• Journal of Korean Society of Environmental Engineers
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• v.27 no.12
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• pp.1340-1346
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• 2005

A water quality modeling study was performed for Chunggye stream during combined sewer overflow(CSO) period, utilizing the diagnostic system for water management in small watershed, CREEK-1(Cyber River for Environment and Economy in Korea). This system integrated geogaphic information system, data base, landscape ecological model(FRAGSTATS), watershed model(SWMM), water quality model (WASP5), and computer graphic. In this study, the watershed model and water quality model were extensively utilized so as to simulate water qualities and flow in Chunggye stream during wet periods. The Chunggye stream watershed was divided into 18 sub-basins in the watershed model and the stream reach into 11 segments in the water quality model. The watershed model was validated against field measurements of BOD, TN, TP, and flow at the downstream location, where the model results showed a reasonable agreement with the field measurements at all parameters. From this study, it was shown that the stream water quality would change along with elapsed time from rainfall start as well as rainfall intensity. The model results indicated that the water quality would significantly upgrade due to the first flush and high sewage ratio of CSO at the beginning of rainfall event, but become degraded along with the runoff increase due to dilution effect.

• Journal of Korean Neurosurgical Society
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• v.63 no.5
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• pp.607-613
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• 2020

Objective : Spontaneous intracranial hemorrhage is a life-threatening disease, and non-lesional spontaneous intraparenchymal hemorrhage (nIPH) and aneurysmal subarachnoid hemorrhage (aSAH) are the leading causes of spontaneous intracranial hemorrhage. Only a few studies have assessed the association between prior physical activity or triggering events and the occurrence of nIPH or aSAH. The purpose of this study is to investigate the role of specific physical activities and triggering events in the occurrence of nIPH and aSAH. Methods : We retrospectively reviewed 824 consecutive patients with spontaneous intracranial hemorrhage between January 2010 and December 2018. Among the 824 patients, 132 patients were excluded due to insufficient clinical data and other etiologies of spontaneous intracranial hemorrhage. The medical records of 692 patients were reviewed, and the following parameters were assessed : age, sex, history of hypertension, smoking, history of stroke, use of antiplatelet or anticoagulation agents, season and time of onset, physical activities performed according to the metabolic equivalents, and triggering event at onset. Events that suddenly raised the blood pressure such as sudden postural changes, defecation or urination, sexual intercourse, unexpected emotional stress, sauna bath, and medical examination were defined as triggering events. These clinical data were compared between the nIPH and aSAH groups. Results : Both nIPH and aSAH most commonly occurred during non-strenuous physical activity, and there was no significant difference between the two groups (p=0.524). Thirty-two patients (6.6%) in the nIPH group and 39 patients (8.1%) in the aSAH group experienced triggering events at onset, and there was a significant difference between the two groups (p=0.034). The most common triggering events were defecation or urination in both groups. Conclusion : Specific physical activity dose no affect the incidence of nIPH and aSAH. The relationship between the occurrence of intracranial hemorrhage and triggering events is higher in aSAH than nIPH.

• The Journal of the Petrological Society of Korea
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• v.19 no.3
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• pp.199-208
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• 2010

The Cenozoic alkali basalts are distributed over Korea, both on central part as Bangnyeongdo, Ganseong, Pyeongtaek-Asan and Jogongni and also on southernmost part Jejudo. The ultramafic mantle xenoliths carried by Korean alkali basalts are spinel lherzolites. Garnet lherzolite that is more stable at the deeper level has not been reported so far, indicating that the lithospheric thickness under Korea does not reach deep enough to the stable zone of garnet lherzolite. The crustal evolution history of the Korean peninsula, at least some part of it, seemingly started since the Archean, it normally should have lithospheric thickness greater than 150 km. However, the mantle xenoliths carried by the Cenozoic alkali basalts indicate the maximum depth of origination in the much shallower range of 60-90 km. Such significantly thinner lithospheric thickness of the Korean peninsula than expected is quite similar to the case of North China Craton having lithospheric thickness of ca. 80 km in average, suggesting thinning of the lithospheric mantle in a depth scale of a few tens of kilometers during the past geologic time. The main causal events for such significant thinning of the lithospheric mantle can be continental collisional events of Paleoproterozoic and early Mesozoic similar to the case of North China Craton, which are also supported by Paleoproterozoic igneous and metamorphic events during the 1.9-2.0 Ga occurring all over the Korean peninsula and also early Mesozoic continental collisional event which has been discussed on lively arguments.

