• Proceedings of the Korea Water Resources Association Conference
• /
• 2019.05a
• /
• pp.334-334
• /
• 2019

기후변화에 능동적으로 대처하기 위해서는 기후변화에 따른 수자원가용량의 변화를 정량적으로 평가할 수 있어야 한다. 평가결과의 신뢰도를 높이기 위해서 기후변화 시나리오는 지역기후 및 유역특성에 적합한 결과를 포함하여야 한다. 또한, 기후변화가 유역의 물순환계에 미치는 영향이 있다면, 물순환 개선 기술을 통해 지속가능한 유역 물환경을 구축하는 것이 필요하다. 유역 물순환 개선 기술은 기후변화가 진행 중에 있거나 예상되는 지역에 대하여 강우로부터 발생되는 유출을 지연, 저류, 침투시켜 지속가능한 물순환 체계를 유지하고 회복하도록 하는 기법이라 할 수 있다. 한국건설기술연구원에서는 기후변화에 따른 영향을 평가하고 적응 대책을 수립하기 위한 실무적인 유역 물순환 개선 및 평가 모형인 CAT3(Catchment hydrologic cycle Assessment Tool 3)을 개발하였으며 본 모형은 침투시설, 저류시설, 습지, 빗물저장시설과 같은 물순환 개선시설에 대한 효과를 정량적으로 평가할 수 있다. 본 연구에서는 팔당댐 상류의 경안천 유역을 대상으로 APCC 기후변화 시나리오 통계적 상세화 자료를 활용하여 물순환 개선 기술의 적용성을 평가하였다. 통계적 상세화 자료는 APCC에서 개발된 AIMS(APCC Integrated Modeling Solution) 플랫폼을 이용하였다. AIMS는 다양한 기후정보를 기반으로 사용자 관점에서 상세화를 수행할 수 있는 장점이 있다. 상세화 기법은 SDQDM(Spatial Disaggregation Quantile Delta Mapping) 방법을 이용하였다. 상세화된 기후자료는 과거자료의 재현성 및 미래 기간에 대한 왜곡도를 평가하기 위해 극한기후지수(Climate Index)를 이용하는데 본 연구에서는 장기간에 걸친 수자원가용량의 평가 및 예측을 위해 연강수량(PRCPTOT)을 사용하였으며 증발산량의 평가 및 예측에 영향을 미치는 온도 관련 극한기후지수는 평균기온 개념의 DTR(TMAX&TMIN)을 이용하였다. 통계적 상세화 과정을 통해 최종적으로 HadGEM2-CC, INMCM4, CanESM2 시나리오를 선택하였으며 각 시나리오별 물순환 개선 기술을 적용한 후 미래의 수문학적 변동성을 평가하였다.

• YAKHAK HOEJI
• /
• v.44 no.5
• /
• pp.440-447
• /
• 2000

Microspheres of felodipine, which is one of the calcium channel blocker using a mixture of Eudragi $t^{R}$ RL, L, E, and cellulose on the base of Eudragi $t^{R}$ RS were investigated. Cremopho $r^{R}$ was added to each preparation of polymers in order to increase the release of felodipine from microspheres. Felodipine-loaded microspheres were prepared by a solvent evaporation method, which is based on dispersion of methylene chloride containing felodipine and polymers in 0.5 w/v % polyvinyl alcohol solution. The average diameter based on the size distribution of the felodipine-loaded microspheres was observed to be ca. 40-55 ${\mu}{\textrm}{m}$. A good and smooth surface were showed in all types of the microspheres. The amount of felodipine loaded was over 90 w/w % in all types of microspheres. The dissolution profiles of felodipine from microspheres were similar with each type of polymer, and about a 60 w/w % of the total amount of felodipine loaded to microsphere was released within 7 hours. Dissolution rate of felodipine from the microsphere was increased by addition of Cremophor. After oral administration of the felodipine-loaded microspheres in PVA solution and felodipine alone in PEG solution to rats, respectively, the pharmacokinetic study revealed that the Tmax values of the microspheres were observed in the range of 0.67~l.0 hr while that of the felodipine solution was obtained 0.33 hr. In addition, the AUC of the microspheres at 0 to 7 hr was remarkably increased in comparison to that of felodipine solution. These results revealed that the microspheres based on Eudragit RS could be a good candidate for the controlled release drug delivery system for felodipine.e.e.e.

