high altitude exposure above 4500 M due to acute mountain sickness (AMS) and insulin resistance corresponding to a increased levels of the stress hormones cortisol and catecholamine [2]. Thus, less stringent conditions were evaluated to determine whether glucose tolerance and insulin sensitivity could be improved by moderate altitude exposure (below 4000 M). In 2003, we and another group in Austria reported that short-term moderate altitude exposure plus endurance-related physical activity significantly improves glucose tolerance (not fasting glucose) in humans [3,4], which is associated with the improvement in the whole-body insulin sensitivity [5]. With daily hiking at an altitude of approximately 4000 M, glucose tolerance can still be improved but fasting glucose was slightly elevated. Individuals vary widely in their response to altitude challenge. In particular, the improvement in glucose tolerance and insulin sensitivity by prolonged altitude hiking activity is not apparent in those individuals with low baseline DHEA-S concentration [6]. In addition, hematopoietic adaptation against altitude hypoxia can also be impaired in individuals with low DHEA-S. In short-lived mammals like rodents, the DHEA-S level is barely detectable since their adrenal cortex does not appear to produce this steroid [7]. In this model, exercise training recovery under prolonged hypoxia exposure (14-15% oxygen, 8 h per day for 6 weeks) can still improve insulin sensitivity, secondary to an effective suppression of adiposity [8]. Genetically obese rats exhibit hyperinsulinemia (sign of insulin resistance) with up-regulated baseline levels of AMP-activated protein kinase and AS160 phosphorylation in skeletal muscle compared to lean rats. After prolonged hypoxia training, this abnormality can be reversed concomitant with an approximately 50% increase in GLUT4 protein expression. Additionally, prolonged moderate hypoxia training results in decreased diffusion distance of muscle fiber (reduced cross-sectional area) without affecting muscle weight. In humans, moderate hypoxia increases postprandial blood distribution towards skeletal muscle during a training recovery. This physiological response plays a role in the redistribution of fuel storage among important energy storage sites and may explain its potent effect on changing body composition. Conclusion: Prolonged moderate altitude hypoxia (rangingfrom 1700 to 2400 M), but not acute high attitude hypoxia (above 4000 M), can effectively improve insulin sensitivity and glucose tolerance for humans and antagonizes the obese phenotype in animals with a genetic defect. In humans, the magnitude of the improvementvaries widely and correlates with baseline plasma DHEA-S levels. Compared to training at sea-level, training at altitude effectively decreases fat mass in parallel with increased muscle mass. This change may be associated with increased perfusion of insulin and fuel towards skeletal muscle that favors muscle competing postprandial fuel in circulation against adipose tissues.

Converged Influence of Professor Support on Academic Procrastination: Focused on the Mediation Effect of Academic Failure Tolerance (교수자 지지가 대학생의 학업적 지연행동에 미치는 융합적 영향: 학업적 실패내성의 매개효과)

  • Song, Seong-Suk;Ham, Hyun-Jin
    • Journal of the Korea Convergence Society
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    • v.12 no.3
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    • pp.225-235
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    • 2021
  • The purpose of this study is to verify the mediated effect of academic failure tolerance in the influence of professor support on academic procrastination of university students. A Google survey was conducted on 211 students at D University in Gyeonggi-do, and descriptive statistics, correlation analysis, and multiple regression were conducted using the SPSS program with collected data. The mediated effect of academic failure tolerance has been verified through three stages of regression analysis (Baron and Kenny) and Sobel Test. The results of the study are as follows; First, professor support has a negative correlation with academic procrastination, and a positive correlation with academic failure tolerance. In addition, there was a negative correlation between academic failure tolerance and academic procrastination. Second, it showed that academic failure tolerance has a full mediated effect in the influence of professor support on academic procrastination. This implies that it is necessary to create an educational environment that can raise the level of professor support and academic failure tolerance of university students in the academic situation. Therefore, this study suggested the need of providing a program of professor support that can improve academic procrastination problems and strengthen the academic failure tolerance of students.

The Relationship between Parenting Attitudes Perceived by Elementary School Students and Their Learned Helplessness: The Moderated Mediation Effect of Academic Failure Tolerance and Resilience (초등학생이 지각한 부모의 양육 태도와 학습된 무기력의 관계: 학업 실패 내성과 회복탄력성의 조절된 매개효과)

  • Choi, Hyun-Jung;Lee, Dong-gwi
    • Korean Journal of School Psychology
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    • v.16 no.2
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    • pp.189-205
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    • 2019
  • This study investigated the extent to which parental attitudes and the moderated mediation effect of academic failure tolerance and resilience affect their level of learned helplessness. The participants included 337 fifth and sixth graders in one elementary school in Chungju-si, Chungcheongbuk-do Province. A survey method was used and the research packet included measures of parenting attitudes, helplessness, academic failure tolerance, and resilience. The results are as follows. First, positive parental attitudes, academic failure tolerance, and resilience were positively correlated with each other whereas learned helplessness was negatively associated with the other three variables. Second, academic failure tolerance partially mediated the relationship between parental attitudes and learned helplessness. Third, resilience moderated the relationship between academic failure tolerance and learned helplessness. Lastly, there was a significant moderated mediation effect of resilience on the link between parental attitudes and learned helplessness through academic failure tolerance. The findings indicates the importance of parenting attitudes perceived by elementary school students, academic failure tolerance, and resilience when designing counseling interventions for those with learned helplessness. This study also discusses its limitations and suggestions for future studies.

