• Journal of the Korean Ceramic Society
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• v.34 no.6
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• pp.620-628
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• 1997

The possibility of the existence of a field-induced micro-macrodomain switching was proposed and examined using 9 mol % PbZrO3-doped 0.6Pb(Ni1/3Nb2/3)O3-PbTiO3 (PNN-PT) systems having rhombohedral symmetry at room temperature. the thermally depoled (freshly prepard) specimens prepared from the rhombohedral side of the system exhibited a relaxor behavior for the whole range of temperature examined (for T

• Biomolecules & Therapeutics
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• v.8 no.3
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• pp.262-268
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• 2000

The bioequivalence of two tiropramide products was evaluated in 18 health male volunteers following oral administration. Test product was Tira $m^{R}$ tablet (Shin Poong SP-102) (Shin Poong Pharm. Co., Ltd.) and reference product was Tirop $a^{R}$ tablet (Dae Woong Pharm. Co., Ltd.) One capsule of the test and reference product containing 100 mg of tropramide.hydrochloride was administered to the volunteers by randomized two period cross-over study (2 $\times$ 2 Latin square method). The drug concentration in plasma was determined by GC/MS for over a period of 12hours after administration. Analysis of variance reveal that there are no differences in AUC (area under the plasma concentration-time curve from time zero to infinity), Cmax (maximum plasma concentration) and Tmax (time to reach Cmax). The differences of mean AUC, Cmax and Tmax between two products were 3.85, 1.47 and -3.6%, respectively. Minimum detectable differences (%) at $\alpha$=0.1 were all less than 20% given as a guideline (18.07, 17.00 and 20.69% for AUC, Cmax and Tmax, respectively). From these results, the two products are bioequivalent.ent.

• Biomolecules & Therapeutics
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• v.6 no.4
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• pp.417-422
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• 1998

Loxoprofen sodium (sodium 2-[4-(2-oxocyclopentylmethyl)phenyl] propionate dehydrate) is a nonsteroidal antiinflammatory drug of $\alpha$-phenyl propionic acid derivative. To test the bioequivalence of loxoprofen, the pharmacokinetic parameters of new preparation of loxoprofen, LENOX was compared with LOXONIN as a reference drug. Fourteen healthy volunteers were entered to the stydy (Yonsei University College of Medicine, Severance Hospital IRB approval No. 9608). They were administered 60 mg of loxoprofen in 2$\times$2 cross-over design. There was one week of drug-free interval between doses. The blood sample was taken on schedule up to 8 hours, and the plasma concentration loxoprofen was measured by reverse phase high-performance liquid chromatography (HPLC) with UV-detector. There were no significant difference between two preparations when AUC, Cmax, and Tmax were compared by ANOVA. The mean differences of AUC, Cmax, and Tmax were within 20% of the reference drug: the values were 2.22,5.61, and 12.50%, respectively. The confidence limits of AUC and Cmax but not Tmax satisfied the bioequivalence criteria. These results suggest that the tested LENOX is bioequivalent to the reference drug.

• Korean Journal of Agricultural Science
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• v.3 no.2
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• pp.207-213
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• 1976

In order to obtain the prediction of the maximum dry density and the optimum moisture content of soil without soil moisture test, compaction test results from 157 different places either under construction or already completed were analyzed. The analyzed results were as follow The relationship between the maximum dry density and the optimum moisture content of the soil showing a correlation coefficient of 0.96 indicated that there was a high correlation between them. From the above relationship we obtained the equation, ${\gamma}_{dmax.}={\frac{1}{0.4193+0.00937W_{opt.}}$ Equation between the optimum moisture content and the maximum wet density of the soil was $W_{opt.}={\frac{0.4193{\gamma}_{tmax.}}{0.937_{\gamma}_{tmax.}-0.01}$, and the values of the optimum moisture content being predicted with the maximum wet density of the soil showed a little difference between those and tested values. The values of the maximum dry density being predicted with the moisture content estimated by the maximum wet density of the soil were within the range of ${\pm}5%$ of its tested values. The relationship between the dry density and the void ratio showed a high correlation between them (${\gamma}=0.9706$). From the above relationship, we obtained the equation, ${\gamma}_{dmax.}={\frac{1}{0.3938+0.3426e}}$.

