• Journal of the Korean Data and Information Science Society
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• 제24권4호
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• pp.877-883
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• 2013

The quadratic inference functions (QIF) method proposed by Qu et al. (2000) and the generalized method of moments (GMM) for marginal regression analysis of longitudinal data with time-dependent covariates proposed by Lai and Small (2007) both are the methods based on generalized method of moment (GMM) introduced by Hansen (1982) and both use generalized estimating equations (GEE). Lai and Small (2007) divided time-dependent covariates into three types such as: Type I, Type II and Type III. In this paper, we compared these methods in the case of Type II and Type III in which full covariates conditional mean assumption (FCCM) is violated and interested in whether they can improve the results of GEE with independence working correlation. We show that in the marginal regression model with Type II time-dependent covariates, GMM Type II of Lai and Small (2007) provides more ecient result than QIF and for the Type III time-dependent covariates, QIF with independence working correlation and GMM Type III methods provide the same results. Our simulation study showed the same results.

• 한국도로학회논문집
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• 제14권5호
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• pp.1-9
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• 2012

PURPOSES: A viscoelastic axisymmetric finite element analysis code has been developed for stress analysis of asphalt pavement structures. METHODS: Generalized Maxwell Model (GMM) and 4-node isoparametric element were employed for finite element formulation. The code was developed using $C^{+}^{+}$ computer program language and named as KICTPAVE. For the verification of the developed code, a structural model of a pavement system was constructed. The structural model was composed of three layers: asphalt layer, crushed stone layer, and soil subgrade. Two types of analysis were considered for the verification: (1)elastic static analysis, (2)viscoelastic time-dependent analysis. For the elastic static analysis, linear elastic material model was assigned to all the layers, and a static load was applied to the structural model. For the viscoelastic time-dependent analysis, GMM and linear elastic material model were assigned to the asphalt layer and all the other layers respectively, and a cyclic loading condition was applied to the structural model. RESULTS: The stresses and deformations from KICTPAVE were compared with those from ABAQUS. The analysis results obtained from the two codes showed good agreement in time-dependent response of the element under the loading area as well as the surface deformation of asphalt layer, and horizontal and vertical stresses along the axisymmetric axis. CONCLUSIONS: The validity of KICTPAVE was confirmed by showing the agreement of the analysis results from the two codes.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.214.1-214.1
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• 2003

Metabonomic analysis using Liquid Chromatography-Mass Spectrometry (LC-MS) was employed to test the feasibility to predict chemical-induced toxicity. Time-dependent metabolic variations were evaluated in rats treated with the model hepatotoxin, ${\alpha}$- naphthylisothiocyanate (ANIT). Urine samples of ANIT treated group and control group were collected up to 7 days postdose. Urine samples were analyzed by gradient HPLC combined with electrospray mass spectrometry. The chromatographic results were data-reduced and analyzed using principal component analysis to show the time dependent biochemical variations induced by ANIT toxicity. (omitted)

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1996년도 가을 학술발표회 논문집
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• pp.473-479
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• 1996

Until now, we assumed in the time-dependent analysis of concrete structure that tensile creep has same characteristics as compressive creep has. But, in according to results of researches, it appears that tensile creep is different from compressive creep in quantity and in mechanics because tensile creep is affected significantly by micro cracking. The test results indicate that the creep behavior of concrete in compression and tension is rather different. The test data shows that the amount of creep under tensile loading is larger than that under compressive loading. In this paper, a realistic tensile creep model is suggested and incorporated in the formulation. In order to get more accurate results of time-dependent analysis. The present study indicates that the long-term deflection of concrete structures under realistic tensile creep model is somewhat larger than that under ordinary compressive creep model.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 1999년도 추계 학술발표회 논문집 Proceedings of EESK Conference-Fall
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• pp.107-112
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• 1999

This paper presents a time domain method for soil-structure interaction analysis for seismic loadings. It is based on the finite element formulation incorporating analytical frequency-dependent infinite elements for the far-field soil. The dynamic stiffness matrices of the far-field region formulated in frequency domain using the present method can be easily transformed into the corresponding matrices in time domain. Hence the response can be analytical computed in time domain. Example analysis has been carried out to verify the present method for an embedded block in a multi-layered half-space. The present methods can be easily extended to the nonlinear analysis since the response analysis is carried out in time domain.

