• 대한핵의학회지
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• 제36권3호
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• pp.203-208
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• 2002

만성간질환 환자에서 호흡곤란을 초래하는 간폐 증후군 발생한다는 사실은 잘 알려져 있다. 단락을 입증하기 위해서는 대비증강심초음파, 폐혈관조영술, $^{99m}Tc-MAA$ 폐관류스캔 등을 이용할 수 있다. 이 중에서도 $^{99m}Tc-MAA$를 이용한 폐관류스캔은 매우 안전하고 간편하게 단락의 존재 여부를 확인할 수 있으며, 단락의 양을 계산할 수도 있다. 정량이 가능하므로 병의 경과를 추적하는 지표로서도 유용할 것이다. 저자들은 $^{99m}Tc-MAA$ 폐관류스캔으로 진단한 간폐증후군의 증례를 문헌고찰과 함께 보고하였다.

• Journal of Pharmaceutical Investigation
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• 제39권3호
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• pp.201-205
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• 2009

Triglyceride solid lipid with medium chain fatty acid, tricaprin (TC), was used as a core matrix of lipid nanoparticles (LN) to solubilize water-insoluble paclitaxel and enhance the stability of nanoparticles by immobilization of incorporated drug in the solid core during storage at low temperature. In the present study, TC-LN containing paclitaxel was prepared by hot melt homogenization method using TC as a core lipid and phospholipids as stabilizers. The particle size of TC-LN containing paclitaxel was less than 200 nm and its zeta potential was around -40 mV. Calorimetric analysis showed TC core could be solidified by freezing and thawing in the manufacturing process in which the hot dispersion should be prepared at elevated temperature and subsequently cooled to obtain solid lipid nanoparticles. The melting transition of TC core was observed at $27.5^{\circ}C$, which was lower than melting point of TC bulk. The particle size of TC-LN remained unchanged when kept at $4^{\circ}C$. Paclitaxel containing TC-LN showed comparable anticancer activity to the Cremophore ELbased paclitaxel formulation against human ovarian (OVCAR-3) and breast (MCF-7) cancer cell lines. Thus, lipid nanoparticles with medium chain solid lipid may have a potential as alternative delivery system for parenteral administration of paclitaxel.

• 대한핵의학회지
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• 제26권2호
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• pp.380-391
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• 1992

This study was designed to evaluate a direct method of $^{99m}Tc$ labeling using $\beta-mercaptoethanol$ as a reducing agent, and to investigate whether $^{99m}Tc$ labeled specific monoclonal antibody against carcinoembryonic antigen (CEA-92) can be used for the scintigraphic localization of human colon cancer xenograft. Purified CEA-92 IgG was fragmented into F $(ab')_2$ and then labeled with $^{99m}Tc$ by transchelation method using glucarate as a chelator. Labeling efficiency, immunological reactivity and in vitro stability of $^{99m}Tc$ CEA-92 F $(ab')_2$ were measured and then injected intravenously into nude mice bearing human colon cancer (SNU-C4). Scintigrams were obtained at 24 hour after injection. Then nude mice were sacrificed and the radioactivity was measured Labeling efficiency of injected $^{99m}Tc$ CEA-92 F $(ab')_2$, immunoreative fraction and in vitro stability at 24 hour of injected $^{99m}Tc$ CEA-92 F $(ab')_2$ was 45.2%, 32.8% and 57.4%, respectively. At 24 hour after injection, % ID/g in kidney (46.77) showed high uptake, but %ID/g in tumor (1.65) was significantly higher than spleen (0.69), muscle (0.16), intestine (0.45), stomach (0.75), heart (0.48) and blood (0.45). There was no significant difference between tumor and liver (1.81). Tumor contrast as quantitated by tumor to blood ratio of $^{99m}Tc$ CEA-92 F $(ab')_2$ was increased significantly (p<0.005) until 24 hours (3.70), and there was no statistical differece from tumor to blood ratio of I-131 CEA-92 F $(ab')_2$. The scintigram demonstrated localization of radioactivity over transplanted tumor, but significant background radioactivity was also noted over kidney and abdomen. It is concluded that CEA-92 F $(ab')_2$ can be labeled with $^{99m}Tc$ by a direct transchelation method using $\beta-mercaptoethanol$ as a reducing agent and $^{99m}Tc$ labeled CEA-92 F $(ab')_2$ can be used for the scintigraphic localization of human colon cancer xenograft in nude mice model.