• Journal of Korean Society on Water Environment
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• v.31 no.1
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• pp.12-18
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• 2015

In this research, the hydrologic effects between a pre-existing urban landuse and low impact development (LID) applied conditions were compared and evaluated. The infiltration trench and tree box filter that were utilized in LID represent only 1% of the catchment area that they drain. Storm event monitoring were conducted from July 2010 to July 2014 on a total of 22 storm events in both LID sites. After LID, hydrological improvement was observed as the sites exhibited a delay (lag time) or reduction in the magnitude, frequency and duration of runoff and flow peaks as the rainfall progress. In addition, the maximum irreducible peak flow reduction for infiltration trench was found to be 61% and 33% for the tree box filter when rainfall was 40 mm and 30 mm, respectively. In designing LID, it is recommended to consider the storage capacity and catchment area, as well as the amount of rainfall and runoff on the site.

• Communications for Statistical Applications and Methods
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• v.18 no.5
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• pp.581-594
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• 2011

The traditional method of 3+3 standard design and model-based Bayesian continual reassessment method (CRM) are commonly used in Phase I clinical trials to identify the maximal tolerated dose(MTD) of a new drug. In this paper we review clinical examples of Phase I trials that were carried out in patients with refractory or relapsed leukemia and myelodysplastic syndrome. The recently proposed 3+1+1 design and rolling-6 design can shorten the trial duration, when a very slow accrual of patients with a simple 3+3 standard design may result in the untimely termination of trials. Too conservative approaches in determining the dose levels in Phase I clinical trials can leave clinical investigators unable to accurately determine the MTD. When determining future patient doses, the designs that use a time-to-event CRM can cooperate late toxicities by accounting for the proportion of the observation period of each enrolled patient. With the CRM design, simulations under different scenarios during the trial are important in detecting the under- or over-estimation of the initial estimate of the dose-limiting toxicity rate for each dose level. We present the advantages and drawbacks of the designs used in Phase I clinical trials for leukemia patients.

• Korean Journal of Applied Biomechanics
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• v.19 no.4
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• pp.739-748
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• 2009

The purpose of this study was to compare successful and failed trials of the dean and jerk exercise performed by an 2008 Beijing Olympic gold medalist. One successful and one failed trial of an Olympic gold medalist (2008 Beijing Olympic 77 kg event) were investigated for this study. A three-dimensional motion analysis was performed, using three digital camcorders (SF: 6Hz). The events were recorded during the 89th Korean National Athletic Games. After analyzing the jerk motion, the following results were found. The successful trial revealed a shorter performance time at Phase 1 and a longer one at Phase 3 and Phase 4 as compared to the failed trial. The vertical displacement of the knee in failed trial was lower than that m the successful one. The differences in the vertical velocity of barbell and knee between the trials were seen at Phase 3 and Phase 4. A faster COM inferior velocity was seen in the successful trial at Phase 3. A more flexed knee angle was seen in the failed trial as compared to the successful trial at E3.

• Journal of the Earthquake Engineering Society of Korea
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• v.13 no.4
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• pp.1-13
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• 2009

Liquefaction is a significant threat to structures on loose saturated sandy soil deposits in the event of an earthquake, and can often cause catastrophic damage, economic loss, and loss of life. Nevertheless, the Korean peninsula has for a long time been recognized as a safe region with respect to the hazard of liquefaction, as the peninsula is located in a moderate seismicity region, and there have been no reports of liquefaction, with the exception of references in some historical documents. However, some earthquakes that have recently occurred in different parts of the world have led to liquefaction in non-plastic silty soils, a soil type that can be found in many of the western coastal areas of Korea. In this study, we first present procedures for evaluating the liquefaction potential, and calculate the liquefaction potential index (LPI) distribution at two western coastal sites using both piezocone penetration test (CPTu) data and standard penetration test (SPT) data. The LPI is computed by integrating liquefaction potential over a depth of 20m, and provides an estimate of liquefaction-related surface damage. In addition, we compared the LPI values obtained from CPTu and SPT, respectively. Our research found that the CRR values from CPTu were lower than those from the SPT, particularly in the range between 40 and 120 for the corrected tip resistance, (qc1N)CS, from the CPTu, or in the range of CRR less than 0.23, resulting in relatively high LPI values. Moreover, it was observed that the differences in the CRR between the two methods were relatively higher for soils with high fine contents.

