• Korean Journal of Radiology
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• 제22권7호
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• pp.1185-1193
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• 2021

Objective: Clear cell sarcoma of the kidney (CCSK) is the second-most common but extremely rare primary renal malignancy in children after Wilms' tumor. The aims of this study were to evaluate the imaging features that could distinguish between CCSK and Wilms' tumor and to assess the features with diagnostic value for identifying CCSK. Materials and Methods: We reviewed the initial contrast-enhanced abdominal-pelvic CT scans of children with CCSK and Wilms' tumor between 2010 to 2019. Fifty-eight children (32 males and 26 females; age, 0.3-10 years), 7 with CCSK, and 51 with Wilms' tumor, were included. The maximum tumor diameter, presence of engorged perinephric vessels, maximum density of the tumor (Tmax) of the enhancing solid portion, paraspinal muscle, contralateral renal vein density, and density ratios (Tmax/muscle and Tmax/vein) were analyzed on the renal parenchymal phase of contrast-enhanced CT. Fisher's exact tests and Mann-Whitney U tests were conducted to analyze the categorical and continuous variables, respectively. Logistic regression and receiver operating characteristic curve analyses were also performed. Results: The age, sex, and tumor diameter did not differ between the two groups. Engorged perinephric vessels were more common in patients in the CCSK group (71% [5/7] vs. 16% [8/51], p = 0.005). Tmax (median, 148.0 vs. 111.0 Hounsfield unit, p = 0.004), Tmax/muscle (median, 2.64 vs. 1.67, p = 0.002), and Tmax/vein (median, 0.94 vs. 0.59, p = 0.002) were higher in the CCSK compared to the Wilms' group. Multiple logistic regression revealed that engorged vessels (odds ratio 13.615; 95% confidence interval [CI], 1.770-104.730) and Tmax/muscle (odds ratio 5.881; 95% CI, 1.337-25.871) were significant predictors of CCSK. The cutoff values of Tmax/muscle (86% sensitivity, 77% specificity) and Tmax/vein (71% sensitivity, 86% specificity) for the diagnosis of CCSK were 1.97 and 0.76, respectively. Conclusion: Perinephric vessel engorgement and greater tumor enhancement (Tmax/muscle > 1.97 or Tmax/vein > 0.76) are helpful for differentiating between CCSK and Wilms' tumor in children aged below 10 years.

• 한국세라믹학회지
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• 제34권6호
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• pp.620-628
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• 1997

The possibility of the existence of a field-induced micro-macrodomain switching was proposed and examined using 9 mol % PbZrO3-doped 0.6Pb(Ni1/3Nb2/3)O3-PbTiO3 (PNN-PT) systems having rhombohedral symmetry at room temperature. the thermally depoled (freshly prepard) specimens prepared from the rhombohedral side of the system exhibited a relaxor behavior for the whole range of temperature examined (for T

• Biomolecules & Therapeutics
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• 제8권3호
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• pp.262-268
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• 2000

The bioequivalence of two tiropramide products was evaluated in 18 health male volunteers following oral administration. Test product was Tira $m^{R}$ tablet (Shin Poong SP-102) (Shin Poong Pharm. Co., Ltd.) and reference product was Tirop $a^{R}$ tablet (Dae Woong Pharm. Co., Ltd.) One capsule of the test and reference product containing 100 mg of tropramide.hydrochloride was administered to the volunteers by randomized two period cross-over study (2 $\times$ 2 Latin square method). The drug concentration in plasma was determined by GC/MS for over a period of 12hours after administration. Analysis of variance reveal that there are no differences in AUC (area under the plasma concentration-time curve from time zero to infinity), Cmax (maximum plasma concentration) and Tmax (time to reach Cmax). The differences of mean AUC, Cmax and Tmax between two products were 3.85, 1.47 and -3.6%, respectively. Minimum detectable differences (%) at $\alpha$=0.1 were all less than 20% given as a guideline (18.07, 17.00 and 20.69% for AUC, Cmax and Tmax, respectively). From these results, the two products are bioequivalent.ent.

• Biomolecules & Therapeutics
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• 제6권4호
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• pp.417-422
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• 1998

Loxoprofen sodium (sodium 2-[4-(2-oxocyclopentylmethyl)phenyl] propionate dehydrate) is a nonsteroidal antiinflammatory drug of $\alpha$-phenyl propionic acid derivative. To test the bioequivalence of loxoprofen, the pharmacokinetic parameters of new preparation of loxoprofen, LENOX was compared with LOXONIN as a reference drug. Fourteen healthy volunteers were entered to the stydy (Yonsei University College of Medicine, Severance Hospital IRB approval No. 9608). They were administered 60 mg of loxoprofen in 2$\times$2 cross-over design. There was one week of drug-free interval between doses. The blood sample was taken on schedule up to 8 hours, and the plasma concentration loxoprofen was measured by reverse phase high-performance liquid chromatography (HPLC) with UV-detector. There were no significant difference between two preparations when AUC, Cmax, and Tmax were compared by ANOVA. The mean differences of AUC, Cmax, and Tmax were within 20% of the reference drug: the values were 2.22,5.61, and 12.50%, respectively. The confidence limits of AUC and Cmax but not Tmax satisfied the bioequivalence criteria. These results suggest that the tested LENOX is bioequivalent to the reference drug.