• 대한핵의학회지
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• 제26권1호
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• pp.140-146
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• 1992

$^{99m}Tc-Methionine$ complexes from enantiomeric and racemic methionines were prepared controlling reaction parameters such as pH and the concentration of stannous chloride. Some radiochromato-graphic systems were also examined to determine the labelling yields of $^{99m}Tc$ complexes. The best resolutions of $^{99m}Tc$ complexes were obtained at ITLC-SA developed with acetone and paper chromatography with n-butanol saturated with 0.3N HCI. In the former system, $HR-{99m}Tc$ and $^{99m}Tc-methionine$ complex remained at origin, while $^{99m}TcO_4^-$ moved with Rf value of 1.0. In latter process, $HR-^{99m}Tc$ stayed at the origin, while $^{99m}TcO_4^-\;and\;^{99m}Tc-methionine$ complexes moved with Rf value of 0.5. By combining of two chromatographic systems, the contents of three $^{99m}Tc$ species were calculated easily. $^{99m}Tc$ Labelling from enantiomeric and racemic methionines had little differences and the optimal condition was found at pH 9.00 and the molar ratio of methionine to stannous chloride of 24:1. The yields of $^{99m}Tc$ complexes from D-, L-, and DL-methionines were 87.6%, 94.1%, and 97.9%, respectively. The results indicated that methionine containing relatively hydrophobic methylthio group $(-SCH_3)$ would be labelled with $^{99m}Tc$ by stannous chloride method.

• 한국전기전자재료학회논문지
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• 제16권12S호
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• pp.1292-1298
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• 2003

In this paper, dc reactor lot the inductive high-Tc superconducting fault current limiter (SFCL) was optimally designed by finite element method(FEM). The Prototype high-Tc do reactor was manufactured and compared to the results of design. This dc reactor consists of 4∼stacked double pancake coils which are wounded with Bi-2223 wire coated with SUS315L. Kapton tape is used for the insulation of turn to turn and layer to layer. Each pancake is connected in series by soldering Finally, optimal design and manufacture method lot the dc reactor is suggested in this paper. Through the comparison of result of optimal design and experimental result of prototype high-Tc superconducting dc reactor, reliance on the design of the high-Tc dc reactor tot the 1.2 kV/80 A SFCL is proved.

• 한국표면공학회지
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• 제56권1호
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• pp.40-54
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• 2023

In this work, we synthesized a novel electrochemical sensing materials based on tetracarboxylic copper phthalocyanine (TcCuPtc) conjugated PANI (TcCuPtc@PANI). The synthesized materials were employed to modify the screen-printed carbon electrode (SPCE) for the selective sensing of 4-nitrophenol. The TcCuPtc was conjugated with conducting polymer of PANI through the electrostatic interaction and π-π electron conjugation, the polymer film of PANI to inhibit the leakage of TcCuPtc from the surface of the electrode. The prepared TcCuPtc@PANI were characterized and confirmed by scanning electron microscopy (SEM) with EDX, ATR-IR, UV-vis absorption spectroscopy, cyclic voltammetry, and differential pulse voltammetry techniques. The prepared TcCuPtc@PANI/SPCE showed an excellent electrocatalytic sensing of 4-NP in the linear concentrations from 3 to 500 nM with a LOD of 0.03 nM and a sensitivity of 8.8294 ㎂/nM cm^-2. However, the prepared TcCuPtc@PANI/SPCE showed selective sensing of 4-NP in the presence of other interfering species. The practical applicability of the TcCuPtc@PANI/SPCE was employed for the sensing of 4-NP in different water samples by standard addition method and showed satisfactory recovery results.

• 한국작물학회지
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• 제50권2호
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• pp.73-78
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• 2005

Demand for the domestic hairy vetch seed production will be increased with the increasing interest of environment-friendly agriculture in Korea. This study was conducted during from 2000 fall to 2003 spring at upland field of National Institute of Crop Science in Suwon, Korea to compare wheat and triticale (TC) as stake crop of hairy vetch (HV), and to know proper seeding rates and ratios between TC and HV for the maximum HV seed production. As supporting crop of HV, TC was superior to wheat at the points of higher HV seed yield, stronger TC stalk for supporting, consistence of ripening stage of two seeds. In seeding method, row seeding was superior to broadcast seeding at the points of less lodging and higher HV seed yield. HV seed yield decreased with the increase of TC seeding rate in mixture cropping (row seeding), particularly at TC seeding rates over 5kg/10a. HV seed yield increased with the increase of HV seeding rate at the condition of TC seeding rates under 5kg/10a in spite of higher lodging of mixed crops at higher HV seeding rate due to higher HV aboveground dry matter. Maximum HV seed yield was obtained at TC seeding rate of $1\~1.5kg/10a$ as indicating HV seed yield 176kg/l0a (CV. Madison) at seeding rate of TC 1kg/10a + HV 2 kg/10a in 2001, and HV seed yield 96kg/10a (CV. Common) at seeding rate of TC 1.5kg/10a + HV 4.5kg/10a in 2003. Use of all-purpose combine harvester for harvesting and appliance for separation of mixed seeds using centrifugal force, which are prerequisite for HV seed production, was excellent in the simultaneous seeds production system of HV and TC.

