• Structural Engineering and Mechanics
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• 제42권4호
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• pp.531-549
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• 2012

Numerous oil tanker losses have been reported and one of the possible causes of such casualties is caused by the structural failure of aging ship hulls in rough weather. In aging ships, corrosion and fatigue cracks are the two most important factors affecting structural safety and integrity. This research is about effect on hull girder ultimate strength behavior of double hull oil tanker according to corrosion after Part I: stiffened panel. Based on corrosion data of Part I (time-dependent corrosion wastage model and CSR corrosion model), when progressing corrosion of fourtypes of double hull oil tankers (VLCC, Suezmax, Aframax, and Panamax), the ultimate strength behavior of hull girder is compared and analyzed. In case of the ultimate strength behavior of hull girder, when occurring corrosion, the result under vertical and horizontal bending moment is analyzed. The effect of time-dependent corrosion wastage on the ultimate hull girder strength as well as the area, section modulus, and moment of inertia are also studied. The result of this research will be useful data to evaluate ultimate hull girder strength of corroded double hull oil tanker.

• 한국세라믹학회지
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• 제24권3호
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• pp.289-295
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• 1987

The changes of physical properties of portland cement pastes and mortars were investigated by addition of sodium gluconate. Flow table experiment and viscosity measurement were took in order to find dispersing effect, and time-dependent changesof viscosity and rates of hydration heat evolution were carried out for the sake of finding retardation effect of hydration. And changes of physical properties of cement pastes and mortars were discussed by setting time, compressive strength and porosity.

• Bulletin of the Korean Chemical Society
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• 제16권11호
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• pp.1113-1118
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• 1995

The Schlo'gl model with the first order transition for a photochemical reaction is considered to study the dynamic behaviors in the neighborhood of the Gaussian white noise by obtaining the explicit results of the time-dependent variance and time correlation function with the aid of approximate methods based on the stationary properties of the system. Then, we discuss the effect of external noise strength on the stability of the model at steady states in detail.

• Bulletin of the Korean Chemical Society
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• 제16권11호
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• pp.1119-1121
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• 1995

The method for the Schlo"gl model with the first order transition is extended to the Scho;gl model with the second order transition for a photochemical reaction. We obtain the explicit results of the time-dependent average and the time correlation function at the unstable steady state of the model in the neighborhood of the Gaussian white noise and then discuss the effect of noise on the dynamic properties.

• 한국식품위생안전성학회지
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• 제11권2호
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• pp.77-82
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• 1996

Green tea catechins(GTC) were studied for its inhibitory effect on human platelet aggregation in vitro, for its antithrombotic effect in mice in viro, and bleeding and clotting time in rats. The catechins were isolated and purified from green tea, which were composed of (-)-epigallocatechin gallate, (-)-epigallocatechin, (-)epicatechin gallate and (-)-epicatechin, GTC produced a potent inhibition of human platelet aggregation in a dose-dependent manner against the stimulants such as ADP, collagen, epinephrine and ristocetin n vitro. GTC also prevented death due to the formation of pulmonary thrombosis by platelet aggregates in mice in a dose-de-pendent manner in viro. GTC increased the bleeding time, whole blood clotting time and plasma clotting time in rats, too. These results suggest that GTC is a promising antithrombotic agent.

• 응용통계연구
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• 제9권1호
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• pp.125-137
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• 1996

시계열 자료는 흔히 반복되지 않는 비정상적인 사건의 영향으로 이상치를 포함한다. 시계열 자료는 관측치들 사이에 종속구조를 갖기 때문에, 이상치의 영향은 다른 통계적 분석에서 보다 더 심각할 수 있다. 본 논문에서는 연속이상치가 예측에 미치는 영향을 파악하는 데에 촛점을 두었다. 특히, l 시점 후 예측오차의 평균제곱의 증가량을 유도하고, 이 증가량으로 연속이상치가 예측에 미치는 영향을 측정하였다. 일반적으로, 연속이상치가 예측 원점에서 아주 가까운 시점에서 발생하지 않았으며 그 증가량은 크지 않음을 밝히고, 실제 자료를 분석하여 확인하였다.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2002년도 제9회 학술 발표회 프로그램과 논문초록
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• pp.41-41
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• 2002

Tolaasin, a pore-forming 1.9 kDa peptide toxin released by Pseudomonas tolaasii, produces brown blotch disease on cultivated oyster mushrooms. To investigate the mechanism of tolaasin-induced cell disruption, we studied the effect of temperature on the hemolytic process. In the kinetic analyses, single exponential function was fitted to the data obtained from temperature-dependent velocity of hemolysis(1/t$\_$50/, implying that there is a major time-limiting factor on the temperature-dependent hemolysis.(omitted)