• Korean Journal of Social Welfare
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• v.57 no.4
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• pp.5-33
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• 2005

In order to examine the causes of the social policy changes in Korea during the late of 1990s, this study tries to compare the social policy decision-making structure between Kim Yong-Sam Government and Kim Dae-Jung Government. This study applies policy network analysis method which measures the relation and power structures of policy actors and as a result shows the characteristics of the policy making structure. Analysing the 6 policy domains and 52 policy events, this study finds that the importance and location of veto points which were created by the social policy decision processes have changed. In Korea, social policy decision processes have been produced power structures in which Ministry of Finance and Economic Planning Board have played a decisive role. In result, these executives can have controlled policy making processes and had veto power, i. e. veto points in policy decision-making structure. But, during Kim Dae-Jung government, accountability issues of financial crisis and reorganization of ministries have changed the importance and location of veto points. Pro-welfare groups of civil society got a chance to penetrate policy decision-making structure during that time. This study argues that these changes of policy decision-making structure may be associated with the social policy changes in Korea during the late of 1990s.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.3
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• pp.311-319
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• 2018

Mitochondrial calcium overload is a crucial event in determining the fate of neuronal cell survival and death, implicated in pathogenesis of neurodegenerative diseases. One of the driving forces of calcium influx into mitochondria is mitochondria membrane potential (${\Delta}{\psi}_m$). Therefore, pharmacological manipulation of ${\Delta}{\psi}_m$ can be a promising strategy to prevent neuronal cell death against brain insults. Based on these issues, we investigated here whether nobiletin, a Citrus polymethoxylated flavone, prevents neurotoxic neuronal calcium overload and cell death via regulating basal ${\Delta}{\psi}_m$ against neuronal insult in primary cortical neurons and pure brain mitochondria isolated from rat cortices. Results demonstrated that nobiletin treatment significantly increased cell viability against glutamate toxicity ($100{\mu}M$, 20 min) in primary cortical neurons. Real-time imaging-based fluorometry data reveal that nobiletin evokes partial mitochondrial depolarization in these neurons. Nobiletin markedly attenuated mitochondrial calcium overload and reactive oxygen species (ROS) generation in glutamate ($100{\mu}M$)-stimulated cortical neurons and isolated pure mitochondria exposed to high concentration of $Ca^{2+}$ ($5{\mu}M$). Nobiletin-induced partial mitochondrial depolarization in intact neurons was confirmed in isolated brain mitochondria using a fluorescence microplate reader. Nobiletin effects on basal ${\Delta}{\psi}_m$ were completely abolished in $K^+-free$ medium on pure isolated mitochondria. Taken together, results demonstrate that $K^+$ influx into mitochondria is critically involved in partial mitochondrial depolarization-related neuroprotective effect of nobiletin. Nobiletin-induced mitochondrial $K^+$ influx is probably mediated, at least in part, by activation of mitochondrial $K^+$ channels. However, further detailed studies should be conducted to determine exact molecular targets of nobiletin in mitochondria.

• Journal of Internet Computing and Services
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• v.17 no.6
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• pp.123-131
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• 2016

Process mining in big data environment utilize a number of data were generated from the business process. It generates lots of knowledge and insights regarding implementation and improvement of the process through the event log of the company's enterprise resource planning (ERP) system. In recent years, various research activities engaged with the audit work of company organizations are trying actively by using the maximum strength of the mining process. However, domestic studies on applicable sales auditing system for the process mining are insufficient under big data environment. Therefore, we propose process-mining methods that can be optimally applied to online and traditional auditing system. In advance, we propose continuous monitoring information system that can early detect and prevent the risk under the big data environment by monitoring risk factors in the organizations of enterprise. The scope of the research of this paper is to design a pre-verification system for risk factor via practical examples in sales auditing. Furthermore, realizations of preventive audit, continuous monitoring for high risk, reduction of fraud, and timely action for violation of rules are enhanced by proposed sales auditing system. According to the simulation results, avoidance of financial risks, reduction of audit period, and improvement of audit quality are represented.