• Journal of Animal Environmental Science
• /
• v.6 no.3
• /
• pp.175-184
• /
• 2000

A lab-scale MF membrane reactor was installed to investigate the membrane permeability, characteristics of membrane fouling at each conditions, and quality of permeate (liquid livestock manure) in the separation of solid-matters using membrane. Experiment was divided three filtration type such as follows; continuous filtration, gravity filtration, and intermittent filtration. As a result of experiment, flux 1 LMH was maintained for 7days, and trans-membrane pressure(TMP) was increased gradually under 10cmHg, but it was increased immediately after 10cmHg, respectively. However, the flux was increased, the Tmax was decreased exponential more and more. During the pure-flux test, most of the fouling of membrane was reversible. At the gravity filtration, permeate could be obtained as 1.75 LMH for 3.5days without any other electronic pressure. As an investigation of membrane surface, this study could be decided that the reason of fouling at the lower flux (Run 1 and 2) was attached matters in membrane surface, but at the higher flux (Run 4-6) was concentration polarization.

• The Korean Journal of Nuclear Medicine Technology
• /
• v.19 no.2
• /
• pp.81-86
• /
• 2015

Purpose This study was to evaluate the usefulness through the comparison of patients group and healthy control group by acquiring a variety of functional parameters index from time-activity curves of salivary gland scintigraphy using $^{99m}Tc$. Materials and Methods From December 2014 to February 2015 with the targets of 30 patients in the patient group who presented themselves with xerostomia and underwent the salivary gland scan and 10 people in healthy control group, approximately 30 minutes of dynamic Scan was carried out after the intravenous bolus injection of 370 MBq of $^{99m}TcO_4{^-}$ and per os stimulation with Vitamin C powder 20 minutes after the injection. The method of quantitative analysis was as follows, the time-activity curve was drawn after the parotid gland and submandible gland were prescribed as a region of interest, a variety of functional parameters index was obtained in each position of the curve, and the patients group and the control group were compared. Results As for the methods applied in comparison and measurement, uptake ratio (UR), time at maximum counts (Tmax), time at minimum counts (Tmin), maximum accumulation (MA), accumulation velocity, maximum secretion (MS), maximum stimulation secretion (MSS), and secretion velocity (SV) were used. In the comparison of functional parameters index of patient group and normal group, the healthy normal group showed significant difference compared to the patient group in all indices except for the minimum radioactivity time (Tmin), and also in terms of variation over time the normal group showed significant difference compared to the patient group (p<0.05). Conclusion Consequently, it was considered that the quantitative analysis that used a variety of functional parameters index would be useful for evaluating the function of the salivary glands of the patients with xerostomia as an objective and standardized information.

• The Korean Journal of Nuclear Medicine Technology
• /
• v.17 no.2
• /
• pp.3-9
• /
• 2013

Purpose: Currently commercially available phantom can reproduce and evaluate only a static situation, the study is incomplete research on phantom and system which is can confirmed functional situation in the kidney by time through dynamic phantom and blood flow velocity, various difference according to the amount of radioactive. Therefore, through this study, it has produced the dynamic kidney phantom to reproduce images through the dynamic flow of the kidney, it desire to evaluate the usefulness of nuclear medicine imaging. Materials and Methods: The production of the kidney phantom was fabricated based on the normal adult kidney, in order to reproduce the dynamic situation based on the fabricated kidney phantom, in this study it was applied the volume pump that can adjust the speed of blood flow, so it can be integrated continuously radioactive isotopes in the kidney by using $^{99m}Tc-pertechnate$. Used the radioactive isotope was supplied through the two pump. It was confirmed the changes according to the infusion rate, radioactive isotopes and the different injection speeds on the left and right, analysis of the acquired images was done by drawn ten times ROI in order to check the reproducibility of each on the front and rear of the kidney and bladder. Results: Under the same conditions infusion rate 40 mL/min fixed to adjust the pressure of the pump when the radiopharmaceuticals between 2-3 minutes in the most integrated in the kidney phantom was excreted inthe bladder. Glomerular filtration rate (GFR), respectively, by each device SYMBIA 1,091 mL/min, FORTE 1,232 mL/min, ARGUS 1,264 mL/min, INFINIA 1,302 mL/min in that there isno statistically significant difference was found, Tmax values and T1/2 values stars from all equipment with no statistically significant difference was found. CV values of the coefficient of variation less than 5% was found to be repeatable, and to 2.67% of the lowest SYMBIA appeared, INFINIA was the highest in the 4.86%. Conclusion: Through this study, the results showed that the dynamic kidney phantom system is able to similarly reproduce renogram in the actual clinical. Especially, the depicted over time for the flow to be excreted through the kidney into the bladder was adequately reproduce, it is expected to be utilized as basic data to check the quality of the dynamic images. In addition, it is considered to help in the field of functional imaging and quality control.