• 대한한방부인과학회지
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• 제18권1호
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• pp.181-191
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• 2005

Purpose : ${\beta}$-sitosterol is kind of phytosterols or plant which are structurally similar to cholesterol. This study was aimed to investigate the inhibitory effect of the ${\beta}$-sitosterol on the proliferation of human uterine leiomyoma cells and the expression of gene related the mechanism of cell apoptosis. Methods : We counted the number of death cells treated with indicated time of the ${\beta}$-sitosterol and investigated cell death rate by cell count assay. Furthermore, flow cytometry analysis and DNA fragmentation assay were used to dissect between necrosis and apoptosis. and then we observed the differential gene expression by western blot analysis. Results : 1) The inhibitory effect on the growth of uterine leiomyoma cell treated with the ${\beta}$-sitosterol $16{\mu}M$ was increased in a time dependent. 2) The result of flow cytometry analysis, subG1 phase arrest related cell apoptosis was investigated 16.97% in uterine leiomyoma cell treated with the ${\beta}$-sitosterol $16{\mu}M$ and showed the fashion of proportional time dependent. 3) The gene expression of p27, p21 related cell cycle was increased according to increasing time interval but cyclin E-CDK2 complex was decreased expression. 4) The character of apoptosis, DNA fragmentation was significantly observed on the time dependent. 5) The expression of pro-caspase 3 and PARP were decreased dependent on treatment with time dependent. Conclusion : This study showed that the ${\beta}$-sitosterol have the inhibitory effect on the proliferation of human uterine leiomyoma cell and the effect was related with apoptosis.

• Structural Engineering and Mechanics
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• 제53권6호
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• pp.1167-1182
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• 2015

In this study, the stresses and electric potential redistributions of a cylinder made from functionally graded piezoelectric material (FGPM) are investigated. All the mechanical, thermal and piezoelectric properties are modeled as power-law distribution of volume fraction. Using the coupled electro-thermo-mechanical relations, strain-displacement relations, Maxwell and equilibrium equations are obtained including the time dependent creep strains. Creep strains are time, temperature and stress dependent, the closed form solution cannot be found for this constitutive differential equation. A semi-analytical method in conjunction with the Mendelson method of successive approximation is therefore proposed for this analysis. Similar to the radial stress histories, electric potentials increase with time, because the latter is induced by the former during creep deformation of the cylinder, justifying industrial application of such a material as efficient actuators and sensors.

• Coupled systems mechanics
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• 제11권6호
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• pp.543-556
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• 2022

Delamination of multilayered inhomogeneous beam that exhibits non-linear relaxation behavior is analyzed in the present paper. The layers are inhomogeneous in the thickness direction. The dealamination crack is located symmetrically with respect to the mid-span. The relaxation is treated by applying a non-linear stress-straintime constitutive relation. The material properties which are involved in the constitutive relation are distributed continuously along the thickness direction of the layer. The delamination is analyzed by applying the J-integral approach. A time-dependent solution to the J-integral that accounts for the non-linear relaxation behavior is derived. The delamination is studied also in terms of the time-dependent strain energy release rate. The balance of the energy is analyzed in order to obtain a non-linear time-dependent solution to the strain energy release rate. The fact that the strain energy release rate is identical with the J-integral value proves the correctness of the non-linear solutions derived in the present paper. The variation of the J-integral value with time due to the non-linear relaxation behavior is evaluated by applying the solution derived.

• 한국전산구조공학회논문집
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• 제37권1호
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• pp.25-31
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• 2024

본 논문에서는 시간 의존적 거동을 고려하기 위한 크리프 거동 해석과 비탄성 해석법을 통해 기존의 설계기준 보다 정확하고 전 시간 단계에서의 CFT 기둥의 해석을 가능하게 하는 수치 해석 모델을 제안하고, 기존의 CFT 기둥에 수행된 실험 결과와 비교하였다. 그 결과 본 논문에서 제안된 수치 해석 모델의 결과가 기존의 설계 기준의 결과보다 정확한 추세를 나타낸다는 것을 파악 할 수 있었다. 검증 이후 세장비에 따른 수치 해석을 수행하여 전반적인 CFT 기둥 부재의 단기 및 장기 지속 하중 거동에 대한 극한 하중의 정도를 확인하였다.

• Structural Engineering and Mechanics
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• 제38권2호
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• pp.171-193
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• 2011

One of the possible alternatives of simulation-based time-dependent reliability assessment of pre-stressed biconcave and biconvex cable trusses, the Monte Carlo method, is applied in this paper. The influence of an excessive deflection of cable truss (caused by creep of cables and rheologic changes) on its time-dependent serviceability is investigated. Attention is given to the definition of the basic random variables and their statistical functions (basic, mutually dependent random variables such as the pre-stressing forces of the bottom and top cable, structural geometry, the Young's modulus of elasticity of the cables, and the independent variables, such as permanent load, wind, snow and thermal actions). Then, the determination of the response of the cable truss to the loading effects, and the definition of the limiting values considering serviceability of the structure are performed. The potential of the method, using direct Monte Carlo technique for simulation-based time-dependent reliability assessment as a powerful tool, is emphasized. Results obtained by the First order reliability method (FORM) are compared with those obtained by the Monte Carlo simulation technique.