Structural analysis of a planetary gear carrier in the slewing reducer for tower crane (타워크레인 선회감속기용 유성기어 캐리어의 구조해석)

  • Cho, Seung-Je;Han, Jeong-Woo;Park, Young-Jun;Lee, Geun-Ho
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.13 no.5
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    • pp.1-7
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    • 2014
  • In this paper the structural analysis of a planet carrier was carried out for the design optimization of a slewing reducer used in tower cranes. The stress changes of the planet carrier according to the tolerance of interference fit were investigated, and the strength was evaluated on the basis of the stress level. The analysis results showed that the tolerance of interference fit have an important influence on the stress level of the planet carrier. To guarantee the static safety of carrier, the tolerances of carrier pinhole and planet pin as well as loading level exerted on the planet carrier should be determined considered correctly.

Financial Debt Burden and Financial Stress (부채부담과 재무스트레스)

  • You, Soye;Park, Jooyung
    • Korean Journal of Human Ecology
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    • v.23 no.1
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    • pp.47-61
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    • 2014
  • The purpose of this study was to identify the relationship among financial debt burden, psychological factors and financial stress. Data was collected by surveying 450 individuals who were over twenty years old, and 384 were used for the analysis. As the result, first, number of sources of debt, use of each debt, marital status/double income, housing, debt amount and financial stress were found to be significantly different among three groups(debt free, non risky, risky). In addition, marital status/double income, gender, housing and income were found to significantly influence to the probability of being one of the three groups. Second, level of debt burden, age, employment and income were found to significantly influence to financial stress, while psychological factors such as risk tolerance and self-control were not. It might be noteworthy that people in debt were likely to have higher level of stress, while the older, employed, and having higher income were likely to have lower level of stress. This study would provide useful information in terms of debt policy to relieve the financial stress.

Fault Tolerant Operation of CHB Multilevel Inverters Based on the SVM Technique Using an Auxiliary Unit

  • Kumar, B. Hemanth;Lokhande, Makarand M.;Karasani, Raghavendra Reddy;Borghate, Vijay B.
    • Journal of Power Electronics
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    • v.18 no.1
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    • pp.56-69
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    • 2018
  • In this paper, an improved Space Vector Modulation (SVM) based fault tolerant operation on a nine-level Cascaded H-Bridge (CHB) inverter with an additional backup circuit is proposed. Any type of fault in a power converter may result in a power interruption and productivity loss. Three different faults on H-bridge modules in all three phases based on the SVM approach are investigated with diagrams. Any fault in an inverter phase creates an unbalanced output voltage, which can lead to instability in the system. An additional auxiliary unit is connected in series to the three phase cascaded H-bridge circuit. With the help of this and the redundant switching states in SVM, the CHB inverter produces a balanced output with low harmonic distortion. This ensures high DC bus utilization under numerous fault conditions in three phases, which improves the system reliability. Simulation results are presented on three phase nine-level inverter with the automatic fault detection algorithm in the MATLAB/SIMULINK software tool, and experimental results are presented with DSP on five-level inverter to validate the practicality of the proposed SVM fault tolerance strategy on a CHB inverter with an auxiliary circuit.

Effects of Multi-Extracts of Mori Folium and of Exercise on Plasma Insulin and Glucose Levels in Streptozotocin-Induced Diabetic Rats

  • Ko, Young-Cheol;Song, Kyung-Hee
    • Nutritional Sciences
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    • v.6 no.4
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    • pp.201-208
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    • 2003
  • This research was conducted to study the effects of the supplementation of multi-extracts of mori folium (MF) and of exercise on plasma insulin and glucose levels in streptozotocin (STZ)-induced diabetic rats. Eight male Sprague-Dawley rats, 4 weeks old, were assigned to each experimental group and were raised in the laboratory for 10 weeks. The animal groups consisted of a normal-control group, a STZ-control group, 3 STZ-induced diabetic groups supplemented ad libitum with various amounts of MF extracts (MF-720, MF-360, and MF-180 groups), and a STZ-induced diabetic group supplemented with MF-360 along with exercise. In the normal-control group, glucose tolerance tests resulted in the peak blood glucose level being achieved in 15 minutes and a fasting blood glucose level being achieved in 60 minutes. In the STZ-control group, the peak blood glucose level was reached after 60 minutes and, even after 90 minutes, blood glucose shown at a significantly higher level compared to the fasting levels. In the groups supplemented with MF extracts, the blood glucose level peaked after 30 minutes of glucose challenge, and returned to the fasting level after 90 minutes; the MF-360 and MF-360+exercise groups showed the best levels of glucose tolerance. Blood glucose levels in the STZ-induced diabetic groups were significantly higher compared to the normal-control group. However, after 7 weeks of supplementation with MF extracts, a significant lowering of blood glucose levels was observed in all groups supplemented with the MF extract. The best effect was observed in the group given MF extract combined with exercise. Compared to the normal-control group, blood insulin levels were significantly lower in all STZ-induced diabetic groups; however, a significantly higher level of insulin was observed in the groups given MF extracts compared to the STZ-control group. This study shows that the supplementation of MF extracts in STZ-induced diabetic rats resulted in increased blood insulin levels and lower blood glucose levels.