• Journal of Acupuncture Research
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• 제18권2호
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• pp.150-160
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• 2001

Objectives ; This study was undertaken to determine whether Carthami-Flos aquacapuncture (CFA) exerts protective effect against oxidant-induced inhibition of $Na^+-K^+$-ATPase activity in cerebral synaptosomes. Methods and Results ; The enzyme activity was dependent on incubation time and enzyme protein concentrations. An oxidant t-butylhydroperoxide (tBHP) at 1 mM concentration caused a significant inhibition of $Na^+-K^+$-ATPase activity, which was prevented by addition of 0.01% CFA. tBHP inhibition and CFA protection were independent on incubation time or enzyme protein concentrations. The enzyme activity was increased by ATP in a dose dependent manner. Effects of tBHP and CFA were not affected by ATP cocentrations. tBHP (1 mM) produced a significant increase in lipid peroxidation in cerebral synaptosomes, which was prevented by 0.01% CFA. CFA decreased oxygen free radicals generated induced by the phorbol-ester in a dose-dependent manner in human neutrophil. Conclusions ; These results suggest that CFA exerts protective effect against tBHP-induced inhibition of $Na^+-K^+$-ATPase activity, which is due to by an antioxidant action resulting from a direct scavenging effect of oxygen free radicals in the cerebral synaptosomes.

• Wind and Structures
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• 제26권4호
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• pp.205-214
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• 2018

In this paper, the thermo-mechanical buckling characteristics of functionally graded (FG) size-dependent Timoshenko nanobeams subjected to an in-plane thermal loading are investigated by presenting a Navier type solution for the first time. Material properties of FG nanobeam are supposed to vary continuously along the thickness according to the power-law form and the material properties are assumed to be temperature-dependent. The small scale effect is taken into consideration based on nonlocal elasticity theory of Eringen. The nonlocal governing equations are derived based on Timoshenko beam theory through Hamilton's principle and they are solved applying analytical solution. According to the numerical results, it is revealed that the proposed modeling can provide accurate critical buckling temperature results of the FG nanobeams as compared to some cases in the literature. The detailed mathematical derivations are presented and numerical investigations are performed while the emphasis is placed on investigating the effect of the several parameters such as material distribution profile, small scale effects and aspect ratio on the critical buckling temperature of the FG nanobeams in detail. It is explicitly shown that the thermal buckling of a FG nanobeams is significantly influenced by these effects. Numerical results are presented to serve as benchmarks for future analyses of FG nanobeams.

• 약학회지
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• 제43권6호
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• pp.827-833
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• 1999

In this study, we have investigated the effect of Biphenyl Dimethyl Dicarboxylate (DDB), a synthetic analogue of Schizandrin C isolated from Schizandrae Fructus on cytochrome $P_450$ lAl and 2Bl, and the protective mechanism against $CCl_4-induced$ hepatotoxicity in rat liver. After DDB was administered into male rats for different periods of time (1~7 days) and with different doses (25, 50, 100 and 200 mg/kg), mRNA levels of CYPlAl were measured by polymearse chain reaction (PCR) and assayed the activities of CYPlAl specific ethoxyresorufin-O-dealkylase (EROD) and CYP2Bl specific benzyloxyresorufin-O-dealkylase (BROD). DDB treatment resulted in increase in CYP2Bl mRNA level and BROD activity, whereas there was no change in CYPlAl mRNA level and EROD activity. This effect of DDB was time-and dose-dependent and reached maximal level by 3 day and 200 mg/kg treatment. In addition, rats were pre-treated with DDB at doses of 25, 50 or 100 mg/kg daily for 4 days, 3-hr after final treatment on the 4th day, $CCl_4$ 0.3ml/kg was intraperitonially injected into the rats to examine the effect of DDB on $CCl_4-induced$ hepatic injury. Serum levels of ALT and AST were determined and histopathological examination was done in rat liver. Furthermore, we have measured hepatic microsomal malondialdehyde(MDA) level, a parameter of lipid peroxidation. Based on serum ALT level and lipid peroxidation, pretreatment of DDB, 50 mg/kg appeared the most protective effect against $CCl_4-induced$ heapatotoxity. These results indicate that DDB stimulates CYP2Bl mRNA level and BROD activity in time and dose dependent manner and suggest that protective effect of DDB on $CCl_4-induced$ hepatotoxicity may be mediated through free radical scavenging.