• 농업과학연구
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• 제3권2호
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• pp.207-213
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• 1976

최대습윤밀도(最大濕潤密度)로서 함수비시험(含水比試驗)을 하지 않고 직접최적합수비(直接最適合水比)와 최대건록밀도(最大乾綠密度)를 추정(推定)하는 관계식(關係式)을 구(求)하기 위(爲)하여 전국(全國)에서 최근(最近)에 공사(工事)를 실시(實施)하였거나 또는 공사중(工事中)에 있는 157개(個) 지구(地區)의 다짐시험(試驗) 결과(結果)를 분석(分析)하여 다음과 같은 결론(結論)을 얻었다. 최대건조밀도(最大乾燥密度)와 최적합수비(最適合水比)의 사이에는 ${\gamma}=0.9636$의 높은 상관성(相關性)을 나타냈고 ${\gamma}_{dmax.}={\frac{1}{0.4193+0.00937W_{opt.}}$의 관계식(關係式)을 얻었다. 최적합수비(最適合水比)에 대응(對應)하는 습윤밀도(濕潤密度)와 최적합수비(最適合水比)는 $W_{opt.}={\frac{1-0.4193{\gamma}_{tmax.}}{0.937_{\gamma}_{tmax.}-0.01}$의 관계식(關係式)을 얻었고 최대습윤밀도(最大濕潤密度)(${\gamma}_{tmax}$)로 추정(推定)한 최적합수비(最適合水比)는 실측치(實測値)와 큰 차이(差異)가 없었다. 최대습윤밀도(最大濕潤密度)로 추정(推定)한 함수비(含水比)에 의하여 최대건조밀도(最大乾燥密度)를 추정(推定)한 결과실측치(結果實測値)와의 오차(誤差)는 ${\pm}5%$내(內)에 속했다. 최대건조밀도(最大乾燥密度)와 공극비(空隙比)는 ${\gamma}=0.9706$의 높은 상관성(相關性)이 인정(認定)되고 ${\gamma}_{dmax.}={\frac{1}{0.3938+0.3426e}}$의 관계식(關係式)을 얻었다.

• 한국국방경영분석학회:학술대회논문집
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• 한국국방경영분석학회 2005년도 추계학술대회 발표 논문집 1분과 : IT 응용
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• pp.89-114
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• 2005

• 정보과학회지
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• 제25권1호
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• pp.27-33
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• 2007

• 정보처리학회지
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• 제12권3호
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• pp.117-124
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• 2005

• The Journal of Advanced Prosthodontics
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• 제9권4호
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• pp.294-301
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• 2017

PURPOSE. Temperature increase of $5.5^{\circ}C$ can cause damage or necrosis of the pulp. Increasing temperature can be caused not only by mechanical factors, e.g. grinding, but also by exothermic polymerization reactions of resin materials. The aim of this study was to evaluate influences of the form material on the intrapulpal temperature during the polymerization of different self-curing resin materials for temporary restorations. MATERIALS AND METHODS. 30 provisonal bridges were made of 5 resin materials: Prevision Temp (Pre), Protemp 4 (Pro), Luxatemp Star (Lux), Structure 3 (Str) and an experimental material (Exp). Moulds made of alginate (A) and of silicone (S) and vacuum formed moulds (V) were used to build 10 bridges each on a special experimental setup. The intrapulpal temperatures of three abutment teeth (a canine, a premolar, and a molar,) were measured during the polymerization every second under isothermal conditions. Comparisons of the maximum temperature ($T_{Max}$) and the time until the maximum temperature ($t_{TMax}$) were performed using ANOVA and Tukey Test. RESULTS. Using alginate as the mould material resulted in a cooling effect for every resin material. Using the vacuum formed mould, $T_{Max}$ increased significantly compared to alginate (P<.001) and silicone (P<.001). In groups Lux, Pro, and Pre, $t_{TMax}$ increased when the vacuum formed moulds were used. In groups Exp and Str, there was no influence of the mould material on $t_{TMax}$. CONCLUSION. All of the mould materials are suitable for clinical use if the intraoral application time does not exceed the manufacturer's instructions for the resin materials.

• 한국임상수의학회지
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• 제37권1호
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• pp.28-33
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• 2020

The aims of this study were to obtain the normal ranges of enhancement parameters for salivary gland in dynamic CT and to investigate the effects of fasting time on contrast enhancement in clinically normal beagle dogs. With five healthy beagle dogs, dynamic CT examination was performed according to fasting times (as fasting times, 12hours, 0 min, 20 min, 40 min, 1 hours, 6 hours, 24 hours). In normal beagles with 12hours fasting, enhancement parameters through the preliminary study were as follows: ImaxA - 472 .49 ± 19.01 HU; ImaxS - 138.95 ± 6.2 5 HU; TmaxA - 25.8 ± 1.79 sec; TmaxS - 69.0 ± 23.11 sec; Teq - 80.5 ± 6.61 sec; T-Aeq - 54.5 ± 5.51 sec (Imax - peak enhancement; Tmax - time to peak enhancement; Teq - time to equilibrium phase; T-Aeq - time between peak enhancement in the common carotid artery and onset of the equilibrium phase; A - common carotid; S - submandibular gland; HU - Hounsfield unit). Additionally, ImaxA and ImaxS were significantly increased in 40 min after eating. Because these results associated with postprandial hemodynamic changes can make the diagnosis of salivary gland diseases more difficult, sufficient fasting time is important for accurate diagnosis.