• Journal of the Korean Geographical Society
• /
• v.36 no.3
• /
• pp.247-257
• /
• 2001

The relationships between the distribution of 132 species, 61 genera evergreen broad-leaved trees and shrubs(EBTS) and climatic factors have discussed. The distributional patterns of EBTS were categorized into seven groups on the basis of the number of distributing sites, distributional attitudes and latitudes. Out of seven group. the cold-tolerant EBTS were common at groups I and II, along tilth Empetrum nigrum var. japonicum. Diapensia lapponics subsp. obovata of group III. However, the warmth-tolerant EBTS were rich at groups III. IV V, and VI The lower distributional limits of cold-tolerant EBTS in the groups I and UU decreased as one moves toward south. The upper distributional limit of warmth-tolerant EBTS in the groups III, IV and V decreased with increasing latitude. However. no clear distributional tendency is noticed in the groups VI and VII. The range of warmth-tolerant EBTS appear to show close relationship with the January mean temperature -4 $\^{C}$ and January mean minimum temperature -9$\^{C}$ than others. On the other hand, that of the cold-tolerant EBTS seem to respond well to the August mean temperature 19$\^{C}$ and August mean maximum temperature 26$\^{C}$ than others.

• Journal of Society of Preventive Korean Medicine
• /
• v.17 no.2
• /
• pp.139-155
• /
• 2013

Purpose : This study was aim to evaluate effects of pharmacodynamics and toxicity in combination therapy of donepezil with Gongjindan. The effects of Gongjindan co-administration on the pharmacokinetics (PK) of donepezil were observed after single and 7-day repeated oral co-administration with 1.5hr-intervals, to evaluate synergic pharmacodynamics and reduce toxicity of combination therapy of donepezil with Gongjindan. Materials and Methods : After 10mg/kg of donepezil treatment, Gongjindan100mg/kg was administered with 1.5hr-intervals. The plasma were collected at 30min before administration, 30min, 1, 2, 3, 4, 6, 8 and 24hrs after end of first and last 7th donepezil treatment, and plasma concentrations of donepezil were analyzed using LC-MS/MS methods. Results : Gongjindan markedly inhibited the absorption of donepezilregardless of sample time, from 30min to 8hrs after end of first 1.5hr-interval co-administration as compared with donepezil single treated rats. Especially the absorption of donepezil was significantly decreased at 2, 4, 6 and 8hrs after co-administration as compared with donepezilsingle treated rats. Accordingly, the Cmax (-26.236%), $AUC_{0-t}$(-26.02%) and $AUC_{0-inf}$(-25.90%) of donepezil in 1.5hr-interval co-administered rats were dramatically decreased as compared with donepezilsingle treated rats, respectively. However, no meaningful changes on the plasma donepezil concentrations and pharmacokinetic parameters were detected after end of last 7th 1.5hr-interval co-administration as compared with donerezil single treated rats, except for non-significant slight increases of Tmax(16.67%) detected in co-administered rats as compared with donepezil single treated rats. Conclusion : These findings are considered as direct evidences that Gongjindan also decreased oral bioavailability of donerezil as inhibited the absorptions, when they were co-administered with 1.5hr-intervals, but they may be adapted after 7 days continuous repeated l.5hr-interval co-administration.