• 한국농공학회지
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• 제39권3호
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• pp.108-114
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• 1997

Concrete is said to have a high degree of extensibility when it is subjected to large deformations without cracking. The cracking behavior of concrete in the field may even be more complex. For example, in mass concrete compressive stresses are developed during the very early period when temperatures are rising, and the tensile stresses do not develop until at a later age when the temperature begins to decline. Actual cracking and failure depend on the combination of factors and indeed it is rarely that a single adverse factor is responsible for cracking of concrete. The importance of cracking and the minimum width at which a crack is considered significant depend on the conditions of exposure of the concrete. The ultrasonic pulse measurements can be used to detect the development of cracks in structures such as dams, and to check deterioration due to frost or chemical action. An estimate of the depth of a crack visible at the surface can be obtained by measuring the transit times across the crack for two different arrangements of the transducers placed on the surface. In this paper, the concrete cracks that artificially introduced crack width is 1 and 2mm, crack depth is 2, 4, 6, 8cm were measured by Tc-To Method In consequence, the measured depth was increased with increase of measuring distance from concrete crack. The most reliable results were shown when the introduced crack width was 1mm, and the measuring distance was 10cm from concrete crack.

• 한국콘텐츠학회논문지
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• 제5권5호
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• pp.133-139
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• 2005

교토대학 원자로실험소의 46-MeV 전자선형가속구를 이용하여 $^{99}Tc$의 중성자포획단면적을 중성자에너지 0.007 eV에서 47 keV에 걸쳐 중성자 비행시간법을 이용하여 측정을 하였다. 이 중성자포획 결과는 $^{10}B(n,\gamma)$반응의 중성자 반응 단면적에 상대적으로 얻어졌다. 얻어진 결과를 확인하기 위해서 교토대학 원자로실험소의 납감속장치를 이용한 결과를 확인하였다. TOF방법으로 얻어진 결과는 0.0253 eV에서의 결과(20.01 b)에 규격화되었다. 기존의 실험결과들과 평가결과들인 ENDF/B-VI, JENDL-3.2, and JEF-2.2은 본 연구에서 TOF와 납감속장치로 얻어진 결과들과 비교 및 검토하였다.

• 핵의학기술
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• 제13권3호
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• pp.61-66
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• 2009

목적: 사구체여과율(Glomerular Filtration Rate, GFR)은 신장 기능의 평가, 의심되는 신장질환의 진단 및 만성적인 신질환에서의 질병의 경과 관찰에 중요한 지표가 되며 다양한 방법을 이용하여 측정할 수 있다. 본 연구에서는 Gates 방법으로 측정되는 사구체여과율, 혈청 크레아티닌을 기초로 한 Cockcroft-Gault (C-G), Modification of Diet in Renal Disease (MDRD) 공식으로 계산한 사구체여과율을 비교하고자 하였다. 실험재료 및 방법: 18세 이상의 다양한 신기능을 가진 217명(남자 127명, 여자 90명, 평균 연령 $51.3{\pm}16.9$세)을 대상으로 하였다. $^{99m}Tc$-DTPA GFR과 혈청 크레아티닌(Serum Cr)을 기초로 한 C-G공식, MDRD 공식으로 계산한 사구체여과율을 비교 분석하였다. 결과: $^{99m}Tc$-DTPA (Gates) GFR은 C-G공식(r=0.864, p<0.0001) 및 MDRD 공식(r=0.831, p<0.0001)과 각각 유의한 상관관계가 있었고, C-C 공식과 MDRD 공식을 이용한 사구체 여과율 사이에도 상관관계가 우수하였다(r=0.933, p<0.0001). 혈청 크레아티닌의 평균은 $3.0{\pm}3.1\;mg/dL$으로 정상 신기능(Scr<1.5mg/dL) 환자에서 $^{99m}Tc$-DTPA GFR (Gates)과 C-G공식(p<0.0001), MDRD 공식(p<0.0001)은 통계적으로 유의하였다. 경증 신부전(Scr 1.5~4.0 mg/dL) 환자에서 Tc-99m DTPA (Gates) GFR과 C-G 공식(p=0.181), MDRD 공식(p=0.127)은 유의한 차이는 없었다. 중증 신부전(Scr>4.0 mg/dL) 환자에서 $^{99m}Tc$-DTPA (Gates) GFR과 C-G 공식(p<0.0001), MDRD 공식(p<0.0001)은 통계적으로 유의하였다. 결론: Gates 방법을 이용한 사구체여과율, C-G, MDRD 공식으로 계산한 사구체여과율 사이에 유의한 상관관계를 확인하였다. 정상 신기능 환자에서 $^{99m}Tc$-DTPA (Gates) GFR은 C-G, MDRD 공식보다 각각 낮았다. 경증 신부전 환자에서 $^{99m}Tc$-DTPA (Gates) GFR과 C-G 공식, MDRD 공식으로 계산한 사구체여과율은 유사하였고, 중증 신부전 환자에서 $^{99m}Tc$-DTPA (Gates) GFR은 C-G, MDRD 공식에 비해 사구체여과율을 과대평가하였다. 신기능의 정도에 따라 사구체여 과율을 평가하는데 있어 어떠한 측정방법이 더 우월한지는 분명하지 않다.