Changes of Cold Tolerance and it Mechanisms at Young Microspore Stage caused by Different Pre-growing Conditions in Rice (벼 수잉기내냉성의 전역조건에 따른 변동과 기구)

  • 이선용;박석홍
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.36 no.5
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    • pp.394-406
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    • 1991
  • It was proved that cold tolerance of rice plants at the young microspore stage was affected by water temperature and nitrogen application from the spikelet differentiation stage to the young microspore stage, and this mechanism could be explained in the point of view of pollen developmental physiology. The cold tolerance of rice plants at the young microspore stage was severely affected by water temperature (Previous water temperature) and nitrogen application(Previous nitrogen application) from the spikelet differentiation stage to the spikelet differentiation stage. Although the duration is only 10 days or so from the spikelet differentiation stage to the young microspore stage, these days are very important period to confirm the cold tolerance of rice plants at the young microspore stage. The higher previous water temperature up to $25^{\circ}C$ and the deeper previous water depth up to 10cm caused the more cold tolerance of rice plants. Water irrigation of 10cm before the cretical stage showed lower cool injury than that of water irrigation of 20cm during the critical stage. The preventive effect of cool injury by combined treatment of the deep water irrigation before and during the critical stage was not additive but synergistic. The cold tolerance of rice plants grown in previous heavy nitrogen level was rapidly decreased when nitrogen content of leaf blade at the young microspore stage was excessive over the critical nitrogen level. Nitrogen content of leaf blade at the changing point of cold tolerance was estimated as about 3.5% for Japonica cultivars and about 2.5% for Indica x Japonica cultuvars. It is considered that these critical nitrogen contents of leaf blade can be used as a index of the safe critical nitrogen level for the preventive practices to cool injury. It was summarized that increase of engorged pollens per anther by high previous water temperature resulted from the increase of number of differentiated microspores per anther, otherwise, the increase of engorged pollens by the decrease of previous nitrogen level was caused by the decrease of the number of aborted microspores per anther.

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Adaptive Intrusion Tolerance Model and Application for Distributed Security System (분산보안시스템을 위한 적응형 침입감내 모델 및 응용)

  • 김영수;최흥식
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.29 no.6C
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    • pp.893-900
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    • 2004
  • While security traditionally has been an important issue in information systems, the problem of the greatest concern today is related to the availability of information and continuity of services. Since people and organizations now rely on distributed systems in accessing and processing critical services and mission, the availability of information and continuity of services are becoming more important. Therefore the importance of implementing systems that continue to function in the presence of security breaches cannot be overemphasized. One of the solutions to provide the availability and continuity of information system applications is introducing an intrusion tolerance system. Security mechanism and adaptation mechanism can ensure intrusion tolerance by protecting the application from accidental or malicious changes to the system and by adapting the application to the changing conditions. In this paper we propose an intrusion tolerance model that improves the developmental structure while assuring security level. We also design and implement an adaptive intrusion tolerance system to verify the efficiency of our model by integrating proper functions extracted from CORBA security modules.

Resposes of Two Cold - Regulated Genes, BN28 and BN115, in Field -Grown Canola (Brassica napus L.) (포장에서 케놀라 저온반응성 유전자 발현)

  • Moontae, Song
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.40 no.1
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    • pp.69-76
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    • 1995
  • Cold acclimation involves changes in gene expression. BN28 and BN115 are two genes which are regulated by cold temperature and assumed having roles in cold acclimation. The objectives of this experiment was to explore the expression of BN28 and BN115 under field conditions. Six winter cultivars were planted at three different dates during the fall. The expression of the genes was determined by northern blot analysis of total RNA taken from leaves 15 to 30 day-intervals after planting. The expression of the two genes was detected within 15 days after planting well before onset of freezing tolerance in plants. This suggestes either their expression was a prerequisite of the freezing tolerance or their expression was regulated by other environmental factors as well as temperature. Two genes showed a different expression pattern suggesting they had a different regulatory system. Although timecourse increase in expression of the cold-regulated genes was matched with increase in freezing tolerance, the difference of expression in cultivar level at specific times of measurement was not correlated with freezing tolerance at the moment.

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