• Proceedings of the Military Operations Research Society of Korea Conference
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• 2005.10a
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• pp.89-114
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• 2005

• Communications of the Korean Institute of Information Scientists and Engineers
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• v.25 no.1 s.212
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• pp.27-33
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• 2007

• Korea Information Processing Society Review
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• v.12 no.3
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• pp.117-124
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• 2005

• The Journal of Advanced Prosthodontics
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• v.9 no.4
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• pp.294-301
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• 2017

PURPOSE. Temperature increase of $5.5^{\circ}C$ can cause damage or necrosis of the pulp. Increasing temperature can be caused not only by mechanical factors, e.g. grinding, but also by exothermic polymerization reactions of resin materials. The aim of this study was to evaluate influences of the form material on the intrapulpal temperature during the polymerization of different self-curing resin materials for temporary restorations. MATERIALS AND METHODS. 30 provisonal bridges were made of 5 resin materials: Prevision Temp (Pre), Protemp 4 (Pro), Luxatemp Star (Lux), Structure 3 (Str) and an experimental material (Exp). Moulds made of alginate (A) and of silicone (S) and vacuum formed moulds (V) were used to build 10 bridges each on a special experimental setup. The intrapulpal temperatures of three abutment teeth (a canine, a premolar, and a molar,) were measured during the polymerization every second under isothermal conditions. Comparisons of the maximum temperature ($T_{Max}$) and the time until the maximum temperature ($t_{TMax}$) were performed using ANOVA and Tukey Test. RESULTS. Using alginate as the mould material resulted in a cooling effect for every resin material. Using the vacuum formed mould, $T_{Max}$ increased significantly compared to alginate (P<.001) and silicone (P<.001). In groups Lux, Pro, and Pre, $t_{TMax}$ increased when the vacuum formed moulds were used. In groups Exp and Str, there was no influence of the mould material on $t_{TMax}$. CONCLUSION. All of the mould materials are suitable for clinical use if the intraoral application time does not exceed the manufacturer's instructions for the resin materials.

• Journal of Veterinary Clinics
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• v.37 no.1
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• pp.28-33
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• 2020

The aims of this study were to obtain the normal ranges of enhancement parameters for salivary gland in dynamic CT and to investigate the effects of fasting time on contrast enhancement in clinically normal beagle dogs. With five healthy beagle dogs, dynamic CT examination was performed according to fasting times (as fasting times, 12hours, 0 min, 20 min, 40 min, 1 hours, 6 hours, 24 hours). In normal beagles with 12hours fasting, enhancement parameters through the preliminary study were as follows: ImaxA - 472 .49 ± 19.01 HU; ImaxS - 138.95 ± 6.2 5 HU; TmaxA - 25.8 ± 1.79 sec; TmaxS - 69.0 ± 23.11 sec; Teq - 80.5 ± 6.61 sec; T-Aeq - 54.5 ± 5.51 sec (Imax - peak enhancement; Tmax - time to peak enhancement; Teq - time to equilibrium phase; T-Aeq - time between peak enhancement in the common carotid artery and onset of the equilibrium phase; A - common carotid; S - submandibular gland; HU - Hounsfield unit). Additionally, ImaxA and ImaxS were significantly increased in 40 min after eating. Because these results associated with postprandial hemodynamic changes can make the diagnosis of salivary gland diseases more difficult, sufficient fasting time is important for accurate diagnosis.

• Journal of Korean Neurosurgical Society
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• v.62 no.6
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• pp.712-722
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• 2019

Objective : Although magnetic resonance guided focused ultrasound (MRgFUS) has been used as minimally invasive and effective neurosurgical treatment, it exhibits some limitations, mainly related to acoustic properties of the skull barrier. This study was undertaken to identify skull characteristics that contribute to optimal ultrasonic energy transmission for MRgFUS procedures. Methods : For ex vivo skull experiments, various acoustic fields were measured under different conditions, using five non-embalmed cadaver skulls. For clinical skull analyses, brain computed tomography data of 46 patients who underwent MRgFUS ablations (18 unilateral thalamotomy, nine unilateral pallidotomy, and 19 bilateral capsulotomy) were retrospectively reviewed. Patients' skull factors and sonication parameters were comparatively analyzed with respect to the cadaveric skulls. Results : Skull experiments identified three important factors related skull penetration of ultrasound, including skull density ratio (SDR), skull volume, and incidence angle of the acoustic rays against the skull surface. In clinical results, SDR and skull volume correlated with maximal temperature (Tmax) and energy requirement to achieve Tmax (p<0.05). In addition, considering the incidence angle determined by brain target location, less energy was required to reach Tmax in the central, rather than lateral targets particularly when compared between thalamotomy and capsulotomy (p<0.05). Conclusion : This study reconfirmed previously identified skull factors, including SDR and skull volume, for successful MRgFUS; it identified an additional factor, incidence angle of acoustic rays against the skull surface. To guarantee successful transcranial MRgFUS treatment without suffering these various skull issues, further technical improvements are required.