• Toxicological Research
• /
• v.20 no.3
• /
• pp.195-203
• /
• 2004

4-Tert-Octylphenol (OP) is a surfactant additive widely used in the manufacture of a variety of detergents and plastic products. OP can disrupt endocrine function in humans and animals. This study was carried out to obtain toxicokinetic parameters of OP in male Sprague-Dawley (SD) rats. Male rats were administered with OP by single oral application of 200 mg/kg body weight. Blood, urine and tissues samples were taken at several time intervals after administration. Analysis of samples for OP was performed by column-switching high performance liquid chromatography (HPLC). In addition, we exam-ined tissue distribution and accumulation of OP after single oral application of 50, 100, and 200 mg/kg, single intravenous injection of 1, 5 and 10 mg/kg or daily application of 50 mg/kg for 14 consecutive days. After single oral administration of 200 mg/kg, Cmax of 213 $\pm$ 123 ng/ml was reached within the first 1.3 hr (Tmax) in the plasma. AUC was calculated for 1,333$\pm$484 ngㆍhr/ml. The final elimination half-life of plasma was longer than that of urine, but urinary clearance was lower than oral. A very small fraction of OP (Fe < 0.0017%) was excreted in urine within 24 hr. These results indicated that the major excretion route of OP was not urine. The mean maximal tissue distribution of OP was obserbed at 6 hr after treatment and slowly decreased time-dependently. High OP concentrations were detected in fat at 24 hr. The OP in fat was slowly released with longer elimination half-life and lower clearance than that of other tissues. OP was not accumulated in the liver following single oral application but 14-day oral treatments resulted in two-fold accumulation. It was probably due to the saturation of detoxification pathways. On the other hand, the mRNA expression of cytochrome P450 isoforms except CYP2C11 was not affected by OP at any dose. The expression of CYP2C11 mRNA decreased in a dose-dependent manner. This result suggests that OP changes expression of the male-specific cytochrome P450 isoforms in rat liver, and these changes are closely related to the toxic and estrogenic effect of OP.

• The Korean Journal of Petroleum Geology
• /
• v.7 no.1_2 s.8
• /
• pp.35-40
• /
• 1999

Chemical and isotopic compositions of hydrocarbon gases were analyBed to characterize the properties of the shallow gases distributed in the southeastern part of the Ulleung Basin, offshore Korea. Sediments from the core were also analyzed to determine the characteristics and relationship to shallow gases. Hydrocarbon gases in the sediments consisted of methane (697.9-6054.4 ppm), ethane, propane, butane and hexane. The total carbon content of the sediments ranges from 1.84fe to $5.11{\%}$ and the total organic carbon content ranges from $0.29{\%} \;to\; 2.65{\%}$. High C/N ratio (>10) indicates that input of terrestrial organic matter was prevalent at the time of deposition. The methane content and stable isotopic data indicate that hydrocarbon gases from the sediments are identified to be thermogenic gas and mixture of both biogenic and thermal gases. Based on the Rock-Eval and carbon isotopic data, the level of thermal maturity of organic matter in the sediments $(Tmax<425^{\circ}C)$ is lower than that of gas. It suggests that thermal gases in the sediments migrated from the deeper sediments than the penetrated depth.

• The Korean Journal of Nuclear Medicine
• /
• v.31 no.4
• /
• pp.427-432
• /
• 1997

Re-188 is useful candidate for therapeutic radionuclide because it has a physical half life of 17 hours, contains beta emissions suitable for therapy(maximum energy 2.12MeV) and emits a gamma ray that is suitable for quantitative diagnostic scanning(155keV). To use Re-188 as a radionuclide compound of angioplasty balloon radiotherapy, we investigated the labelling method and biodistribution of Re-188-DTPA We postulated that labeled Re-188-DTPA is preferable because it would be excreted via urinary system more easily than other compounds. To label Re-188 with DTPA, 1ml of 222MBq(6mCi) of Re-188 was added to DTPA solution(DTPA 20mg, $SnCl_2{\cdot}2H_2O$ 10mg, pH 3.5) and boiled at $100^{\circ}C$ for 120min in water bath. pH was adjusted to 5 with 2.3% sodium acetate. Labeling efficiency was measured using TLC-SG(acetone, saline). We evaluated biodistribution of Re-188-DTPA in sacrificed mice at 10 and 60 minutes after injection. We acquired images of kidneys, and drew time-activity curves in normal dogs and rats and calculated Tmax and Tl/2 in rats. The labelling efficiency was 95.7% on average. Labelling of Re-188-DTPA was.stable(90% after 5hours) in vitro at room temperature. According to time-activity curves of dogs and rats, it took 15 to 20 minutes after injection for Re-188-DTPA to be washed out through kidneys. In conclusion, Re-188-DTPA was successfully labeled, Re-188-DTPA was stable in vitro and was excreted early via kidneys in animals. We could recommend Re-188-DTPA as radionuclide of potential use in angioplasty balloon radiotherapy.